University of the Ozarks

Background: Metabolic dysfunction associated steatotic liver disease (MASLD) is the most prevalent liver disease worldwide with an estimated 25% of U.S. adults having MASLD. MASLD is typically regarded as a diet driven disease, with the Western diet (high fat, high sugar, low fiber) being a major driver. Recently, evidence suggests MASLD can be present regardless of body weight. There is not good evidence on how prevalent this is, but reports suggest it could be as high as nearly 30% of MASLD patients. As such, there is a critical need to better understand MASLD independent of weight to ensure all individuals with the disease are receiving proper diagnosis and treatment. Methods: Young female rats were fed either a Control (AIN-93G) or Western (45% fat, 34% sugar) diet for 8 weeks. Histology, RT-qPCR, and standard biological assays were performed to analyze differences in hepatic function and fatty acid analysis was used to analyze fatty acid deposition in the liver, adipose tissue, and brain. Results: There were no statistically significant differences in the weights of rats consuming a Control or Western diet. However, consuming a Western diet had increased histological evidence of fat deposition and inflammation compared to Control. Rats consuming a Western diet also displayed increased ( p<0.05) hepatic triglyceride content and relative expression of several key genes involved in lipogenesis and oxidative stress. Fatty acid analysis found Western diet rats to have increased (p<0.05) hepatic monounsaturated fatty acid (MUFA) content, while adipose tissue of those same animals had decreased (p<0.05) MUFAs. Conclusions: The Western diet plays a significant role in the development of MASLD independent of differences in weight. This model may serve to better elucidate mechanisms at play in lean MASLD. We are currently conducting additional experiments on the role of alcohol in this phenomenon. WVU Davis College Dean's Opportunity Fund and the UVM Food Systems Research Center. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

An 82-year-old woman with COPD presented to the emergency department with cough, increasing sputum production, wheezing, and worsening shortness of breath for two weeks. On imaging studies, the patient was found to have a right upper lobe spiculated nodule and an endobronchial lesion with near total occlusion of the right lower lobe bronchus with sub-segmental atelectasis. Bronchoscopy with EBUS-TBNA of subcarinal and right hilar lymph nodes revealed lung cancer with clear cell phenotype. Given the predominance of clear cell morphology, the diagnosis of metastatic renal or ovarian cancer was entertained. However, there was no evidence of renal or ovarian lesions on the PET-CT scan, ruling out the possibility. Salivary gland type lung cancer (STLC), which is responsible for less than 1% of all lung cancer cases in adults, was also considered. The two distinct STLCs that may have similar morphologic appearances are hyalinizing clear cell carcinoma (HCCC) and mucoepidermoid carcinoma (MEC). The other type of tumour in the lung that demonstrates a clear cell phenotype is perivascular epithelioid cell neoplasms or PEComa, which are mesenchymal in origin. Immunohistochemical staining was strongly positive for p63, CK5/6, CK7, CK-LMW, and negative for TTF-1, Napsin A, p16, and CK20. Additional staining, including HMB-45, S-100, and mucicarmine, were also negative. Next-generation sequencing for the salivary gland fusion panel, including EWSR1-ATF1 fusion and EWSR1 gene rearrangement for HCCC and MAML2 gene rearrangements for MEC, was negative. She was diagnosed with non-small cell lung cancer favouring squamous cell carcinoma with clear cell phenotype, a rare entity.

ulf and Shea (2002) called for investigators to use more complex skills in human movement research in order to gain insight into the motor skill learning process that will extend beyond knowledge from relatively simplistic labbased studies.Fitts Law

Giysilerde estetik ve modaya uygunluğu yanı sıra, performans ve konfor özellikleri gibi önemli özellikler aranmaktadır. Giysilerin ısıl konfor sağlaması için, soğuğa karşı yüksek ısıl dirence sahip olması gerekmektedir. Çalışma kapsamında, seamless makinelerde termofizyolojik konfor özellikleri iyileştirilmiş içlikler, çevre dostu ürünler olarak geliştirilmiştir. Çeşitli çevre koşullarında yüksek ısı yalıtımı isteyen kişilerin kullanabileceği özellikler taşıması için çalışmalar yapılmıştır. Termal ısıl konforu etkileyebilecek üretim parametrelerini dikkate alarak üretimi gerçekleşen yün, NILIT-heat, polyester (PES), polipropilen (PA) ve özel fonksiyonel ipliklerle kombine edilmiş 10 adet numune üretilmiştir. Çalışmada, ısıl dirence sahip farklı yapıdaki termal kumaş türlerinin, ısıl direnç (Alambeta Parametreleri) ve MMT parametreleri incelenmiştir ve çok kriterli analiz sonucunda ise termal fonksiyonel özellikleri barından numuneler seçilmiştir. Isıl yalıtımın sağlanması için numunelerde daha çok yün, termal izolasyonlu özel ipliklerin özellikle PES ile kombinasyonu önerilirken, su buharı geçirgenliği beklenen bölgelerde ise; PES, PA ve yün kombinasyonlarının kullanımı uygun bulunmuştur.

The trees at the heart of this paper are not an isolated story but contribute to the machinery of the settler colonial present, feeding off indigenous dispossession of the Arkansas Ozarks. In this paper, I explore “trail trees,” a form of culturally-modified tree used to sustain and perpetuate replacement narratives romanticizing a lost Native American past and constructing a pure, modern, scientific “reality” of White settler possession of the region. My critique is directed at the settler colonial worldview and the systems through which it is constructed, legitimated, and spread. I ask: What is at stake for advocates for the existence of “trail trees”? What can disrupt and dismantle the “trail tree” discourse and the replacement narrative that it functions within? What work can we do to create an opening for anti-colonial praxis? The answers to these questions involve direct engagement with conservation and conservationists and the narratives of replacement that suffuse their work.

COVID‐19 has created one of the world's worst pandemics and is associated with various life‐threatening complications and infections, possibly due to various internal and external host factors. Cytomegalovirus (CMV) coinfection is one of those infections. We present a challenging case of severe COVID‐19 infection managed in our ICU care facility with concomitant CMV infection. We aim to highlight the significance of early diagnosis and prompt management for a better outcome.

Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage (DAH). Glucocorticosteroids (CS) represent the first line therapy for IPH. Although most patients respond to CS, steroid refractoriness is seen in an appreciable minority of patients. This paper reviews and evaluates the efficacy and safety profile of liposomal dexamethasone 21-palmitate (liposteroid) for the treatment of IPH. Medline, Embase and Web of Science biomedical databases were searched between 1980 and 2020 to identify papers describing patients with IPH, who were treated with liposteroid. A total of five articles were identified. Four in the form of case reports and one as a case series. A total of 12 pediatric patients (5 boys, 7 girls) were identified, with a median age of 2.3 years (range 0.5-8.6). Liposteroid therapy in intravenous doses ranging 0.06-0.1 mg/kg body weight appeared to be effective for both remission induction therapy, and maintenance therapy. There was no mortality among patients treated with liposteroid, either in the acute phase or during follow-up. The majority of patients for whom long-term follow-up data were available, were cured or in disease remission. No acute adverse events were reported, and long-term side effects were minimal and tolerable. Liposteroid represents a potential alternative or supplement to conventional CS therapy, as it appears to be more efficacious and associated with fewer side effects. Larger prospective, controlled trials are necessary to be able to define more precisely the therapeutic role of liposteroid in IPH.