Sumitomo Chemical (United States)

São limitadas as informações sobre a atividade residual de herbicidas aplicados no controle das soqueiras do algodoeiro e o seu potencial para afetar o desenvolvimento e a produtividade do milho semeado na safra seguinte. O objetivo desse trabalho foi identificar o efeito carryover promovido pela aplicação única e sequencial de herbicidas utilizados no controle das soqueiras do algodoeiro e estimar o intervalo de segurança entre o manejo químico da soqueira do algodoeiro e a semeadura do milho. Foram conduzidos simultaneamente dois experimentos em casa de vegetação, um para aplicação única e outro para aplicação sequencial dos tratamentos herbicidas. Os experimentos foram instalados em esquema fatorial 15 x 5, delineados em blocos casualizados com quatro repetições. O primeiro fator foi composto por tratamentos herbicidas e o segundo fator por cinco épocas de semeadura do milho após a aplicação (0, 30, 60, 90 e 120 dias). As parcelas experimentais foram compostas de vasos plásticos com capacidade para 3 dm3 preenchidos com solo de textura argilosa (470 g kg-1 de argila), seco e peneirado. Os herbicidas utilizados foram 2,4-D, glyphosate, saflufenacil, [imazapic+imazapyr], dicamba, fluroxypyr e sulfentrazone. Conclui-se que a aplicação sequencial da maioria dos tratamentos proporcionou um aumento na atividade residual dos herbicidas avaliados. Os tratamentos 2,4-D (1340 g ha-1), 2,4-D + glyphosate (1340 + 720 g ha-1) e 2,4-D + glyphosate + saflufenacil (1340 + 720 + 105 g ha-1) apresentaram os menores intervalos de segurança e foram aqueles que apresentaram o menor risco de afetar o milho semeado em sucessão, mesmo em aplicações sequenciais. Contudo, os tratamentos constituídos pela associação com herbicidas de maior atividade residual no solo como o dicamba, fluroxypyr, sulfentrazone e [imazapic+imazapyr], apresentaram maior potencial de carryover para a cultura do milho, sendo observado intervalo de segurança superior a 94 dias após a aplicação sequencial de 2,4-D + glyphosate + sulfentrazone.

This research has explored the creation process of new business models and the role of organisation in that process, in order to enhance the knowledge about how to create a new business model effectively. The multiple case-study method was applied to this research. The samples are four new business models which have been developed at a SOGO-SHOSYA, a Japanese company in recent years. We found that the creation process of a new business model is entrepreneurial process in all the cases and that those entrepreneurial activities are conducted based on not the Schumpeterian but the Kirznerian theory. We also found that there are common management practices to encourage Kirznerian entrepreneurship, which led to the creation of the new business models. Based on those findings, we have proposed propositions on how to create a new business model effectively.

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A new pyrrolinone compound, methyl 1-[1-(3,5-dichlorophenyl)-1-methylethyl]-2,3-dihydro-4-methyl-2-oxo-3-phenyl-1H-pyrrole-3-carboxylate (PC-1), has herbicidal activity against early watergrass (Echinochloa oryzicola). This compound showed good selectivity between rice (Oryza sativa) and early watergrass due to the introduction of a methoxycarbonyl group into the pyrrolinone structure. To elucidate the mechanism of PC-1's phytotoxicity, the effects of esterase inhibitors (triphenyl phosphate, tributyl phosphate and fenitrothion) and a cytochrome P450 monooxygenase inhibitor (1-aminobenzotriazole) on the actions of PC-1 were examined. Triphenyl phosphate and fenitrothion reduced the phytotoxicity of PC-1 in hydroponics and greenhouse tests. Porcine liver esterase converted PC-1 to 1-[1-(3,5-dichlorophenyl)-1-methylethyl]-4-methyl-3-phenyl-3-pyrrolin-2-one (PC-2) and this reaction was inhibited by triphenyl phosphate. The PC-2 content of early watergrass treated with PC-1 was 4 times that of rice. These results suggest that PC-1 is a prodrug and is converted to PC-2 by esterase, and that the amount of PC-2 produced in PC-1-treated plants is related to the sensitivity of early watergrass and rice to PC-1. © Pesticide Science Society of Japan

We have examined aspects of the development of telemedicine and telecare in Japan. Despite Japan's reputation as an integrated and technocratic country, the diffusion of telemedicine has fallen below expectations, notwithstanding the urgent need to solve the problems of an ageing society. There has been a fragmentation of objectives and perspectives within the corporate (manufacturing) sector and within the policy sector of central and local government. There has also been a broader fragmentation between manufacturers, government and users (doctors and hospitals). As a result, the success or failure of individual projects appears to depend not on the quality of the technology, and often not on the evident importance of the social need, but on the overall coherence of a complex socio-technical system.

The antagonism of the antipseudomonal activity of ceftazidime by meropenem (1a) was much less than those by imipenem (2a) and panipenem (2b). To reveal the major structural features of carbapenem compounds responsible for the antagonism, we investigated the structure-activity relationships of carbapenems to their antagonism of the antipseudomonal activity of ceftazidime and to their beta-lactamase-inducibility in P. aeruginosa. The antagonistic effect of 1a was less than that of desmethyl-meropenem (1b). Two other meropenem-analogues (3, 4), with the highly basic C-2 side chain, showed greater antagonistic effects than that of 1a, which has a weakly basic C-2 side chain. The beta-lactamase-inducibility of 1a in P. aeruginosa was lower than those of 2a, 1b and 4. These results indicated that the antagonism of the antipseudomonal activity of ceftazidime by carbapenems was due to the induction of beta-lactamase in P. aeruginosa. As a result of the study on the structure-activity relationships, we clarified that the introduction of a 1beta-methyl group and/or the reduction of the basicity (cationic character) of the C-2 side chain in carbapenem skeleton decreased the antagonistic effect of carbapenems on the antipseudomonal activity of ceftazidime resulted mainly from the decreasing the beta-lactamase inducibility.

Previously, we described the synthesis and biological properties ofcarbapenem compounds having a 5'-aminocarbonyl pyrrolidin-3'-ylthio group as C-2 side chain and demonstrated that meropenem (MEPM) having a ljS-methyl group and the 5/-dimethylaminocarbonyl-2pyrrolidinylthio group exhibits an extended antibacterial spectrum including anti-pseudomonal activity and high stability to renal dehydropeptidase-I (DHP-I)1}.So far, only two other carbapenems, imipenem (IPM) and panipenem (PAPM), have been approved for clinical use.The structure of MEPM differs from that of IPMand PAPMby the presence of a l/J-methyl group and the basicity of the amino group in the C-2 side chain.The basicity of MEPM is much lower than that of IPM and PAPM2~4), therefore, its physicochemical properties differ from those of the others.Wehave shown that the basicity of the C-2 side chain, but not the presence of a ljS-methyl group, correlates with their degree of

Essential hypertension is one of the most common diseases that exacerbate the risk of cardiovascular or cerebrovascular attacks. Although the etiology of essential hypertension remains unclear, recent investigations have revealed that an enhancement of Na(+)-proton (Na(+)-H+) exchange activity is a frequently observed ion transport abnormality in hypertensive patients and animal models. To test the hypothesis that increased Na(+)-H+ exchange causes hypertension, we produced transgenic mice overexpressing Na(+)-H+ exchanger and analyzed their Na+ metabolism and blood pressure. Urinary excretion of water and Na+ was significantly decreased in transgenic mice, and systolic blood pressure was elevated after salt loading. The impaired urinary excretion of Na+ suggested that the Na(+)-H+ exchanger overexpressed in the renal tubules increased reabsorption of Na+, which caused a blood pressure elevation by Na+ retention after excessive salt intake. Our results demonstrate that overexpression of Na(+)-H+ exchanger can be a genetic factor that interacts with excessive salt intake and causes salt-sensitive blood pressure elevation.