University of Bouira

An integrated computational study combining density functional theory and molecular dynamics simulation were performed to elucidate the adsorption mechanism of acetaminophen on Copper Oxide (CuO) and Zinc Oxide (ZnO) nanoparticles in aqueous media. The global electronic descriptors of the optimized adsorption complexes show clear differences. CuO/acetaminophen exhibits E HOMO = −7.33, E LUMO = −6.87 (ΔEgap = 0.461 eV), low chemical hardness (η = 0.23), high softness (S = 4.33) and very large electrophilicity (ω = 109.35). In contrast, ZnO/acetaminophen has E HOMO = −5.76, E LUMO = −0.92 (ΔE gap = 4.84 eV), η = 2.42, S = 0.41 and ω = 2.30, indicating CuO as a much stronger electron acceptor. Fukui and MEP maps identify the carbonyl (O11) and phenolic (O7) oxygens as primary donors (O11 f − = 0.1398, f + = 0.0866, f° = 0.2264). NBO analysis reveals larger donor → acceptor stabilization for CuO (E 2 = 37.7 kcal/mol) than ZnO (E 2 = 8.5 kcal/mol), consistent with significant LP(O/N) → metal charge-transfer on CuO. MD simulations corroborate stronger binding on CuO (E ads = −276 to −277.6 kcal/mol) than ZnO (−219 to −230 kcal/mol) over 290-318 K. Energy decomposition shows that (E deformation = −182 to −186 kcal/mol) dominates stabilization in both systems, while CuO displays a much larger E rigid (−93 to −95 kcal/mol) than ZnO (−36 to −45 kcal/mol). RDFs and non-bonded decomposition indicate short range, electrostatic coordination bonding on CuO (1.9–2.0 Å), and longer-range, dispersion H-bonding dominated contacts on ZnO (> 3.5 Å). These descriptors support a mechanism in which CuO favors charge transfer coordination (chemisorption), while ZnO favors relaxation assisted physisorption. This could guide the development of practical adsorbents for water treatment. CuO for strong sequestration and ZnO for reversible capture. • Mechanistic Contrast. • Electronic Structure Drivers. • Primary Adsorption Sites. • Stronger Binding to CuO. • Charge Transfer Evidence. • Practical Implications for Water Treatment.

Background: Dietary anthocyanins have been recognized for their potent antioxidant and hypolipidemic properties. However, the efficacy of anthocyanin-rich dietary interventions in modulating the lipid metabolism of physically active cohorts remains unclear. Aims: This exploratory, placebo-controlled pilot study aimed to evaluate whether a short-term (22-day) dietary supplementation with anthocyanin-rich red cabbage juice or red onion salad significantly modulates lipid profile parameters, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG), in healthy amateur soccer players. Methods: Fifteen male amateur soccer players (mean age: 24.86 ± 5.93 years) were enrolled and randomly assigned to three groups: red cabbage, red onion, and placebo. Over a 22-day period, participants consumed their assigned supplement while maintaining their regular physical activity levels. Venous blood samples were collected via the cubital vein before baseline and post-intervention for lipid profile parameters. Statistical significance was assessed using paired t-tests and Analysis of Variance (ANOVA) or Welch’s ANOVA where appropriate, with the significance threshold set at p ≤ 0.05. Results: Intra-group analyses revealed no statistically significant amelioration in lipid parameters within the red cabbage or red onion cohorts. However, a significant elevation in LDL-C concentrations was observed in the placebo group, increasing from 0.63 ± 0.13 to 0.70 ± 0.11 g/L (p = 0.037). This observation likely reflects the influence of extraneous, uncontrolled variables rather than a direct consequence of the intervention. Conclusions: The findings indicate that short-term dietary supplementation with anthocyanins does not significantly alter the lipid profiles of amateur soccer players. This lack of physiological response may be attributable to the optimized lipid metabolism characteristic of physically active individuals or the exploratory nature of the study design. While these preliminary data provide a foundation for future, adequately powered investigations in athletic populations, the results should be interpreted with caution due to the limited sample size. Keywords: Anthocyanins; Red Cabbage; Red Onion; Amateur Soccer Players; Lipid Profile.

The science of dream interpretation has long been distinguished by its close and multifaceted connections with various sciences, disciplines, and fields of knowledge.Owing to its engagement with a phenomenon related to the unseen and occurring during sleep-a state marked by ambiguity and concealment-it relies extensively on the outcomes of other sciences.Dreams, as the primary subject of this discipline, initially appear as internal mental images experienced during sleep.However, once narrated, they become spoken or written texts that are governed by linguistic rules, particularly those of Arabic grammar.This study seeks to explore the relationship between the science of dream interpretation and Arabic grammar by examining how grammatical principles contribute to the interpretive process.It highlights the role of syntactic structures, sentence patterns, grammatical functions, and linguistic analysis in facilitating the transition from the apparent wording of a narrated dream to its deeper interpretive meanings.By demonstrating the ways in which grammatical data are employed in deriving signification, the paper underscores the interdisciplinary nature of dream interpretation and affirms the central role of Arabic grammar in shaping and guiding the interpretive act.

Our current era is witnessing tremendous technological advancement across all fields, with education being one of the most prominent areas that must keep pace with digital transformation and meet its requirements.As a result, many modern electronic systems and applications in education have emerged, most notably distance learning in all its digital forms, in response to what is known as the "information society" phase.Today, the Internet provides a wide variety of electronic content supported by multiple computing tools and artificial intelligence applications, which include diverse elements such as images, texts, animations, and interactive videos.For this content to be effective, it requires dynamic organization and linkage through the use of instructional design based on clear objectives and concepts, taking into account the sequence and progression of the content, along with the design of a learner-centered interactive interface.Artificial intelligence technology gives educational systems tremendous capacity for development, achieving learning objectives, reaching all individuals seeking education, and providing the required information and knowledge with high quality, without excessive financial cost or physical effort.It is expected that AI-supervised digital learning environments will become the primary platform for global education, as they control stored information and knowledge and help learners access it in appropriate ways, anytime and anywhere.The learner remains the core of this type of learning, representing the real wealth that countries aim to invest in by nurturing creative and thinking minds.Therefore, modern educational philosophies have adopted smart learning systems centered around the learner, focusing on building electronic learning environments that support social interaction, multicultural interaction, and ensure high-quality learning with efficiency and effectiveness.

Abstract Lipomas are benign mesenchymal neoplasms composed of mature adipose tissue, most frequently found in subcutaneous regions. We report a case of a pure intra-thyroid lipoma. A 55-year-old Moroccan woman presented with a longstanding cervical mass. Clinical examination revealed a goitre, and thyroid function tests showed a euthyroid profile. Cervical ultrasound revealed a large right lobar thyroid nodule and a 6 mm left-sided nodule classified as EU-TIRADS 3, with no suspicious features. The patient underwent a total thyroidectomy after discussion of management options; the patient preferred definitive surgical management. Histopathological examination demonstrated a follicular adenoma occupying the entire right lobe, while the left lobe contained a 6 mm, well-circumscribed, encapsulated lipomatous lesion composed entirely of mature adipocytes, with no associated thyroid tissue. Only histopathological images are available for inclusion. This case highlights the rarity of pure intra-thyroid lipoma and emphasizes the role of careful histopathological assessment in distinguishing fat-containing thyroid lesions.