University of South Florida Sarasota–Manatee

Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells and a rapidly evolving treatment landscape. Bispecific antibodies targeting B-cell maturation antigens (BCMA) have emerged as promising therapeutic options for relapsed and/or refractory multiple myeloma (RRMM). This retrospective study evaluated the efficacy and safety of teclistamab, a BCMA-directed bispecific antibody, in patients with RRMM with renal impairment (RI) at baseline compared to those without. Conducted across seven academic centers, the study included 195 patients with RRMM, of whom 34 had baseline RI. Performance status, previous lines of treatment, and prior BCMA exposure were identified as significant predictors of progression-free survival. Notably, patients with RI demonstrated overall response rates and toxicity profiles comparable to those without RI, although they required more packed red blood cell transfusions. No statistically significant differences were observed in adverse events, including cytokine release syndrome and infections. Overall, the findings support the efficacy and safety of teclistamab in patients with RRMM and RI, highlighting the need for prospective clinical trials to optimize the treatment strategies for this population.

Abstract Many countries operate trapping programs to detect incursions of tephritid fruit fly pests (Diptera: Tephritidae). Food-based attractants are an important component of trapping systems, as they are neither species- nor sex-specific. Liquid protein baits, including an aqueous solution of torula yeast plus borax (TYB), have traditionally been used. However, such baits are short-lasting and must be replaced frequently. Several dry, synthetic food baits, all containing ammonium acetate, putrescine, and trimethylamine hydrochloride, have been developed as potential replacements for TYB. A recent study reported that, in five different countries, a new vial-lure dispenser (containing these same three components) attracted similar or greater numbers of Mediterranean fruit flies, Ceratitis capitata (Wiedemann), than TYB-baited traps. In all locations the TYB was replaced weekly, while the vial-lures were not replaced over eight consecutive weeks of trapping. Here, we present additional data from three different regions on the performance of vial-lure dispensers relative to TYB and several other synthetic food-based lures. Results from Florida and Guatemala showed that traps baited with vial-lures captured an equivalent or greater number of C . capitata as traps baited with TYB, whereas in Hawaii TYB was significantly more attractive than the vial-lures. No consistent differences were evident between vial-lures and the other synthetic food baits tested. The present study does not identify the most effective replacement for TYB for monitoring C . capitata . Regardless of the specific bait used, however, the extended field longevity characteristic of synthetic food-based attractants will reduce the high servicing costs associated with TYB-baited traps.

The events of 2020 brought national attention to long-standing systemic inequities, particularly those affecting communities of color, as a convergence of public health and social justice crises. One prominent concern was police violence in the Black American community. In response, many communities explored alternative approaches to public safety, including the integration of social workers into policing to support individual well-being. This secondary qualitative data analysis, based on a phenomenological study conducted in 2022, aimed to understand social workers’ perspectives on policing in the post-2020 era, particularly those who served in law enforcement settings. Analysis of responses from 40 participants revealed two major themes: distrust and contextual impermanence. These findings offer insights into collaboration and trust-building among police, social workers, and communities, while also highlighting the complexities of training and the evolving nature of policing.

Introduction / Purpose Chronic subdural hematomas (cSDH) represent the most common form of intracranial hemorrhage in the elderly, with an estimated incidence ranging from 2 to 21 cases per 100,000 individuals. Although the incidence has increased over the past decade, the specific effects of cSDH on various domains of cognitive function remain inadequately characterized. In light of these gaps in the literature, the present study was aimed to assess cognitive performance of patients with cSDH at two distinct time points during treatment to better delineate the trajectory of cognitive outcomes in this population. Materials / Methods Patients with a diagnosis of cSDH treated at our institution were enrolled and prospectively followed during the study period from August 2024 until August of 2025. We successfully administered the Montreal Cognitive Assessment (MoCA) and the Controlled Oral Word Association (COWA) in 27 patients prior to the initiation of standard of care procedures. Of these patients, 5 underwent the examination at two time points: before undergoing a standard of care intervention (craniotomy, MMA embolization, medication management) and at 3 ‐ 6 months (+/ ‐ 3 weeks) following the date of treatment. In addition, 7 more patients were enrolled, and one assessment was performed with a second one expected to be completed at the time of conference presentation. Additional information such as thickness of the hematoma, information regarding baseline level of cognitive functioning, and radiographic appearance of the hematoma were also collected. Results One assessment was successfully completed in 27 patients. 5 patients completed the assessments at both time points. In addition, 7 more patients were enrolled, with a second assessment expected to be completed at the time of conference presentation. Scores on the MoCA assessment prior to the initiation of standard of care procedures ranged from 5/30 to 28/30, with the average score being an 8/30. Of those who have completed a follow up assessment, the average score on the MoCA increased by 7.5 points, respectively. Interestingly, the same trend was not observed for scores on the COWA at both time points. The average length of time between each assessment was 3.5 months (+/‐ 3 weeks). GCS scores increased in those with clinical improvement. No interruptions to standard of care workflows were noted. Correlations between changes in assessment scores and appearance of the hematoma at 3‐6 months are being finalized and prepared for the SVIN conference. Conclusions Preliminary analyses have demonstrated that diminished size and resolution of the hematoma is associated with higher scores on the MoCA and the COWA in some patients, mirroring findings in the literature. However, in some patients, MoCA scores decreased despite decreased hematoma volume, which demonstrates the complexity of measuring cognitive function in this population. No standard of care workflow interruptions were noted.

Objective: The objective of this open-label, interventional, prospective clinical study was to evaluate the effectiveness of a multimodal wound matrix (MWM) in moving chronic, nonhealing wounds that had failed prior therapies onto a healing trajectory. The overall response rate was the proportion of subjects who had greater than 40% reduction in size after 4 weeks of treatment. Secondary objectives included the percentage area reduction (PAR) after 4 and 12 weeks, incidence of ulcer closing, and changes in quality of life. Approach: An open-label, interventional, prospective cohort, real-world evidence study was conducted following the STROBE criteria. Criteria included chronic nonhealing wounds of multiple etiologies in subjects with extensive comorbidities. Results were compared with data from the U.S. Wound Registry. Results: A total of 111 subjects entered the screening phase and 64 were treated. Fifty-three wounds were eligible for the dataset that included 18 diabetic foot ulcers, 19 venous leg ulcers, 2 pressure injuries, 1 surgical, 1 lower extremity wound, and 12 unclassified etiologies. The objective response rate was 42%. The 4-week PAR was 34%. The 12-week PAR was 66%. Eighteen wounds closed by week 12. Innovation: MWM is a formulation technology developed to address the major obstacles that prevent healing. Results were evaluated in a patient population with extensive comorbidities that had failed prior treatments and would be generally excluded from controlled trials. Conclusion: The results from this study support the contention that MWM achieves substantial clinical improvement in a complex patient population not enrolled in clinical trials and demonstrates an advancement in wound management.

This special issue of SLAS Technology highlights bio-inspired computing and machine learning analytics for mental well-being in life sciences innovation. It highlights the emerging behavioral health technologies integrating big biological data, artificial intelligence, cloud/fog computing, machine learning, bio-inspired computation, the Internet of Medical Things, wireless technologies, security and privacy, semantic database, and content. The large volume of behavioral health data, often referred to as big data, requires innovative and scalable machine learning, deep learning, and intelligent algorithms to process it effectively.

ABSTRACT Scant research exists that focuses on males as survivors of commercial sexual exploitation (CSE). Moreover, the unknown needs and services for males paired with a lack of understanding regarding the exploitation of males leads to criminal justice personnel viewing them as non-victims. A 2013 service-provider survey regarding the sexual exploitation of males by ECPAT-USA found that male survivors are vastly under reported, are at danger of significant health risks, receive fewer services, and the number of gay and transgender survivors has been overestimated in estimates of the total number of male survivors. The current study updated the 2013 ECPAT-USA report and expanded the scope by also exploring services for those exploited in labor trafficking and transgender individuals as well as service changes due to COVID-19. Ten years later service agencies report that little has changed regarding risk factors, negative impacts, and services available. Some variations in agency reports include notations of additional types of illicit drugs used by CSE males, mention of intellectual disability as a CSE risk factor, greater recognition of Internet usage (i.e. as a recruitment tool and means of exploitation), and reports of women and youth perpetrators. The findings of this study suggest that the awareness and services for male and transgender CSE survivors has not seen substantial change since the 2013 report. Thus, the current study aims to raise awareness of the continued need for increased services for male CSE survivors. The problems that CSE survivors face are severe, and a cultural shift is needed toward viewing males as victims too and deserving of services.

IntroductionMeasures designed to comprehensively assess Parkinson’s disease (PD) irrespective of disease stage and treatment status may be unable to capture nuances in disease progression, particularly in early-stage PD. The objective of this paper is to develop PARkinson’s COMposite Scales (PARCOMS) with increased responsiveness to clinical decline using items of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) for three discrete cohorts of patients.MethodsPatients with confirmed PD from the Parkinson’s Progression Markers Initiative (PPMI) data were assigned to three cohorts based on use of dopaminergic treatment, stage of disease, and presence of motor complication. For each cohort, items from MDS-UPDRS Part I (PARCOMS-Non-Motor) and Parts II and III (PARCOMS-Motor) were selected based on responsiveness using partial least squares (PLS) regression. The responsiveness of the scales was estimated using mean-to-standard deviation ratios (MSDRs) of their change values.ResultsCompared to the original MDS-UPDRS, MSDRs for PARCOMS-Motor increased 13.1% (untreated cohort, n = 430), 78.2% (treated-without-motor-complications cohort, n = 426), and 100.6% (treated-with-motor-complications cohort, n = 538). The MSDR increases observed for PARCOMS-Non-Motor were 13.9%, 6.8%, and 20.7%, respectively. Across cohorts, turning in bed and speech items were large contributors to the PARCOMS-Motor scales. Items for cognitive impairment and urinary problems were substantial contributors to PARCOMS-Non-Motor across cohorts. There was variability in the weighting of items representing different clinical concepts across cohorts for each composite, confirming heterogeneity in disease progression across disease stages.ConclusionsPD stage-specific composite measures were developed and demonstrated greater sensitivity to change than the original MDS-UPDRS, supporting the value of weighted composites tailored for disease stage.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40120-025-00771-5.

This survey study examines the role of technology in academic business librarianship, focusing on essential tools and skills for success, as well as librarians’ perceptions, comfort levels, and engagement with professional development. The findings suggest a correlation between the use of specialized software and databases and time dedicated to business librarian tasks; highlight the importance of training in new technologies, particularly artificial intelligence (AI); and reveal that some librarians face skill gaps and limited access due to insufficient funding or lack of time. This study’s findings provide insights into competencies, access, and technology adoption strategies in academic business librarianship.