University Grants Committee

A new sensing strategy towards hydrogen peroxide based on metal coordination polyelectrolyte-driven self-assembly of alkynylplatinum(II) 2,6-bis(benzimidazol-2'-yl)pyridine (bzimpy) complex was demonstrated. The cationic in situ-generated Ag(I)-thiocholine coordination polyelectrolytes were shown to induce the supramolecular self-assembly of anionic low-energy red-emissive alkynylplatinum(II) bzimpy complexes via non-covalent Pt(II)⋅⋅⋅Pt(II), electrostatic and π-π stacking interactions. The presence of hydrogen peroxide was shown to inhibit the formation of coordination polyelectrolytes and the coordination polyelectrolyte-induced self-assembly of platinum(II) complexes. The weakening of Pt(II)⋅⋅⋅Pt(II), electrostatic and π-π stacking interactions was supported by UV-vis absorption, emission, and resonance light scattering (RLS) studies. The present assay was also applied to probe glucose indirectly based on the enzymatic reaction of glucose oxidase on the substrate. Operating in a label-free manner, together with the low-energy red emission and large Stokes shift of alkynylplatinum(II) complexes, these features render the proposed design attractive for biological applications.

Banks have so far weathered well the financial turbulence caused by COVID-19 while at the same time being central in the economic and financial response. As the crisis moves from its initial phase as a short-term liquidity shock, the financial sector is facing increasing volumes of non-performing loans, raising the spectre of a banking solvency crisis. In economies already burdened with low-quality assets, the COVID-19 fallout is intensifying existing problems with legacy loans heightening the risk of a banking crisis. These issues are now being worsened by the impact of inflation and the invasion of Ukraine. Thus, addressing increasing volumes of bad loans, while supporting the proper functioning of the financial system, is a major challenge with systemic repercussions for a range of economies. This paper identifies a great paradox: since the bank rescues of the 2008–9 Global Financial Crisis there has been a disproportionate focus on the liability side of bank balance sheets through resolution measures such as bail-in and the accumulation of bail-inable debt. Post-crisis bank resolution regimes have overlooked solutions lying within the asset side of bank balance sheets. This paper analyses historical evidence to argue that concentrating on a liability-focused approach to the exclusion of asset-side solutions is ill-conceived. An excessive accumulation of non-performing loans on the asset side of bank balance sheets inevitably renders resolution interventions on the liability/equity side ineffective or at the very least insufficient to maintain banking system viability and financial stability. Bank asset restructuring involving the use of asset management companies, asset protection schemes and even capital injections can play a critical role in achieving an expeditious restoration of banking systems’ health following a major macroeconomic, sustainability or financial crisis.

BackgroundCigarette smoking is associated with nasopharyngeal cancer (NPC) risk. Whether quitting reduces the risk is unclear. We investigated the associations of NPC with duration of and age at quitting in an endemic region.MethodsWe investigated the associations between NPC and quitting in a multicenter case-control study in Hong Kong with 676 newly diagnosed NPC cases and 1,285 hospital controls between 2014 and 2017, using a computer-assisted self-administered questionnaire. Multivariable unconditional logistic regression yielded adjusted odds ratios (AORs) of NPC by quitting status, duration and age of quitting, combinations of duration and age of quitting, and quitting to smoking duration ratio, compared with current smoking.ResultsQuitting (AOR: 0.72; 95% CI: 0.53–0.98) and never smoking (0.73, 0.56–0.95) were associated with lower NPC risk. NPC risk decreased with (i) longer quitting duration (p < 0.01), reaching significance after 11–20 (0.62, 0.39–0.99) and 21+ years (0.54, 0.31–0.92) of quitting; (ii) younger quitting age (p = 0.01), reaching significance for quitting at <25 years (0.49, 0.24–0.97); and (iii) higher quitting to smoking duration ratio (p < 0.01), reaching significance when the ratio reached 1 (0.60, 0.39–0.93). Quitting younger (age <25) appeared to confer larger reductions (49% for ≤10 years of quitting, 50% for 11+ years) in NPC risk than quitting at older ages (25+) regardless of quitting duration (16% for ≤10 years, 39% for 11+ years).ConclusionsWe have shown longer duration and younger age of quitting were associated with lower NPC risk, with dose-response relations. Our findings support including smoking as a cause of NPC. Stronger tobacco control measures and quitting services are needed to prevent NPC.

Chiral self-recognition and self-discrimination are of vital importance to biological processes. In this work, 2D regular rhombic nanocrystals (RS-NC) were fabricated through heterochiral self-discrimination between chiral polynuclear gold(I)-sulfido complex enantiomers, [(R-BINAP)4 Au10 S4 ]Cl2 (R-Au10 ) and [(S-BINAP)4 Au10 S4 ]Cl2 (S-Au10 ), in MeOH without the need for any surfactants or templates. The monitoring of nanocrystals (NCs) formation by TEM and DLS has uncovered the self-assembly process and shape evolution of the NCs and revealed a screw-dislocation dictated spiral growth of the rhombic NCs. Upon addition of chiral anions, the morphology of the gold NCs was found to change from rhombic to strip and quasi-hexagonal nanosheets, arising from reverse and rotational layer-by-layer stacking to give the bilayer NCs. By applying a high temperature, rhombic gold nanoisland films were obtained from the rhombic NCs. The current study has provided a simple strategy towards the construction of regular geometric 2D NCs as well as their chiral anion-tuned and reverse and rotational stacking-determined morphology change by heterochiral self-discrimination.

Abstract It is of great significance to track the platinum drugs in real time with super‐resolution to elucidate their mechanism of action, such as their behavior and distribution in live cells. Such information is required for further drug development. However, it is always challenging to design platinum complexes suitable for such research. Herein, we design a luminescent building block (L) for metal complexes and a dinuclear platinum complex (Pt2L) for super‐resolution imaging. Because of its super‐large Stokes shift and excellent photophysical properties, Pt2L is capable of serving as an ideal candidate for super‐resolution imaging with extremely low luminescence background and high photobleaching resistance. Moreover, upon light stimulation, a matter flux of Pt2L escaping from autolysosomes to nucleus was observed, which represents a new transportation path. Utilizing the photoactivated escape properties, we can regulate the nuclear accessibility of Pt2L form autolysosomes with photo‐selectivity, which provides a new way to improve the targeting of platinum drugs.

The tridentate dpmp ligand was reacted with CuI salt and cyano ligand affording selectively and unexpectedly the polymetallic Cu11 complex 2 along one‐step reaction. The formation of this derivative 2 can be explained by self‐assembling processes controlled by adaptive coordination‐driven supramolecular chemistry. The solid‐state photophysical behavior of 2 was studied suggesting TADF properties.

A series of cyclometalated iridium(III) complexes has been designed and synthesized, and their photophysical, photochromic, and electrochemical properties have been studied. The X-ray crystal struc...

ABSTRACTWe develop a model of informational interdependence between financial markets and the real economy, linking economic uncertainty to information production and aggregate economic activities in general equilibrium. The mutual learning between financial markets and the real economy creates a strategic complementarity in their information production, leading to self‐fulfilling surges in economic uncertainties. In a dynamic setting, our model characterizes self‐fulfilling uncertainty traps with two steady‐state equilibria and a two‐stage economic crisis in transitional dynamics.