Universidad José Vasconcelos

The integral development of initial stage infants (ISI) depends on various factors, being the two of the most important aspects the nutritive food and body mass index (height and weight), which generates the healthy life of ISI evaluated in this investigation, and correlated with his educative yielding in early-age educational institution located in the Tijuana city. The age of infants analyzed were from 0 to 36 months, being 10 infants of this age, and observed that with a good nutritive diet, which was obtained the body mass index (BMI), and an efficient educative yielding, and showed a correlation rate of 0.82, indicating that these relevant factors mentioned above, were very important in the integral development of infants of this age and his educative yielding. In this scientific study was applied specialized strategies as dynamic and visual actions in school and in house of infants supported by his fathers, obtaining good results in the teaching-learning process (TLP), obtained of the statistical correlation in this important investigation.

La llegada del actual régimen político mexicano (2018-2024) significó un cambio en las concepciones Estado y educación pública. Tras un largo período en donde prevalecieron las relaciones llamadas neoliberales, el discurso oficial destacó la formulación de políticas dirigidas al desarrollo local y al asistencialismo a favor de los pobres. Este cambio impactó en la reconducción del modelo de desarrollo económico y en la reformulación del proyecto educativo, el cual se conformó tardíamente, en 2022, en torno a objetivos extracurriculares: erradicar al individualismo identificado como neoliberal y apostar por un modelo educativo decolonial, libertario, comunitario y humanista. Así, el presente artículo revisa algunos planteamientos ideológicos de la propuesta educativa del gobierno de Manuel López Obrador y analiza el presupuesto que la enseñanza no debe centrarse no en el estudiante, sino en la comunidad o territorio como eje pedagógico.

Abstract Lynch syndrome is a rare pathology triggered by several genetic mutations that predispose individuals to various tumors. Although uncommon, urothelial carcinoma of the upper urinary tract can present with different characteristics. Here, we present the case of a patient with Lynch syndrome who developed a multifocal, recurrent lesion. A young woman with Lynch syndrome underwent screening at 30 years of age. She presented with macroscopic hematuria, underwent a urinary tract ultrasound, and was diagnosed with bladder cancer. The lesion was resected, and after a few years, she presented with a tumor of the right renal pelvis. Subsequently, a laparoscopic radical nephroureterectomy was performed. As the patient had an allergy to iodinated contrast, we continued screening with cystoscopy, urinary tract ultrasound, and oncotic cytology in the urine. After several years, she developed a new recurrence in the left renal pelvis and left ureter. Despite multiple tumors, as the patient had a single kidney, a therapy with lower morbidity was selected. This comprised endoscopic resection of the lesion and laser ablation at its base. After years of follow-up, the patient showed no evidence of disease recurrence and remained under follow-up. Lynch syndrome is a pathology with the potential for multisite tumors. It is extremely important for urologists to understand this syndrome because urothelial tumors of the upper urinary tract may be the initial manifestation of this syndrome. Screening must be individualized for each patient, considering the limitations of each method.

La Ciencia Social en América Latina ha pasado por variadas y sugerentes etapas. Del ensayo social y político cuyo origen se remonta a los primeros momentos de la historia del pensamiento latinoamericano se pasa, al mediar el siglo, al cientificismo o época de la sociología empírica. Es la época en que José Ingenieros, José Vasconcelos, José Carlos Mariátegui, Vicente Sáenz, Alberto Masferrer y otros autores que fueron capaces de visualizar grandes intuiciones acerca de la sociedad latinoamericana, son abandonados y sustituidos por nuevos héroes, esta vez de habla inglesa y de origen sajón: Talcott Parsons, Robert Merton y sus interpretadores y traductores —a veces más esto que aquello— que surgieron abundantes en los países latinoamericanos. Se inicia la etapa de la sociología llamada científica, la cual gira alrededor de un leitmotiv: la medición. Los estudios devienen científicos en cuanto sean capaces de medir algo. No escapa a nadie la raigambre neo-positivista de esta tendencia que se arraiga fuertemente en la ciencia social latinoamericana

Background: Ischemic heart disease is the main cause of mortality in Brazil. Sudden cardiac death is often the initial presentation of a myocardial infarction, however Basic Life Support (BLS) undertraining is real not only for lay rescuers but for health care providers in Brazil. A group of medical students from the Universidade Federal do Ceara (UFC) founded in 1996 the Cardiorespiratory Resuscitation Education Program (PERC) with a goal of disseminating BLS techniques. Objective: Emphasize the importance of creating social projects to propagate BLS techniques in underserved populations. Methods: An experience of over 23 years of BLS training with a non profit medical student group in the northeast of Brazil will be reported. Results/Discussion: The group is formed by students from the first to the last year of the UFC medical school. They are trained by cardiology faculties and senior members on the most recent ILCOR guidelines for BLS. A member usually stays in the program for two or three years and during this time is responsible to facilitate free classes in schools, public hospitals, health centers and medical schools. These courses are based on one lecture followed by a hands on training on CPR manikins. Pre and post testing are applied to evaluate satisfaction and learning. With 23 years of experience, a total of 11,841 people were directly trained by our program: 4.626 lay rescuers, 3.124 medical/nursing students and 4.091 health providers. A satisfaction rate is above 95%. The impact of this program in our community is immeasurable. Conclusion: Even though these courses don’t replace the official AHA-BLS training, nonprofit organizations as PERC can play an important role in communities with limited resources, helping to disseminate BLS techniques and maybe decreasing the mortality and morbidity associated with the sudden cardiac death in those areas.

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer an unprecedented opportunity to remuscularize infarcted hearts. However, the majority of hiPSC-CMs die post transplantation into the ischemic environment, limiting their regenerative potential. CM death occurs in the first few days post-transplantation due to ischemia. Attempts to promote intramyocardial vascularization (i.e. delivery of growth factors or cells) have not led to significant improvements due to poor cell retention and the long time required for new vessels to form and carry blood compared to the rapid death of transplanted CMs. Here, we used ready-made microvessels harvested from adipose tissue - that form a vasculature and carry blood within the first days post subcutaneous implantation - to re-vascularize ischemic rat hearts and improve hiPSC-CM survival. We performed left anterior descending artery ligation in immunocompromised rats to model MI. hiPSC-CMs (10 x10 6 ) with (CM+V) or without (CM-only, control) microvessels were delivered by intra-myocardial injection 2 weeks post MI. Cardiac function was assessed by echocardiography and pressure-volume loop. Delivery of microvessels from GFP rats allowed assessment of microvessel persistence. Compared to hiPSC-CM transplantation alone, microvessels promoted a 6-fold increase in hiPSC-CM survival, with reduction in scar size and a significantly superior functional recovery. While delivery of CM-only stabilized the heart preventing further fractional shortening decline, delivery of CM+V resulted in reversal of fractional shortening loss. This was supported by PV-loop data (ejection fraction: sham, ~20%; CM-only, ~31%; CM+V, ~39%; 4 wks). Moreover, microvessels showed unprecedented persistence and integration (>60%, 4 wks), resulting in 2-fold increase in vessel area and graft perfusion (as early as day 5 post-transplantation). This was achieved despite the very low number of cells (~2 x10 5 ) delivered in the form of microvessels. These findings provide a novel approach to cell-based therapies for MI whereby incorporation of ready-made microvessels can serve as a personalized delivery system to improve functional outcomes in cell replacement therapies.

B cells play a crucial role in the pathogenesis of SLE (systemic lupus erythematosus). B lymphocyte stimulator levels (BLyS) are correlated with anti-dsDNA antibody levels and disease activity in SLE. Belimumab is a human monoclonal antibody that binds to BLyS preventing its binding to B-cell receptors and it is indicated for cutaneous-articular manifestations. This study reports a case of SLE thrombocytopenia refractory to conventional immunosuppressive therapies and rituximab, that might have responded to Belimumab.