York College, City University of New York

Purpose The current study aims to explore factors influencing Muslim customers’ revisit intention toward non-Halal-certified international restaurant outlets by considering the mediating roles of restaurant image and price fairness and the moderating roles of service quality. Design/methodology/approach A purposive sampling method was used. Self-administered survey questionnaires were distributed around shopping malls in Kuala Lumpur, Putrajaya, the Northern region and the East Coast of Malaysia. Only 603 questionnaires were fully completed among 626 collected questionnaires. The SMART-PLS version 4 software was used to analyze the collected via structural equation modeling. Findings The findings demonstrated that food quality, authenticity and Halalness positively impacted price fairness, restaurant image and revisit intention. The restaurant image also positively mediated the relationship between authenticity, Halalness and revisit intention while the restaurant image sequentially mediated the association between food quality, price fairness and revisit intention. Furthermore, the service quality was discovered to positively moderate the relationship between the restaurant image and revisit intention. Practical implications The findings contributed to food premise organizations, particularly non-Halal-certified international food outlets, in attracting Muslim customers. Originality/value The stimulus–organism–response theory application was incorporated with food quality, authenticity and Halalness, price fairness and restaurant image to identify the contributing factors to revisit intention for non-Halal-certified restaurants among Muslim consumers in Malaysia.

This study assessed the intersectionality of chronic diseases (CDs) and sociodemographic characteristics on mental health treatment utilization among New York City (NYC) adults. We analyzed the 2019–2020 NYC Community Health Survey data, a representative sample of non-institutionalized adults. CDs included obesity, diabetes, hypertension, and asthma. Log-linear regression models assessed main and conditional effects of CDs and sociodemographic factors on mental health treatment utilization. Predicted probabilities illustrated significant interactions. Most of the 17,584 adults (weighted N = 6,437,401) were aged 25–44 years, female, heterosexual, non-Hispanic white, U.S.-born, married, college-educated, and employed. Regarding CD distribution, 49.6% had 0 CDs, 44.9% had 1–2 CDs, and 5.6% had more than 2 CDs. Approximately 16% of all adults reported using mental health treatment services in the past 12 months. In the main effects model, a dose-response relationship was observed between the number of CDs and the likelihood of receiving mental health treatment (p < 0.001). Other factors associated with higher treatment rates included being aged 25–44, female, gay/lesbian/bisexual/other, non-Hispanic white, U.S.-born, unmarried, having higher education, being unemployed or not in the labor force, and having health insurance. The conditional effects model revealed significant interactions between CDs and race/ethnicity, sexual orientation, education level, and household poverty status (all p < 0.05). Findings highlight the complex interplay between CDs and sociodemographic factors in using mental health treatment among NYC adults. Although treatment rates generally increased with more CDs, this pattern varied significantly across key sociodemographic groups. These disparities underscore the need for targeted, intersectional approaches in mental health policy and program design.

ABSTRACTCannabidiol (CBD) is one of the most extensively studied cannabinoids and is used for myriad conditions. Its oral pharmacokinetics are complex, exhibiting non‐linear absorption, significant food effects, and variable exposure in hepatic impairment. Existing physiologically based pharmacokinetic (PBPK) models for oral CBD have largely relied on fitted first‐order absorption or fitted dissolution profiles, limiting their mechanistic and predictive capabilities and extrapolation, particularly regarding the mechanistic details of its absorption. This study developed and verified the first PBPK model for oral CBD with mechanism‐based oral absorption based on our prior published PBPK model. It incorporated mechanism‐based absorption using the multi‐layer gut wall within the advanced dissolution, absorption, and metabolism (M‐ADAM) model within Simcyp. Pharmacokinetic parameters for CBD or population parameters related to absorption were obtained from the literature or optimized. Some physiological parameters (e.g., luminal bile salt and lymph flow rate) were adjusted mechanistically to account for CBD's sesame oil formulation and meal characteristics. The model well captured the CBD concentration‐time profiles and key pharmacokinetic parameters, including area under the concentration‐time curve (AUC), peak concentration (Cmax), and time to maximum concentration (tmax) across diverse doses, fed/fasted states, and in patients with hepatic impairment (mild, moderate, severe). Predictions were consistently within two‐fold of observed data. This work offers a robust foundation for the mechanistic understanding of CBD's complex oral absorption. The verified models can optimize CBD dosing strategies, predict potential drug–drug interactions, and evaluate CBD pharmacokinetics in various specific populations, ultimately contributing to safer and more effective clinical use.

This study sought to investigate the prevalence and sociodemographic determinants related to breast and cervical cancer screening among ever-married women aged 15 to 49years in Jordan. This research employed secondary data from the 2023 Jordan Population and Family Health Survey (JPFHS), which included 12,547 ever-married women aged 15 to 49. Weighted multivariable logistic regression analyses were conducted to quantify screening prevalence and identify related covariates, presented as adjusted odds ratios (AORs) with 95% confidence intervals (CIs). The prevalence of screening for breast and cervical cancer was 15.2% and 16.2%, respectively. Increased screening participation was substantially correlated with advanced age, larger home affluence, higher parity, previous sexually transmitted infections (STIs), and exposure to radio communications. Women aged 35-49 were more likely to receive breast (AOR: 4.0; 95% CI: 2.6-6.0) and cervical cancer screening (AOR: 5.5; 95% CI: 3.3-9.2) compared to those aged 15-24years. Women in the highest wealth quintile had a greater likelihood of being screened for breast cancer (AOR: 2.1; 95% CI: 1.6-2.8) and cervical cancer (AOR: 2.6; 95% CI: 1.9-3.5). Moreover, breast cancer screening correlated with recent healthcare service consumption (AOR: 1.3; 95% CI: 1.1-1.6), while cervical cancer screening had a favorable association with elevated educational attainment (AOR: 1.6; 95% CI: 1.2-2.3). Living in rural areas was inversely correlated with cervical screening participation (AOR: 0.7; 95% CI: 0.6-1.0). CONCLUSION: Screening rates for breast and cervical cancer among Jordanian women are inadequate. Interventions that facilitate equitable access-especially aimed at younger, less educated, rural, and low-income women-are crucial for enhancing participation and diminishing inequities in early cancer detection.

Anatomic location of white adipose tissue is a determinant of cardiometabolic risk. To understand differences within/between adipose depots, we generated 65,668 single-nucleus transcriptomes from human subcutaneous or intraabdominal adipose tissue (SAT/IAT). Unsupervised analysis revealed 26 adipose-resident cell clusters including two subpopulations of mature adipocytes, characterized by high vs. low expression of adipocyte maturation genes (ADIPOMAT hi vs. ADIPOMAT lo ). ADIPOMAT lo adipocytes demonstrate a low-differentiation, pro-inflammatory, and pro-fibrotic transcriptome. IAT-resident ADIPOMAT lo were more abundant in higher BMI donors, while SAT-resident ADIPOMAT lo associated with impaired glycemia. TSHZ3 was identified as a candidate regulator of ADIPOMAT lo transcriptome. TSHZ3 knockdown in adipogenic progenitors inhibited differentiation, with downregulation of early adipogenic regulators (e.g. CEBPA/B, PPARG) and mature adipocyte genes. Heterozygous deletion of Tshz3 in mice reduced SAT and IAT weight. Here, we show that adipocyte subsets with distinct transcriptomic signature reside in human WAT; altered TSHZ3-mediated transcriptional regulation may contribute to low-maturation subpopulation linked to metabolic disease.

Endometrial cancer is the most common gynecologic malignancy worldwide, and its incidence and mortality rates have increased over the past decade. Although early-stage disease is effectively treated via hysterectomy, a dearth of molecularly targeted therapies means that prognoses are far poorer for those with disseminated or recurrent disease. Herein, we describe the exploration of 3 biomarkers-human epidermal growth factor receptor 2 (HER2), mucin-16 (MUC16), and CD24-as potential radiotheranostic targets for endometrial cancer. Methods: Immunocytochemical staining was used to evaluate the expression of HER2, MUC16, and CD24 in endometrial cancer and healthy uterine and healthy endometrial cell lines. Subsequently, similar immunofluorescence staining analyses were performed with patient-derived endometrial cancer, healthy cervix, and healthy endometrium tissue samples. Stochastic bioconjugation methods were used to append deferoxamine (DFO) to a trio of monoclonal antibodies: trastuzumab (αHER2), AR9.6 (αMUC16), and ATG-031 (αCD24). These immunoconjugates were labeled with [89Zr]Zr4+, and the invivo performance of the resulting immuno-PET probes-[89Zr]Zr-DFO-trastuzumab, [89Zr]Zr-DFO-AR9.6, and [89Zr]Zr-DFO-ATG-031-was interrogated via PET imaging and biodistribution experiments in cell line and patient-derived murine models of endometrial cancer. Results: Immunofluorescent staining revealed that endometrial cancer cells and tissue samples expressed elevated levels of HER2, MUC16, and CD24 compared with healthy control cells and tissue samples. [89Zr]Zr-DFO-trastuzumab, [89Zr]Zr-DFO-AR9.6, and [89Zr]Zr-DFO-ATG-031 were synthesized with high radiochemical conversion (>95%), radiochemical purity (>95%), specific activity (4-5 mCi/mg), and immunoreactivity (>80%). The 3 immuno-PET probes exhibited significantly different behavior in mice bearing subcutaneous endometrial cancer xenografts: [89Zr]Zr-DFO-ATG-031 provided the highest tumor uptake (>30 %ID/g) and tumor-to-background contrast; [89Zr]Zr-DFO-trastuzumab produced moderate yet promising results; and [89Zr]Zr-DFO-AR9.6 yielded substandard images. Subsequent imaging experiments in mice bearing patient-derived xenografts reinforced the potential of the CD24- and HER2-targeted immuno-PET probes. Conclusion: [89Zr]Zr-DFO-ATG-031 and [89Zr]Zr-DFO-trastuzumab exhibit significant promise for immuno-PET imaging of endometrial cancer. These probes may prove beneficial in the clinic, not only for the noninvasive staging and monitoring of the disease but also as companion imaging agents for HER2- and CD24-targeted therapeutics.

The IRS Volunteer Income Tax Assistance (VITA) program offers free tax preparation services to eligible individuals and practical experience for accounting students. While beneficial, sustaining it within higher education faces challenges. Prior research on VITA has largely centered on student experiences; this study expands the scope by gathering insights from VITA site partners, coordinators, and experienced reviewers. It identifies the critical challenges such as a shortage of qualified volunteers, inadequate training, deficient computer skills among volunteers, scheduling conflicts, funding limitations, and suboptimal work environments. It highlights the program’s advantages and difficulties, providing insights for improving tax policy and accounting education.

Indoor air quality (IAQ) impacts human health, productivity, and well-being. As buildings become more energy-efficient and tightly sealed, the need for effective ventilation systems that maintain adequate IAQ grows. Energy Recovery Ventilators (ERVs) ensure adequate IAQ by bringing fresh outdoor air indoors while minimizing costly energy wastage. ERVs provide major economic, health, and well-being benefits and are a critical technology in the fight against climate change. However, little is known about the impact of ERV operation on the generation and fate of particulate and gaseous indoor air pollutants, including toxic, carcinogenic, allergenic, and infectious air pollutants. Specifically, the air pollutant crossover, aerosol deposition within ERVs, the chemical identity and composition of aerosols and volatile organic compounds emitted by ERVs themselves and by the accumulated pollutants within them, and the effects on bioaerosols must be investigated. To fill these research gaps, both field and laboratory-based experimental research that closely mimics real-life conditions within a controlled environment is needed to explore critical aspects of ERVs’ effects on indoor air pollution. Filling the research gaps identified herein is urgently needed to alert and inform the industry about how to optimize ERVs to help prevent air pollutant generation and recirculation from these systems and enhance their function of pollutant removal from residential and commercial buildings. Addressing these knowledge gaps related to ERV design and operation will enable evidence-based recommendations and generate valuable insights for engineers, policymakers, and heating, ventilation and air conditioning (HVAC) professionals to create healthier indoor environments.

Caregiving and career have been primarily studied by management scholars for their incompatibility. Largely ignored have been the consequences of this approach for the lives of workers. Yet the need for both childcare and eldercare is on the rise, women are increasingly integrated into the workforce, and, for many, retirement is being delayed. Particularly in the United States, workers and their families are experiencing a crisis of care. In this curated piece, we identify—and aim to dismantle—four myths that have allowed management research and practice to segment care and work. Contributors bring economics, feminist theory, sociology, organizational behavior, and careers perspectives to provide a broader vision both of the problem and of how management research might advance toward theoretical and practical solutions.