Universidad Real

ObjectiveTo assess use of bone-targeting agents (BTA) in patients with confirmed bone metastases (BM) from breast cancer (BC), non-small cell lung cancer (NSCLC) or prostate cancer (PC).DesignRetrospective cohort study.SettingRegional hospital-based oncology database of approximately 2 million patients in England.ParticipantsPatients aged ≥18 years with a diagnosis of BC, NSCLC or PC as well as BM between 1 January 2007 and 31 December 2018, with follow-up to 30 June 2020 or death; BM diagnosis ascertained from recorded medical codes and unstructured data using natural language processing (NLP).Main outcomes measuresInitiation or non-initiation of BTA following BM diagnosis, time from BM diagnosis to BTA initiation, time from first to last BTA, time from last BTA to death.ResultsThis study included 559 BC, 894 NSCLC and 1013 PC with BM; median age (Q1–Q3) was 65 (52–76), 69 (62–77) and 75 (62–77) years, respectively. NLP identified BM diagnosis from unstructured data for 92% patients with BC, 92% patients with NSCLC and 95% patients with PC. Among patients with BC, NSCLC and PC with BM, 47%, 87% and 88% did not receive a BTA, and 53%, 13% and 12% received at least one BTA, starting a median 65 (27–167), 60 (28–162) and 610 (295–980) days after BM, respectively. Median (Q1–Q3) duration of BTA treatment was 481 (188–816), 89 (49–195) and 115 (53–193) days for patients with BC, NSCLC and PC. For those with a death record, median time from last BTA to death was 54 (26–109) for BC, 38 (17–98) for NSCLC and 112 (44–218) days for PC.ConclusionIn this study identifying BM diagnosis from both structured and unstructured data, a high proportion of patients did not receive a BTA. Unstructured data provide new insights on the real-world use of BTA.

Este livro compõe os anais do evento Educação & Inovação - I Congresso Internacional. Os trabalhos aqui reunidos permitiram discutir as transformações que o ensino-aprendizagem vem experimentando nos últimos anos e que perpassam não só questões tecnológicas, mas também pedagógicas. Espera-se que esta obra contribua para uma discussão ampla e transversal sobre o futuro da educação e a educação do futuro, compreendendo seus impactos nos sujeitos e no coletivo. Uma reflexão que deve estar alinhada ao tipo de sociedade que queremos deixar para as próximas gerações.

Virtual constraints are invariant relations imposed on a control system via feedback as opposed to real physical constraints acting on the system. Nonholonomic systems are mechanical systems with non-integrable constraints on the velocities. In this work, we introduce the notion of virtual nonholonomic constraints in a geometric framework. More precisely, it is a controlled invariant distribution associated with an affine connection mechanical control system. We demonstrate the existence and uniqueness of a control law defining a virtual nonholonomic constraint and we characterize the trajectories of the closed-loop system as solutions of a mechanical system associated with an induced constrained connection. Moreover, we characterize the dynamics for nonholonomic systems in terms of virtual nonholonomic constraints, i.e., we characterize when can we obtain nonholonomic dynamics from virtual nonholonomic constraints.

This paper provides a preliminary study of the Novohispanic poet Francisco de Terrazas’s Nuevo Mundo y Conquista. In the first part it is documented all the information regarding the poet’s biography and oeuvre, while the second consists of a detailed analysis of the epic poem’s preserved octaves in order to reconstruct its argument and study it further.

This chapter explores the contribution of the Action Learning and Action Research Association World Congress 2015 to our learning. It draws on the experience of carrying out appreciative action research and summarizes our understanding of the poetic principle of appreciative inquiry (AI), in particular the role of playful provocation as part of an appreciative, dialogical and collaborative change methodology. The poetic principle of AI makes language central to the process of inquiry and means that the language of inquiry has important outcomes in and of itself. The concept of poetics is closely linked to play, expressed through language and other forms of symbolic representation. The use of imagery, metaphor and stories helps to deepen inquiry and enables people to articulate tacit, intuitive and unconscious knowledge.

Peer tutoring has proven to be an effective method for teaching reading. In this experiment 106 2nd grade students received nine sessions of the LEO-PAR-D peer tutoring program. Participants performed reciprocal tutoring, supervising partner reading, asking questions and giving points for reading or responding correctly. In addition, they made predictions and answared to questions about the texts. The reading level was assessed before and after intervention with the tests ACL-2, TECLE and PEES. In all three cases there was a significant improvement. The effect size was small for reading comprehension and moderate for reading efficiency.The results of this experiment indicate that the LEO-PAR-D program could be useful in improving some aspects of reading, therefore, further investigation is warranted to evaluate the program effectiveness with a stronger design.

Esta investigación establece las discrepancias en la aplicación de la Didáctica y Metodología empleada por el docente de matemática, relacionada con la unidad programática Computación e Informática de la E.B.V. Está ubicada en el contexto de la investigación evaluativa y el procedimiento metodológico aplicado está centrado en el método descriptivo-exploratorio, para lo cual se diseñó un instrumento conformado por 36 ítems referido, por una parte, a lo real (ES) y por la otra, a lo ideal (DEBERÍA SER). Su aplicación a los docentes de matemática que laboran en la III Etapa, facilitó el acopio de la información, cuyo análisis derivó entre otros, los siguientes resultados: .-Existe, en general, una alta discrepancia entre el "ES" y el "DEBERIA SER" del perfil metodológico de los docentes. .- Los docentes manifiestan, la no inclusión y desarrollo de la unidad programática Computación e Informática en su planificación anual.

Maquira coriacea es un árbol de valor comercial que se encuentra a lo largo y ancho de los bosques de la llanura aluvial inundable de la Amazonía. En este documento se describe su reproducción, su patrón de dispersión y otros atributos sobre la biología y ecología de su población. Se observaron densidades de hasta 14 individuos por hectárea con DAP > 10 cm, con un área basal de 2 m2/ha y un volumen de 38 m3/ha. El principal periodo de fructificación coincidió con la inundación anual, pero también se produjeron frutos en otros periodos del año. Se encontró regeneración natural con densidades de hasta 150 ind/m2 concentrados alrededor de los árboles madre; sin embargo, su permanencia fluctúa a lo largo del año por la mortalidad causada por las inundaciones y la marchitez en los periodos secos. Con el fin de desarrollar modelos de (1) relación altura-diámetro y (2) incremento de diámetro, se usaron principalmente datos de crecimiento de nueve parcelas de muestreo de una ha. Estas relaciones indican que el límite óptimo de diámetro de apeo para obtener el máximo volumen de producción es de 115-130 cm de DAP, los cuales pueden ser obtenidos en 135-300 años. Debido a que se ha observado producción de semillas en individuos muchos más pequeños, tales límites diamétricos no deberían ser desventajosos para la regeneración.