Teledyne Princeton Instruments (United States)

Achieving bright and long-lived emission with π-conjugated organic chromophores in the solid state presents a significant challenge but also an opportunity for applications ranging from nanoscale electronics to heterogeneous photocatalysis. Tetraryl[n]cumulenes, organic molecules consisting of three or more cumulative double bonds, are highly modular systems with tunable redox and optoelectronic properties, yet their utility remains limited due to rapid quenching from aryl group planarization or excimer formation. Herein, we demonstrate that the incorporation of a tetraryl[3]cumulene-based organic linker within the metal-organic framework (MOF) CORN-MOF-9 (CORN = Cornell University) suppresses these quenching pathways, allowing for bright and long-lived emission. Extensive transient absorption (TA) and photoluminescence (PL) spectroscopic studies support the unique properties of the MOF and also confirm it exhibits spectral diffusion, leading to red-shifted steady-state emission compared to molecular analogs in solution. Overall, our findings represent a new avenue to unlock the promising photochemical properties of cumulenes within materials platforms, paving the way for their use in various applications. Introduction.

Many fields or disciplines (e.g., uncertainty analysis in measurement science) require a combination of probability distributions. This technical note examines three methods for combining probability distributions: weighted linear pooling, geometric pooling, and the law of combination of distributions (LCD). Although these methods have been discussed in the literature, a systematic comparison of them appears insufficient. In particular, there is no discussion in the literature regarding the potential information loss that these methods may cause. This technical note aims to fill this gap. It provides insights into these three methods under the normality assumption. It shows that the weighted linear pooling method preserves all the variability (including heterogeneity) information in the original distributions; neither the geometric pooling method nor the LCD method preserves all the variability information, leading to information loss. We propose an index for measuring the information loss of a method with respect to the weighted linear pooling method. This technical note also shows that the weighted linear pooling method can be used as an alternative to the traditional random-effects meta-analysis. Three examples are presented: the combination of two normal distributions, the combination of three discrete distributions, and the determination of the Newtonian constant of gravitation.

Teledyne Digital Imaging has a long history of providing state-of-the-art sensors for both ground and space astronomy applications spanning visible to mid-infrared wavelengths. This paper provides an overview on recent technical developments of the COSMOS large format 8k x 8k deeply cooled CMOS camera for ground-based astronomy. Salient features of the custom back illuminated sensor developed for this camera are presented, including having a 10μm pixel pitch with dual conversion gain HDR (>100dB), very low temporal noise (< 1 e- rms) and dark current (<0.05 e-/p/s at - 25°C), greater than 90% quantum efficiency, as well as excellent linearity and response uniformity required for astronomy applications. The readout channel in the 64Mpixel sensor utilized in COSMOS consists of column-parallel two-stage oversampled analog-to-digital converters with programmable resolution from 14-to-16 bit output with 5 us row conversion time in 14- bit. While internal on-chip CDS is utilized to achieve nominal temporal noise values of 1.8e_rms with rolling shutter, external CDS with multi-sampling (CMS) further reduces temporal noise to sub-electron levels and when combined with dual conversion gain HDR readout, dynamic range of over 100dB is realized in a single exposure. The sensor and accompanied ceramic package having a 24 cm diagonal dimension are situated inside a permanently sealed light-weighted high-vacuum chamber thermally connected in parallel to 4 multi-stage TE coolers which are capable of cooling the sensor to < -40 °C in low power mode.

A growing number of increasingly complex instruments have been integrated into autonomous underwater vehicles over the past two decades. While these newly glider integrated sensors provide unprecedented insight into ocean processes, the large data volumes collected by these instruments cannot be efficiently telemetered to shore. Shoreside processing is not possible until after recovery and the use of these data for realtime applications is limited. If vehicles are lost during challenging conditions, or in denied areas, no useful data will be recovered. Thus, there is a need for a sensor agnostic real-time processing software and hardware architecture for autonomous underwater vehicles. The findings detailed here describe initial results from the development and testing of an acoustic Doppler current profiler (ADCP) linear inversion algorithm that will serve as the first test case for the implementation of real-time data processing system onboard a Slocum glider. A new Teledyne RD Instruments Pathfinder ADCP mounted on Slocum glider RU33 and deployed off the coast of New Jersey near a moored buoy with downward looking ADCP. Though quality controls steps and several derived parameters warrant further analysis, initial results from the linear inversion algorithm are highly correlated with the buoy current measurements.

The philosophy of Enterprise Security Risk Management (ESRM) drives a risk-based approach to managing any security risks, physical or logical and holistically applies to every security process. There are globally established risk principles that are common among any developed risk management standard. This model associates the relationship of risk principles to the practice of managing security risks. The ESRM processes, when successfully and consistently adapted to a security program, will define what a progressive security program looks like, drive strategic through initiatives, build the business understanding of security’s role to develop a budgeting strategy, and initiate board-level, risk-based reporting. The management security leader's role in ESRM is to manage risks and unthinkable harm to enterprise assets and stockholder in partnership with the business leaders whose assets are exposed to those risks management. ESRM is part of educating business leaders on the realistic of impacts. These identified risks, presenting any potential strategies to mitigate those impacts, and enacting the option chosen by the business in line with acceptable levels of business risk tolerance. The present data should be used to showcase how our service helps identify, evaluate, and mitigate risks at face value that would be detrimental to a company’s long-term prosperity. We need to show how using our security risk management will ultimately benefit the company's work by improving policies and procedures and reducing other expenses through the use of risk principles management.

The quality of data generated for the analysis of environmental samples is critical to State and Federal regulatory agencies to ensure that decisions based upon the amounts of contaminants in environmental samples are truly protective of public health. The quality and validation of these measurements using the approved analytical methodology could be significantly enhanced by incorporating certified reference materials as part of the quality control protocols, yet this has not been widely implemented. Data from certified reference materials can provide critical information that can impact assessments regarding data use that is unavailable by other means. Using the analysis of Cr(vi) in soil extracts as the test case, some of the issues surrounding the use of certified reference materials for environmental applications are discussed in this paper, including the relative cost, and the availability and applicability regarding element coverage and content.

BackgroundA poorly understood protein‐losing enteropathy (PLE) disorder has been reported in Yorkshire Terrier dogs.ObjectivesTo describe clinical features, intestinal histopathology, and outcome in Yorkshire Terrier dogs with PLE, and to identify variables predictive of outcome.AnimalsThirty client‐owned Yorkshire Terrier dogs with PLE.MethodsRetrospective study. Records of dogs with a diagnosis of PLE were reviewed. Intestinal histopathology was interpreted using the World Small Animal Veterinary Association gastrointestinal histopathology classification system. Discriminate analysis techniques were used to identify variables predictive of outcome.ResultsFemales outnumbered males (20/30). Median age was 7 years (range 1–12). Common clinical signs were diarrhea (20/30), vomiting (11), ascites and abdominal distension (11), and respiratory difficulty (8). Histopathologic abnormalities included villous lymphatic dilatation, crypt lesions, villous stunting, and variable increases in cellularity of the lamina propria. All dogs were treated with glucocorticoids. Of 23 dogs with long‐term follow‐up, 9 had complete, and 3 had partial, resolution of signs, and 11 failed to respond to treatment. Median survival of responders was 44 months and of nonresponders was 12 months, with 4 dogs experiencing peracute death. Vomiting, monocytosis, severity of hypoalbuminemia, low blood urea nitrogen concentration, and villous blunting were predictive of survival <4 months.ConclusionsIn addition to classic GI signs, Yorkshire Terriers with PLE often show clinical signs associated with hypoalbuminemia and low oncotic pressure. Lymphatic dilatation, crypt lesions, and villous stunting are consistent histopathologic findings. Clinical outcomes are variable, but many dogs experience remission of clinical signs and prolonged survival.

It is proposed that the normal particle states of matter and antimatter has identical twin states with reversed negative quantities, including time-reversal. These negative-valued particles will be referred to as anti-matter and anti-antimatter to differentiate them from normal particles.

Electron multiplying CCDs have revolutionized the world of low light imaging by bringing improved detection limits along with high readout rates; however, it remains to be seen whether they offer any benefits to the world of spectroscopy. Here we review the performance of current CCD and EMCCD detectors and compare their performance for low light level spectroscopy applications. In particular, we look at the detection limits of both technologies for real applications and examine all the parameters that affect these limits in a practical situation. We compare sensitivities, dark signal, noise factors and readout noise with the latter two as the ultimate limitations for detection. We also look at emerging new technology for low light spectroscopy applications which optimizes the parameters discussed without the disadvantages of the current technologies. Theoretical signal to noise data comparing conventional CCD and EMCCD technologies is presented and discussed. Experimental signal to noise comparisons are made for Raman spectra obtained using both conventional and electron multiplying CCDs in conjunction with a confocal Raman microscope. It is concluded that traditional CCDs have a superior detection limit and equal sensitivity to that of EMCCDs and are far superior for high quality quantitative data measurements.