Deep learning-based object detection algorithms in medical imaging: Systematic review.

Numerous techniques, especially those based on deep learning (DL), have been developed and applied to a wide range of tasks, including image recognition, classification, object detection, and image segmentation, as a result of extensive research in the field of image processing. Image processing has become crucial in the medical field, with segmentation emerging as a crucial method for organ identification, disease detection, and abnormality analysis in medical images. Convolutional neural networks (CNNs), one of the many approaches, have recently demonstrated great promise in resolving intricate problems associated with medical image analysis because of their capacity to automatically learn hierarchical features. In this review, we discuss recent developments in deep CNNs for medical image segmentation. The architectures and features of the most popular CNN-based models are examined, along with the different publicly accessible medical imaging datasets that are used in studies and the evaluation metrics that are frequently used to gauge segmentation performance and accuracy, also the advantages and disadvantages of each one. In addition, we look at comparative research and the shortcomings of existing approaches, offering suggestions for future lines of clinical relevance.

1 - Congruence of deep learning in biomedical engineering: future prospects and challenges

The use of machine learning (ML) has been increasing rapidly in the medical imaging field, including computer-aided diagnosis (CAD), radiomics, and medical image analysis. Recently, an ML area called deep learning emerged in the computer vision field and became very popular in many fields. It started from an event in late 2012, when a deep-learning approach based on a convolutional neural network (CNN) won an overwhelming victory in the best-known worldwide computer vision competition, ImageNet Classification. Since then, researchers in virtually all fields, including medical imaging, have started actively participating in the explosively growing field of deep learning. In this paper, the area of deep learning in medical imaging is overviewed, including (1) what was changed in machine learning before and after the introduction of deep learning, (2) what is the source of the power of deep learning, (3) two major deep-learning models: a massive-training artificial neural network (MTANN) and a convolutional neural network (CNN), (4) similarities and differences between the two models, and (5) their applications to medical imaging. This review shows that ML with feature input (or feature-based ML) was dominant before the introduction of deep learning, and that the major and essential difference between ML before and after deep learning is the learning of image data directly without object segmentation or feature extraction; thus, it is the source of the power of deep learning, although the depth of the model is an important attribute. The class of ML with image input (or image-based ML) including deep learning has a long history, but recently gained popularity due to the use of the new terminology, deep learning. There are two major models in this class of ML in medical imaging, MTANN and CNN, which have similarities as well as several differences. In our experience, MTANNs were substantially more efficient in their development, had a higher performance, and required a lesser number of training cases than did CNNs. "Deep learning", or ML with image input, in medical imaging is an explosively growing, promising field. It is expected that ML with image input will be the mainstream area in the field of medical imaging in the next few decades.

Chapter 11 - Artificial intelligence for pathology

Along with the development of medical imaging technology, medical image analysis has become a crucial part of clinical diagnosis. However, traditional image analysis methods rely on manual feature extraction and expert evaluation, triggering problems such as low efficiency and lack of accuracy. Deep learning techniques, especially convolutional neural networks (CNNs), have made significant breakthroughs in medical image analysis in recent years. The aim of this paper is to study the application of deep learning in medical imaging, and explore the advantages and development potential in early disease diagnosis, image segmentation and feature extraction. This paper reviews the basic principles of deep learning and analyses the applicability of deep learning in medical imaging by combining the characteristics of medical imaging. Through systematic analysis of existing literature, this paper summarises the remarkable achievements of deep learning in processing, analysing and applying it to various medical images, such as Optical Coherence Tomography (OCT), Magnetic Resonance Imaging (MRI) and so on. It has been shown that deep learning methods can significantly improve the accuracy and efficiency of medical image processing and demonstrate performance due to traditional methods in tasks such as classification. However, how to improve the interpretability of models and the generalisability of clinical applications are still current research hotspots and challenges.

Deep learning is a fast flattering highest development in the machine learning technique leading to augment performance in diverse medical applications. The tributary artificial intelligence is rapidly becoming metamorphic in the domain of Healthcare Technology rendering facility to analyze the medical data with high rapidity and exactness. Due to the overwhelming development of artificial intelligence (AI), the contemporary encroachments of deep learning employing advanced and futuristic deep learning methods has become a vivacious research domain for processing medical data in the health care industries. This paper presents a complete analysis about the deep structured learning based methods used in medical image analysis and also elucidate about the advancement of convolutional neural network which is a major class of deep neural networks used in medical image processing. It also gives insight about the fundamentals of deep learning methods and reviews in image interpretation. It also explains about the implementation of an integrated framework for medical image synthesis combining Speckle GAN and Di-Conv-AE-Net.

Deep learning has attracted great attention in the medical imaging community as a promising solution for automated, fast and accurate medical image analysis, which is mandatory for quality healthcare. Convolutional neural networks and its variants have become the most preferred and widely used deep learning models in medical image analysis. In this paper, concise overviews of the modern deep learning models applied in medical image analysis are provided and the key tasks performed by deep learning models, i.e. classification, segmentation, retrieval, detection, and registration are reviewed in detail. Some recent researches have shown that deep learning models can outperform medical experts in certain tasks. With the significant breakthroughs made by deep learning methods, it is expected that patients will soon be able to safely and conveniently interact with AI-based medical systems and such intelligent systems will actually improve patient healthcare. There are various complexities and challenges involved in deep learning-based medical image analysis, such as limited datasets. But researchers are actively working in this area to mitigate these challenges and further improve health care with AI.

Pancreatic cancer is a highly lethal disease with a poor prognosis. Its early diagnosis and accurate treatment mainly rely on medical imaging, so accurate medical image analysis is especially vital for pancreatic cancer patients. However, medical image analysis of pancreatic cancer is facing challenges due to ambiguous symptoms, high misdiagnosis rates, and significant financial costs. Artificial intelligence (AI) offers a promising solution by relieving medical personnel's workload, improving clinical decision-making, and reducing patient costs. This study focuses on AI applications such as segmentation, classification, object detection, and prognosis prediction across five types of medical imaging: CT, MRI, EUS, PET, and pathological images, as well as integrating these imaging modalities to boost diagnostic accuracy and treatment efficiency. In addition, this study discusses current hot topics and future directions aimed at overcoming the challenges in AI-enabled automated pancreatic cancer diagnosis algorithms.

Machine learning techniques such as deep learning methods have produced promising results in medical images analysis. This work proposes a user-friendly system that utilizes deep learning techniques for detecting and diagnosing diseases using medical images. This includes the design of CAD-based project that can reduce human factor-related errors while performing manual screening of medical images. The system accepts medical images as input and performs segmentation of the images. Segmentation process analyzes and identifies the region of interest (ROI) of diseases from medical images. Analyzing and segmentation of medical images has assisted in the diagnosis and monitoring of some diseases. Diseases such as skin cancer, age-related fovea degeneration, diabetic retinopathy, glaucoma, hypertension, arteriosclerosis, and choroidal neovascularization can be effectively managed by the analysis of skin lesion and retinal vessels images. The proposed system was evaluated on diseases such as diabetic retinopathy from retina images and skin cancer from dermoscopic images.

Deep learning approaches have demonstrated great achievements in the field of computer-aided medical image analysis, improving the precision of diagnosis across a range of medical disorders. These developments have not, however, been immune to the appearance of adversarial attacks, creating the possibility of incorrect diagnosis with substantial clinical implications. Concurrently, the field has seen notable advancements in defending against such targeted adversary intrusions in deep medical diagnostic systems. In the context of medical image analysis, this article provides a comprehensive survey of current advancements in adversarial attacks and their accompanying defensive strategies. In addition, a comprehensive conceptual analysis is presented, including several adversarial attacks and defensive strategies designed for the interpretation of medical images. This survey, which draws on qualitative and quantitative findings, concludes with a thorough discussion of the problems with adversarial attack and defensive mechanisms that are unique to medical image analysis systems, opening up new directions for future research. We identified that the main problems with adversarial attack and defense in medical imaging include dataset and labeling, computational resources, robustness against target attacks, evaluation of transferability and adaptability, interpretability and explainability, real-time detection and response, and adversarial attacks in multi-modal fusion. The area of medical imaging adversarial attack and defensive mechanisms might move toward more secure, dependable, and therapeutically useful deep learning systems by filling in these research gaps and following these future objectives.

Segmentation of a brain tumor is one of the most difficult tasks in the analysis of medical images. The purpose of brain tumor segmentation is to create an accurate outline of brain tumor areas. Gliomas are the most common type of brain tumors. Diagnosis of patients with this disease is based on the analysis of the results of magnetic resonance imaging and segmentation of the tumor boundaries manually. However, due to the time-consuming nature of the manual segmentation process and errors, there is a need for a fast and reliable automatic segmentation algorithm. In recent years, deep learning methods have shown promising effectiveness in solving various computer vision problems, such as image classification, object detection and semantic segmentation. A number of methods based on deep learning have been applied to segmentation of brain tumors, and promising results have been achieved. The article proposes a hybrid method for solving the problem of segmentation of brain tumors based on its MRI images based on the U-Net architecture, the encoder of which uses a model of a deep convolutional neural network pre-trained on a set of ImageNet images. Among such models were used VGG16, VGG19, MobileNetV2, Inception, ResNet50, EfficientNetb7, InceptionResnetV2, DenseNet201, DenseNet121. Based on the hybrid method, the TL-U-Net model was implemented, and numerical experiments were carried out to train it with different encoder models for segmentation of brain tumors based on its MRI images. Computer experiments on a set of MRI images of the brain showed the effectiveness of the proposed approach, the best encoder model turned out to be the neural network Densenet121, which provided indicators of segmentation accuracy MeanIoU=90.34%, MeanDice=94.33%, accuracy=94.17%. The obtained estimates of segmentation accuracy are comparable or exceed similar estimates obtained by other researchers.

With the rise of deep learning, medical image analysis has undergone fundamental change, presenting new possibilities to physicians in terms of achieving higher accuracy more efficiently, and greater automation in disease diagnosis and prognosis. In this paper, we discuss recent progress in utilizing deep learning techniques such as convolutional neural network (CNN), recurrent neural network (RNN), generative adversarial network (GAN), and transformer-based model for medical image analysis. Image classification, segmentation, and anomaly detection in modalities such MRI, CT, Xray, and ultrasound have been strongly improved by these architectures. Yet, such progress brings challenges, namely scarcity of sufficient data, interpretability of models, computational intensity, and robust generalization to diverse clinical datasets. At the same time regulatory concerns and ethical questions on the use of AI diagnostics are still constraining large scale adoption. This paper provides a comprehensive review of state-of-the art deep learning models in medical imaging, reviews the current limitations, and envisions future research directions in federated learning, explainable AI, and quantum enhanced deep learning. Such insights are intended to guide researchers and clinicians in the optimization of AI driven medical image analysis for optimized patient care and clinical decision making.

Introduction: Precise segmentation of the liver from computed tomography (CT) scans is an essential component in the diagnosis and treatment of liver diseases such as hepatocellular carcinoma. Manual segmentation can be time-consuming and subject to variability, spurring the application of automated systems based on deep learning. We introduce a 3D U-Net-based convolutional neural network for end-to-end segmentation of the liver from volumetric CT images. The model is trained and tested on the LiTS dataset using a standard preprocessing pipeline and an in-house composite loss function—AdvancedComboLoss—combining Dice Loss, Binary Cross-Entropy, and Focal Tversky Loss to balance class imbalance and boundary accuracy. The network handles entire 3D volumes with spatial context retained between anatomical planes and is trained on a GPU-enabled setup with the PyTorch environment. Objectives: To develop a highly accurate and computationally efficient 3D U-Net-based deep learning model for automated liver segmentation from volumetric CT scans, addressing challenges like class imbalance, anatomical variability, and low tissue contrast, using a custom loss function (AdvancedComboLoss) and a standardized preprocessing pipeline. Methods: The methodology adopted is volumetric liver segmentation from a specially designed 3D U-Net architecture specific to medical CT scans. The process entails preprocessing of raw CT scans into a common shape and intensity range and training a fully convolutional 3D neural network that learns the spatial relationships among all three anatomical planes. The model uses an encoder-decoder architecture with skip connections to maintain fine-grained structural information, allowing for accurate delineation of liver regions. A hybrid loss function—integrating Dice, Binary Cross-Entropy, and Focal Tversky losses—is used to direct the learning process to optimize overlap of regions, accuracy of classification, and class imbalance. Results: Experimental outcomes demonstrate that the model has a Dice score of 0.9604 and voxel-wise accuracy of 0.9979, indicating excellent performance in segmentation as well as strong agreement with expert annotations. The model presented in this paper presents a solid, scalable, and clinically valuable approach to automated liver segmentation with future potential to integrate into multi-stage liver and tumor analysis workflows. Conclusions: Herein, we built and tested a 3D U-Net deep learning architecture for unsupervised liver segmentation from abdominal CT volumes. Through utilization of volumetric convolutions as well as through a well-engineered composite loss function, the model was successful in capturing complicated liver anatomy as well as being able to hold high performance even on varied CT volumes. The power of the method is not just in its quantitative performance but also in its capability to generate anatomically consistent and visually plausible segmentations, making it extremely relevant to actual clinical workflows. Although there are some limitations—constrained batch size and absence of data augmentation—there is room for improvement, the findings affirm that deep learning can be an effective tool for automating key tasks in medical image analysis. As a whole, this paper adds a robust and effective segmentation model that would be potentially embedded in wider diagnostic workflows, ending up improving the accuracy, speed, and scalability of liver evaluation in clinical practice. In brief, this paper adds a high-fidelity, scalable, and computationally effective solution for computer-aided liver segmentation, pushing the application of artificial intelligence in clinical decision-making and medical image analysis.

Recent revolutionary advances in deep learning (DL) have fueled several breakthrough achievements in various complicated computer vision tasks. The remarkable successes and achievements started in 2012 when deep learning neural networks (DNNs) outperformed the shallow machine learning models on a number of significant benchmarks. Significant advances were made in computer vision by conducting very complex image interpretation tasks with outstanding accuracy. These achievements have shown great promise in a wide variety of fields, especially in medical image analysis by creating opportunities to diagnose and treat diseases earlier. In recent years, the application of the DNN for object localization has gained the attention of researchers due to its success over conventional methods, especially in object localization. As this has become a very broad and rapidly growing field, this study presents a short review of DNN implementation for medical images and validates its efficacy on benchmarks. This study presents the first review that focuses on object localization using the DNN in medical images. The key aim of this study was to summarize the recent studies based on the DNN for medical image localization and to highlight the research gaps that can provide worthwhile ideas to shape future research related to object localization tasks. It starts with an overview on the importance of medical image analysis and existing technology in this space. The discussion then proceeds to the dominant DNN utilized in the current literature. Finally, we conclude by discussing the challenges associated with the application of the DNN for medical image localization which can drive further studies in identifying potential future developments in the relevant field of study.

Organ-on-a-chip (OOC) is a new type of biochip technology. Various types of OOC systems have been developed rapidly in the past decade and found important applications in drug screening and precision medicine. However, due to the complexity in the structure of both the chip-body itself and the engineered-tissue inside, the imaging and analysis of OOC have still been a big challenge for biomedical researchers. Considering that medical imaging is moving towards higher spatial and temporal resolution and has more applications in tissue engineering, this paper aims to review medical imaging methods, including CT, micro-CT, MRI, small animal MRI, and OCT, and introduces the application of 3D printing in tissue engineering and OOC in which medical imaging plays an important role. The achievements of medical imaging assisted tissue engineering are reviewed, and the potential applications of medical imaging in organoids and OOC are discussed. Moreover, artificial intelligence - especially deep learning - has demonstrated its excellence in the analysis of medical imaging; we will also present the application of artificial intelligence in the image analysis of 3D tissues, especially for organoids developed in novel OOC systems.