University Consortium of Pori

BackgroundCommercial high-sensitivity cardiac troponin T (hs-cTnT) assays measure both intact and degraded cTnT forms (i.e. total cTnT) and values are often elevated in chronic kidney disease (CKD) patients. The measurement of long cTnT forms has recently shown improved specificity for acute myocardial infarction compared to total cTnT. However, the associations between long cTnT and adverse long-term outcomes in CKD are unknown.MethodsAltogether, 136 CKD stage 4–5 patients not on dialysis were included in this prospective cohort study. Long cTnT and total cTnT levels before dialysis initiation were measured using investigational in-house immunoassays. The associations between cTnT measurements and all-cause mortality, incident major adverse cardiovascular or cerebrovascular events (MACCE), new-onset atrial fibrillation (NOAF) and a composite adverse outcome (all-cause mortality or MACCE) were assessed.ResultsMean age was 61 (±13) years, 47 (34.6%) were female and median values for long cTnT and total cTnT were 1.9 (1.3–3.0) ng/L and 37 (23–66) ng/L, respectively. After a median follow-up of 6.2 (4.6–7.7) years, 62 (45.6%) patients had died, 36 (26.5%) had experienced MACCE, 28 (23.3%) NOAF and 76 (55.9%) a composite adverse outcome. In multivariable Cox models adjusted for age, sex and coronary artery disease (CAD), long cTnT and total cTnT were independently associated with all-cause mortality, NOAF and the composite adverse outcome, while only total cTnT was associated with MACCE. Replacing the adjustment for CAD with kidney transplantation in the multivariable models weakened the significance of the associations.ConclusionsWe describe for the first time associations between long cTnT and long-term cardiovascular adverse outcomes and all-cause mortality in a prospective cohort of CKD stage 4–5 patients.Trial registrationhttps://www.ClinicalTrials.gov NCT04223726. Retrospectively registered in December 10, 2019.Supplementary informationThe online version contains supplementary material available at 10.1186/s12882-026-04803-6.

The association between playing digital games and watching esports has, to date, been an explicit assumption of many works, specifically that there is a strong and direct correlation between playing games and watching esports. The conflation of game play and esports serves to create conceptual confusion and a lack of clarity in research, both in HCI and beyond. This exploratory, atheoretical work demonstrates that some correlations exist between game play and spectating esports; however, many measures were not found to have statistically significant associations. Furthermore, the observed correlations were found to have small effect sizes and explained little variance of esports spectating measures. Results question fundamental assumptions of many works, which assume a strong association between playing games and spectating esports, raising concerns about their validity and applicability. Furthermore, they highlight the need for further research into the interactions of digital games and the systems which have emerged around them.

Abstract How can we ethically include nonhuman animals during methodological considerations in organizational and business ethics research? Additionally, what methodological opportunities and challenges do multispecies research approaches present for these research areas? Building on critical posthumanist theory, the feminist ethic-of-care tradition in animal ethics, and the aesthetics of posthuman methodologies, this article develops a novel avenue for multispecies methodological research that expands current approaches to organizational and business ethics research beyond a purely human-centric lens. Empirical materials include diary excerpts about one author’s daily ethical encounters with her dogs and video clips of dog–human relationships, along with aesthetic reflections from two other researchers. Our reflections are shaped by posthumanist theorizing and critically problematize the seemingly static, anthropocentric categorizations of researcher , positionality , and research participant within the ethically complex context of multispecies research. Beyond discussing our findings in relation to recent business ethics research, we propose a methodological avenue for studying the aesthetic hybridization of humanimal subjectivities, including subtle bodily interactions between dogs and humans. This avenue fosters more aesth-ethically attuned and species-inclusive research methodologies in animal organization studies (AOS) and the broader fields of business ethics and organization studies, which are especially critical in the Anthropocene.

Computer has changed our human world more than any other human invention. It has enabled invention of nuclear bomb, information systems, digital communication and digital currencies, artificial intelligence and recently programs with human-like conversation ability. In the following is presented a brief overview of these developments and described with examples the use of chatGPT for teaching students to program in natural language.

This study is based on the results of observations that show that students' learning scores in science lessons about climate and its changes are still low. This study aims to improve learning outcomes at SDN Pojok 1 in science lessons on climate and its changes using interactive spinner media and using the Problem-Based Learning learning model. This study is PTK for grade IV students, with data from tests and observations analyzed descriptively quantitatively. The findings of this study indicate that learning outcomes related to conceptual understanding of 22 students who took the test, obtained a percentage of 72.72% completion rate in cycle 1 and 95.45% in 22 students in cycle II. It can be concluded that the implementation of the Problem-Based Learning model assisted by spinner media has been proven to improve science learning outcomes. Therefore, the Problem-Based Learning model assisted by spinner media can be the right choice for teachers to make teaching and learning activities more diverse and interesting in the classroom.

Abstract Background Migratory birds generally have tightly scheduled annual cycles, in which delays can have carry-over effects on the timing of later events, ultimately impacting reproductive output. Whether temporal carry-over effects are more pronounced among migrations over larger distances, with tighter schedules, is a largely unexplored question. Methods We tracked individual Arctic Skuas Stercorarius parasiticus , a long-distance migratory seabird, from eight breeding populations between Greenland and Siberia using light-level geolocators. We tested whether migration schedules among breeding populations differ as a function of their use of seven widely divergent wintering areas across the Atlantic Ocean, Mediterranean Sea and Indian Ocean. Results Breeding at higher latitudes led not only to later reproduction and migration, but also faster spring migration and shorter time between return to the breeding area and clutch initiation. Wintering area was consistent within individuals among years; and more distant areas were associated with more time spent on migration and less time in the wintering areas. Skuas adjusted the period spent in the wintering area, regardless of migration distance, which buffered the variation in timing of autumn migration. Choice of wintering area had only minor effects on timing of return at the breeding area and timing of breeding and these effects were not consistent between breeding populations. Conclusion The lack of a consistent effect of wintering area on timing of return between breeding areas indicates that individuals synchronize their arrival with others in their population despite extensive individual differences in migration strategies.

The interlamellar cohesion of thermal spray coatings influences greatly their mechanical properties and ability to use coatings in different loading conditions and wear/erosion resistance. In the present study, micro-tensile testing of free-standing coatings was utilized to evaluate the mechanical response of thermally sprayed coatings. In addition, the longitudinal uniaxial fracture strength of free-standing coatings could be determined by a tensile test. The coating materials studied were NiCr and NiCrBSi coatings sprayed by atmospheric plasma spraying (APS), high velocity oxy-fuel (HVOF), and high velocity air-fuel (HVAF) processes. The different materials used for the coatings sprayed by different methods yield different microstructures, different stress-strain relation in tensile testing. Different tensile test response was found to be related to cohesion strength between lamellas, and thus was affecting the cavitation erosion wear. The effect of other factors such as hardness and residual stresses on cavitation resistance were also discussed. Such results are crucial to understand the suitability of microstructures obtained by TS processes for different wear conditions.

Desa Braja Harjosari, Lampung Timur adalah salah satu desa yang berbatasan langsung dengan Taman Nasional Way Kambas (TNWK). Desa ini telah berhasil menangani konflik gajah dan manusia dan terus berupaya mempertahankannya. Wilayah desa ini juga terdapat padang savana yang berbatasan langsung dengan kawasan konservasi TNWK. Padang savana ini dapat dikembangkan sebagai kawasan wisata untuk mendongkrak perekonomian desa. Pengabdian ini merupakan kegiatan pendampingan langsung di bawah Program TFCA Sumatera 2019-2021 Konsorsium Unila-AleRT dalam pengembangan potensi wisata tersebut. Pada akhir kegiatan pengabdian, enam paket wisata telah ditetapkan dan dikelola oleh Kelompok Sadar Wisata Braja Harjosari. Paket wisata tersebut adalah paket berkemah, menikmati matahari terbit dan tenggelam, bakar ikan, susur sungai, pengamatan satwa liar, dan swa foto.

Abstract Introduction: Post-activation potentiation has an influence on short duration and high intensity function. This study aimed to answer this question whether post-activation potentiation protocol in different models has effect on anaerobic performance in women Wushu athletes. Methods: Women elite Taolu Wushu athletes participated in current crossover design study. (i) specific Wushu WU (Wushu WU); (ii) Strength-based WU (StreWU); and (iii) Speed-based WU (SpeWU) were performed by Wushu athletes in three inconsecutive days separated by 48 h. Five minutes after each WU protocols, Running-Based Anaerobic Sprint Test (RAST) was performed. Heart rate, immediately, and blood lactate were measured for 4 times: before WU protocols, immediately after WU protocols, before RAST, immediately after RAST.Results: Data analysis revealed significant differences in 4 time points of lactate levels (p=0.001; d=1.71), although no significant difference among protocols was observed. Values of variables obtained from RAST showed that StreWU had a significant impact on minimum power (p<0.05; d=-0.795) comparing to WushuWU and on fatigue index comparing to SpeWU (p<0.05; d=-0.799). No significant differences were found among the WU protocols for peak power and mean power.Conclusion: All WU protocols had mostly the same effect, and PAP was not very effective. Possibly, the WU protocols generated too much fatigue, due to the short-term rest time. However, longer intervals would likely enter the realm of post-activation performance enhancement, which is distinct from PAP.

BackgroundThis ongoing follow-up study evaluated the persistence of efficacy and immune responses for 6 additional years in adults vaccinated with the glycoprotein E (gE)-based adjuvanted recombinant zoster vaccine (RZV) at age ≥50 years in 2 pivotal efficacy trials (ZOE-50 and ZOE-70). The present interim analysis was performed after ≥2 additional years of follow-up (between 5.1 and 7.1 years [mean] post-vaccination) and includes partial data for year (Y) 8 post-vaccination.MethodsAnnual assessments were performed for efficacy against herpes zoster (HZ) from Y6 post-vaccination and for anti-gE antibody concentrations and gE-specific CD4[2+] T-cell (expressing ≥2 of 4 assessed activation markers) frequencies from Y5 post-vaccination.ResultsOf 7413 participants enrolled for the long-term efficacy assessment, 7277 (mean age at vaccination, 67.2 years), 813, and 108 were included in the cohorts evaluating efficacy, humoral immune responses, and cell-mediated immune responses, respectively. Efficacy of RZV against HZ through this interim analysis was 84.0% (95% confidence interval [CI], 75.9–89.8) from the start of this follow-up study and 90.9% (95% CI, 88.2–93.2) from vaccination in ZOE-50/70. Annual vaccine efficacy estimates were >84% for each year since vaccination and remained stable through this interim analysis. Anti-gE antibody geometric mean concentrations and median frequencies of gE-specific CD4[2+] T cells reached a plateau at approximately 6-fold above pre-vaccination levels.ConclusionsEfficacy against HZ and immune responses to RZV remained high, suggesting that the clinical benefit of RZV in older adults is sustained for at least 7 years post-vaccination. Clinical Trials Registration. NCT02723773.