Terumo (Germany)

Calculating the collection efficiency (CE) of CD34+ cells in leukocytapheresis (LVL) is critical to understanding the performance of cell collection. Traditional CE values are typically based on both pre- and post-apheresis calculations of the pooled cells (CE1), or they may be based only on the pre-procedure pool calculation (CE2) and total blood volume (TBV) processed. However, determining the actual CD34+ concentration in peripheral blood (PB) during LVL is more problematic. New crude CE (CruCE) takes into account the recruitment and extraction of CD34+ cells during LVL. This study aims to retrospectively compare traditional (CE2, CE1) and CruCE and to assess the variables that influence new CruCE-including donor characteristics, procedure characteristics, and device setting parameters-in both large-volume LVL and non-LVL. Data from adult donors who underwent autologous and allogeneic collections of PB stem cells between January 2020 and April 2023 were retrospectively included. Our series comprises 123 autologous and 37 allogeneic LVL procedures. The median of CD34+ CE2, CE1, and CruCE was 51%, 65%, and 74% in autologous donors and 58%, 69%, and 76% in allogeneic donors. In multivariate analysis, TBV processed and prior CD34+ cell count in PB showed a positive and a negative correlation with CruCE in autologous and allogeneic settings, respectively. In conclusion, CruCE may be closer to actual CE in comparison to CE2 and CE1. LVL and low CD34+/μL prior to the procedure may enhance CD34+ cell CE.

This study proposes a dynamic capability modeling method based on AIGC, grounded in the theoretical framework of key capabilities. By leveraging large language models to analyze e-commerce job data from recruitment platforms, the method can extract and categorize core capabilities while simultaneously identifying emerging ones. Dynamic updates of the capability model are achieved through parameter fine-tuning and continuous model optimization, thereby improving its adaptability and accuracy. Beyond the e-commerce sector, this method can also provide valuable insights for recruitment and training in other industries, as well as for talent development in higher education institutions.

テルモ株式会社で製造販売している輸液剤について，取り違えリスクの低減につながるような確認しやすい表示デザインを検討した．看護師にとって確認しやすいかを検証するため，使用される頻度が比較的高い輸液剤10製品を対象に，現在販売している表示デザイン（以下，「従来の表示」）と新規に設定した表示デザイン（以下，「新表示」）を比較した．看護師11名を対象に指示箋と輸液剤の確認課題を与え，誤認の有無，視線情報，確認時間，主観評価を測定した．結果，誤認は従来の表示で1件発生し，主観評価では，新表示の方がわかりやすい，読みやすいという回答が9割以上を占めた．その理由として識別に必要な情報が中央に集中している新表示のレイアウトが有効に働いたことが考えられる．引き続き実使用時の意見も確認しながら，より良い表示デザインを目指し工夫を重ねていく．

Sickle cell disease (SCD) is a group of inherited health conditions affecting 7.74 million people worldwide. Regular automated red blood cell exchange (aRBCX) transfusions have been shown to improve control and management of SCD compared with manual RBCX (mRBCX). The aim of this study was to estimate the lifetime clinical and economic impact of aRBCX versus mRBCX in two United Kingdom-based populations with SCD (paediatrics initiated aged 5 years and adults initiated aged 38 years) that were clinically indicated for chronic disease-modifying transfusions (DMTs). An individual patient-level simulation model was developed to estimate lifetime quality-adjusted life years (QALYs) and healthcare costs. DMT administration programmes aligned with recommended treatment schedules. Monte Carlo methods determined baseline characteristics and clinical event occurrence. Pragmatic review findings and expert opinion informed model parameters and assumptions. Second-order probabilistic sensitivity analysis (PSA) was performed for 1000 individuals' lifetimes over 500 iterations. Per individual, aRBCX reduced acute clinical events by 19% in both populations versus mRBCX. The time spent receiving chelation therapy reduced by 63 and 32 months for paediatric-initiated and adult-initiated individuals, respectively. Total lifetime DMT costs were reduced by £71,217 and £30,740 for paediatric-initiated and adult-initiated individuals, respectively. Overall, aRBCX increased QALYs and reduced costs by 0.29 and £112,811 in paediatric-initiated individuals and 0.24 and £61,895 in adult-initiated individuals. aRBCX was cost-effective in 100% of PSA iterations for both populations. aRBCX shows potential to improve health outcomes and reduce healthcare costs for individuals with SCD initiating a chronic DMT programme.

We report on midterm follow-up of the EPI-Flex postmarket study in France, assessing the safety of the Thoraflex on a nationwide scale. A prospective, multicenter trial was conducted of all frozen elephant trunk procedures using Thoraflex in France between April 4, 2016, and April 3, 2019. Patients were divided into elective surgery (n = 214) and nonelective surgery (n = 137). We defined safety end points as age-adjusted 3-year survival including in-hospital mortality and a composite secondary end point including new stroke, spinal cord injury, acute kidney injury requiring dialysis, recurrent laryngeal nerve palsy, massive blood transfusion (>10 packs of red blood cells), and unexpected repeated thoracic endovascular aortic repair or aortic surgery within 30 days. We included 351 patients (73% male; median age, 61 years; interquartile range, 55-70 years). In-hospital mortality rate was 54 of 351 (15.4%) and did not differ between elective and nonelective cases (P = .1). Classification random forest analysis, trained for 16 preoperative and perioperative covariates with 500 trees, identified age, deep hypothermia, and each time of cardiopulmonary bypass, visceral ischemia, or myocardial ischemia as the most influential factors associated with in-hospital mortality. Including in-hospital mortality, 3-year age-adjusted survival rates for elective and nonelective patients were 76% ± 6% and 70% ± 8%, respectively (P = .23). The composite end point significantly affected in-hospital mortality (P = 10-5) and 3-year age-adjusted survival rates (P = 10-3). Our results highlight that frozen elephant trunk with a Thoraflex remains a complex and evolving strategy for aortic arch diseases. Careful patient selection and optimized procedure engineering are essential to mitigate procedural risks.

7. mednarodna konferenca o tehnologijah in poslovnih modelih za krožno gospodarstvo: zbornik konference. Fakulteta za kemijo in kemijsko tehnologijo Univerze v Mariboru je v sodelovanju s Strateško razvojno-inovacijskim partnerstvom – Mreže za prehod v krožno gospodarstvo (SRIP – Krožno gospodarstvo), s katerim upravlja Štajerska gospodarska zbornica, organizirala 7. mednarodno znanstvenoraziskovalno, strokovno in razvojno konferenco Tehnologije in poslovni modeli za krožno gospodarstvo (Technologies & Business Models for Circular Economy; TBMCE), ki je potekala od 4. do 6. septembra 2024 v Grand hotelu Bernardin. Teme TBMCE 2024 so zajemale aktualna vprašanja tehnološkega razvoja in odgovornosti družbe na njeni razvojni poti k bolj odgovornemu, krožnemu ravnanju z viri. Konferenčni program je vključeval okroglo mizo z naslovom Prehod v krožno gospodarstvo v Jugovzhodni Evropi, 5 panelnih diskusij, plenarno in 2 uvodni predavanji, ustna predavanja in predstavitve v obliki posterjev. Dogodek je potekal pod pokroviteljstvom Ministrstva za gospodarstvo, turizem in šport in Ministrstva za kohezijo in regionalni razvoj. Kot soorganizatorji so se nam pridružili EIT RawMaterials RIS središča Adria in SPIRIT Slovenija ter Pomurski tehnološki park v sklopu projektov GREENE 4.0 in CI-Hub.

The objective of this research was to evaluate the percentage of the digestive tract components in KUB chickens reared in a Free-Range system on Clitoria ternatea pastures. This study was conducted at Afro Farm from September to November 2022. The research materials consisted of 70 eight-week-old female KUB chickens with body weights ranging from 300 to 400 grams each. The self-mixed feed had nutritional content with a Metabolic Energy of 2,949.04 Kcal/kg, crude protein of 17.11%, crude fat of 4.94%, crude fiber of 4.95%, calcium of 1.07%, phosphorus of 0.92%, methionine of 0.47%, lysine of 0.91%, and Clitoria ternatea pasture. The experimental design used was a Completely Randomized Design (CRD) with 2 treatments and 7 replications, where R0 represented intensive KUB chicken husbandry and R1 represented Free-Range KUB chicken husbandry, followed by a t-test. The results of the research showed that Free-Range husbandry significantly affected (P<0.05) the percentage of digestive tract components compared to intensive husbandry. The t-test results, except for the percentage of Gizzard weight (1.69<2.17), showed differences between the Free-Range and intensive systems, with the percentage of Proventriculus weight (5.51>2.17), Small Intestine (5.50>2.17), and Cecum (4.13>2.17) being higher in the Free-Range system. The results indicate that the Free-Range husbandry system on Clitoria ternatea pastures can be an alternative for KUB chicken rearing because it has a positive impact on the percentage of KUB chicken digestive tract component weights, except for the gizzard, which showed no difference. Based on this research, it can be concluded that the Free-Range system on Clitoria ternatea pastures can be considered as an alternative husbandry method for KUB chickens due to its positive effect on the percentage of KUB chicken digestive tract component weights. Keywords: Percentage of digestive tract component weight, KUB chicken, Free-Range, Clitoria ternatea.

Recensió de Biel, Lucja, i Kockaert, Hendrik J. (2023). Handbook of terminology: vol. 3. Legal terminology. John Benjamins

O escorpionismo lidera o ranking de ocorrências de acidentes com animais peçonhentos no Brasil, sendo as crianças o grupo de maior vulnerabilidade às complicações do acidente. Este é o relato de caso de um paciente de 6 anos que evoluiu com choque cardiogênico após acidente escorpiônico grave. Na abordagem diagnóstica e terapêutica do paciente, a utilização do ultrassom point-of-care otimizou o tempo de administração de medicamentos, auxiliou nos procedimentos invasivos necessários e promoveu avaliação imediata após terapias instituídas, em cada fase da abordagem. O intuito deste relato é demonstrar a importância dessa ferramenta na avaliação clínica do paciente com sinais de escorpionismo grave no setor de emergência.