- Research Article
- 10.1182/blood-2025-790
Low-dose oral decitabine and cedazuridine among patients with low-risk myelodysplastic syndromes
- Nov 03, 2025
- Blood
- Guillermo Garcia-Manero + 29 more +29
Publications from 2021 to 2026
Showing 10 of 15 papers
Low-dose oral decitabine and cedazuridine among patients with low-risk myelodysplastic syndromes
Ratcliffe-on-Soar Power Station, 1963-2024: Historic Building Record
Photographic and written record of power station buildings accompanied by archival research. Ratcliffe on Soar was one of 10 coal-fired power stations based around the 500MW turbo-generator set built by the Central Electricity Generating Board (CEGB) during the 1960s; released for construction in 1963, the plant was completed in 1967 and first commissioned in 1968. Together with Cottam and West Burton in Bassetlaw District, it is one of three such 'super-stations' of 2,000MW capacity within the lower Trent Valley. In response to increasing awareness and concern regarding anthropogenic climate change, however, government policy has shifted away from fossil fuels, and the 1960s coal-fired stations have been sequentially shut down and decommissioned, with demolition their ultimate fate. Ratcliffe-on-Soar was the final station to close, ceasing generation at the end of September 2024 when, for the first time since the opening of Holborn Junction power station (the Edison Electric Light Station) in London in 1882, the UK has no coal-fired capacity, marking the end of a 142-year long era in the history of national electricity generation. The power satation is located on the south bank of the River Trent in south-west Nottinghamshire, close to its confluence with the Soar, hard on the border with Derbyshire to the north-west (with which the Trent here forms the county boundary) and with Leicestershire to the south-west (the county boundary formed by the Soar). It lies immediately north-east of the village of Ratcliffe on Soar and 1km south-west of Thrumpton, lying c.12km south-west of the county town of Nottingham. It is located within the civil parish of Ratcliffe on Soar and the administrative district of Rushcliffe. The power station comprises a standard grouping of structures based around the generating core of boiler house, turbine hall with attached control room, and precipitator block, served by a single chimney to the north and a massive, enclosed 400kV switch-house located axially to the south. A total of eight natural-draught cooling towers are arranged in a single field to the west of the generation buildings, while an extensive coaling plant, associated stock area and enclosing rail loop are sited to the east. All constituent buildings of the plant are described to a level commensurate with a 'Level 2' record as defined by Historic England, cross-referenced to a comprehensive photographic record and illustrated with copies of original design drawings/diagrams and early photographs as appropriate. Further, a review of the readily available archival sources at the National Archives, the Nottinghamshire Archives and on-site at the power station itself, allowed for a context, both historical and technical, to be established in which to interpret the form and function of the site and its component parts. The station as a whole is considered within its landscape setting, and its 'Heritage Values' are assessed in evidential, historical, aesthetic and communal terms, in line with Historic England guidelines. The programme of historic building recording allowed for a detailed study and record of the buildings, their construction, operation and general developmental history to be made, so far as possible from a non-intrusive survey, in accordance with current Historic England guidance. Together with similar studies at a number of contemporary power station sites, it forms part of a significant 'preservation by record' of an important class of industrial heritage asset.
Read moreSome Believe, Not All Achieve: The Role of Active Learning Practices in Anxiety and Academic Self-Efficacy in First-Generation College Students†
First-generation college students face a variety of barriers in higher education compared with their continuing-generation peers. Active learning practices in STEM classrooms can potentially narrow the achievement gap by increasing academic self-efficacy, or confidence in academic abilities. However, these practices can also provoke anxiety in students. Given that anxiety can impair cognitive performance, we sought to understand how first-generation students perceive active learning practices and whether these perceptions affect the anticipated benefits of active learning. As part of a larger study on pedagogical practices in anatomy and physiology courses at the community college level, we asked students to rate various active learning techniques on how much each provoked anxiety and how much each contributed to their learning. All students (N = 186) rated some techniques as more anxiety-provoking than others (e.g., cold calling); however, compared to continuing-generation students, first-generation students’ ratings tended to be higher. First-generation students anticipated doing more poorly in a course and attained lower final grades. Notably, the use of active learning practices did not improve first-generation students’ academic self-efficacy: by the end of term, academic self-efficacy decreased in non-white first-generation students whereas other students showed little change. When introducing active learning strategies, instructors may need to proactively address underrepresented minority students’ emotional reactions and ensure that all students experience success with these practices early in a course as a way to bolster academic self-efficacy.
Read moreEffects of Dementia-Specific Education for Nursing Students.
The numbers of people living with dementia are overwhelming. Dementia education is important to prepare nursing students to care for this population. The purpose of this study was to determine the effects of a virtual dementia experience on nursing students' attitudes and empathy for people with dementia, dementia knowledge, and self-confidence for dementia care. The design was a 2-group, pretest-posttest using a convenience sample of undergraduate nursing students (n = 112). The intervention group (n = 56) participated in a virtual dementia experience. Both groups experienced improved attitudes toward people with dementia, increased dementia knowledge, improved self-confidence for dementia care, and improved empathy (Perspective Taking). However, the virtual dementia experience did not lead to improved outcomes compared to the standard teaching approaches. Dementia-specific education had a significant influence on students' attitudes, knowledge, self-confidence, and empathy, whereas the type of education did not impact outcomes.
Read moreAbstract 27: Implications of Legislative Efforts on Layperson CPR Education
Introduction: Although bystander CPR has been shown to increase rates of survival from out-of-hospital cardiac arrest, recent work has demonstrated low rates of layperson training across the US. In an attempt to increase layperson CPR training, states have passed legislation that mandates CPR training before high school graduation. No study has assessed the impact of this legislation on likelihood of CPR training. Objectives: We assessed whether an association existed between state mandated CPR training during high school and the likelihood of young adults being currently trained or ever trained in CPR. We hypothesized younger individuals in states with required CPR training by graduation would be more likely to be currently trained or ever trained in CPR. Methods: From 09/2015-11/2015, we conducted a nationwide cross-sectional study of the US adult population using random-digit telephone dialing (n=9,022). Data were weighted by state and assessed through univariate and multivariate analyses controlling for confounding variables. Individuals age 18-24 years old were considered “young” and healthcare workers were excluded in the analysis. Subjects in the five states whose mandatory training laws began in or before the 2013-2014 school year were considered. Results: Of the 9,022 participants, individuals were classified by whether they lived in state that mandated training (n=924) or did not (n=8,084). After accounting for confounding variables, 33% of all laypeople in states with mandated training were currently trained while 27% of laypeople in states without mandated training were currently trained (OR: 1.28, 95%CI: 1.07-1.48, p=0.01). Younger adults were 59% more likely to be currently trained in states with mandated training than in states without it (OR: 1.59, 95%CI 1.34-1.89, p<0.01). In addition, younger adults were also 48% more likely to be ever trained in states with mandated training (OR: 1.48, 95%CI: 1.02-2.10 p=0.04). Conclusion: Younger adults were more likely to be trained in states with laws mandating CPR training for high school graduation. In addition, younger adults were more likely to have ever been trained in states with laws requiring compulsory CPR training for high school graduation.
Read moreScientific Archives
Le sacré et la mémoire :anthropisation des espaces boisés et reforestation des espaces anthropiques dans le Golfe de Guinée
Enfer vert et civilisation Les tropiques qui s’étendent des deux côtés de l’Atlantique n’ont pas fini de susciter dans les esprits européens des métaphores infernales, alimentées par cinq cents ans de discours à la fois philosophique, littéraire et scientifique sur des paysages perçus comme l’antithèse d’une nature domestiquée et soumise, imaginée comme le seul vrai décor possible au théâtre des civilisations. Le discours sur le paysage est de fait indissociable d’une conversation plus large ...
Read moreAbstract 17335: Dietary Carbohydrate Quality Affects Plasma Lipid Profile and the Microbiome
Considerable data is available on the effect of carbohydrate (carb) quantity on CVD risk factors but data for carb quality is limited. Our objective was to determine the relative comparability for an isocaloric exchange of unrefined-carb (endosperm+germ+bran, e.g., whole wheat flour), refined-carb (endosperm only, e.g., white flour) and simple-carb (sucrose, e.g., high fructose corn syrup), on cardiometabolic risk factors and the gut microbiome. All foods/beverages (60%E total carb, 15%E protein, 27%E fat [7%E SFA, 10%E MUFA, 10%E PUFA], 80mg cholesterol/1000 kcal) were provided to study subjects (n=11 men and women, 65 years, BMI 27.5 kg/m 2 , LDL-C ≥100 mg/dL) for 5 weeks (randomized, single-blind, cross-over design). Body weight was maintained constant. At the end of each diet phase plasma lipid profile, inflammatory factors and glucose homeostasis were determined using standard methods. Fecal microbiota taxa was characterized by 16S rRNA sequencing and data analyzed using QIIME and PathoScope. Plasma LDL-C levels differed among diets (125 ± 29 mg/dL b , 129 ± 29 mg/dL a,b and 136 ± 24 mg/dL a , unrefined-, simple- and refined-carb , respectively). Carb quality had no significant effect on HDL-C, TG, FFA, glucose, insulin, CRP or IL-6 levels. There were 21 genera that had a mean relative abundance (RA) of ≥1% and 4 genera (Roseburia, Oscillospira, Ruminococcus and Coprococcus) varied significantly across diets but after multiple testing adjustment, only Roseburia RA variations remained significant ( 2.58% a , 0.99% b , and 0.81% b , unrefined-, simple- and refined-carb , respectively). Interesting trends were observed between the RA of the following genera and plasma lipids: Roseburia was negatively associated with LDL-C (r=0.28, p=0.097) and HDL-C (r=-0.39, p=0.022); Oscillospira was negatively associated with TG (r=-0.53, p=0.097), and Anaerostipes was positively associated with TG (r=0.40, p=0.0585) levels. These data suggest that carb quality alters the RA of butyrate-producing bacteria, presumably leading to higher short chain fatty acid production, with subsequent alterations in plasma lipids. This study provides novel information about the impact of carb quality on the phylogenetic structure and functional capacity of the fecal microbiome.
Read moreAtrial Support Pacing in Heart Failure: Results from the Multicenter PEGASUS CRT Trial
Cardiac resynchronization therapy (CRT) efficacy trials to date used atrial-synchronous biventricular pacing wherein there is no or minimal atrial pacing. However, bradycardia and chronotropic incompetence are common in this patient population. This trial was designed to evaluate the effect of atrial support pacing among heart failure patients receiving a CRT defibrillator. PEGASUS CRT was a multicenter, 3-arm, randomized study. At 6 weeks, patients were randomized to DDD mode at a lower rate of 40 bpm (DDD-40; control arm), or one of the following 2 treatment arms: DDD-70, or DDDR-40. The primary endpoint was a clinical composite endpoint that included all-cause mortality, heart failure events, NYHA functional class, and patient global self-assessment. Subjects were classified as improved, unchanged, or worsened at 12 months. There were 1,433 patients randomized, of whom 66% were male, mean age was 67 ± 11 years, and mean left ventricular ejection fraction was 23 ± 7%. The average follow-up time was 10.5 ± 3.5 months and 1,309 patients contributed to the primary endpoint. No significant differences were observed in the composite endpoint between either of the 2 treatment arms compared to the control arm (P>0.05 for both comparisons). Additionally, there were no differences among the groups in mortality or heart failure events. In advanced heart failure patients treated with CRT, atrial support pacing did not improve clinical outcomes compared to atrial tracking. However, atrial pacing did not adversely affect mortality or heart failure events.
Read moreA Regional Academic Partnership for the Early Identification and Retention of At-Risk Nursing Students