TransMIT (Germany)

RPE65 biallelic mutation-associated inherited retinal degeneration (IRD) is currently the only IRD for which gene therapy is approved. This narrative review provides a brief overview of the disease and an update of the current literature on outcomes following the approval of treatment with voretigene neparvovec (LuxturnaTM) in 2017 (USA) and Europe (2018). Post-marketing results confirm a significant therapeutic effect of this gene augmentation on rod function similar to that seen in the phase 1 to 3 clinical trials. The full-field chromatic light sensitivity test is an appropriate test to demonstrate early and sustained effects of treatment. Visual acuity and visual fields may improve in less advanced disease. Accelerated chorioretinal atrophy (CRA) is a previously unrecognised adverse effect that is now reported in 13 % to 50 % of treated eyes. If central, visual acuity loss and paracentral visual field defects may occur. Further studies are needed to identify patients at risk of CRA in order to maximize patient benefit from a costly intervention.

Atmosphere-breathing electric propulsion systems provide a competitive advantage for the lower orbit altitudes since the propellant is collected directly from the atmosphere. The effectiveness of this technology depends on crucial aspects such as the collection and compression performance characterization, as well as the drag estimation and compensation. In the first part of this study, the lower Mars and Earth atmospheric characterization is derived based on current models and mission data. This characterization is a reliable dataset for the boundary conditions for the simulations carried out in the second part of this study. The proposed computational framework based on the Direct Simulation Monte Carlo method aims to investigate the collection and compression performances and to estimate the drag. The numerical comparison with a literature case validates the numerical setup presented in this study. The effect of different gas-surface interaction models is investigated by comparing the results yielded by the Maxwellian model (fully specular and partially diffuse reflection) and the Cercignani-Lampis-Lord model. Since the intermolecular collisions can become more relevant at the inlet of the ionization stage, both the variable hard and variable soft sphere models are briefly examined, as well as the inclusion of gas-phase reactions. Finally, the simulation results of the two cases for the low Mars orbit (150 and 140 km) are compared to the Earth case (180 km).

Ergot alkaloids, naturally occurring mycotoxins of Claviceps fungi, pose health risks. This necessitates accurate analysis methods to ensure food safety. This study explored the open-source miniaturized all-in-one 2LabsToGo system to analyze ergot alkaloids in whole rye samples. It is suited for sustainable atline analysis as it combines all planar chromatography tasks, allowing low-cost quality control in milling plants. The LOD and LOQ of ergocristine were determined to be 0.4 and 1.2 ng/zone, respectively. Detectability of ergot alkaloids was proven to be below the current maximum limit of 500 µg/kg for rye milling products. The repeatability (%RSD) was 4.1 % and the coefficient of determination of the analytical response (R2) was 0.9918 for ergocristine. The mean recovery rate of ergot alkaloids in spiked whole rye grain was close to 100 %. Results of screening whole rye for ergot alkaloids were successfully verified by comparison with those obtained by conventional status quo HPTLC instrumentation.

Abstract Conventional phase‐shifting transformers (PST) have been utilized for power flow control in transmission networks for many years. Compared to the slow reacting PSTs, recently trending unified power flow controllers (UPFC) enable much faster power flow control. This paper introduces a decentralized power flow control scheme for power flow controllers (PFCs) without the need for communication between the PFCs. For each PFC, an influence area is defined. The line loading of the transmission lines in this influence area is monitored in real‐time operation and if there is an overloading of a line, a feedback control scheme is used to mitigate the overloading of the line. As the power flow control of UPFC is dependent of the network topology and the UPFC converter limit, additional control measures are introduced to circumvent potential critical scenarios. Supplementary control measures are also developed to increase the robustness of control scheme for the simultaneous operation of UPFC with slow reacting PST. Using RMS simulation in DIgSILENT PowerFactory, the developed control method is validated in the IEEE 68‐Bus NETS/NYPS test bench network. The method is also validated for UPFCs with overlapping influence areas and the combination of fast acting UPFCs and slow acting PST devices.

Large populations of unowned cats constitute an animal welfare, ecological, societal and public health issue worldwide. Their relocation and homing are currently carried out in many parts of the world with the intention of relieving suffering and social problems, while contributing to ethical and humane population control in these cat populations. An understanding of an individual cat’s lifestyle and disease status by veterinary team professionals and those working with cat charities can help to prevent severe cat stress and the spread of feline pathogens, especially vector-borne pathogens, which can be overlooked in cats. In this article, we discuss the issue of relocation and homing of unowned cats from a global perspective. We also review zoonotic and non-zoonotic infectious agents of cats and give a list of practical recommendations for veterinary team professionals dealing with homing cats. Finally, we present a consensus statement consolidated at the 15th Symposium of the Companion Vector-Borne Diseases (CVBD) World Forum in 2020, ultimately to help veterinary team professionals understand the problem and the role they have in helping to prevent and manage vector-borne and other pathogens in relocated cats.Graphical

Root extracts of three goldenrods were screened for antimicrobial compounds. 2Z,8Z- and 2E,8Z-matricaria esters from European goldenrod (Solidago virgaurea) and E- and Z-dehydromatricaria esters from grass-leaved goldenrod (Solidago graminifolia) and first from showy goldenrod (Solidago speciosa) were identified by high-performance thin-layer chromatography combined with effect-directed analysis and high-resolution mass spectrometry or nuclear magnetic resonance spectroscopy after liquid chromatographic fractionation and isolation. Next to their antibacterial effects (against Bacillus subtilis, Aliivibrio fischeri, and Pseudomonas syringae pv. maculicola), they inhibited the crop pathogenic fungi Fusarium avenaceum and Bipolaris sorokiniana with half maximal inhibitory concentrations (IC50) between 31 and 107 μg/mL. Benzyl 2-hydroxy-6-methoxybenzoate, for the first time found in showy goldenrod root, showed the strongest antifungal effect, with IC50 of 25-26 μg/mL for both fungal strains.

The popularity and increasing demand for botanicals are correlated with the growth of nutraceuticals and new functional products on the market. Unfortunately, also fraudulent practices are increasi...

This article aims to build awareness of the growing global crisis in social, economic and environmental terms from different disciplinary approaches. The authors respond to the message of Pope Francis presented in his Encyclical Letter published in 2015. The article provides a short current overview of the discourse and presents three hypotheses anchored in the disciplines of Psychology, Health and Theology for a deeper discussion of Pope Francis's viewpoints on the challenges to humankind and how to address them. It thereby contributes to the discourse on health and religion with regard to the Pope's message to the world community. The article leads to an interdisciplinary conclusion and directions for future research and practice.