University of London Institute in Paris

In 1966, ten years after Morocco gained independence from French colonial rule, a group of decolonial writers founded the journal Souffles (1966–1972). Its mission was to deconstruct the suffocating binaries, concepts, and essentialisms that trapped Morocco in an enduring French cultural imperialism or hermetic cultural atavism. In this article, I draw a critical genealogy between leading Moroccan anti-imperial thinkers including Abdellatif Laâbi, Abdelkébir Khatibi, Mohammed Khaïr-Eddine, and Abdellah Taïa’s latest novel Vivre à ta lumière (2022). Just as the Souffles generation exposed the politics of illiteracy that had cemented the conditions of oppression during the Protectorate and its violent aftermath under the reign of Hassan II, so I argue that Taïa inhabits his mother’s illiterate tongue in the novel as a decolonial language that refuses to make itself legible to monologic forms of European, or Moroccan neocolonial, intellectualism. Attentive to the metatextual tropes of language, words, letters, scripts, and even envelopes as spaces in which Taïa reworks hegemonic colonial and absolutist narratives, I explore the poetic potential of illiteracy not as a cultural lack, relegated to silence in Morocco’s post-independence struggle for national sovereignty, but as a potent instrument of postcolonial literary critique.

Myeloid neoplasms arising after methotrexate

Dans cet entretien, Henry Bernstein revient sur la fondation des études agraires critiques et les principaux concepts qu’il a développés pour une étude marxiste de la sociologie rurale. Il montre comment l’opposition entre léninisme et populisme se rejoue dans l’épistémologie de la structure de classe de la paysannerie.

La problématique des rapports entre l’agriculture et le capitalisme resurgit à intervalles réguliers, et suscite des controverses entre des chercheurs se réclamant, de près ou de loin, de Marx et de ses continuateurs. Des deux côtés de la Manche, la fin des années 1960 et le début des années 1970 constituent un moment important de redécouverte, de discussion et de réinterprétation des travaux marxistes sur la question paysanne et agraire. Pourtant, le débat en France à cette époque tranche nettement avec celui qu’on peut observer au sein du « peasants seminar » de la School of Oriental and African Studies (SOAS) de Londres. Ce regain d’intérêt pour la paysannerie et l’agriculture s’accompagna en Angleterre d’une relecture des thèses classiques de Marx, d’Engels, de Lénine ou encore de Kautsky. Il ne s’agissait pas de « jeter le bébé marxiste avec l’eau du bain », comme ce fut le cas en France, mais bien de prolonger et d’enrichir l’analyse marxiste classique et de l’actualiser dans un contexte marqué par les luttes anticoloniales, la remise en cause du « productivisme », et la remise en question du modèle soviétique.

Journal Article Gilbert Simondon, Imagination and Invention. Translated by Joe Hughes and Christophe Wall-Romana Get access Gilbert Simondon, Imagination and Invention. Translated by Joe Hughes and Christophe Wall-Romana. (A Univocal Book.) Minneapolis: University of Minnesota Press, 2022. xxxiii + 205 pp. Giovanni Menegalle Giovanni Menegalle University of London Institute in Paris, Paris, France giovanni.menegalle@ulip.lon.ac.uk Search for other works by this author on: Oxford Academic Google Scholar French Studies, knae053, https://doi.org/10.1093/fs/knae053 Published: 23 March 2024

Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer. However, treatment for hepatitis B is limited when considering the huge base of infected people. The immune response against hepatitis B is mediated mainly by CD8+ T cells, which are key to fighting invading viruses, while regulatory T cells prevent overreaction of the immune response process. Additionally, follicular T helper cells play a key role in B-cell activation, proliferation, differentiation, and formation of germinal centers. The pathogenic process of hepatitis B virus is generally the result of a disorder or dysfunction of the immune system. Therefore, we present in this review the critical functions and related biological processes of regulatory T cells and follicular T helper cells during HBV infection.

BackgroundCrohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microscopic detection of filamentous structures close to the epithelium of TnfΔARE mice, a mouse model of CD-like ileitis pointed towards segmented filamentous bacteria (SFB), a commensal mucosal adherent bacterium involved in ileal inflammation.ResultsWe show that the abundance of SFB strongly correlates with the severity of CD-like ileal inflammation in two mouse models of ileal inflammation, including TnfΔARE and SAMP/Yit mice. SFB mono-colonization of germ-free TnfΔARE mice confirmed the causal link and resulted in severe ileo-colonic inflammation, characterized by elevated tissue levels of Tnf and Il-17A, neutrophil infiltration and loss of Paneth and goblet cell function. Co-colonization of SFB in human-microbiota associated TnfΔARE mice confirmed that SFB presence is indispensable for disease development. Screening of 468 ileal and colonic mucosal biopsies from adult and pediatric IBD patients, using previously published and newly designed human SFB-specific primer sets, showed no presence of SFB in human tissue samples, suggesting a species-specific functionality of the pathobiont. Simulating the human relevant therapeutic effect of exclusive enteral nutrition (EEN), EEN-like purified diet antagonized SFB colonization and prevented disease development in TnfΔARE mice, providing functional evidence for the protective mechanism of diet in modulating microbiota-dependent inflammation in IBD.ConclusionsWe identified a novel pathogenic role of SFB in driving severe CD-like ileo-colonic inflammation characterized by loss of Paneth and goblet cell functions in TnfΔARE mice. A purified diet antagonized SFB colonization and prevented disease development in TnfΔARE mice in contrast to a fiber-containing chow diet, clearly demonstrating the important role of diet in modulating a novel IBD-relevant pathobiont and supporting a direct link between diet and microbial communities in mediating protective functions.8ntX7JCRAmgBnFgN24WWkMVideo

The novel HLA-C*08:258 and -C*12:374 alleles differ from HLA-C*08:02:01:01 and -C*12:03:01:01 by one nucleotide substitution.

The new HLA-DRB1*15:213 allele results from one nucleotide substitution in exon 3 of HLA-DRB1*15:02:01.