- Dissertation
- 10.14264/bb015c6
Design and construction of a 3D ultra-low field MRI instrument using a dynamic small permanent magnet array and coil-based inductive magnetometer
- Sep 10, 2021
- The University of Queensland
- Jiasheng Su
Nuclear magnetic resonance imaging (MRI) has become the gold standard for many imaging applications. It is routinely used to detect diseases and tissue pathologies due to its superior soft tissue contrast and high spatial resolution. Unlike other imaging techniques such as X-rays, computed tomography, it does not harm patients with ionising radiation.However, MRIs are expensive and only a small portion of patients who would benefit from them can access them. The pursuit of higher sensitivity has generated a trend towards increasing the already large static magnetic field. This has improved imaging quality but has made this technology more expensive and further hindered MRI accessibility. The main cost driver of MRI machines is the strong magnet.The collection of techniques being developed to overcome the intrinsic low NMR sensitivity has fostered interest in low field (LF) MRI to improve cost-effectiveness of MRI. First, the purchase and operational cost of LF systems is relatively low. Second, they are more compatible with other instrumentation which enables versatile concepts such as application-specific open systems and intraoperative imaging. LF systems can offer a wide range of configurations by using permanent magnets. Third, the small fringe field lowers the risk to patients and workers and makes the magnet easier to site. Fourth, artefacts which rely on the strength of field are reduced, as well as the specific absorption rate (SAR) in tissues.Ultra-low field (ULF) MRI systems employ field strengths lower than 10 mT. These systems can complement the advantages of LF systems mentioned above with additional potential benefits. The requirement of homogeneity in ULF is relaxed extensively. It is possible to adjust the strength and direction of the measurement field, allowing flexibility in pulse sequences. Moreover, ULF systems operate in the low kHz frequency range, avoiding the need for radio frequency (RF) noise shielding and enhancing T1-weighted contrast.Most ULF MRI research concentrates on using expensive and fragile sensors, produces the magnetic fields through resistive coils and employs linear gradient fields for encoding. Although ULF systems are important low-cost and portable MRI candidates, they still need considerable space to generate linear fields and need expensive and bulky high permeability shielding to suppress ambient noise.This PhD project develops two major solutions towards a portable and low-cost ULF MRI system: a software gradiometer based on machine learning for ambient noise cancellation and a fast iterative algorithm with total variation (TV) regularisation for image reconstruction. In addition, a concept for a dynamical permanent magnet array (PMA) ULF MRI system is proposed with nonlinear 3D spatial encoding.First, I introduce an experimental setup as a platform for evaluating the MR signal in the ULF regime using a Helmholtz coil as a framework. It is composed of a measurement field, an NMR console, a transmit and receive coil, and a shielding box. The NMR signal is successfully acquired and analysed in partial shielding and full shielding. The results suggest that partial shielding of ULF MRI instruments has the potential to generate a strong signal. This system is built for a subsequent study on noise cancellation presented in following chapter.The second study is a convolutional neural network (CNN) based software gradiometer for background noise cancellation. It includes three ambient noise monitoring coils which are placed away from the NMR sensing coil. The noise induced in the sensing coils is estimated using machine learning. The results show that the software gradiometer reduces ambient noise and can be used to relax shielding requirements, thereby reducing the size and weight of the shielding box.The concept of using small magnets for 3D-spatial encoding in dynamical PMA based ULF MRI is described. It uses small rectangular permanent magnets to generate a 3D-spatial encoding field. The encoding magnets move along an optimised trajectory to achieve an encoding matrix with a low condition number. A prototype of the 3D-spatial encoding has been built and its feasibility tested. The described encoding system can reduce the volume and energy requirements and improve the portability of ULF MRI systems.Finally, iterative imaging reconstruction algorithms for ULF MR are studied. The current state-of-the-art methods are evaluated, which includes Simultaneous Iterative Reconstruction Technique (ART/SIRT), Conjugate Gradient Least Squares (CGLS), and the Chambolle-Pock (CP) algorithms. A dynamic weight Column Action Reconstruction Technique (dwCART) method is proposed and applied to image reconstruction with TV regularisation in the setting of undersampling. In the absence of having a finalised prototype to acquire real ULF MRI imaging data, the methods are tested on CT models (using both simulated and real CT data). The dwCART algorithm performed best on the tested CT problems. It paves the way for fast and accurate imaging with the PMA-based ULF MRI system.
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