Zachodniopomorska Szkoła Biznesu w Szczecinie

Purpose This review explores the role of physical activity in preventing and treating depression across diverse groups. It critically assesses recent evidence and identifies the most effective exercise interventions by systematically analysing studies published between 2017 and 2025. Methods The analysis covered peer-reviewed randomised controlled trials, systematic reviews, and meta-analyses focusing on links between various physical activities and depression symptoms in different age groups. Results The findings confirm that physical activity has clear antidepressant effects, with moderate to large effect sizes depending on exercise type and intensity. Aerobic exercise shows standardised mean differences (SMDs) from -0.496 to -1.156, resistance training shows SMDs between -0.66 and -1.06, and high-intensity interval training provides moderate effects (SMDs of -0.42 to -0.496). Suggested mechanisms include increased brain-derived neurotrophic factor, improved neurotransmitter function, lower inflammation, and balanced HPA-axis activity, which help reduce depressive symptoms. Conclusion Physical activity is a safe, evidence-based, and cost-effective option for preventing and treating depression. Adding structured exercise programmes to everyday routines and healthcare practice can improve mental wellbeing, quality of life, and help lower the global burden of depressive disorders across all age groups.

Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultrarare microvascular disease caused by the deficiency of the metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motifs 13). Approximately half of all cases remain undiagnosed until a triggering event in adulthood; therefore, the prevalence rates may be underestimated. The current standard of care is based on regular transfusions of fresh frozen plasma, which often lead to allergic reactions in patients. Recombinant ADAMTS13 (rADAMTS13) is a novel treatment for cTTP, which has been approved for use in the USA, Europe, and Japan. The primary objective of this real-world data collection was to comprehensively analyze the clinical data of pediatric patients with cTTP and to provide real-world evidence of the effectiveness of rADAMTS13 treatment in the pediatric population. Nine pediatric patients with cTTP were treated with an intravenous infusion of rADAMTS13 every 2 weeks. The results showed an increase in platelet count and a decrease in lactate dehydrogenase levels compared with baseline. None of the patients experienced any adverse events or complications as a result of treatment. Patients reported an improved quality of life due to fewer hospital visits and a reduced number of recurrent episodes of cTTP. Treatment with rADAMTS13 resulted in the normalization of laboratory parameters in all pediatric patients with cTTP.

oraz inne obszary bada regionalnych

Breast cancer (BC) is among the most frequently diagnosed malignant tumours in females. The optimal treatment of early HR+, HER2-, and lymph node-negative (N0) BC remains challenging. Since individual assessment of recurrence risk and expected benefits from adjuvant chemotherapy (CT) based on clinicopathological features alone appear inadequate, gene expression profiling tests have been developed. This study aimed to evaluate the impact of Oncotype DX Breast Recurrence Score® (Oncotype DX Breast RS) test results on physicians' decisions concerning adjuvant CT in the Polish population. The PONDx survey investigated the real-life use of Oncotype DX Breast RS in 204 pa- tients with HR+, HER2-, N0 BC in 8 clinical reference centres in Poland. Data on clinicopathological features and changes in treatment based on the Oncotype DX Breast RS test were collected. Chemotherapy plus endocrine therapy (ET) was initially recommended in 44.8% and ET alone in 55.2% of patients. After the introduction of recurrence score results, the recommendation for CT decreased significantly: relative reduction of 25.5% (95% CI: 11.7-52.3) and absolute reduction of 11.4% (95% CI: 1.9-21.0). Among patients initially recommended for CT, treatment was de-escalated in 62.2%; conversely, among patients initially recommended for ET alone, 29.7% were escalated to CT after testing. The relative reduction was especially pronounced in post-menopausal patients (29.6%) and in those with lobular BC (42.9%). The Oncotype DX Breast RS result significantly influenced treatment decisions, with 44.3% of patients changing treatment, thus avoiding overtreatment or undertreatment. The Oncotype DX Breast RS test improves patient management and increases physician confidence in treatment recommendations.

This article focuses on the design of distance learning for a national minority mother tongue lessons. During a pandemic, the implementation of ICT in the teaching process creates new opportunities for teachers and sets a new quality in education. The author drew attention to the individual elements of the didactic process that should be take into account by every teacher. In designing, it is also extremely important to organize many didactic situations that activate and eveninspire the student.

Sentinel lymph node biopsy is routinely used in breast cancer patients with clinically negative axillary lymph nodes. Locoregional relapses after negative sentinel lymph node biopsy are infrequent, occurring in up to 3% of patients. Six thousand and eight patients underwent breast cancer surgery in our center between 2006 and 2015. We analyzed 1466 patients with negative sentinel lymph node biopsy and no prior systemic treatment. Mastectomy without irradiation was used in 25.4% of these patients and breast-conserving surgery with adjuvant radiotherapy in 74.6%. Forty-seven (3.21%) locoregional relapses were identified within a median of 51months (10-138months). The molecular type was analyzed as a risk factor for locoregional relapses and distant metastases. The locoregional relapse location was then analyzed as a risk factor for distant metastases. Triple-negative breast cancer (P=.003), age <40year (P=.007), multifocality (P=.011), and mastectomy (P<.0001) were risk factors for locoregional relapses. Patients who developed locoregional relapses more frequently developed distant metastases (P<.0001). The distribution of molecular types did not differ significantly in patients with locoregional relapses and distant metastases, concentrating in triple-negative and Luminal B tumor cases with distant metastases in almost 58% of cases, while not occurring in Luminal A patients. The locoregional-to-distant metastasis interval was shorter in cases of chest wall and lymph nodes relapse compared with breast-only relapse locations(P=.028). Molecular type, especially triple-negative, young age, mastectomy without adjuvant irradiation, and multifocality are risk factors for locoregional relapse in sentinel lymph node biopsy negative breast cancer patients. Locoregional relapse is an important risk factor for developing distant metastasis, except in Luminal A breast cancer patients and those who suffer from breast-only relapse.

The twenty-first century is a time of enormous educational expansion in European Union countries, especially in the area of mass higher education. There is a great diversity of educational fields in each member state at all three levels of higher education. This diversity is a positive phenomenon, because it favours the formation of a creative economy. The multiplicity of disciplines enables the creation of innovations that use knowledge from many, seemingly quite distant fields. There are a number of factors influencing a given person’s choice of one such field of education over another. In this article, it is examined whether gender is one of the important factors. In each of the European Union countries, ten fields and all three levels of higher education are analysed. The study is based on data from the Eurostat database covering the years 2013-2015.

The purpose of the paper is to divide the European Union countries into groups of most similar distributions of graduates’ fields of education. The study covers three education levels – bachelor’s, master’s, doctoral – and ten different fields. As a measure of the degree of similarity of distributions D statistic was used, which is the maximum absolute value of the difference between two cumulative distribution functions. Data from 2015 were used for computations. On the basis of the values of the D statistic calculated for each of the pairs of distributions the countries were divided into relatively uniform classes. The implemented procedure enabled to distinguish one compact cluster of countries in the case of the bachelor’s level of education, two unlike sets in the case of the master’s level and one relatively homogenous group in the case of the doctoral level.

Wojewodztwo zachodniopomorskie nie nalezy do czolowki polskich regionow pod wzgledem innowacyjności gospodarki. Przeklada sie to na kondycje lokalnej sceny start- -upowej, ktora nie jest wymieniana wśrod glownych polskich ekosystemow (liderami pozostają Warszawa, Wroclaw, Krakow), jak i nie jest porownywalna z nieodleglymi globalnymi hubami start-upowymi (Berlin, Kopenhaga, Goteborg). Rownolegle w regionie inwestuje sie znaczne kwoty za pośrednictwem instrumentow finansowych, a takze podejmowane są liczne starania mające na celu rozbudowe ekosystemu start-upowego.