Universidade Católica de Petrópolis

This theoretical essay integrates critical perspectives on cross-cultural psychology, the concept of human mobility, and a policy implementation model to propose a renewed framework for professional practice. Starting from the recognition of cultural diversity as a fundamental reality (Matsumoto & Juang, 2004), the article examines criticisms of Western bias and "intellectual extractivism" in the field (Anjum & Aziz, 2024; Henrich et al., 2010). It is argued that adopting the term "mobility", rather than "migration", offers a more fluid and less charged lens for understanding human displacement and its psychological impacts (Cresswell, 2006). Next, Secchi's public policy model (Abad, 2017) is used as a framework to operationalize the implementation of the APA Multicultural Guidelines (2017), promoting epistemic justice and practical competence. It is concluded that a relevant and ethical cross-cultural psychology must be anti-colonial, sensitive to power and mobility dynamics, and committed to structured processes of institutional change.

The online version contains supplementary material available at 10.1007/s44164-025-00101-x.

The development of innovative treatments for American Cutaneous Leishmaniasis is crucial due to severe side effects of current treatment and the emergence of non-responder parasites. To address such a challenge the incorporation of epoxy-α-lapachone (ELAP) into a microemulsion (ME), named ELAP-ME, represents a promising therapeutic approach. In previous studies, ELAP-ME demonstrated efficacy in controlling infection in the BALB/c-Leishmania (Leishmania) amazonensis model, advancing in the technology readiness level with a drug prototype. To further validate its potential as a drug prototype, the histopathological effects of ELAP-ME were investigated in healthy BALB/c mice as a preclinical approach stage. Mice were administered with a fixed dose of ELAP-ME microemulsion (∼7μg/kg) and evaluated at different short-term after administration (4, 12, and 24h). Histopathological analysis of the liver, kidney, lung, heart, and brain revealed only mild alterations. These findings confirm the low toxicity profile of ELAP-ME, highlighting its safety and supporting its continued advancement as a pharmacological alternative for the treatment of leishmaniasis.

ABSTRACTIntroductionLidocaine is widely used in pediatric anesthesia for airway topicalization to modulate undesirable airway and circulatory reflexes, yet its effectiveness remains unclear. Therefore, we aimed to perform a meta‐analysis evaluating the impact of topical lidocaine on respiratory adverse events in children undergoing airway management.MethodsPubMed, Embase, and Cochrane databases were systematically searched for studies comparing topical lidocaine with placebo, no intervention, or intravenous lidocaine for pediatric airway management. Statistical analysis was performed using R (version 4.4.1). Odds ratios (ORs) were used for binary outcomes and mean differences for continuous outcomes, with 95% confidence intervals (CIs) computed using a random‐effects model.ResultsFourteen randomized controlled trials comprising 1937 pediatric patients were included, of whom 917 (47%) received airway topicalization. In those receiving topical lidocaine, there was a significant reduction in the incidence of laryngospasm (OR 0.50; 95% CI 0.27 to 0.95; p = 0.033), desaturation (OR 0.49; 95% CI 0.25 to 0.98; p = 0.043), and sore throat (OR 0.31; 95% CI 0.16 to 0.58; p < 0.001). However, no significant differences were observed for bronchospasm (OR 0.50; 95% CI 0.11 to 2.35; p = 0.382), cough (OR 0.56; 95% CI 0.28 to 1.11; p = 0.099), severe cough (OR 1.30; 95% CI 0.18 to 9.51; p = 0.793), hoarseness (OR 1.41; 95% CI 0.17 to 11.96; p = 0.754), vomiting (OR 1.95; 95% CI 0.47 to 7.99; p = 0.355), and heart rate (beats/min) (MD 0.08; 95% CI −6.31 to 6.47; p = 0.98).ConclusionOur findings suggest that topical lidocaine may reduce the incidence of undesirable airway reflexes such as laryngospasm, desaturation, and sore throat in children undergoing airway management. However, its benefit for other perioperative respiratory adverse events requires further investigation, especially in high‐risk populations.Trial RegistrationPROSPERO registration number: CRD42024614863

ABSTRACTAlzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functions, it is well established that AD is associated with cardiovascular risk factors beyond only cerebral decline. In this study, we measured hemodynamic parameters related to cardiovascular and cerebrovascular function in 5xFAD mice with AD and their littermates. Specifically, we measured cardiovascular pulse wave velocity parameters, a marker of arterial stiffness and cardiovascular risk, and cerebrovascular pulse wave velocity, a novel technique to measure cerebral arterial stiffness. Our results showed that while 5xFAD mice exhibited significant differences in ejection time, pulse pressure, and Tei index, many other cardiovascular and cerebral parameters were not different. Despite reports that amyloid plaque deposition begins at an early age of 1.5 months in 5xFAD mice, our results did not indicate significant cardiovascular changes. Studies to elucidate cardiovascular and cerebrovascular parametric changes should be done at later ages where the underlying changes are more profound.

O texto investiga as relações entre o pensamento do intelectual francês Michel de Certeau (1925 - 1986) e a obra Ludwig Wittgenstein (1889 ‒ 1951). Para tanto, foca no conceito de “heterologia”, proposto por De Certeau, relacionando-o aos limites da linguagem e à natureza do sujeito, percebidos na filosofia de Wittgenstein. Logo, partindo da revisão bibliográfica e analisando a obra de Michel de Certeau à luz da filosofia da linguagem de Wittgenstein, este trabalho procura demonstrar que as dificuldades em compreender o Outro nas humanidades transcendem o âmbito epistemológico. A heterologia certeauniana, ao encontrar um fundamento na impossibilidade wittgensteiniana de apreender o sujeito metafísico pela linguagem, revela que a natureza do Outro como um sujeito que escapa à descrição linguística constitui um desafio tanto epistemológico quanto metafísico para as humanidades. Palavras-chave: Michel de Certeau. Ludwig Wittgenstein. Heterologia. Epistemologia. Metafísica.

Motor neuron disease and parkinsonism syndromes associated with chronic HIV infection are extremely rare, with only a few cases reported in major medical databases. We report a case from Brazil involving a patient with a chronic, well-controlled HIV infection for approximately 15 years, demonstrating a good response to highly active antiretroviral therapy. Despite the absence of viral replication, the patient developed atypical clinical and topographical features consistent with both pyramidal and extrapyramidal syndromes. This raises the question of whether such findings could be linked to chronic HIV infection, occurring simultaneously even in the absence of active viral replication, particularly given that other potential diagnoses were excluded.