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Cognitive behavioral therapy for chronic pain supported by digital patient feedback and artificial intelligence: Do patients with socioeconomic risk factors benefit?

Dr. Owens is supported by a Career Development Award from the VA Health Services Research and Development Program.

The study of theoretical and applied aspects of understanding the concept “legal orientation” in legal science is relevant, of practical interest and requires scientific consideration. Globalization generates radical changes that can lead to both further evolution of humanity and adverse consequences. The search for joint survival and development programs depends on the legal culture that determines the legal orientations of social actors. The purpose of this paper was to figure out the theoretical and applied aspects of understanding the concept “legal orientation” in legal science. This study is based on an interdisciplinary approach and considers the knowledge of various sciences about human behaviour. General scientific and special scientific methods of cognition of social phenomena and processes were used to conduct the study. Among general scientific methods, methods of logical-semantic and terminological analysis, anthropological, system-structural, causal-functional, data analysis, praxeological, and content analysis were used. Experimental methods of observation, conversations, surveys, and questionnaires were used to obtain empirical data. The presented results of the theoretical and applied study of the concept “legal orientation” in legal science allowed figuring out at least four meanings of its use, showed its inextricable connection with the concept “value orientations” – a dynamic system that regulates social behaviour and human activity, and therefore requires constant diagnostics. Based on the diagnosis of the value orientations of the student youth of the National University of Life and Environmental Sciences of Ukraine, methodical recommendations were developed to form the system of value orientations of a young individual who obtains higher education, which will be consonant with the system of value orientations of Ukraine. The results of this study will be useful for researchers investigating the axiological and praxeological components of human activity in various spheres of social life; for state and public institutions related to the implementation of strategies for the development of civil society and the rule of law, for teachers and lecturers in the education and upbringing of future citizens of Ukraine, as well as for all stakeholders.

The NEPTUNE project constitutes the thermal-hydraulic part of the long-term Electricité de France and Commissariat à l’Energie Atomique joint research and development program for the next generation of nuclear reactor simulation tools. This program is also financially supported by the Institut de Radioprotection et Sûreté Nucléaire and AREVA NP. The project aims at developing a new software platform for advanced two-phase flow thermal hydraulics covering the whole range of modeling scales and allowing easy multiscale and multidisciplinary calculations. NEPTUNE is a fully integrated project that covers the following fields: software development, research in physical modeling and numerical methods, development of advanced instrumentation techniques, and performance of new experimental programs.The analysis of the industrial needs points out that three main simulation scales are involved. The system scale is dedicated to the overall description of the reactor. The component or subchannel scale allows three-dimensional computations of the main components of the reactors: cores, steam generators, condensers, and heat exchangers. The current generation of system and component codes has reached a very high level of maturity for industrial applications. The third scale, computational fluid dynamics (CFD) in open medium, allows one to go beyond the limits of the component scale for a finer description of the flows. This scale opens promising perspectives for industrial simulations, and the development and validation of the NEPTUNE CFD module have been a priority since the beginning of the project. It is based on advanced physical models (two-fluid or multifield model combined with interfacial area transport and two-phase turbulence) and modern numerical methods (fully unstructured finite volume solvers). For the system and component scales, prototype developments have also started, including new physical models and numerical methods.In addition to scale-specific developments, the generalized use of multiscale calculations is also expected to be a major means to meet the industrial needs. The coexistence of different simulation scales together with the fast growth of computing power multiplies the computation possibilities. In particular, thanks to the recent progress of CFD tools, one can imagine local zooms in some critical parts of the reactor components. The NEPTUNE multiscale platform will offer advanced coupling functionalities based on state-of-the-art software architecture and new numerical coupling techniques.Finally, despite the existence of a huge worldwide database of two-phase flow experiments, the validation of new physical models (more local, more complex) requires new experimental data. That is the reason why for several years we have been developing new instrumentation techniques such as four-sensor optical probes, X-ray tomography, and hot-wire anemometry. These techniques will be used for new experimental programs (currently being launched) that have been defined in connection with the high-priority industrial applications (departure from nucleate boiling, pressurized thermal shock, loss-of-coolant accident, etc.).

Integration of a real time expert system and a modern graphic display system in a Swedish nuclear power plant control room

The elimination of CFC 11 in the manufacture of integral skin foam (ISF) remains a challenge for the polyurethanes industry. The use of HFA 22, which has significantly lower ozone depletion potential (ODP), is a step in the right direction but is not the ultimate solution. HFA 123, pentane and water blowing have been evaluated as potential altematives. But each change in the Chemical system results in the need for other modifications. Integration of all these into the manufacturing process places severe pressure on the steering wheel producer, working inside increasingly stringent time constraints. UTA-Clifford and ICI Polyurethanes recognised that further development of water-blowing technology was the preferred way forward, and that the fastest route to solve these pressing problems was through close partnership. So, a joint development programme was undertaken, using statistical design of experiment techniques. This proved to be a powerful approach, significantly reducing development time and providing an optimum solution. Confirmation was obtained during a pre-production trial at UTA-Clifford, when a wide range of steering wheels was successfully produced. The optimised system was fully acceptable when used in combination with an in-mould coating; UTA-Clifford will introduce the technology into production in 1992.

Complementary and conventional cancer care: The integration of two cultures

The introduction of an automatic gearbox as an optional extra for the British Motor Corporation’s (BMC) (from 1968 the British Leyland Motor Corporation’s (BLMC)) 850cc Mini enabled Automotive Products (AP) to gain the Queen’s Award in 1966. AP produced the gearbox after a joint development programme with the BLMC, and the close supplier-customer relationship which emerged has been a strong element in shaping the path of post-innovation developments. Minor modifications to the gearbox enabled BLMC to offer automatic versions of their 1100 and 1300 ranges, which like the Mini used the company’s A-series engines. Moreover, a direct descendant of the original award-winning gearbox is still produced for the Mini Metro. In 1972 a further strand of post-innovation development was established with the launch of a new design of the original gearbox, which was suitable for larger capacity engines of between 1300 and 2500cc. In addition to applications in BLMC cars, AP have also supplied this uprated gearbox for use in Lancia’s Beta, Gamma and Delta models.

The current market driver for semiconductor package technology is to provide more functionality and improve performance without increasing package size. Vertically configured 3D package technology addresses this issue for a broad number of enterprise products. Initially, the 3D package contained two or more semiconductor die elements mounted on top of one another most often interconnected using a common substrate interposer. Adapting through silicon via (TSV) technology for die-on-die interface on the other hand has the potential to further improve both package performance and package assembly efficiency. Progress in this area has accelerated through the cooperation and joint development programs between a number of government, industry and technical universities. An early high volume application for TSV was for the small CMOS image sensors used in wireless handsets to enable the vertical joining of the sensor and related logic element. Although the TSV process is touted as the 'next big thing' in semiconductor packaging, capabilities and methodologies for providing wafers and die elements for stacking currently vary a great deal between suppliers. Although TSV technology has the potential to revolutionize semiconductor packaging, it currently remains hostage to a very limited homogeneous family of products; MEMS, memory and image sensors. In addition, there are a number of processes and methodologies that are considered proprietary and may require licensing agreements and additional fees for their use. Industry roadmaps, however, continue to point toward the eventual use of TSV in developing new generations of high performance system-in-package products. What You Will Learn: This webinar will explore two basic approaches to TSV formation, via-first and via-last: Via-first integration forms very small via holes in the wafer during front-end processing. Via-last integration may occur before or after bonding wafers or joining individual die elements to one another (Die-on-Die). Due to the increased thickness of pre-joined die, the via-last process typically provides somewhat larger via holes than the via-first variation. Who Should View This Webinar: This Webinar has been developed specifically for product and circuit design professionals, systems engineers as well as assembly and test engineering specialists for OEM, ODM and EMS providers. About the presenter: Vern Solberg is a technical consultant for Invensas Corporation specializing in SMT and microelectronics design and manufacturing technology. Vern is a US delegate to the JISSO International Council (JIC) and is currently an active member of IEEE, SMTA, IMAPS and the IPC. He has served the industry for more than thirty years in areas related to both commercial and aerospace electronic products and is active as an author and educator. Solberg holds several patents for 3D semiconductor packaging innovations and is the author of Design Guidelines for Surface Mount and Fine-Pitch Technology and furnishes the 'Designers Notebook' column for SMT magazine. On Demand Webinar

Early closure of European Pimagedine trial

Individuals engaged in the fields of artificial kidney and artificial heart have often mistakenly stated that "the era of artificial organs is over; regenerative medicine is the future." Contrarily, we do not believe artificial organs and regenerative medicine are different medical technologies. As a matter of fact, artificial organs developed during the last 50 years have been used as a bridge to regeneration. The only difference between regenerative medicine and artificial organs is that artificial organs for the bridge to regeneration promote tissue regeneration in situ, instead of outside the body (for example, vascular prostheses, neuroprostheses, bladder substitutes, skin prostheses, bone prostheses, cartilage prostheses, ligament prostheses, etc.). All of these artificial organs are successful because tissue regeneration over a man-made prosthesis is established inside the patient's body (artificial organs to support regeneration). Another usage of the group of artificial organs for the bridge to regeneration is to sustain the functions of the patient's diseased organs during the regeneration process of the body's healthy tissues and/or organs. This particular group includes artificial kidney, hepatic assist, respiratory assist, and circulatory assist. Proof of regeneration of these healthy tissues and/or organs is demonstrated in the short-term recovery of end-stage organ failure patients (artificial organs for bridge to regeneration). A third group of artificial organs for the bridge to regeneration accelerates the regenerating process of the patient's healthy tissues and organs. This group includes neurostimulators, artificial blood (red cells) blood oxygenators, and plasmapheresis devices, including hemodiafiltrators. So-called "therapeutic artificial organs" fall into this category (artificial organs to accelerate regeneration). Thus, almost all of today's artificial organs are useful in the bridge to regeneration of healthy natural tissues and organs. It does not matter whether these tissues are cultivated inside or outside the patient's body. Thus, we strongly believe in the need for joint development programs between artificial organ technologies and regenerative medicine technologies. In particular, the importance of using both man-made substitute organ technologies and natural tissue-derived substitute organ technologies is stressed for improved medical care in the future.

Planning effective joint development programs in shared river basins is thought to become better when such programs are preceded by integrated studies. This paper aims to provide such a study through a situation analysis with regard to the vulnerability of water resources systems in the Eastern Nile Basin (ENB). The focus was on using internationally recognized indicators and indices that can provide an insight about the situation in the region in a concise and illustrative fashion. A framework for assessing vulnerability of water systems was outlined and applied to the region. Based on a careful survey, a list of 31 indicators used for vulnerability assessment were identified and categorized to separate hydro-physical indicators from other indicators of socio-economic or political nature. The identified indicators were evaluated for the three ENB countries and illustrated in radar diagrams. Interpretations were drawn describing the vulnerability situation in each country. The main findings are: (1) vulnerability of water resources is highest in Sudan, followed by Ethiopia and then Egypt; (2) while vulnerability in Egypt stems mainly from hydro-physical factors; in Sudan and Ethiopia it is directly related to poverty and underdevelopment; (3) Higher stresses on available water resources in Egypt are due to increases in total withdrawals; while in Sudan and Ethiopia it is mainly due to water mal-distribution and quality deterioration; (4) governance factors in the three countries hinder the proper management of the available water resources.

A curious stopping rule from Hoechst Marion Roussel

In an effort to improve the reliability of high pressure centrifugal compression equipment, NOVA Corporation of Alberta began a program in the early 1970s to find alternatives to lube and seal oil systems. This program was successful, resulting in the application, testing and utilization of mechanical dry gas seals and active magnetic bearings in NOVA 's gas transmission system. This paper covers the development history of dry seals and magnetic bearings for centrifugal compressors in high pressure natural gas service. The operating principles, experiences and advantages of mechanical dry seals and active magnetic bearings are also discussed. History NOVA Corporation of Alberta has over 30 years of experience with pipeline and compressor equipment associated with the planning, design, construction, operation and maintenance of a 14 000 km natural gas transportation system. This system includes 36 compressor stations totalling 388 mW, 825 major receipt and delivery stations and carries over 75% of marketed Canadian natural gas production. Centrifugal compressors inherently present operating problems associated with maintenance, reliability, and safety. As an operator of 63 gas turbine compressor units, NOVA has always been concerned with these operating problems. Internal studies conducted in the early 1970s indicated that over 80% of the downtime on NOVA's centrifugal compressors was related to problems with the seal or lube oil systems. This prompted NOVA to initiate a program aimed at the elimination of these oil systems. In 1976, NOVA entered into a joint development program for a mechanical dry 1$ seal with John Crane Inc. By 1978, a dry seal was available witch reliably replaced the conventional seal oil system in centrifugal compressors. Dry seal development and enhancement continues. NOVA is also working with Pacific Wietz, a German seal manufacturer, on the application of an alternative design of a mechanical dry seal. In 1982, NOVA became aware of a new device developed by a French manufacturer (Societe de Mecanique Magnetique -S2M) which could be the key to completely eliminating the oil system in centrifugal compressors. This device was an active magnetic bearing system. A prototype was installed in one of NOVA's operating compressors which had already been retrofitted with mechanical dry seals. NOVA was pleased with the results on the prototype installation, and has been engaged in a product enhancement and retrofit program since that time. In 1984, Magnetic Bearings Inc. (MBI), a subsidiary of Kollmorgan Corporation was formed and licenced by S2M tomanufacture magnetic bearings in the Western Hemisphere. The first magnetic bearing installation took place in October, 1985. It yielded the world's first oil free mainline compressor unit. This unit is an Ingersoll-Rand CDP 230, 10 444 kW ISO compressor with a 1590 kg shaft and a 5440 kg thrust load. There are currently over 10 000 operating hours on this combined mechanical seal/magnetic bearing installation (Fig. la). Mechanical Dry Gas Seal Operating Principle The mechanical dry seal design is based on technology originally developed for air bearings.