AI-enabled case detection model for infectious disease outbreaks in resource-limited settings

Excessive withdrawal of groundwater for agricultural irrigation can cause seawater intrusion into coastal aquifers. Such a case will in turn results in deterioration of irrigation water quality. Determination of irrigation water quality with traditional methods is a time-consuming and costly process. However, machine learning algorithms can be useful tools for modeling and estimating groundwater quality used for irrigation water purposes. In this study, TDS, PS, SAR, and Cl parameters of groundwater were estimated with models based on EC and pH variables. For this purpose, prediction performances of two different deep learning methods (convolutional neural network (CNN) and deep neural network (DNN)) and two different classical machine learning (Random Forest (RF) and extreme gradient boosting (XGBoost)) methods were compared. In addition, predictive uncertainty of the models was determined by quantile regression (QR) analysis. Performance criteria and results of uncertainty analysis revealed that CNN (in testing phase, NSE = 0.95 for TDS, NSE = 0.96 for PS, NSE = 0.67 for SAR and NSE = 0.93 for CI) and DNN (in testing phase, NSE = 0.91 for TDS, NSE = 0.91 for PS, NSE = 0.57 for SAR and NSE = 0.94 for Cl) models had quite a close performance in estimation of TDS, PS, SAR, and Cl parameters and higher than the other two classical machine learning methods. As a result, the CNN model can be considered the best performing model in estimating all quality parameters due to the highest NSE and lowest RMSE values. In addition, the Taylor diagram showed that the values estimated using the CNN model had the highest correlation with the measured data. It was determined that the model with the lowest uncertainty based on the PICP statistics was DNN, followed by the CNN model. However, the CNN model has predicted outliers more accurately. Present findings proved that deep learning models could offer efficient tools for predicting irrigation water quality parameters.

The main goal of this research was to accurately diagnose diseases in pepper plants using convolutional neural network (CNN) models and visual parameters features. Thus, we aimed to build a computing system that can utilise visual cues to identify plant diseases with almost 100% reliability. A total of 2,200 images were trained and tested on a dataset, which was divided into healthy leaves and those with bacterial ailments. The images were preprocessed, resized to 300x300 pixels, and then segmented to extract the relevant traits from them. This CNN model, in a word, is accurate because it detects diseases with 99.65% accuracy. If we want to speak of a high accuracy rate, that's the CNN model. It learns to identify the intricate patterns and features in pepper plants that are associated with diseases. CNN can make revolutionary changes to the identification of plant diseases and help prevent crop damage through timely treatments. Automatic identification of the disease makes life easier for both agriculturists and scientists. The results underscore the importance of image preprocessing, segmentation, and feature extraction in improving the ability of CNN models to locate diseases. Additionally, the performance of the CNN model was compared with other machine learning models such as KNN, Decision Tree, ANN, and Random Forest. It was found that the developed CNN model can predict the response with greater accuracy than the others. Modern high-tech precision farming systems might utilise proposed CNN models for plant disease diagnosis.

We have recently shown that histological phenotypes focusing on clear and eosinophilic cytoplasm in clear cell renal cell carcinoma (ccRCC) correlated with prognosis and the response to angiogenesis inhibition and checkpoint blockade. This study aims to objectively show the diagnostic utility of clear or eosinophilic phenotypes of ccRCC by developing an artificial intelligence (AI) model using the TCGA-ccRCC dataset and to demonstrate if the clear or eosinophilic predicted phenotypes correlate with pathological factors and gene signatures associated with angiogenesis and cancer immunity. Before the development of the AI model, histological evaluation using hematoxylin and eosin whole-slide images of the TCGA-ccRCC cohort (n=435) was performed by a urologic pathologist. The AI model was developed as follows. First, the highest-grade area on each whole slide image was captured for image processing. Second, the selected regions were cropped into tiles. Third, the AI model was trained using transfer learning on a deep convolutional neural network, and clear or eosinophilic predictions were scaled as AI scores. Next, we verified the AI model using a validation cohort (n=95). Finally, we evaluated the accuracy of the prognostic predictions of the AI model and revealed that the AI model detected clear and eosinophilic phenotypes with high accuracy. The AI model stratified the patients' outcomes, and the predicted eosinophilic phenotypes correlated with adverse clinicopathological characteristics and high immune-related gene signatures. In conclusion, the AI-based histologic subclassification accurately predicted clear or eosinophilic phenotypes of ccRCC, allowing for consistently reproducible stratification for prognostic and therapeutic stratification.

BackgroundAlthough capsule endoscopy (CE) is a crucial tool for diagnosing small bowel diseases, the need to process a vast number of images imposes a significant workload on physicians, leading to a high risk of missed diagnoses. This study aims to develop an artificial intelligence (AI) model and application based on convolutional neural networks that can automatically recognize various lesions in small bowel capsule endoscopy.MethodsThree small bowel capsule endoscopy datasets were used for AI model training, validation, and testing, encompassing 12 categories of images. The model’s performance was evaluated using metrics such as AUC, sensitivity, specificity, precision, accuracy, and F1 score to select the best model. A human-machine comparison experiment was conducted using the best model and endoscopists with varying levels of experience. Model interpretability was analyzed using Grad-CAM and SHAP techniques. Finally, a clinical application was developed based on the best model using PyQt5 technology.ResultsA total of 34,303 images were included in this study. The best model, MobileNetv3-large, achieved a weighted average sensitivity of 87.17%, specificity of 98.77%, and an AUC of 0.9897 across all categories. The application developed based on this model performed exceptionally well in comparison with endoscopists, achieving an accuracy of 87.17% and a processing speed of 75.04 frames per second, surpassing endoscopists of varying experience levels.ConclusionThe AI model and application developed based on convolutional neural networks can quickly and accurately identify 12 types of small bowel lesions. With its high sensitivity, this system can effectively assist physicians in interpreting small bowel capsule endoscopy images.Future studies will validate the AI system for video evaluations and real-world clinical integration.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12876-024-03482-7.

Understanding the learning mechanism of convolutional neural networks in spectral analysis

e13581 Background: Medical research in the areas of immunotherapies and targeted therapies has been drawing heavy attention and investment as the number of approved therapies continue to rise. Advanced findings on cancer treatment based on rich healthcare records help doctors to understand patient’s characteristics. The more accurate one can make a mathematical model predicting the likelihood of disease appearance, progression or treatment initiation, the better a proactive and effective targeting solution can be provided. Methods: Create positive/negative labels for patients who start to receive treatment or not within a time-sensitive window. Based on EHR records as Procedures, Prescription, and Diagnosis (PPD), patient’s feature interrelationship can be determined by a conditional probability matrix. Map PPD data to a well-designed patient-image profiles based a modified genetic algorithm to optimize and measure closeness. A Convolutional Neural Networks (CNN) model is then used to extract characteristics from patients’ feature image and learn the local patterns. Training the CNN model together with other upgraded AIML models is used to enhance overall prediction precision. Results: 144 different aggregated PPD features for patients with Chronic Lymphocytic Leukemia (CLL) were selected from the databases. Overall, the number of positive patients, who received treatment due to disease progression, is around 3% among 60K cases in each cohort, which is an extremely unbalanced dataset that is a challenge task for model training. In practice, we care about the model precision at k, which is the percentage of truly identified patients with k highest prediction scores. Comparing to common machine models like Random Forest, XGBoost and CatBoost, our proposed CNN model boosts the ensemble of baseline model performance in terms of average prediction precision at 1000 from 14.9% to 17.1%, which is about 15% relative percentage increase. Using this approach, many more truly identified patients could potentially receive targeted treatment on time. Patients’ top features and key feature interactions can also be identified as important references. Conclusions: The novel CNN boosting algorithm considers both aggregated PPD feature pairs using the graphical structure, significantly improves prediction model performance, and increases the model interpretability. In summary, the proposed model can help identify more potential patient candidates and determine precise treatment options.

Solar energy-based technologies have developed rapidly in recent years, however, the inability to appropriately estimate solar energy resources is still a major drawback for these technologies. In this study, eight different artificial intelligence (AI) models namely; convolutional neural network (CNN), artificial neural network (ANN), long short-term memory recurrent model (LSTM), eXtreme gradient boost algorithm (XG Boost), multiple linear regression (MLR), polynomial regression (PLR), decision tree regression (DTR), and random forest regression (RFR) are designed and compared for solar irradiance prediction. Additionally, two hybrid deep neural network models (ANN-CNN and CNN-LSTM-ANN) are developed in this study for the same task. This study is novel as each of the AI models developed was used to estimate solar irradiance considering different timesteps (hourly, every minute, and daily average). Also, different solar irradiance datasets (from six countries in Africa) measured with various instruments were used to train/test the AI models. With the aim to check if there is a universal AI model for solar irradiance estimation in developing countries, the results of this study show that various AI models are suitable for different solar irradiance estimation tasks. However, XG boost has a consistently high performance for all the case studies and is the best model for 10 of the 13 case studies considered in this paper. The result of this study also shows that the prediction of hourly solar irradiance is more accurate for the models when compared to daily average and minutes timestep. The specific performance of each model for all the case studies is explicated in the paper.

Sleep, notably active sleep (AS) and quiet sleep (QS), plays a pivotal role in the brain development and gradual maturation of (pre) term infants. Monitoring their sleep patterns is imperative, as it can serve as a tool in promoting neurological maturation and well-being, particularly important in preterm infants who are at an increased risk of immature brain development. An accurate classification of neonatal sleep states can contribute to optimizing treatments for high-risk infants, with respiratory rate (RR) and heart rate (HR) serving as key components in sleep assessment systems for neonates. Recent studies have demonstrated the feasibility of extracting both RR and HR using near-infrared spectroscopy (NIRS) in neonates. This study introduces a comprehensive sleep classification approach leveraging high-frequency NIRS signals recorded at a sampling rate of 100 Hz from a cohort of nine preterm infants admitted to a neonatal intensive care unit. Eight distinct features were extracted from the raw NIRS signals, including HR, RR, motion-related parameters, and proxies for neural activity. These features served as inputs for a deep convolutional neural network (CNN) model designed for the classification of AS and QS sleep states. The performance of the proposed CNN model was evaluated using two cross-validation approaches: ten-fold cross-validation of data pooling and five-fold cross-validation, where each fold contains two independently recorded NIRS data. The accuracy, balanced accuracy, F1-score, Kappa, and AUC-ROC (Area Under the Curve of the Receiver Operating Characteristic) were employed to assess the classifier performance. In addition, comparative analyses against six benchmark classifiers, comprising K-Nearest Neighbors, Naive Bayes, Support Vector Machines, Random Forest (RF), AdaBoost, and XGBoost (XGB), were conducted. Our results reveal the CNN model’s superior performance, achieving an average accuracy of 88%, a balanced accuracy of 94%, an F1-score of 91%, Kappa of 95%, and an AUC-ROC of 96% in data pooling cross-validation. Furthermore, in both cross-validation methods, RF and XGB demonstrated accuracy levels closely comparable to the CNN classifier. These findings underscore the feasibility of leveraging high-frequency NIRS data, coupled with NIRS-based HR and RR extraction, for assessing sleep states in neonates, even in an intensive care setting. The user-friendliness, portability, and reduced sensor complexity of the approach suggest its potential applications in various less-demanding settings. This research thus presents a promising avenue for advancing neonatal sleep assessment and its implications for infant health and development.

This paper compares the performance of five different supervised machine learning (SL) algorithms to identify the practical model for tracking copper using solution cathode glow discharge optical emission spectroscopy (SCGD-OES). A total of 4500 SCGD-OES spectra were collected, corresponding to 15 different copper concentrations ranging from 10.3 mg l−1 to 59.6 mg l−1, for training and validating five models: K-nearest neighbors (KNN), random forest (RF), artificial neural network (ANN), convolutional neural network (CNN), and recurrent neural network (RNN). Then, performance of these models were evaluated based on accuracy, precision of predictions and training time. In terms of accuracy, the relative error (RE) was 3% for the CNN model and 4% for the ANN model. Conversely, the RE increased from 21% and 43% for the RF and RNN models to 103% for the KNN model due to the unpredictability of Cu concentration outside the training range. Regarding precision, the relative standard deviation (RSD) values were similar across all models, with the lowest RSD being 3% for the CNN model and the highest being 5% for the RF model. The training time indicated that the KNN and RF models provided the best learning speed, while the CNN model had the slowest learning speed, taking 5 times longer than the ANN model. The accuracy of the ANN and CNN models is in agreement with inductively coupled plasma-optical emission spectroscopy (ICP-OES), with a average difference not exceeding 6% when tracking six different Cu concentrations, both inside and outside the training range. Additionally, this research investigated the weight distribution in the hidden layers of the ANN, CNN, and RNN models and feature importances in the RF model to enhance understanding of the internal structure of models and assist analysts in selecting the practical model for tracking heavy metals based on SCGD-OES.

PurposeSemantic segmentation is a fundamental part of the surgical application of deep learning. Traditionally, segmentation in vision tasks has been performed using convolutional neural networks (CNNs), but the transformer architecture has recently been introduced and widely investigated. We aimed to investigate the performance of deep learning models in segmentation in robot-assisted radical prostatectomy (RARP) and identify which of the architectures is superior for segmentation in robotic surgery.Materials and MethodsIntraoperative images during RARP were obtained. The dataset was randomly split into training and validation data. Segmentation of the surgical instruments, bladder, prostate, vas and seminal vesicle was performed using three CNN models (DeepLabv3, MANet, and U-Net++) and three transformers (SegFormer, BEiT, and DPT), and their performances were analyzed.ResultsThe overall segmentation performance during RARP varied across different model architectures. For the CNN models, DeepLabV3 achieved a mean Dice score of 0.938, MANet scored 0.944, and U-Net++ reached 0.930. For the transformer architectures, SegFormer attained a mean Dice score of 0.919, BEiT scored 0.916, and DPT achieved 0.940. The performance of CNN models was superior to that of transformer models in segmenting the prostate, vas, and seminal vesicle.ConclusionsDeep learning models provided accurate segmentation of the surgical instruments and anatomical structures observed during RARP. Both CNN and transformer models showed reliable predictions in the segmentation task; however, CNN models may be more suitable than transformer models for organ segmentation and may be more applicable in unusual cases. Further research with large datasets is needed.

The classification process is also used in artificial intelligence (AI), which is intelligence created by a computer, so that it can mimic actions like humans in general and can capture events that occur in the surrounding environment. Seeing the very high development of the international coffee trade, it can be concluded that if there is a type of coffee that has the best quality, it will be sought after by coffee importing countries. Batik is cloth that is painted using canting and liquid wax to form motifs or patterns that have high artistic value. Batik has a variety of unique and distinctive patterns that reflect the region where the batik motif originates. One area that has batik motifs in Indonesia is batik in the North Coastal Region of Java Island. In this area, various batiks are produced according to the characteristics of the area itself. Regarding information related to the introduction of types of batik motifs, perhaps it comes from people who have batik skills and batik craftsmen who best understand batik as a whole, while the general public does not really know about batik motifs. Because batik has different motifs and batik motifs in some areas have motifs that are almost uniform but not the same. One of the technologies that can be used is deep learning. The purpose of this study is to propose a Convolutional Neural Network (CNN) and Transfer Learning (TL) model to be implemented in an intelligent system for the process of image classification of coffee bean types. The method used in this study is the PSOCNN transfer learning model VGG16 From the results of tests carried out on 2 models, namely the CNN model, the PSOCNN transfer learning model VGG16. it was found that the highest accuracy was obtained when classifying batik motives images using the PSOCNN-transfer learning model VGG16, which was 83%. The level of accuracy that is increased when compared to the usual CNN model indicates that the use of transfer learning has a good effect on the level of accuracy obtained. Although an increase of 6% is significant, but with this increase it opens up opportunities to increase even higher by using other transfer learning models

Among the many deep learning methods, the convolutional neural network (CNN) model has an excellent performance in image recognition. Research on identifying and classifying image datasets using CNN is ongoing. Animal species recognition and classification with CNN is expected to be helpful for various applications. However, sophisticated feature recognition is essential to classify quasi-species with similar features, such as the quasi-species of parrots that have a high color similarity. The purpose of this study is to develop a vision-based mobile application to classify endangered parrot species using an advanced CNN model based on transfer learning (some parrots have quite similar colors and shapes). We acquired the images in two ways: collecting them directly from the Seoul Grand Park Zoo and crawling them using the Google search. Subsequently, we have built advanced CNN models with transfer learning and trained them using the data. Next, we converted one of the fully trained models into a file for execution on mobile devices and created the Android package files. The accuracy was measured for each of the eight CNN models. The overall accuracy for the camera of the mobile device was 94.125%. For certain species, the accuracy of recognition was 100%, with the required time of only 455 ms. Our approach helps to recognize the species in real time using the camera of the mobile device. Applications will be helpful for the prevention of smuggling of endangered species in the customs clearance area.

Distinguishing pericarpium citri reticulatae of different origins using terahertz time-domain spectroscopy combined with convolutional neural networks

This study leveraged Convolutional Neural Network (CNN) models to estimate canopy height in Southeast Australian forests before and after the 2019–2020 bushfire event, using inputs from Sentinel-1, Sentinel-2, spectral indices, and terrain features and GEDI canopy height (rh99) as target variables. Our research consisted of three primary objectives: (1) an evaluation of GEDI rh99 canopy height in relation to an nDSM derived from airborne LiDAR, (2) the development of two CNN models for pre- and post-fire scenarios, and (3) utilizing the trained CNN models to generate pre- and post-fire canopy height maps and canopy height change maps across the continuous landscape. GEDI rh99 accuracy analysis revealed R 2 = 0.85, RMSE = 7.25 m and nRMSE = 0.23 for pre-fire GEDI and R 2 = 0.78, RMSE = 10.1 m and nRMSE = 0.3 for post-fire GEDI. The pre-fire CNN model achieved R 2 = 0.75, RMSE = 7.29 m and nRMSE = 0.22, and post-fire CNN model achieved R 2 = 0.62, RMSE = 11.67 m, and nRMSE = 0.34 when validated against nDSM. Bias analysis was conducted, revealing that GEDI rh99 underestimated nDSM across all canopy height ranges, and slope has no significant impact on GEDI accuracy. Notably, post-fire GEDI rh99 exhibited significant underestimation in high to extreme fire severity. The CNN models’ prediction displayed overestimation in short forests < 20 m and increasing underestimation in taller forests > 20 m and underestimation in high and extreme fire severity. Subsequent investigation indicated that canopy layer thinning in high fire severity conditions resulted in weak GEDI waveform signals and consequent bias. Additionally, the GEDI rh99 bias was propagated to the CNN models, together with insensitivity of spectral band values to canopy height in dense and burnt forests potentially contributed to models’ bias. Finally, we demonstrated CNN models’ ability to monitor forest recovery by generating canopy height maps spanning East Gippsland from 2019 to 2023.

High-risk breast lesions (HRLs) are associated with future risk of breast cancer. Considering the pathological subtypes, malignancy upgrade rate differs according to each subtype and depends on various factors such as clinical and radiological features and biopsy method. Using artificial intelligence and machine learning models in breast imaging, evaluations can be made in terms of risk estimation in different research areas. This study aimed to develop a machine learning model to distinguish HRL cases requiring surgical excision from lesions with a low risk of accompanying malignancy. A total of 94 patients who were diagnosed with HRL by image-guided biopsy between January 2008 and March 2020 were included in the study. A structured database was created with clinical and radiological characteristics and histopathological results. A machine learning prediction model was created to make binary classifications of lesions as malignant or benign. Random forest, decision tree, K-nearest neighbors, logistic regression, support vector machine (SVM), and multilayer perceptron machine learning algorithms were used. Among these algorithms, SVM was the most successful. The estimations of malignancy for each case detected by artificial intelligence were combined and statistical analyses were performed. Considering all cases, the malignancy upgrade rate was 24.5%. A significant association was observed between malignancy upgrade rate and lesion size (P = 0.004), presence of mammography findings (P = 0.022), and breast imaging-reporting and data system category (P = 0.001). A statistically significant association was also found between the artificial intelligence prediction model and malignancy upgrade rate (P < 0.001). With the SVM model, an 84% accuracy and 0.786 area-underthe- curve score were obtained in classifying the data as benign or malignant. Our artificial intelligence model (SVM) can predict HRLs that can be followed up with a lower risk of accompanying malignancy. Unnecessary surgeries can be reduced, or second line vacuum excisions can be performed in HRLs, which are mostly benign, by evaluating on a case-by-case basis, in line with radiology-pathology compatibility and by using an artificial intelligence model.