An ECG denoising technique based on AHIN block and gradient difference max loss

<title>Abstract</title> Electrocardiogram (ECG) signals are critical to identify various cardiac abnormalities. However, the accuracy of ECG-based clinical interpretations can be significantly compromised due to contamination from various artifacts. Traditional ECG denoising methods often struggle to maintain the balance between noise suppression and preservation of essential ECG characteristics. This study presents, for the first time, a deep learning (DL)-based autoencoder (AE) for robust ECG denoising and artifact cancellation and automated ECG diagnosis and classification. Unlike traditional methods, AEs are designed to learn efficient data representations, making them well-suited for distinguishing between clean signals and noise without extensive computational demands. The proposed approach leverages the PTB Diagnostic ECG Database (PTBdb) and introduces various types of noise derived from the MIT-BIH Noise Stress Test Database, including muscle artifacts (MA), electrode motion artifacts (EM), baseline wander (BW), and their combinations. The proposed AE model is trained to eliminate these noise components effectively while preserving the critical morphological features of the ECG signals. To assess the performance of the introduced method, comprehensive experiments are performed to compare clean, noisy, and AE denoised ECG signals. The AE's performance is further benchmarked against classical denoising techniques, assessing key metrics such as signal to noise ratio (SNR), mean square error (MSE), root mean square error (RMSE) and a percent root-mean square difference (PRD). The results elucidate that the introduced AE-based denoising framework not only outperforms conventional techniques in noise suppression but also enhances the reliability of ECG signal interpretation, making it an effective solution for implementation in clinical settings.

Effective and powerful methods for denoising real electrocardiogram (ECG) signals are important for wearable sensors and devices. Deep Learning (DL) models have been used extensively in image processing and other domains with great success but only very recently have been used in processing ECG signals. This paper presents several DL models namely Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM), Restricted Boltzmann Machine (RBM) together with the more conventional filtering methods (low pass filtering, high pass filtering, Notch filtering) and the standard wavelet-based technique for denoising EEG signals. These methods are trained, tested and evaluated on different synthetic and real ECG datasets taken from the MIT PhysioNet database and for different simulation conditions (i.e. various lengths of the ECG signals, single or multiple records). The results show the CNN model is a performant model that can be used for off-line denoising ECG applications where it is satisfactory to train on a clean part of an ECG signal from an ECG record, and then to test on the same ECG signal, which would have some high level of noise added to it. However, for real-time applications or near-real time applications, this task becomes more cumbersome, as the clean part of an ECG signal is very probable to be very limited in size. Therefore the solution put forth in this work is to train a CNN model on 1 second ECG noisy artificial multiple heartbeat data (i.e. ECG at effort), which was generated in a first instance based on few sequences of real signal heartbeat ECG data (i.e. ECG at rest). Afterwards it would be possible to use the trained CNN model in real life situations to denoise the ECG signal.

Electrocardiogram (ECG) signals are crucial for monitoring cardiac activity and diagnosing various cardiovascular conditions. However, these signals are often contaminated by different types of noise, such as baseline wander, muscle artifacts, and power line interference, which can obscure critical information and hinder accurate diagnosis. This study used a 1-Dimensional Convolutional Neural Network (1D CNN) architecture with seven convolutional layers for denoising ECG signals. The model utilizes a fully convolutional autoencoder approach, comprising an encoder that transforms noisy input signals into compact feature representations and a decoder that reconstructs the cleaned signals. The proposed architecture was tested using the MIT-BIH Noise Stress Test Database, which includes ECG recordings with simulated noise conditions. Performance evaluation metrics such as Mean Squared Error (MSE), Signal-to-Noise Ratio (SNR), and Mean Absolute Deviation (MAD) were used to assess the model's effectiveness. Results showed a low MSE of 0.034, a high SNR of 15.8 dB, and a MAD of 0.754, indicating significant noise reduction and high-quality signal reconstruction. These findings demonstrate that the 1D CNN architecture effectively reduces various types of noise in ECG signals, thereby enhancing signal quality and facilitating more accurate analysis and diagnosis. The model's ability to maintain the integrity of crucial ECG features while removing noise suggests its potential utility in clinical applications for improving cardiovascular disease diagnosis

With the advent of the aging era, healthcare and elderly care have become the focus of medical care, especially the care of the elderly with dementia. Patients’ confidential data hiding is a useful technology for healthcare and patient information privacy. In this study, we implement an intelligent healthcare system using the multiple-coefficient quantization technology in transform domain to hide patients’ confidential data into electrocardiogram (ECG) signals obtained by ECG sensor module. In embedding patients’ confidential data, we first consider a non-linear model for optimizing the quality of the embedded ECG signals. Next, we apply simulated annealing (SA) to solve the non-linear model so as to have good signal-to-noise ratio (SNR), root mean square error (RMSE), and relative RMSE (rRMSE). Accordingly, the distortion of the PQRST complexes and the ECG amplitude is very small so that the embedded confidential data can satisfy the requirements of physiological diagnostics. In end devices, one can receive the ECG signals with the embedded confidential data and without the original ECG signals. Experimental results confirm the effectiveness of our method, which remains high quality for each ECG signal with the embedded confidential data no matter how the quantization size Q is increased.

Electrocardiogram (ECG) signals are significantly distorted during recording by muscle artifact (MA), causing signal frequency overlap and making it difficult to interpret ECG data correctly. Deep learning (DL) methods for signal processing have shown promising results. However, there is a significant necessity in building proper DL models with appropriate datasets. We propose an enhanced hybrid deep learning framework called HRGB-Net based on residual neural network (ResNet), global channel attention block (GCAB), and bidirectional-long-short-term memory (Bi-LSTM) blocks for filtering the MA noise from ECG by using three distinctive MIT-BIH real-time datasets from the PhysioNet repository by creating suitable datasets for training. We use both raw ECG data and short-time Fourier-transformed (STFT) ECG data for comparative analysis with three neural network models: a convolutional neural Network (CNN), a fully connected neural network (FCNN), and a regression-based LSTM (Reg-LSTM-DNN) model to assess the proposed model. The signal-to-noise ratio (SNR) of noisy ECG signals is varied from - 7dB to 2dB to analyze the mean square error (MSE) and correlation coefficient (CC) performances after the denoising process. Our proposed method utilizes the regression ability to remove MA noise and generate a clean ECG signal with improved values of these signal parameters. The STFT-trained and tested ECG data shows better results than the raw ECG data for efficiently eliminating the MA with a 98.82% correlation coefficient and optimal MSE value of 0.053068. The results prove our proposed HRGB-Net model's remarkable ability to outperform the neural network models and other standard techniques.

Electrocardiogram (ECG) signals are electrical signals generated corresponding to activity of heart. ECG signals are recorded and analysed to monitor heart condition. In initial raw form, ECG signals are contaminated with different types of noises. These noises may be electrode motion artefact noise, baseline wander noise and muscle noise also known as electromyogram (EMG) noise etc. In this paper, a descendent structure consists of adaptive filters is used to eliminate the three different types of noises (i.e., motion artefact noise, baseline wander noise and muscle noise). The two different adaptive filtering algorithms have been implemented; least mean square (LMS) and recursive least square (RLS) algorithm. The performance of these filters are compared on the basis of different fidelity parameters such as mean square error (MSE), normalised root mean squared error (NRMSE), signal-to-noise ratio (SNR), percentage root mean squared difference (PRD), and maximum error (ME) has been observed.

Electrocardiogram (ECG) signal enhancement is necessary in telemedicine. In such ECG monitoring systems, noises like muscle artifacts, electrode motion and baseline wander are often embedded in the ECG signals during acquisition and transmission. In this study, a novel method is proposed for the ECG signal enhancement based on the finding that ECG signals extracted over a big data share significant similarities in the morphology for a particular person. We construct a guided filter and reform it by a Butterworth high-pass filter. The Butterworth high-pass filter is utilized to remove the baseline wander. The advantageous edge-preserving guided filter is then applied to remove the rest noise, of which frequencies are between the ECG signals. Very promising results with high accuracy and the edge-preserving features have been achieved in the comparative experiments. We evaluated the proposed denoising method using ECG signals from the MIT-BIH Arrhythmia database and the Noise Stress Test database. The experimental results demonstrate that the proposed method achieves better signal-to-noise ratio (SNR) and lower root mean square error (RMSE) when compared to the wavelet with subband dependent thresholding (WT-Subband), Back Propagation Neural Network and Stockwell transform methods. Using the proposed method, the average output SNR ranges from 8.57 to 19.28 dB, and the average RMSE is less than 0.41.

Abstract: Motion interference is a major issue in the process of acquiring electrocardiogram (ECG) signals. It introduces noise and artifacts into the ECG signal, causing signal distortion and deformation, thus affecting the accuracy of subsequent analyses and diagnoses. This study introduces a deep learning-based model for motion artifact removal in ECG signals, namely MSCT, which combines Multi-Scale Convolution with Transformer encoder to extract the local and global features of ECG signals and motion artifacts. The comparative experiments are conducted on the MIT-BIH arrythmia database which is contaminated with the motion artifact from MIT-BIH noise stress test database. Our MSCT model shows significantly higher Cosine Similarity and output signal-to-noise ratio (SNR), and lower Root Mean Square Error (RMSE) and Multi-Scale Entropy Based Weighted Percentage Root-mean-square Difference (MSEWPRD), compared with that of the three previous methods on the motion artifact-corrupted data with various input SNR (-6 dB, 0 dB and 6 dB). Especially, when the input SNR is -6 dB, the proposed MSCT achieves the results 6.15±2.83%, 0.25±0.14 mV, 0.91±0.08, 9.20±3.74 dB for MSEWPRD, RMSE, Cosine Similarity and SNR, respectively. All the four metrics, including quantitative and qualitative metrics, have demonstrated the superiority and robust of the MSCT model proposed in this study. Furthermore, the time-domain and frequency-domain plots of a randomly selected denoising segment at -6 dB effectively showcase the superior performance of our denoising method.

PO-04-175 RECONSTRUCTING TWELVE-LEAD ELECTROCARDIOGRAM SIGNALS FROM A SINGLE-LEAD SIGNAL USING GENERATIVE ADVERSARIAL NETWORKS

Electrocardiogram (ECG) signals are frequently utilized for detecting important cardiac events, such as variations in ECG intervals, as well as for monitoring essential physiological metrics, including heart rate (HR) and heart rate variability (HRV). However, the accurate measurement of ECG traditionally requires a clinical environment, thereby limiting its feasibility for continuous, everyday monitoring. In contrast, Photoplethysmography (PPG) offers a non-invasive, cost-effective optical method for capturing cardiac data in daily settings and is increasingly utilized in various clinical and commercial wearable devices. However, PPG measurements are significantly less detailed than those of ECG. In this study, we propose a novel approach to synthesize ECG signals from PPG signals, facilitating the generation of robust ECG waveforms using a simple, unobtrusive wearable setup. Our approach utilizes a Transformer-based Generative Adversarial Network model, designed to accurately capture ECG signal patterns and enhance generalization capabilities. Additionally, we incorporate self-supervised learning techniques to enable the model to learn diverse ECG patterns through specific tasks. Model performance is evaluated using various metrics, including heart rate calculation and root mean squared error (RMSE) on two different datasets. The comprehensive performance analysis demonstrates that our model exhibits superior efficacy in generating accurate ECG signals (with reducing 83.9% and 72.4% of the heart rate calculation error on MIMIC III and Who is Alyx? datasets, respectively), suggesting its potential application in the healthcare domain to enhance heart rate prediction and overall cardiac monitoring. As an empirical proof of concept, we also present an Atrial Fibrillation (AF) detection task, showcasing the practical utility of the generated ECG signals for cardiac diagnostic applications. To encourage replicability and reuse in future ECG generation studies, we have made both the dataset and the code publicly available.

Electrocardiogram (ECG) signal processing aims basically 1) at artifact reduction to make the ECG signals cleaner and better interpretable by human or machine observers, 2) at revealing aspects not immediately observable in plain measured ECG signals even after artifact reduction, or 3) at diagnostics decision support and automated ECG signal interpretation, including classification of ECG signals into different classes associated with normal or pathological heart function. Thus, sports related applications aside, body surface ECG signal processing aims at enhancing ECG based diagnostics. In this Chapter, we review and demonstrate a statistical signal processing approach, independent component analysis (ICA), which is inherently very suitable for ECG signal processing regarding the aims 1) and 2) above, and also equally applicable as a component in systems aimed at accomplishing the aim 3). For more on general ECG signal processing, the reader is directed to the textbook written by Sornmo & Laguna (2005), and for a thorough treatment of ICA to the Hyvarinen’s book (Hyvarinen et al., 2001). A concise review on ICA in ECG signal processing has been presented by Castells et al. (2007a). In this Chapter, we describe and illustrate several widely adopted applications of ICA in ECG signal processing, and discuss associated practical aspects, some of which are not generally found in the literature. The treatment of the matter is aimed at conceptual and practical understanding, leaving the mathematical derivations and proofs far mostly for the interested reader to find in the references. ICA (Castells et al., 2007a; Comon, 1994; Hyvarinen et al., 2001; Hyvarinen & Oja, 2000; Naik & Kumar, 2011) is a statistical signal processing method for decomposing a set of signals into a set of mutually independent component signals. In general, in the applications of ICA, including in ECG signal processing, the objective is that the resulting independent component signals are the original source signals. Since ICA operates purely based on the input signals and a few assumptions, ICA belongs to the class of methods called blind source separation methods. For ICA, a source signal is called an independent component (IC). The terms ‘IC’ and ‘source signal’ are here used interchangeably. For ECG, the source signals are the bioelectrical signals generated by the heart, and all the possible artifact signals. Generally, ICA input signals are the observed signals, which may be measurement time series, such as sampled voltage values in time as in the case of ECGs, image pixel values, or basically any sets of values fulfilling the assumptions of ICA. In the sequel, the term

Electrocardiogram (ECG) signal quality indices (SQIs) are essential for improving diagnostic accuracy and reliability of ECG analysis systems. In various practical applications, the ECG signals are corrupted by different types of noise. These corrupted ECG signals often provide insufficient and incorrect information regarding a patient’s health. To solve this problem, signal quality measurements should be made before an ECG signal is used for decision-making. This paper investigates the robustness of existing popular statistical signal quality indices (SSQIs): relative power of QRS complex (SQIp), skewness (SQIskew), signal-to-noise ratio (SQIsnr), higher order statistics SQI (SQIhos) and peakedness of kurtosis (SQIkur). We analysed the robustness of these SSQIs against different window sizes across diverse datasets. Results showed that the performance of SSQIs considerably fluctuates against varying datasets, whereas the impact of varying window sizes was minimal. This fluctuation occurred due to the use of a static threshold value for classifying noise-free ECG signals from the raw ECG signals. Another drawback of these SSQIs is the bias towards noise-free ECG signals, that limits their usefulness in clinical settings. In summary, the fixed threshold-based SSQIs cannot be used as a robust noise detection system. In order to solve this fixed threshold problem, other techniques can be developed using adaptive thresholds and machine-learning mechanisms.

Fetal Electrocardiogram (ECG) signal extraction from non-invasive abdominal ECG signal is one of the important clinical practices followed to observe the fetal health state. Information about heart growth and health conditions of a fetus can be observed from fetal ECG signals. However, acquiring fetal ECG from abdominal ECG signals is still considered as a challenging task in biomedical analysis. This is mainly due to corrupted high amplitude maternal ECG signals, low signal to noise ratio of fetal ECG signal, difficulties in reduction of QRS (Q wave, R wave, S wave) complexities, fetal ECG signal superimposed characteristics, other motion, and electromyography artifacts. To reduce these conventional challenges, in fetal ECG analysis of a novel Conditional Generative adversarial network (CGAN) is introduced in this research work to extract the fetal ECG signal. The proposed classification model was classified efficiently in fetal ECG signals from non-invasive abdominal ECG signals. The experimental analysis demonstrates that the proposed network model provides better results in terms of sensitivity, specificity, and accuracy compared to the conventional fetal ECG extraction models like singular value decomposition, periodic component analysis, and Adaptive neuro-fuzzy inference system.

Electrocardiogram (ECG) signal recording is a challenging task in the field of biomedical engineering. ECG is the cardiac recording of systematic electrical activity arising from the electro-physiological rhythm of the heart muscle. But, during processing, the ECG signal is contaminated with different types of noise in the medical environment. An immense task is the separation of the preferred signal from noises caused by artifacts like muscle noise, power line interference (PLI), baseline wandering (BW), and motion artifacts (MA). Hence, our paper focuses on 50 Hz PLI which is a major artifact/noise affecting the recorded ECG signal. This paper comprehensively reviews fundamental concepts of different denoising techniques. Some of the pioneers’ works are also concisely explained in the paper. Further, in this work, comparative analysis is carried out using notch filter, adaptive filter, discrete wavelet transform (DWT) and empirical mode decomposition (EMD) for filtering 50 Hz PLI noise. A considerable improvement in signal-to-noise ratio (SNR) can be observed from the results when compared with SNR input and SNR output values. Performance comparisons of all the four techniques are also analyzed based on variations in noise frequency. The simulations were carried out in the environment of MATLAB 2019b®. This work epitomizes the significance of our quantitative evaluation, in which adaptive filters are found to perform better with respect to the SNR, whereas DWT performs better with assessment of mean square error (MSE).

Present paper deals with design and development of digital FIR filters. Heart diseases, which are one of the death reasons, are among the several serious problems in this century and as per the latest survey, 60% of the patients die due to Heart diseases. Electrocardiogram (ECG) signal plays a vital role in the monitoring and diagnosis of the health conditions of human heart. The basic ECG signal has the frequency range from .5Hz to 100Hz. The most significant noises that corrupt ECG signal are power line interference and baseline wanders. It becomes difficult for the Specialist to diagnose the diseases if artifacts are present in the ECG signal. Designing digital filters to reduce these noises is very important in ECG signal processing. In this work a digital FIR filter for reducing 50Hz power line noise in ECG signal is designed and implemented with different windowing methods as of Hamming, Kaiser, and Chebyshev. The work has been done in MATLAB environment. The result obtained for all FIR filters are compared by comparing the waveforms of the original and filtered ECG signals. The filter which gives the best results is the one using Chebyshev Window.