United Biomedical (United States)

The current investigation was carried out to determine the growth and yield and Quality parameters of chilli (Capsicum spp.) as influenced by different levels of growth regulators i.e. Naphthalene Acetic Acid (NAA) and Gibberellic Acid (GA₃) There were seven treatments as follows: 1) Control (no PGR application); 2, 3, and 4) three NAA levels (30, 40, and 50 ppm), and 5, 6, and 7) three GA₃ levels (9, 10, and 11 ppm), respectively. The results reflected that the use of PGR affects plant height, number of fruits/plants, fruit length, diameter, and average weight of fruits. Among the treatments, NAA (40 ppm) (T₂) and GA₃ (10 ppm) (T₅) were recorded as significantly better than the control and other treatments. The tallest plants (50 cm) and the longest (15 cm) and widest (6 cm) fruit and highest average fruit weight (3 g) were recorded for T₂, while the greatest number of fruits per plant (30) was recorded for T₅ as well as the highest average fruit weight (4 g). Among all the parameters measured, the control (T₀) always revealed the lowest values. Significant differences among treatments were confirmed by the statistical analysis at P < 0.05. Based upon these produce characteristics, it can be recommended that application of NAA 40 ppm and GA₃ 10 ppm under field conditions can improve growth and productivity in chilli. Res. Agric. Livest. Fish. Vol. 12, No. 2, August 2025: 253-258

Fungal infections affect millions of people globally, ranging from minor skin conditions to life-threatening diseases. Ketoconazole (KCZ)MS, a potent synthetic imidazole, remains widely prescribed. This study reports the synthesis of N-nitrosoacetylpiperazine (N-NAP), a nitroso derivative of a KCZ-degradant, with the N-nitroso group confirmed by 1H-15N HMBC spectroscopy, and their genotoxic potential was evaluated using two (Q)SAR tools. The identified KCZ NDSRIs are categorized as class-3 as per QSAR, and the predictions showed as genotoxic positive (Cohort-of-concern). The acceptable intake (AI) levels of both nitrosamines were determined using the carcinogenic potency categorization approach (CPCA) and belonged to potency category-3. Following ICH Q14 recommendations, the LC-TQ-MS/MS method was optimized for the detection and quantification of KCZ-NDSRIs at trace amounts in KCZ pharmaceuticals. This study advances two Sustainable Development Goals (SDGs). It supports SDG 3 (good health and well-being, targets 3.8 & 3.d) by utilizing (Q)-SAR and CPCA analyses and contributes to SDG 9 (industry, innovation, and infrastructure, target 9.4) via a validated LC-TQ-MS/MS method for quantifying NDSRIs as per ICH Q2(R2). The chromatographic separation was optimized using a Waters X-bridge BEH C18 column (150 mm × 2.1 mm, 2.5 µm) with gradient elution. Mobile phases consisted of 0.1% formic acid in water and acetonitrile with a column oven temperature of 40 °C and a pump flow rate of 0.4 mL min-1. Aligned with ICH Q14, this approach defines the analytical target profile (ATP) and established conditions (ECs) and incorporates risk assessment and reporting categories. The robustness and validation of the current method were executed following the ICH Q2(R2) guidelines. The sustainability of the proposed method was demonstrated using cutting-edge tools, like AGREE, Modified GAPI, BAGI, RAPI CaFRI and RGB12, reinforcing its white and green and sustainable nature.

In response to these concerns, using organic fertilizers, such as poultry manure (PM) and vermicompost (VC), has gained attention as a viable strategy to reduce reliance on chemical fertilizers. Organic fertilizers improve soil quality by enhancing

Abstract An efficient, mild, and regioselective synthesis of substituted 1‐methyl‐1H‐tetrazole using methyl 2,2,2‐trichloroacetimidate is described. The substrate scope of the methodology has been established with wide variety of tetrazoles. N1‐Methylated tetrazoles were synthesized with high yields (85%–97%).

[Deliverable pending final approval by the EC] This deliverable has the objective to provide the outcomes of the activities performed in Work Package (WP) 2 “Specifications”. The activities included the design of the 5G-IANA Automotive Open Experimentation Platform (AOEP) and the requirements specification of each architecture layer. The specified 5G-IANA architecture capitalizes on the 5G prospect of being a unified multi-service platform by orchestrating Vertical Services based on virtualized network slices and coordination of distributed edge-to-cloud deployment. The 5G-IANA AOEP aims to provide an open and flexible experimentation platform to third-parties developers (e.g., SMEs) that want to develop new 5G-based services devoted to the Automotive vertical. The availability of an easy-to-use experimentation environment can facilitate the launch of new services creating new market opportunities. Moreover, 5G-IANA will actively address the configuration of the 5G network (e.g., network slicing, edge resources, etc.) with the objective of supporting in the best way the requirements of the new services. In this way, it will be also possible to verify if the current 5G implementation can adequately satisfy the highly demanding performance requirements of Automotive services.

This document provides the first update to the Conceptual Model and Reference Architecture of PolicyCLOUD (the initial document has been submitted as Deliverable D2.2). This second version (Deliverable D2.6) provides the definition of the overall architecture and its components, focuses on the integration aspects of the architecture and presents example scenarios and associated data sources from the project’s Use Cases including end-to-end data path analysis. The final update of the deliverable will be published in M30. A second version of the PolicyCLOUD Conceptual Model & Reference Architecture (originally submitted as Deliverable D2.2) is presented in this document. The final update of the deliverable will be submitted in M30. The PolicyCLOUD Conceptual Model presents the overall project concept along 2 main axes. Along the first data axis PolicyCLOUD delivers Cloud Gateways and APIs to access data sources and adapt to their interfaces so as to simplify interaction and data collection from any source. Along the second main axis, the Policies Management Framework of PolicyCLOUD allows the definition of forward-looking policies as well as their dynamic adaptation and refocusing to the population they are applied on. Based on the project’s offerings along the main two axes of the Concept, five main building blocks (in a layered manner) define its Architecture: (1) The Cloud Based Environment and Data Acquisition, (2) Data Analytics, (3) the Policies Management Framework, (4) the Policy Development Toolkit and (5) The Marketplace. The architecture also includes a Data Governance Model, Protection and Privacy Enforcement and the Ethical Framework as depicted in figure 2. The architecture allows for integrated data acquisition and analytics. It also allows data fusion with processing and initial analytics (see 7.6.5) as well as seamless analytics (see 7.6.6) on hybrid data at rest. The main focus of the updates of the document is on the Integration in PolicyCLOUD which follows three directions: (i) architecture integration, (ii) integration with the cloud infrastructure and (iii) integration with Use Case scenarios through the implementation of end-to-end scenarios. Additional integration activities take place along the two frameworks of PolicyCLOUD, (a) the Data Governance model, protection and privacy enforcement mechanism and (b) the Ethical and Legal Compliance framework. For end-to-end data path analysis we have used two Use Case scenarios: (i) the scenario of Use Case 1: “Radicalization incidents” and the scenario of Use Case 2: “Visualization of negative and positive opinions on social networks for different products”.

The objective of this deliverable is to report the results of the activities performed in the first phase of CYRENE’s Work Package 2. The main output is related to the requirements that have been collected from relevant standards and literature review, project pilot partners, as well as external stakeholders. The document can be divided in four main parts. In the first one, an overview of the Supply Chains is given, describing both their classification, including three different views (business, technical and sectorial) of the SCs, and their security aspects, consisting of the threat landscape, legal framework, SC security and Risk Management standards and SC risk assessment methodology and tools. In the second part, an overview of the EU Certification schemes is provided, encompassing the general definition and requirements (policy, legal, standards, methodologies, technical) regarding the security certification. Moreover, in the third part, the document reports on the methodology used for collecting, analyzing and validating the requirements through the project’s Advisory Boards. The feedback obtained from the proposed questionnaire for requirements validation are presented in this part and conclusions are drawn afterwards. Finally, the fourth part of the deliverable deals with the three Targets of Evaluation (ToEs), namely, the Business, Technical, and Sectorial. Their descriptions and the respective validated requirements are provided in this section. Two appendixes are included in the document. The first one gives information on a glossary that forms the basis of the concepts used in the project, while the second one gives details regarding the first workshop organized with the Advisory Boards at the end of the first six months of the project.

A nanoprobe responsive to specific biomarkers with aggregation-induced emission has been developed for locating and guiding resection of tumors via optoacoustic and fluorescence imaging.