University of the Third Age

The article explores the deep symbolism of mythological thinking and its impact on the perception and functioning of wind instruments in the cult rites of ancient civilizations. The author examines the connections between Egyptian and ancient Greek mythological concepts and Old Testament texts, highlighting the significant role of breathing in the creation of humanity and the sacredness of air. During this time, wind instruments played an active role in ritual performances, underscoring the mystical significance of trumpet sounds in the Holy Scriptures. This practice led Moses to establish the offering of solemn sacrifices accompanied by trumpets and to create the Levite caste as ceremonial musicians. In the Greco-Hellenistic period, this inclination to equate air with the human soul continued in the beliefs of Greek philosophers such as Anaximenes, Anaxagoras, and Diogenes. They regarded air as synonymous with the human soul and the essence of human existence, which aligned with the mythological worldview of the ancient Greeks and their depictions of gods with instruments, including wind instruments. Thus, there is a continuous interpretation of wind instruments as a vital aspect of worldview and practical ritual application. This trend can also be observed in the Christian rite, where wind instruments are utilized differently. While their practical use was restricted in Orthodox liturgy, they can be found in the lexicon of liturgical texts. The expressiveness of brass sounds was transformed into poetic expressions often used to glorify saints, martyrs, and revered figures within the Christian church. This influence is evident in the ritual texts of Greco-Byzantine hymnography, which were translated from Greek into Church Slavonic as part of Ukraine’s adoption of the Christian rite. The frequent use of “brass” imagery in music also appears in non-musical notation, especially in the sign “kulisma with a trumpet”, as well as in melodies. Methodology: The author employed source analysis, historical research, musical theory, and cultural studies to conduct this investigation. Scientific novelty: This study traces the influence of metaphorical thinking on the sacralization of wind instruments and their evolving roles in ritual practices across different periods.

Euler's theorem about the relationship between the numbers of individual elements of planar graphs (vertices, edges, faces) is also satisfied when the graph has zero vertices. The problem of the existence or not of such graphs has so far been the subject of very few studies. Plus, research that didn't prove anything. The paper presents an interpretation of this kind of graphs as mathematical formations lying on piecewise smooth surfaces. The lines of intersection of two or more smooth surfaces (faces of a graph) form edges without a vertex of the graph. The elementary properties of such graphs are discussed, the method of counting non-isomorphic 0-vertex graphs and their importance in physics and chemistry are given.

Abstract BackgroundThere are multiple neurodegenerative diseases that directly affect speech [1]. However, its utilization as a robust indicator for cognitive impairment is under‐investigated. In many cases, mild cognitive decline progresses to a neurodegenerative disease and its detection is of utmost importance, since it is at this stage that treatment is most effective. One of our core goals is developing techniques for differentiating between patients with cognitive decline and healthy cohorts, by utilizing only speech samples [2]. Such samples are obtained from verbal elicitation tasks designed for cognitive assessment, e.g. picture descriptions and narration of everyday activities.MethodAudio recordings from cognitive assessment tasks are fed through our platform to a Natural Language Processing and Machine Learning pipeline, employing an automatic discovery procedure of predictive salient biomarkers, to train an advanced classification system. The biomarker collection includes features that characterize voice, speech, language structure, composition and usage, and are engineered to highlight symptoms of neurodegenerative disorders. Biomarkers undergo multiple stages of filtering, processing and transformation to train and fine‐tune the final model. Diagnostic performance of the output classifier is obtained on an unseen test set, to ensure a robust generalization of the platform.ResultOur platform utilizes the set of automatically selected, cross‐linguistic digital biomarkers to obtain sensitivity and specificity scores of 81% and 84% respectively, compared against medical expert diagnosis. The most salient biomarkers with respect to identifying our pathological cohort, relate to feature categories of Syntactic Complexity, Content Word usage, Lexical Repetition, Syntactic Errors and Function Words, with weight contributions of ∼ 16%, 14%, 13%, 12% and 11% respectively. Our platform provides additional, detailed population and patient‐based descriptive analytics to enhance transparency and explainability of the results.ConclusionEarly detection of cognitive decline facilitates early intervention, treatment and proactive care, delaying disease progression and reducing symptom severity. We believe that our platform provides an effective solution for risk factor estimation and our findings incentivize further research into speech analysis techniques for the prediction of cognitive decline.[1] Boschi, Veronica, et al.,Frontiers in psychology 8 (2017): 269.[2] Vassiliki Rentoumi et al., Alzheimer's & Dementia, Wiley, volume 16, 2020.

Background and aimsAtrial fibrillation (AF) is often complicated by disabling conditions in the elderly. COVID-19 has high mortality in older people. This study aimed at evaluating the relationship of pre-infection AF with characteristics and survival of older COVID-19 patients.MethodsWe retrospectively analyzed inpatients aged ≥ 60 years enrolled in GeroCovid Observational, a multicenter registry endorsed by the Italian and the Norwegian Societies of Gerontology and Geriatrics. Pre-COVID-19 sociodemographic, functional, and medical data were systematically collected, as well as in-hospital mortality.ResultsBetween March and June 2020, 808 COVID-19 subjects were enrolled (age 79 ± 9 years; men 51.7%). The prevalence of AF was 21.8%. AF patients were older (82 ± 8 vs. 77 ± 9 years, p < 0.001), had a higher CHA2DS2-VASc score (4.1 ± 1.5 vs. 3.2 ± 1.5, p < 0.001) and were more likely to present almost all comorbidities. At multivariable analysis, advanced age, white blood cell count, the presence of heart and peripheral artery diseases were significantly associated with the presence of AF. In-hospital mortality was higher in AF patients (36.9 vs. 27.5%; OR = 1.55, 95% CI = 1.09–2.20; p = 0.015). A decision tree analysis showed that, in AF subjects, preserved functional status at admission was the most important factor associated with survival. In patients without AF, baseline COVID-19 severity was the most relevant variable related to clinical prognosis.ConclusionsAF is frequent in older patients with COVID-19, in whom it associates with clinical complexity and high mortality. Pre-infection disability shapes the prognosis of this extremely vulnerable segment of hospitalized subjects.Clinical trial registrationGeroCovid Observational was registered at www.clinicaltrials.gov (NCT04379440).

Objectives: The spread of COVID-19 has undeniably unsettled the social, psychological and emotional life of the entire world population. Particular attention should be paid to older adults with dementia, given their vulnerability to emotional stressors. The aim of this retrospective study is to evaluate the impact of the first wave quarantine related to Covid-19 on psychological and affective well-being of older adults with mild/major neurocognitive disorders and of their caregivers.Methods: Data on participants' assessment before the quarantine (PREQ) were retrospectively collected. Patients with Mild Cognitive Impairment (MCI) or dementia were recruited from different Centers for Cognitive Decline and Dementia in Italy. During the quarantine, psychological and affective well-being were evaluated by phone through the administrations of scales measuring anxiety and depression (DASS), perceived stress (PSS), coping strategies (COPE) and the caregivers' burden (CBI). The scales' results were compared across participants' PREQ cognitive level (Mini Mental State Examination, MMSE ≥25, 23–24, and ≤ 22) with multiple linear regression models.Results: The sample included 168 patients (64% women) with a mean age of 79 ± 7 years. After adjusting for potential confounders, more severe cognitive impairment was independently associated with higher DASS and PSS score, and poorer coping strategies (p < 0.05). Cognitive functioning was also inversely associated with CBI.Conclusions: The impact of the quarantine on the psycho-affective well-being of individuals with MCI and dementia and on caregivers' burden varies according to the PREQ cognitive functioning with more severely impaired patients having worse outcomes.

The rise in antimicrobial resistance has prompted the development of alternatives to combat bacterial infections. Bald’s eyesalve, a remedy used in the Early Medieval period, has previously been shown to have efficacy against Staphylococcus aureus in in vitro and in vivo models of chronic wounds. However, the safety profile of Bald’s eyesalve has not yet been demonstrated, and this is vital before testing in humans. Here, we determined the safety potential of Bald’s eyesalve using in vitro, ex vivo, and in vivo models representative of skin or eye infections. We also confirmed that Bald’s eyesalve is active against an important eye pathogen, Neisseria gonorrhoeae. Low levels of cytotoxicity were observed in eyesalve-treated cell lines representative of skin and immune cells. Results from a bovine corneal opacity and permeability test demonstrated slight irritation to the cornea that resolved within 10 min. The slug mucosal irritation assay revealed that a low level of mucus was secreted by slugs indicating moderate mucosal irritation. We obtained promising results from mouse wound closure experiments; no visible signs of irritation or inflammation were observed. Our results suggest that Bald’s eyesalve could be tested further on human volunteers to assess safety for topical application against bacterial infections.

After publication of our article it came to our attention that it contains a number of errors with regard to the citations. The details are provided below.

In this article, we present findings on the characteristics of community of practice appearing in sustainable education in reference to preserving natural and cultural heritage. Our research originated in the poststructuralist theory of practice and in concepts of social learning. Freire’s learning theory was the basis for establishing the thesis that critical awareness is necessary for sustainable innovation. The empirical section of our research is based on an ethnographical collection of data in three different environments. We analysed cases of connected learning and activities, based both in local community and participants’ needs. All three cases join learning with innovative practices that develop social and environmental well-being. Our results reveal that innovative practices develop in connection with transformative learning: the dialogical linking of scientific and local behaviour and the identity of participants.