Epileptic seizure detection using wavelet transform based sample entropy and support vector machine

This paper proposes a new method for feature extraction and recognition of epileptiform activity in EEG signals. The method improves feature extraction speed of epileptiform activity without reducing recognition rate. Firstly, Principal component analysis (PCA) is applied to the original EEG for dimension reduction and to the decorrelation of epileptic EEG and normal EEG. Then discrete wavelet transform (DWT) combined with approximate entropy (ApEn) is performed on epileptic EEG and normal EEG, respectively. At last, Neyman-Pearson criteria are applied to classify epileptic EEG and normal ones. The main procedure is that the principle component of EEG after PCA is decomposed into several sub-band signals using DWT, and ApEn algorithm is applied to the sub-band signals at different wavelet scales. Distinct difference is found between the ApEn values of epileptic and normal EEG. The method allows recognition of epileptiform activities and discriminates them from the normal EEG. The algorithm performs well at epileptiform activity recognition in the clinic EEG data and offers a flexible tool that is intended to be generalized to the simultaneous recognition of many waveforms in EEG.

EEG (Electroencephalograph) is a technique for identifying neurological disorders. Epilepsy is a disorder of the central nervous system characterized by loss of consciousness and convulsions. EEG is the recording of electrical activity of the brain signals that can be used to diagnose the epilepsy condition. Epilepsy occurs irregularly and unpredictably manner due to temporary electrical disturbance of the brain. The aim of this project is Epileptic seizure detection in multichannel EEG. In this paper, the normal, pre-ictal (background) and ictal (epileptic) EEG signals are studied using higher order spectra (HOS). This paper deals with the study of the normal, pre-ictal (background) and ictal (epileptic) EEG signals using Higher Order Spectra (HOS). The measures obtained were shown which distinguish epileptic EEG from normal and background EEG with high confident level.

Epilepsy is one of the frequent brain disorder that may consequence in the brain dysfunction and cognitive disorders. Epileptic seizures can occur due to transient and unexpected electrical interruptions of brain. EEG (ElectroEncephaloGram) is one of the non-invasive methods for analyzing the human brain dynamics that affords a direct evaluation of cortical behavior. Seizures are featured by short and episodic neuronal synchronous discharges with considerably enlarged amplitude. This uneven synchrony may happen in the brain accordingly i.e., partial seizures visible only in few channels of the EEG signal or generalized seizures, which are seen in every channel of the EEG signal involving the whole brain. Existing analysis of epilepsy depends on difficult visual screening by extremely trained clinicians. Data recordings create very lengthy data, and therefore the inspection and identification of epilepsy takes more time for diagnosis. At present time computerized systems are usually established to make the diagnosis simpler. This paper discusses an implementation of automated epileptic EEG detection system using neural networks. In this paper, a statistical parameter regarded as Sample Entropy (SampEn), is used as a method for feature extraction for performing the task of classifying EEG signals, which are normal, ictal and interictal. Here the value of SampleEn plays a vital role in the diagnosis of Epileptic seizures. It is been observed that the value of SampEn falls suddenly during an Epileptic Seizure, and hence this information delineates the exact occurrence of Epilepsy. Classification strategies are based on models like Back-propagation Neural Network (BPNN),Support Vector Machine(SVM) and Extreme Learning Machine (ELM). Hybrid ELM (HELM) is the classification method devised in the current paper and is the first of its kind to be implemented for EEG classification. This classification method uses the Analytical Hierarchy Process (AHP) method to select the input weights and hidden biases, the ELM algorithm to analytically determine the output weights and the Levenberg-Marquardt (LM) algorithm to learn the network. Experimental results show that automatic epilepsy detection using sample entropy (SampEn) and Hybrid ELM achieves better accuracy in lesser time.

Most epileptic EEG classification algorithms are supervised and require large training data sets, which hinders its use in real time applications. This paper proposes an unsupervised multi-scale K-means (MSK-means) algorithm to distinguish epileptic EEG signals from normal EEGs. The random initialization of the K-means algorithm can lead to wrong clusters. Based on the characteristics of EEGs, the MSK-means algorithm initializes the coarse-scale centroid of a cluster with a suitable scale factor. In this paper, the MSK-means algorithm is proved theoretically being superior to the K-means algorithm on efficiency. In addition, three classifiers: the K-means, MSK-means and support vector machine (SVM), are used to discriminate epileptic EEGs from normal EEGs using six features extracted by the sample entropy technique. The experimental results demonstrate that the MSK-means algorithm achieves 7% higher accuracy with 88% less execution time than that of K-means, and 6% higher accuracy with 97% less execution time than that of the SVM.

For the low recognition rate of motor imagery ElectroEncephaloGram (EEG) signals using single feature in Brain-Computer Interface (BCI) research, a feature extraction method combining brain function network and sample entropy is proposed. According to the neural mechanism appearing in Event Related Synchronization/Event Related Desynchronization (ERS/ERD) phenomenon and the contralateral mapping mechanism between cortex and limb motor imagery, the μ rhythm is denoised by wavelet packet transform. The brain function network is constructed for left hemispherical brain region and right hemispherical brain region by μ rhythm of 27 left channels and 27 right channels respectively. The mean node degree and the mean clustering coefficient are calculated as the brain function network characteristics, and the feature vectors combining the distribution and directivity are constructed by the sample entropy of C3 and C4 channels with the μ rhythm. The Support Vector Machine (SVM) is used to classify the left hand and right hand motor imagery EEG signals. The results show that the feature extraction method based on brain function network and sample entropy achieves better classification result, and the highest classification rate reached 90.27%.

In the study of detection of an epileptic seizure using Electroencephalogram (EEG), pattern recognition has been recognized as a valued tool. In this pattern recognition study, the first time the authors have attempted to use time domain (TD) features such as waveform length (WL), number of zero-crossings (ZC) and number of slope sign changes (SSC) derived directly from filtered EEG data and from discrete wavelet transform (DWT) of filtered EEG data for the detection of an epileptic seizure. Further, the authors attempted to study the performance of other time domain features such as mean absolute value (MAV), standard deviation (SD), average power (AVP), which had been attempted by other researchers. The performance of the TD features is studied using naive Bayes (NB) and support vector machines (SVM) classifiers for the university of Bonn database with fourteen different combinations of set E with set A to D. The proposed scheme was also compared with other existing scheme in the literature. The implementation results showed that the proposed scheme could attain the highest accuracy of 100% for normal eyes open and epileptic data set with direct as well as DWT based TD features. For other data sets, the highest accuracy is obtained with DWT based TD features using SVM. However, no significant difference in the classification of 14 data sets with TD features filtered EEG data and from DWT of filtered EEG data.

Electroencephalography signals are typically used for analyzing epileptic seizures. These signals are highly nonlinear and nonstationary, and some specific patterns exist for certain disease types that are hard to develop an automatic epileptic seizure detection system. This paper discussed statistical mechanics of complex networks, which inherit the characteristic properties of electroencephalography signals, for feature extraction via a horizontal visibility algorithm in order to reduce processing time and complexity. The algorithm transforms a time series signal into a complex network, which some features are abbreviated. The statistical mechanics are calculated to capture distinctions pertaining to certain diseases to form a feature vector. The feature vector is classified by multiclass classification via a k‐nearest neighbor classifier, a multilayer perceptron neural network, and a support vector machine with a 10‐fold cross‐validation criterion. In performance evaluation of proposed method with healthy, seizure‐free interval, and seizure signals, firstly, input data length is regarded among some practical signal samples by optimizing between accuracy‐processing time, and the proposed method yields outstanding performance on the average classification accuracy for 3‐class problems mainly for detection of seizure‐free interval and seizure signals and acceptable results for 2‐class and 5‐class problems comparing with conventional methods. The proposed method is another tool that can be used for classifying signal patterns, as an alternative to time/frequency analyses.

Currently, with the bloom in artificial intelligence (AI) algorithms, various human-centered smart systems can be utilized, especially in cognitive computing, for the detection of various chronic brain diseases such as epileptic seizure. The primary goal of this research article is to propose a novel human-centered cognitive computing (HCCC) method for segment-wise seizure classification by employing multiresolution extracted data with directed transfer function (DTF) features, termed as the multiresolution directed transfer function (MDTF) approach. Initially, the multiresolution information of the epileptic seizure signal is extracted using a multiresolution adaptive filtering (MRAF) method. These seizure details are passed to the DTF where the information flow of high frequency bands is computed. Thereafter, different measures of complexity such as approximate entropy (AEN) and sample entropy (SAEN) are computed from the extracted high frequency bands. Lastly, a k-nearest neighbor (k-NN) and support vector machine (SVM) are used for classifying the EEG signal into non-seizure and seizure data depending on the multiresolution based information flow characteristics. The MDTF approach is tested on a standard dataset and validated using a dataset from a local hospital. The proposed technique has obtained an average sensitivity of 98.31%, specificity of 96.13% and accuracy of 98.89% using SVM classifier. The average detection rate of the MDTF approach is 97.72% which is greater than the existing approaches. The proposed MDTF method will help neuro-specialists to locate seizure information drift which occurs within the consecutive segments and between two channels. The main advantage of the MDTF approach is its capability to locate the seizure activity contained by the EEG signal with accuracy. This will assist the neurologists with the precise localization of the epileptic seizure automatically and hence will reduce the burden of time-consuming epileptic seizure analysis.

Mortality and intraventricular hemorrhage (IVH) are common adverse outcomes in preterm infants and are challenging to predict clinically. Sample entropy (SE), a measure of heart rate variability (HRV), has shown predictive power for sepsis and other morbidities in neonates. We evaluated associations between SE and mortality and IVH in the first week of life. Participants were 389 infants born before 32 weeks of gestation for whom bedside monitor data were available. A total of 29 infants had IVH grade 3 or 4 and 31 infants died within 2 weeks of life. SE was calculated with the PhysioNet open-source benchmark. Logistic regressions assessed associations between SE and IVH and/or mortality with and without common clinical covariates over various hour of life (HOL) censor points. Lower SE was associated with mortality by 4 HOL, but higher SE was very strongly associated with IVH and mortality at 24-96 HOL. Bootstrap testing confirmed SE significantly improved prediction using clinical variables at 96 HOL. SE is a significant predictor of IVH and mortality in premature infants. Given IVH typically occurs in the first 24-72 HOL, affected infants may initially have low SE followed by a sustained period of high SE. SE correlates with IVH and mortality in preterm infants early in life. SE combined with clinical factors yielded ROC AUCs well above 0.8 and significantly outperformed the clinical model at 96 h of life. Previous studies had not shown predictive power over clinical models. First study using the PhysioNet Cardiovascular Toolbox benchmark in young infants. Relative to the generally accepted timing of IVH in premature infants, we saw lower SE before or around the time of hemorrhage and a sustained period of higher SE after. Higher SE after acute events has not been reported previously.

Depression is a mental disorder that affects emotional and physical state of a person. It is a state of extreme sadness and dejection. The electroencephalographic (EEG) signals can be used to detect the alterations in the brain’s electrochemical potential. The highly irregular and complex EEG signal variations can be determined by different processing tools. The present work is based on the automated classification of the normal and depression EEG signals. The discrete cosine transform (DCT) decomposes the normal and depression EEG signals into different frequency sub-bands. Nonlinear methods such as sample entropy, correlation dimension, fractal dimension, largest Lyapunov exponent, Hurst exponent and detrended fluctuation analysis are applied to the DCT coefficients and the extracted characteristic features are ranked using t-value. These significant features are fed to decision tree (DT), support vector machine (SVM), k-nearest neighbor (kNN) and naive Bayes (NB) classifiers. Five significant features are selected and the SVM classifier with radial basis function (RBF) results in a classification accuracy of 93.8%, sensitivity of 92% and specificity of 95.8%.

This study evaluated the amount, and particularly, the structure of variability in postural control accompanying an unstable shoe (US) application. Mediolateral and anterior-posterior center of pressure signals plus electromyographic profiles of the tibialis anterior and gastrocnemius medialis were recorded in 29 asymptomatic men while wearing both US and flat shoes. Statistical analysis included common measures of dispersion as well as sample entropy and largest Lyapunov exponent estimates. Data were compared by two-way repeated-measures analysis of variance. Corresponding main effects of footwear revealed that, in contrast to the flat shoes condition, the US intervention consistently increased center of pressure and electromyographic net fluctuations and rendered the overall system less complex, as reflected by the lower sample entropy and higher Lyapunov exponent values observed throughout. Accordingly, employing US in stance should be functional concerning motor development; however, the greater sensitivity of US users to external perturbations must not be overlooked and warrants further investigation.

Epileptic seizures detection is largely based on analysis of Electroencephalogram signals. The ambulatory EEG recordings generate very lengthy data which require a skilled and careful analysis. This tedious procedure necessitates the use of automated systems for epileptic seizure detection. This paper proposes one such automated epileptic seizure detection technique based on Probabilistic Neural Network (PNN) by using a time frequency domain characteristics of EEG signal called Approximate Entropy(ApEn). Our method consists of EEG data collection, feature extraction and classification. EEG data from normal and epileptic subjects was collected, digitized and then fed into the PNN. For feature extraction, the wavelet coefficients are derived using Discrete Wavelet Transformation. For the feature selection stage a new methodology is proposed, which is, comparing the ApEn values of wavelet coefficients of different EEG data. The experimental results portray that this proposed approach efficiently detects the presence of epileptic seizures in EEG signals and showed a reasonable accuracy.

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