Universidade Federal de Roraima

Abstract 4-Quinolones are a class of heterocycles traditionally known for their biological properties. More recently, those derivatives have gained attention as versatile ligands for the construction of metal-centered molecular materials, such as coordination polymers (CPs), opening new possibilities for environmental applications. In this study, a novel dicarboxylated organic compound, 1-ethyl-4-oxo-1,4-dihydroquinoline-3,6-dicarboxylic acid ( H 2 L ), was synthesized and employed to construct zinc-based materials. The synthetic parameters (temperature, time, modulator type, and modulator/ligand precursor ratio) were systematically evaluated, notably highlighting the replacement of the conventional solvothermal solvent (DMF) with a greener alternative (H 2 O) to synthesize the Zn-based materials. Under optimized conditions, two new materials were obtained, namely Material 1 (synthesized in DMF) and Material 2 (synthesized in H 2 O). Additionally, Material 2 - [Zn(L)(H 2 O)] n - was obtained as single crystals and structurally characterized via synchrotron X-ray diffraction. As for the application, Material 2 demonstrated an adsorption capacity of 24.6 mg g -1 for the removal of the toxic dye methylene blue (MB). Different adsorption essays revealed that the Langmuir isotherm and pseudo-second-order kinetic model best described the behavior of Material 2 . This material achieved 100% selectivity toward the cationic dye (MB) and demonstrated excellent reusability, with only approximately 10% loss in removal efficiency over three adsorption/desorption cycles. Post-adsorption characterization provided valuable insights into the underlying interaction mechanisms. Together, these results highlight the potential of the developed quinolone-based coordination polymer as an efficient material for environmental remediation applications and underscore the relevance of further exploring this emerging class of compounds. Graphical Abstract

As metodologias ativas têm sido amplamente discutidas no contexto educacional contemporâneo como estratégias capazes de promover maior participação dos estudantes no processo de ensino-aprendizagem. No ensino superior, essas abordagens buscam superar modelos tradicionais centrados na transmissão de conteúdo, estimulando o protagonismo discente, o pensamento crítico e a autonomia na construção do conhecimento. Nesse sentido, a aprendizagem significativa destaca-se como um importante referencial teórico, uma vez que enfatiza a relação entre os conhecimentos prévios dos estudantes e as novas informações adquiridas durante o processo educativo. O presente estudo teve como objetivo analisar, por meio de uma revisão de literatura, as contribuições das metodologias ativas no ensino superior para o desenvolvimento da aprendizagem significativa. Trata-se de uma pesquisa de abordagem qualitativa, realizada a partir da análise de artigos científicos publicados entre 2010 e 2025, encontrados nas bases de dados SciELO, Google Scholar, PubMed, ERIC e Portal de Periódicos da CAPES. Os resultados evidenciam que estratégias como aprendizagem baseada em problemas, aprendizagem baseada em projetos, sala de aula invertida e estudo de caso contribuem para o desenvolvimento da autonomia, do pensamento crítico e da capacidade de resolução de problemas. Além disso, tais metodologias favorecem a integração entre teoria e prática, promovendo experiências de aprendizagem mais significativas e contextualizadas. Conclui-se que as metodologias ativas representam importantes ferramentas pedagógicas para fortalecer o processo de aprendizagem significativa no ensino superior, contribuindo para a formação de profissionais mais críticos, reflexivos e preparados para os desafios da sociedade contemporânea.

Introduction Rapid land-use change in the Peruvian Amazon threatens soil processes that sustain productivity and ecosystem resilience. This study assessed soil functioning indicators along a land-use intensification gradient in Ucayali, Peru. Methods We evaluated physicochemical (texture fractions, pH, organic matter, cation-exchange capacity, carbon, and micronutrients) and biological indicators (cultivable microbial groups, microbial biomass carbon, respiration, and macrofauna) from 54 independent composite topsoil samples (0–20 cm) across seven land-use systems, multiple localities, and soil texture classes. Principal component analysis and univariate tests were applied to identify multivariate gradients and significant differences among groups. Results PCA revealed a dominant texture–fertility gradient contrasting sand-rich soils with finer-textured soils associated with higher CEC, organic matter, total carbon, and micronutrients (notably Mn and Cu). Significant differences among land-use systems were detected for CEC, OM, Mn, pH, Cu, SOC, and sand. Cacao agroforestry differed from pasture and oil palm systems in key fertility indicators. Biological indicators showed weaker global separation, although macrofauna differed significantly among land uses. Conclusion Soil texture modulated baseline fertility and the expression of land-use impacts. Cacao agroforestry and secondary forests occupied transitional positions between forests and intensive systems. A reduced monitoring set including texture fractions, OM, CEC, pH, Mn, and selected biological metrics is recommended for tracking soil degradation in heterogeneous Amazonian landscapes.

Conducting multicenter, longitudinal epidemiological studies on emerging pathogens in real time during health emergencies presents significant challenges, especially in low- and middle-income countries, where substantial logistical and resource constraints hinder the rapid design and implementation of research protocols. This is particularly difficult when the disease spreads rapidly and its nature changes due to the onset of vaccination. During the COVID-19 pandemic, a cohort study (AVISA) was conducted in eleven research sites to assess seroprevalence. The objective of this study is to identify the challenges to the successful execution of the AVISA study through a retrospective analysis of quantitative and qualitative indicators. The rapid spread of SARS-CoV-2 infections, particularly in large urban areas in Brazil, and the initiation of COVID-19 vaccination in January 2021 posed significant challenges for recruiting individuals who met the eligibility criteria. Participant enrollment was slower than initially planned, and fewer participants from the youngest and oldest cohorts were recruited. The implementation of the study protocol encountered significant logistical and operational challenges due to the evolving COVID-19 context, including the effects of vaccination, the loosening of social distancing measures, and difficulties conducting household visits and collecting samples in high-risk areas. To ensure participant retention and protocol adherence, the study employed flexible strategies, including rescheduling visits, enhancing communication, and mobilizing experienced staff, which were crucial for maintaining data collection and study continuity over time. Despite concurrent demands of the COVID-19 response, Instituto Butantan and its partners successfully mobilized resources, staff, and infrastructure to conduct the AVISA study across 11 sites, leveraging existing collaborations from prior clinical trials. The study conducted over 16,000 household visits, collected nearly 7,000 blood samples, and gathered detailed clinical and sociodemographic data from participants. Despite the complexities of conducting real-time research during a public health emergency, the AVISA study demonstrated that large-scale, multi-site longitudinal studies can be implemented in resource-constrained settings through adaptive strategies, institutional partnerships, and flexible field operations. The lessons learned offer essential insights for strengthening the design and execution of epidemiological studies in future health emergencies, particularly in low- and middle-income contexts.

The oral health of patients admitted to Intensive Care Units (ICU) presents specific challenges, culminating in an increased risk of nosocomial infections. The oral cavity, compromised by factors such as deep sedation and mechanical ventilation, rapidly transforms into a reservoir of pathogens, favoring the aspiration of secretions and the subsequent Ventilator-Associated Pneumonia (VAP). This review article delves into: (1) the physiopathological particularities of the critical patient's oral health and the mechanisms of oropharyngeal colonization; (2) the irreplaceable role of the dental surgeon in the ICU team, detailing their preventive interventions; (3) the mechanisms of antimicrobial resistance facilitated by oral biofilm; and (4) the latest evidence on the effectiveness of oral hygiene protocols combining mechanical removal and antiseptic agents in reducing VAP. It is concluded that the institutionalization of rigorous oral hygiene protocols including toothbrushing, supervised or performed by a hospital dentist, and the judicious use of antiseptics (mainly 0.12% chlorhexidine) are cost-effective measures that drastically reduce the incidence of VAP. It is crucial, however, that further studies focus on the impact of these interventions on outcomes such as mortality, length of stay, and the emergence of bacterial resistance.

Este artigo acadêmico busca analisar o compliance como instrumento de prevenção de ilícitos empresariais e da efetivação da função social da empresa, com base na Lei nº 11.101/2005, que regula a recuperação judicial, extrajudicial e a falência do empresário e da sociedade empresária. Diante disso, a pesquisa adota abordagem qualitativa fundamentada em revisão bibliográfica, para compreender como o método de integridade contribui para evitar fraudes que comprometem a continuidade das atividades empresariais. O estudo discute o compliance como cultura organizacional pautada pela ética, transparência e responsabilidade social, capaz de orientar a conduta corporativa. Ainda, será analisado o funcionamento em conformidade legal, que fortalece a governança e reduz os riscos de ilícitos voltados ao ramo empresarial. Observa-se que, em alguns casos, os programas são aplicados de forma simbólica. Assim, a pesquisa evidencia a relevância do compliance na prevenção de crimes falimentares, preservação da função social da empresa e fortalecimento da confiança institucional.

Este artigo aborda a Nova História Indígena e as ideias de tempo Ingarikó, visando à construção de uma proposta de ensino da história do povo a partir de suas epistemologias, das vozes dos sábios indígenas e da análise de documentos audiovisuais elaborados por visitantes e pesquisadores que estiveram no território Ingarikó. Esses documentos, consultados em Plataformas Digitais na internet, têm a intenção de serem utilizados nas aulas de História das escolas das comunidades Ingarikó. PALAVRAS-CHAVE: Ingarikó; Ensino de História Indígena; audiovisual.

Esta pesquisa tem como objetivo analisar o impacto das características dos candidatos ao governo estadual em suas prestações de contas eleitorais. Utilizou-se uma pesquisa de caráter descritivo, com abordagem quantitativa e procedimentos documentais. Os dados foram coletados no site DivulgaCand, no período de agosto a dezembro de 2022. A amostra é composta pelas principais prestações de contas eleitorais dos candidatos ao governo estadual nas eleições de 2018 e 2022, totalizando 162 prestações de contas de 148 candidatos distintos. As rubricas de receitas e despesas foram analisadas e relacionadas às características dos candidatos quanto a gênero, tipo de candidatura, escolaridade, raça/cor e ideologia. Os resultados evidenciam um possível perfil predominante: homens, em busca da primeira eleição, com escolaridade superior, brancos e ideologicamente de direita. Essas características impactam as prestações de contas, sobretudo no que diz respeito a privilégios e vantagens de alguns grupos em relação a outros, além de influenciar a distribuição dos recursos e a forma dos gastos de campanha. Conclui-se ressaltando a existência de desigualdades e desafios entre os candidatos que participam das campanhas eleitorais, destacando-se a importância de que a legislação atue por meio de ações afirmativas capazes de contribuir para a redução dessas desigualdades.