Universidad Nacional de Entre Ríos

Somatostatin-expressing low-threshold spiking interneurons (SOM-INs) constitute a key inhibitory population in the dorsal striatum, yet their contribution to parkinsonian states and L-DOPA-induced dyskinesia (LID) remains poorly understood. Here, we combined in vivo behavioral assays, chemogenetics, and ex vivo electrophysiology to examine how nigrostriatal dopamine loss and dopaminergic therapy shape SOM-INs' activity and function. During LID, SOM-INs displayed increased c-Fos expression, revealing their recruitment during dyskinetic states. Patch-clamp recordings showed that SOM-INs in control mice fire tonically with characteristic abrupt pauses. While their firing patterns are preserved after dopamine depletion and L-DOPA therapy, dopamine depletion shifted their interspike interval distribution toward longer intervals, indicating reduced intrinsic activity. This deficit was partially reversed by chronic L-DOPA. Consistent with their expression of Drd1/Drd5 transcripts, SOM-INs were excited by the D1/D5 receptor agonist SKF81297 across groups. Chemogenetic inhibition experiments revealed a functional role for SOM-INs in early rotarod learning, demonstrating their contribution to motor skill acquisition, but did not affect baseline motor output in sham or parkinsonian mice. Moreover, SOM-IN inhibition during chronic L-DOPA treatment modestly but consistently exacerbated LID expression selectively during the wearing-off phase, without altering parkinsonian symptoms or the therapeutic efficacy of L-DOPA. Notably, SOM-IN inhibition did not modify the long-duration antiparkinsonian response that persisted after discontinuing L-DOPA. Together, these findings identify SOM-INs as an intrinsically active striatal interneuron population whose excitability is shaped by dopamine depletion and dopamine receptor stimulation, and whose activity restrains dyskinetic responses to dopaminergic overstimulation. Their selective influence on dyskinesia, but not on the therapeutic actions of L-DOPA, highlights SOM-INs as a potential target for circuit-level interventions aimed at improving the motor side-effect profile of dopaminergic therapies.

Abstract The growing demand for plant-based proteins has prompted the exploration of alternative sources such as cowpea ( Vigna unguiculata ), due to its high protein content (23-25%). This study compared two protein extraction methods: 1-the pH-shift method at pH 7.5, 8.0, and 9.0, and at the natural pH of the cowpea flour–water dispersion (pH 6.4); 2- pH-shift protein extraction assisted by high-intensity ultrasound (HIUS; 400 W, 60 min, pulse 2 s on/2 s off, T < 30 °C). Protein yield, structural modifications, thermal stability, and techno-functional properties were assessed. Protein content ranged from 77.85% to 83.0%. HIUS increased yield at all pH conditions, including at pH 6.4. HIUS induced partial unfolding, increased surface hydrophobicity, and decreased thermal stability as a function of pH-shift extraction. These structural changes improved solubility at pH 6.0 and enhanced emulsifying capacity, especially in I7.5-US and I8-US, forming emulsions with smaller droplet sizes. I6.4-US was particularly attractive, providing yields and solubility comparable to or higher than I9 while avoiding the use of highly alkaline solutions. Although HIUS-assisted extraction slightly reduced protein purity due to co-extraction of non-protein compounds, it represents a simpler and more sustainable approach. This strategy supports the development of plant-based protein ingredients with high functionality and reduced chemical usage.

El título de este editorial surge del asombro y la alegría que significan las importantes contribuciones que conforman este número en condiciones tan difíciles para la Universidad Pública Argentina, para las y los docentes e investigadores y personal administrativo...

La caracterización de escalas espaciales y temporales en ambientes fluviales presenta desafíos significativos debido a la complejidad de los procesos morfodinámicos. Los resolutores GPU ofrecen cálculo paralelo acelerado con tiempos notablemente reducidos, aunque su aplicación está limitada a ciertos problemas. Este trabajo presenta un código GPU de desarrollo propio comparado con OpenFOAM SedFoam (CPU) para analizar el transporte de una duna del río Paraná en carácter bidimensional con perfil longitudinal. Los resultados contribuyen al desarrollo de herramientas numéricas extrapolables a otros ambientes. Este enfoque permite simular múltiples escenarios hidrosedimentológicos para identificar factores determinantes en cambios morfológicos y comprender la respuesta del sistema ante variaciones en parámetros hidrológicos y sedimentológicos. La comparación entre arquitecturas de procesamiento evaluará precisión y desempeño computacional.

ABSTRACT Fibromyalgia is characterized by widespread musculoskeletal pain accompanied by sleep disturbances and cognitive dysfunction, among other symptoms. Patients frequently report difficulties with memory, but objective assessment of these impairments remains limited. This study aimed to evaluate working memory performance in fibromyalgia patients using two established paradigms: the change detection task, which primarily measures storage capacity, and the n-back task, which assesses both storage and manipulation of information. For the change detection task, the behavioral outcomes assessed were the hit rate, false alarm rate, capacity estimate and response times. The electrophysiological measure evaluated was the contralateral delayed activity. For the n-back, the behavioral outcomes were the same, except for the capacity estimate. Electrophysiologically, the P2 and P3 from the evoked potentials were the outcomes of the task. Behaviorally, results demonstrated that fibromyalgia patients exhibited lower memory capacity than controls (1.90 vs 2.64), in the change detection task, which involved differences in the hit rate and false alarm rate, whereas no behavioral differences were found for the n-back task. In contrast, no differences were found for any of the electrophysiological outcomes in any of the tasks. Taken together, we found evidence supporting a reduction in working memory capacity in fibromyalgia, although it is not reflected in electrophysiological measures.

A total of 600 polychaete species are known in Argentina, mostly marine. Freshwater representatives are poorly documented, with only 22 species reported for the Neotropical region. This study presents the first record of Stratiodrilus brevicirrus (Histriobdellidae, Polychaeta) in Entre Ríos Province, Argentina, extending its known distribution from southern Brazil into the Pampean region. Specimens were collected during seasonal macroinvertebrate surveys in 2021 across streams of the Lower Uruguay River Basin. A total of 42 individuals were found in rocky and vegetated substrates and identified using updated taxonomic keys. Voucher specimens were deposited in the Museo Ciencias Naturales de La Plata. This is the second record of the genus Stratiodrilus in the country and the first for this species. Although collected free-living, known host families (Aeglidae and Trichodactylidae) were also present. This record highlights the importance of surveying underexplored freshwater systems, provides new data for national species checklists, and supports future conservation planning in fluvial environments.

Background: Catheter ablation (CA) has been shown to be effective in patients with recurrent ventricular tachycardia (VT); however, its role in patients with electrical storm (ES) has not been studied in randomized trials.Objective: The aim of this study was to analyze ES cases treated with CA.Methods: This was a retrospective analysis of patients treated with CA for ES due to sustained monomorphic VT (SMVT). Procedure success was defined as lack of inducible VT at the end of ablation, partial success as the induction of non-clinical VT, and failure as inducible clinical VT.Results: Sixteen procedures were performed in 14 patients: 10 successful, 3 partially successful, and 3 failures. All patients were free from ventricular arrhythmia immediately after ablation. Ten patients (71.4%) were free from VT and 86.7% free from ES [8 (3–30)-month follow-up]. Five patients (35.7%) died from causes unrelated to arrhythmia.Conclusions: Catheter ablation is associated with acute suppression of VT in all patients with ES due to SMVT and with a recurrence-free outcome in most of them.

La Emergencia Socio Sanitaria (en adelante ESS) desatada por la pandemia de la COVID-19 modificó radicalmente las condiciones de vida de la población, afectando diversos ámbitos, desde lo familiar hasta lo institucional y comunitario. Si bien en un primer momento las repercusiones se asociaron principalmente con lo sanitario, las consecuencias de la ESS se extendieron a todas las dimensiones sociales, políticas y económicas, revelando la profunda interconexión entre ellas. Este artículo se centra en la dimensión organizacional e institucional en la gestión local del riesgo en la ciudad de Paraná entre los años 2020 y 2022, con el fin de explorar cómo las estructuras y dinámicas organizacionales fueron centrales en la respuesta ante la crisis. Para ello, retomamos las conclusiones obtenidas en el proyecto de investigación “Prácticas implementadas en la gestión local de riesgos ante la emergencia socio-sanitaria por COVID-19 en la ciudad de Paraná en 2020-2022”, de la Facultad de Trabajo Social (Universidad Nacional de Entre Ríos). El análisis de la ESS nos permite evidenciar que las intervenciones sociales, políticas y sanitarias, en sus diferentes niveles, no sólo respondieron a una necesidad inmediata de control sanitario, sino que también expusieron las fortalezas y debilidades de las organizaciones locales frente a un desafío global. Así, la reflexión institucional se nos presenta como una herramienta clave para analizar la gestión local de riesgos, dado que los contextos locales, con sus propias dinámicas y recursos, desempeñan un papel fundamental en la configuración de respuestas adecuadas y oportunas. En primer lugar, abordamos algunos enfoques teóricos para entender la gestión del riesgo a nivel local como un proceso integral y multidimensional donde la organización y lo institucional son factores determinantes para intervenciones eficaces y sostenibles durante la ESS. A continuación, presentamos resultados sobre las capacidades estatales desplegadas por el municipio de Paraná para gestionar la ESS. En tercer lugar, reflexionamos sobre el rol de las organizaciones de la sociedad civil en la gestión local del riesgo. Finalmente, concluimos con algunas reflexiones sobre la necesidad de repensar las estructuras organizacionales y las políticas públicas a nivel local, con el fin de fortalecer las capacidades de respuesta ante futuras emergencias. Resaltamos que comprender la dimensión institucional y organizacional de la gestión local del riesgo no solo es esencial para la intervención inmediata en situaciones de emergencia, sino también para el diseño de políticas públicas que promuevan la gestión de los riesgos en todos los aspectos (prevención, mitigación, atención de la emergencia). La ESS ha puesto en evidencia la necesidad de fortalecer las capacidades organizativas tanto de los actores gubernamentales como de actores locales para responder de manera más efectiva a la gestión de los riesgos.