Telio (Norway)

To identify BKPyV, the VP1 protein sequence was analyzed and classified into genotypes in 246 RTRs before and after RTx from deceased donors during a one-year observation period. Quantitative assessment of BKPyV was conducted via qPCR. Prior to RTx, genotypes I and IV were identified in the urine (7.27 × 106; 1.20 × 105) and in serum (5.75 × 104; 1.12 × 104). After RTx, genotype I was predominant; identification of DNAuria-BKPyV (62.07%) and BKPyV-DNAemia (55.56%) peaked after three months, and the highest DNAuria-BKPyV titer was also observed after three months (6.48 × 109), whereas the BKPyV-DNAemia titer did not peak until after six months (2.21 × 107). The highest number of copies of genotype IV in the urine was observed after six months (9.54 × 109), while the highest titer in the serum was not observed until after 12 months (3.88 × 106). DNAuria-BKPyV precedes BKPyV-DNAemia, affects a larger group of patients, and has a greater and more easily detected viral load, which makes it not only an earlier marker, but the key predictive marker of greater clinical value than later detection of BKPyV-DNAemia alone. Early monitoring of DNAuria-BKPyV should be the basis of classical screening, and not merely an addition to it, and therapeutic interventions should be undertaken early to prevent nephropathy.

Kunstig intelligens (KI) er i ferd med å radikalt endre hvordan folk jobber og løser problemer i organisasjoner – og ikke minst hvordan man tar beslutninger. Ny forskning viser imidlertid at det store flertallet av KI-prosjekter ikke blir satt i drift og brukt. I denne studien undersøker vi hvordan elleve norske og internasjonale KI-prosjekter gjennomføres for å støtte operasjonelle beslutninger. Vi identifiserer de viktigste praksisene, de mest fremtredende fallgruvene og de mest avgjørende suksessfaktorene basert på en kvalitativ analyse av 28 intervjuer fra organisasjoner som har implementert KI. Funnene indikerer at å lykkes med KI krever grundig problemforståelse, et godt datagrunnlag, tålmodighet, samarbeid og bygging av tillit til systemet. Ved å følge disse prinsippene kan organisasjoner øke sannsynligheten for å realisere verdien av KI. Studien konkluderer med at KI riktig implementert kan støtte og forbedre menneskelige beslutningsprosesser og dermed fremme mer bærekraftige og effektive beslutninger i organisasjoner. English abstract How to Develop and Implement Artificial Intelligence for Smarter Organizational Decision-Making Artificial intelligence (AI) is radically changing how people work and solve problems in organizations, not to mention how decisions are made. However, new research shows that the vast majority of AI projects are not put into operation and used. In this study, we examine how 11 Norwegian and international AI projects are conducted to support operational decisions. We identify the most important practices, most prominent pitfalls, and the key success factors based on a qualitative analysis of 28 interviews with organizations that have implemented AI. The findings indicate that succeeding with AI requires thorough problem understanding, a solid data foundation, patience, collaboration, and building trust in the system. By following these principles, organizations can increase the likelihood of realizing the value of AI. The study concludes that AI, when properly implemented, can support and enhance human decision-making processes, thereby promoting more sustainable and effective decisions in organizations.

Υπάρχουν εννοιακές μεταφορές που προκύπτουν από εικονιστικά σχήματα [Johnson 1987], τα οποία είναι επαναλαμβανόμενα μοτίβα που βασίζονται στις σωματικές-αντιληπτικές-κινητικές εμπειρίες των ομιλητών και λειτουργούν ως εννοιακές πηγές για την προσέγγιση και την οργάνωση των εμπειριών και την κατανόηση και την ερμηνεία των εννοιακών στόχων. Ένα εικονιστικό σχήμα μπορεί να συνδυαστεί με άλλα ανεξάρτητα εικονιστικά σχήματα ή να εμπλουτιστεί από άλλα εξαρτώμενα σχήματα. Ένα πολύπλοκο-σύνθετο εικονιστικό σχήμα που προκύπτει από τον συνδυασμό δύο ανεξάρτητων σχημάτων (της ΠΟΡΕΙΑΣ και του ΠΕΡΙΕΚΤΗ) είναι εκείνο της ΕΚΠΟΜΠΗΣ. Στο επίκεντρο του άρθρου βρίσκονται τρεις γλωσσικές μεταφορές που προκύπτουν από αυτό το σχήμα και οι οποίες εντοπίζονται στις τραγωδίες Οἰδίπους ἐπί Κολωνῷ («οὐ γὰρ αὐδᾶν ἡδὺ τἀκίνητ᾽ ἔπη» 624) και Ἀντιγόνη («ὄρσεις με τἀκίνητα διὰ φρενῶν φράσαι» 1060, «κίνει» 1061) του Σοφοκλή.

Sensitivity assessment of 300 Cercospora beticola isolates collected from North Greece revealed that 38% of the population was highly resistant to at least one of the demethylase inhibitors (DMIs) difenoconazole, epoxiconazole and flutriafol. Resistance factors greater than 50, 100 and 100 were calculated for the most resistant C. beticola isolates to flutriafol, epoxiconazole and difenoconazole, respectively. DMI-resistant isolates carried fitness penalties in terms of mycelial growth, sporulation and pathogenicity, probably accounting for their low frequencies in the field. Pearson correlation analysis revealed a positive cross-resistance relationship between all three DMIs tested suggesting the existence of a target-gene (CbCyp51) related resistance mechanism in the observed phenotypes. Sequence analysis of the CbCyp51 gene from sensitive and DMI-resistant isolates revealed a novel mutation (E149K) present only in C. beticola isolates resistant to all three fungicides tested. To the best of the author's knowledge, this is the first report of this target-site mutation associated with high resistance levels to all flutriafol, epoxiconazole and difenoconazole fungicides. No target-site mutations were found in the rest of DMI-resistance phenotypes. A compound-specific induced CbCyp51 overexpression was observed in C. beticola isolates with specific resistance to flutriafol, epoxiconazole, and difenoconazole, while no indication of constitutive overexpression was found. Overall, the results of the present study provide insights on the mechanisms responsible for the occurrence of high DMI-resistance in the field and a basis for establishing effective strategies for the control of C. beticola in sugar beet fields in Greece.

This review summarises the current research on Welsh speakers’ experiences accessing mental health support. Identified themes include identity, the therapeutic relationship, lack of resources and lack of awareness of Welsh culture and language.

Paragangliomas are rare neuroendocrine tumors originating from paraganglionic cells in the autonomic nervous system and which are capable of secreting catecholamines and causing hypertensive crises. Although typically benign, they can exhibit aggressive features and present with varied clinical manifestations depending on location and catecholamine activity. Herein, we report an unusual case of a 28-year-old male who initially presented with bilateral grade IV hypertensive retinopathy, an uncommon initial manifestation of paraganglioma. Fundus examination revealed severe hypertensive retinopathy with exudative retinal detachment. Laboratory evaluation demonstrated markedly elevated plasma and urinary catecholamines and metanephrines. Imaging, including computed tomography (CT) and iodine-123 metaiodobenzylguanidine (MIBG) scintigraphy, confirmed a highly vascularized mass near the left adrenal gland, consistent with extra-adrenal paraganglioma. The patient's hypertension was medically stabilized prior to successful surgical tumor resection. Postoperatively, blood pressure normalized without medication, and significant improvement was observed in retinal findings, including resolution of disc edema and macular exudates. This case highlights the importance of considering paraganglioma in the differential diagnosis of malignant hypertension with ocular involvement, even when typical systemic symptoms of catecholamine excess are absent. Prompt recognition and intervention can lead to favorable visual and systemic outcomes.

Η εισαγωγή θεμάτων της σύγχρονης φυσικής στο λύκειο είναι ένα από τα ζητούμενα στη Διδακτική της Φυσικής μιας και υπάρχουν έρευνες που δείχνουν ότι η ενσωμάτωσή της στα προγράμματα σπουδών αυξάνει το ενδιαφέρον των μαθητών. Η Σωματιδιακή Φυσική αποτελεί βασικό κομμάτι της σύγχρονης φυσικής και η εισαγωγή της στο λύκειο μέσω μιας Διδακτικής Μαθησιακής Ακολουθίας έχει ως στόχο να γεφυρώσει την κλασική και την σύγχρονη φυσική.

Η χρήση σύγχρονης τεχνολογίας, εστιασμένη στον τομέα των φυσικών επιστημών, αποκτά ιδιαίτερο ενδιαφέρον όταν απευθύνεται σε μαθητές με Διαταραχή Αυτιστικού Φάσματος μέσα από εκπαιδευτικές δραστηριότητες συμπεριληπτικού προσανατολισμού. Υπό αυτό το πρίσμα, σχεδιάστηκε, αναπτύχθηκε και υλοποιήθηκε ένα εκπαιδευτικό ψηφιακό λογισμικό με στόχο τη διδασκαλία βασικών εννοιών μηχανικής χρησιμοποιώντας συνεργατικά μοντέλα ανάμεσα σε μαθητές τυπικής ανάπτυξης και μαθητές με ΔΑΦ, Ε΄ και ΣΤ΄ Δημοτικού. Τα αποτελέσματα της έρευνας ανέδειξαν την θετική συμβολή του συγκεκριμένου ψηφιακού εργαλείου αφενός στην ουσιαστικότερη κατανόηση εννοιών μηχανικής και αφετέρου στην καλλιέργεια των ελλειμματικών κοινωνικών χαρακτηριστικών των μαθητών της οικίας διαταραχής.

Η μελέτη που παρουσιάζεται αποτελεί μέρος διδακτορικής διατριβής, η οποία έχει ως στόχο να αναδείξει και να κάνει ορατές τις διαδικασίες μάθησης και ανάπτυξης των παιδιών προσχολικής ηλικίας στις φυσικές επιστήμες. Σκοπός είναι, να προσφέρει νέους και συστηματικούς τρόπους για να γίνουν ορατά και να χαρτογραφηθούν τα εξατομικευμένα «μαθησιακά μονοπάτια» των μικρών παιδιών κατά τη διάρκεια του επιστημονικού παιχνιδιού σε συνθήκες τάξεις. Παρουσιάζονται, αναλύονται και ερμηνεύονται εμπειρικά δεδομένα από