Multiresolution directed transfer function approach for segment-wise seizure classification of epileptic EEG signal.

This paper analyzes the underlying complexity and non-linearity of electroencephalogram (EEG) signals by computing a novel multi-scale entropy measure for the classification of seizure, seizure-free and normal EEG signals. The quality factor (Q) based multi-scale entropy measure is proposed to compute the entropy of the EEG signal in different frequency-bands of interest. The Q -based entropy (QEn) is computed by decomposing the signal with the tunable-Q wavelet transform (TQWT) into the number of sub-bands and estimating K-nearest neighbor (K-NN) entropies from various sub-bands cumulatively. The optimal selection of Q and the redundancy parameter (R) of TQWT showed better robustness for entropy computation in the presence of high- and low-frequency components. The extracted features are fed to the support vector machine (SVM) classifier with the wrapper-based feature selection method. The proposed method has achieved accuracy of 100% in classifying normal (eyes-open and eyes-closed) and seizure EEG signals, 99.5% in classifying seizure-free EEG signals (from the hippocampal formation of the opposite hemisphere of the brain) from seizure EEG signals and 98% in classifying seizure-free EEG signals (from the epileptogenic zone) from seizure EEG signals, respectively, using the SVM classifier. We have also achieved classification accuracies of 99% and 98.6% in classifying seizure versus non-seizure EEG signals and the individual three classes, namely normal, seizure-free and seizure EEG signals, respectively. The performance measure of the proposed multi-scale entropy has been found to be comparable with the existing state of the art epileptic EEG signals classification methods studied using the same database.

Epilepsy is a persistent neurological condition of the brain in which the activity of the brain goes out of normal state. Classification and Analysis of EEG signal is the early approach for epilepsy diagnosis. During this paper, we have a tendency to propose an EEG signal classification approach based on Support Vector Machine (SVM) classifier. In extracting features from the raw EEG data we applied the Hilbert Transform method and used its coefficients. Then, after the PCA dimension reduction a two-class SVM classifier is used for EEG signals automatic classification, one class for healthy subjects and another for subjects with epilepsy. In SVM classifier we need to divide the EEG signals into a training dataset and testing dataset for classification. We have used five sets of EEG signals which are publicly accessible on EEG time series database. The evaluation and comparison of SVM based classifier with two other classification methods such as KNN and LVQ based classifier was done. The average classification accuracy of our study is 95.33%.

Electroencephalogram (EEG) comprises valuable details related to the different physiological state of the brain. In this paper, a framework is offered for detecting the epileptic seizures from EEG data recorded from normal subjects and epileptic patients. This framework is based on a discrete wavelet transform (DWT) analysis of EEG signals using linear and nonlinear classifiers. The performance of the different combinations of two-class epilepsy detection is studied using Support Vector Machine (SVM) and neural network analysis (NNA) classifiers for the derived statistical features from DWT. In this new approach first parse EEG signals to sub-bands in different categories with the help of discrete wavelet transform (DWT) and then we derive statistical features such as Mean, Median, Standard Deviation, Kurtosis, Entropy, Skewness for each sub-band. These features, extracted from details and approximation coefficients of DWT sub-bands, are used as input to Principal Component Analysis (PCA). The classification is based on reducing the feature dimension using PCA and deriving the Support Vector Machine (SVM) and neural network analysis (NNA). In classification of normal and epileptic, results obtained exhibited an accuracy of 100% by applying NNA and 99% by SVM it has been found that the computation time of NNA classifier is lesser than SVM to provide 100% accuracy.

In this paper, we propose a novel vigilance enhancement method based on audio stimulation of pure tone at 250 Hz. We induced two different levels of vigilance state; vigilance decrement (VD) and vigilance enhancement (VE). The VD state was induced by performing a modified version of the Stroop Color-Word Task (SCWT) for approximately 45 minutes. Likewise, the VE state was induced by incorporating audio stimulation of 250 Hz into the SCWT for 45 minutes. We assessed the levels of vigilance on 20 healthy subjects by utilizing Electroencephalogram (EEG) signals and machine learning. The EEG signals were analyzed using four types of entropies; Approximate Entropy (AE), Sample Entropy (SE), Fuzzy Entropy (FE), and Differential Entropy (DE). We then quantified vigilance levels using statistical analysis and support vector machines (SVM) classifier. We found that the proposed VE method has significantly reduced the reaction time (RT) by 44% and improved the accuracy of target detection by 25%, (p <; 0.001) compared to VD state. Besides, we found that 30 min of audio stimulation has reduced the RT by 32% from the beginning to the end of VE phase of the experiment. The entropy measures show that the temporal profile of the EEG signals has significantly increased with VE. The classification results showed that SVM technique with DE features across all frequency bands can detect VE levels with accuracy varying between (92.10± 02.24)% to (98.32± 01.14)%, sensitivity of (92.50± 02.33)% to (98.66± 01.00)%, and specificity of (91.70± 02.32)% to (97.99± 01.05)%. Results also showed that the classification performance using DE has outperformed the other entropy measures by an average of +8.07%. Our results demonstrate the effectiveness of the proposed 250 Hz audio stimulation method in improving vigilance level and suggest using it for future cognitive enhancement studies.

Currently, pain assessment using electroencephalogram signals and machine learning methods in clinical studies is of great importance, especially for those who cannot express their pain. Since newborns are among the high-risk group and always experience pain at the beginning of birth, in this research, the severity of newborns has been investigated and evaluated. Other studies related to the annoyance of newborns have used the EEG signal of newborns alone; therefore, in this study, the intensity of newborn pain was measured using the electroencephalogram signal of 107 infants who were stimulated by the heel lance in three levels: no pain, low pain and moderate pain were recorded as a single trial and evaluated. The support vector machine (SVM), K-Nearest Neighbors (KNN) and Ensemble bagging classifiers were trained using the K-fold cross-validation method and features of the brain’s time-frequency domain. The results were obtained with accuracies of 72.8 ± 2, 84.4 ± 1.3 and 82.9 ± 1.6%, respectively. Also, in examining the problem of distinguishing pain and no pain, the electroencephalogram signal of 74 infants was evaluated, and similar to the three-class mode, with the 10-fold validation method, we reached the highest accuracy of 100% in Bagging classifier and 98.6 ± 0.1 accuracy in KNN and SVM classifiers.

Brain-Computer Interface (BCI) or Human-Machine Interface now becoming vital biomedical engineering and technology field which applying EEG technologies to provide assistive device technology (AT) to humans. Hence, this paper presents the results of analyzing EEG signals from various human cognitive states to extract the suitable EEG features that can be employed to control BCI devices which can be used by disabled or paralyzed people. The EEG features in term of power spectral density, spectral centroids, standard deviation and entropy are selected and investigated from two different mental exercises; (i) quick solving math and (ii) relax (do nothing). The selected features then are classified using Linear Discriminant Analysis (LDA), Support Vector Machine (SVM) and K-Nearest Neighbors (k-NN) classifier. Among all these features, the best accuracy have been achieved by the power spectral density. The accuracies of this feature are 95%, 100%, 100% with LDA, SVM and K-NN respectively. Finally, the translation algorithm will be constructed using selected and classified EEG features to control the BCI devices.

Depression is a mental disorder that affects emotional and physical state of a person. It is a state of extreme sadness and dejection. The electroencephalographic (EEG) signals can be used to detect the alterations in the brain’s electrochemical potential. The highly irregular and complex EEG signal variations can be determined by different processing tools. The present work is based on the automated classification of the normal and depression EEG signals. The discrete cosine transform (DCT) decomposes the normal and depression EEG signals into different frequency sub-bands. Nonlinear methods such as sample entropy, correlation dimension, fractal dimension, largest Lyapunov exponent, Hurst exponent and detrended fluctuation analysis are applied to the DCT coefficients and the extracted characteristic features are ranked using t-value. These significant features are fed to decision tree (DT), support vector machine (SVM), k-nearest neighbor (kNN) and naive Bayes (NB) classifiers. Five significant features are selected and the SVM classifier with radial basis function (RBF) results in a classification accuracy of 93.8%, sensitivity of 92% and specificity of 95.8%.

Analysis of brain activities and remote control are among the current issues that are being studied. Analysis of signals arising during brain functions is electroencephalography (EEG). EEG signals have intellectual, visual stimulation, and motion resultant forms. Especially, EEG signals generated by visual stimulus are within the scope of this study. In this study, research was carried out on the classification of EEG signals formed in a person looking at visual figures. For these studies, first of all, EEG signals from the brain were recorded with images and filtered to remove noise. Then, the features were extracted from the signals. In this study, Moment 5 feature was also used in addition to the features used in many studies such as mean, median, standard deviation and entropy. Then, classification was made using Support Vector Machine (SVM), k Nearest Neighbor (KNN), and Decision Tree (DT) algorithms. Classification was made for 4 different visual shapes used, since these shapes are square, circle, triangle, and star, and the same categorical names were used in the classification stage. As a result of the classification of EEG signals; SVM and KNN algorithms have determined which shape is viewed with 99.99% accuracy. These results show that different signals are produced in the brain according to the structure of the shape viewed. This situation shows that it can be used as a method to give patients the opportunity to express their requests just by looking or thinking.

Many approaches have been proposed using Electroencephalogram (EEG) to detect epilepsy seizures in their early stages. Epilepsy seizure is a severe neurological disease. Practitioners continue to rely on manual testing of EEG signals. Artificial intelligence (AI) and Machine Learning (ML) can effectively deal with this problem. ML can be used to classify EEG signals employing feature extraction techniques. This work focuses on automated detection for epilepsy seizures using ML techniques. Various algorithms are investigated, such as Bagging, Decision Tree (DT), Adaboost, Support vector machine (SVM), K-nearest neighbors(KNN), Artificial neural network(ANN), Naïve Bayes, and Random Forest (RF) to distinguish injected signals from normal ones with high accuracy. In this work, 54 Discrete wavelet transforms (DWTs) are used for feature extraction, and the similarity distance is applied to identify the most powerful features. The features are then selected to form the features matrix. The matrix is subsequently used to train ML. The proposed approach is evaluated through different metrics such as F-measure, precision, accuracy, and Recall. The experimental results show that the SVM and Bagging classifiers in some data set combinations, outperforming all other classifiers

Epilepsy is one of the frequent brain disorder that may consequence in the brain dysfunction and cognitive disorders. Epileptic seizures can occur due to transient and unexpected electrical interruptions of brain. EEG (ElectroEncephaloGram) is one of the non-invasive methods for analyzing the human brain dynamics that affords a direct evaluation of cortical behavior. Seizures are featured by short and episodic neuronal synchronous discharges with considerably enlarged amplitude. This uneven synchrony may happen in the brain accordingly i.e., partial seizures visible only in few channels of the EEG signal or generalized seizures, which are seen in every channel of the EEG signal involving the whole brain. Existing analysis of epilepsy depends on difficult visual screening by extremely trained clinicians. Data recordings create very lengthy data, and therefore the inspection and identification of epilepsy takes more time for diagnosis. At present time computerized systems are usually established to make the diagnosis simpler. This paper discusses an implementation of automated epileptic EEG detection system using neural networks. In this paper, a statistical parameter regarded as Sample Entropy (SampEn), is used as a method for feature extraction for performing the task of classifying EEG signals, which are normal, ictal and interictal. Here the value of SampleEn plays a vital role in the diagnosis of Epileptic seizures. It is been observed that the value of SampEn falls suddenly during an Epileptic Seizure, and hence this information delineates the exact occurrence of Epilepsy. Classification strategies are based on models like Back-propagation Neural Network (BPNN),Support Vector Machine(SVM) and Extreme Learning Machine (ELM). Hybrid ELM (HELM) is the classification method devised in the current paper and is the first of its kind to be implemented for EEG classification. This classification method uses the Analytical Hierarchy Process (AHP) method to select the input weights and hidden biases, the ELM algorithm to analytically determine the output weights and the Levenberg-Marquardt (LM) algorithm to learn the network. Experimental results show that automatic epilepsy detection using sample entropy (SampEn) and Hybrid ELM achieves better accuracy in lesser time.

Epilepsy is the most common neurological disorder characterized by recurrent seizures due to the abnormality of brain neuronal discharge. One of the tools to help neurologists diagnose epilepsy relies on EEG signals extensively because it can represent the brain's neuron activity. Due to the EEG signal being considered a complex biological signal, the signal complexity-based feature extraction method is suitable for characterizing epileptic EEG signals. One method for extracting EEG signals is entropy which is able to quantify signal complexity. Several previously proposed methods were wavelet entropy and IMF entropy. This study proposed multi-distance signal level difference (MSLD) entropy as a feature extraction method to extract the EEG signal complexity. The decomposed signal from MSLD was then extracted using entropy measurement. In the classification process, a Support Vector Machine (SVM) was applied to classify the normal, pre-ictal, and ictal signals of EEG signals. The highest accuracy of 96% was obtained using cubic SVM as the classifier. The proposed method provides an alternative method for analyzing EEG or other biomedical signals based on signal complexity.

Alcoholism is a complex condition that mainly disturbs the neuronal networks in Central Nervous System (CNS). This disorder not only disturbs the brain, but also affects the behavior, emotions, and cognitive judgements. Electroencephalography (EEG) is a valuable tool to examine the neuropsychiatric disorders like alcoholism. The EEG is a well-established modality to diagnose the electrical activity produced by the populations of neurons in cerebral cortex. However, EEG signals are non-linear in nature; hence very challenging to interpret the valuable information from them using linear methods. Thus, using non-linear methods to analyze EEG signals can be beneficial in order to predict the brain signals condition. This paper presents a computer-aided diagnostic method for the detection of alcoholic EEG signals from normal by employing the non-linear techniques. First, the EEG signals are subjected to six levels of Wavelet Packet Decomposition (WPD) to obtain seven wavebands (delta ([Formula: see text]), theta ([Formula: see text]), lower alpha (la), upper alpha (ua), lower beta (lb), upper beta (ub), lower gamma (lg)). From each wavebands (activity bands), 19 non-linear features such as Recurrence Quantification Analysis (RQA) ([Formula: see text]), Approximate Entropy ([Formula: see text]), Energy ([Formula: see text]), Fractal Dimension (FD) ([Formula: see text]), Permutation Entropy ([Formula: see text]), Detrended Fluctuation Analysis ([Formula: see text]), Hurst Exponent ([Formula: see text]), Largest Lyapunov Exponent ([Formula: see text]), Sample Entropy ([Formula: see text]), Shannon’s Entropy ([Formula: see text]), Renyi’s entropy ([Formula: see text]), Tsalli’s entropy ([Formula: see text]), Fuzzy entropy ([Formula: see text]), Wavelet entropy ([Formula: see text]), Kolmogorov–Sinai entropy ([Formula: see text]), Modified Multiscale Entropy ([Formula: see text]), Hjorth’s parameters (activity ([Formula: see text]), mobility ([Formula: see text]), and complexity ([Formula: see text])) are extracted. The extracted features are then ranked using Bhattacharyya, Entropy, Fuzzy entropy-based Max-Relevancy and Min-Redundancy (mRMR), Receiver Operating Characteristic (ROC), [Formula: see text]-test, and Wilcoxon. These ranked features are given to train Support Vector Machine (SVM) classifier. The SVM classifier with radial basis function (RBF) achieved 95.41% accuracy, 93.33% sensitivity and 97.50% specificity using four non-linear features ranked by Wilcoxon method. In addition, an integrated index called Alcoholic Index (ALCOHOLI) is developed using highly ranked two features for identification of normal and alcoholic EEG signals using a single number. This system is rapid, efficient, and inexpensive and can be employed as an EEG analysis assisting system by clinicians in the detection of alcoholism. In addition, the proposed system can be used in rehabilitation centers to evaluate person with alcoholism over time and observe the outcome of treatment provided for reducing or reversing the impact of the condition on the brain.

Brain-Computer Interface (BCI) systems establish a control and communication relationship between the human brain and computers including robots or other devices to help individuals with severe motor disabilities. The classification of motor and mental imagery electroencephalogram (EEG) signals is complicated because these signals are usually case-specific and distinct models must be trained for each subject to process and classify his/her EEG signals. Moreover, in BCI systems EEG signals are processed online, so the time latency must be very low. In this paper, we have proposed a method based on signal-to-image conversion to investigate image processing techniques in the pair-wise classification of motor and mental imagery EEG signals. We first decomposed EEG signals of each trial into four sub-bands. Then, for each sub-band, we converted EEG time series to 2-dimensional (2D) images using covariance between signals of all channels. Then, statistical, textural and PCA-based features were extracted from these images and fed to a support vector machine (SVM) classifier. Our results were promising in the offline processing and achieved an average classification accuracy of 79.57%.

Background and purposeRenal cell carcinoma (RCC) is a heterogeneous group of cancers. The collagen fiber content in the tumor microenvironment of renal cancer has an important role in tumor progression and prognosis. A radiomics model was developed from dual-energy CT iodine maps to assess collagen fiber content in the tumor microenvironment of ccRCC.MethodsA total of 87 patients with ccRCC admitted to our hospital were included in this retrospective study. Among them, 59 cases contained large amounts of collagen fibers and 28 cases contained a small amount of collagen fibers. We established a radiomics model using preoperative dual-energy CT scan Iodine map (IV) imaging to distinguish patients with multiple collagen fibers from those with few collagen fibers in the tumor microenvironment of ccRCC. We extracted features from dual-energy CT Iodine map images to evaluate the effects of six classifiers, namely k-nearest neighbor (KNN), support vector machine (SVM), extreme gradient boosting (XGBoost), random forest (RF), logistic regression (LR), and decision tree (DT). The effects of the models built based on the dynamic and venous phases are also compared. Model performance was evaluated using quintuple cross-validation and area under the receiver operating characteristic curve (AUC). In addition, a clinical model was developed to assess the clinical factors affecting collagen fiber content.ResultsCompared to KNN, SVM, and LR classifiers, RF, DT, and XGBoost classifiers trained with higher AUC values, with training sets of 0.997, 1.0, and 1.0, respectively. In the validation set, the highest AUC was found in the SVM classifier with a size of 0.722. In the comparative test of the active and intravenous phase models, the SVM classifier had the best effect with its validation set AUC of 0.698 and 0.741. In addition, there was a statistically significant effect of patient age and maximum tumor diameter on the collagen fiber content in the tumor microenvironment of kidney cancer.ConclusionRadionics features based on preoperative dual-energy CT IV can be used to predict the amount of collagen fibers in the tumor microenvironment of renal cancer. This study better informs clinical prognosis and patient management. Iodograms may add additional value to dual-energy CTs.

The problem with development of the support vector machine (SVM) classifiers using modified particle swarm optimization (PSO) algorithm and their ensembles has been considered. Solving this problem would allow fulfilling the high-precision data classification, especially Big Data classification, with the acceptable time expenditures. The modified PSO algorithm conducts a simultaneous search of the type of kernel functions, the parameters of the kernel function and the value of the regularization parameter for the SVM classifier. The idea of particles' «regeneration» served as the basis for the modified PSO algorithm. In the implementation of this algorithm, some particles change the type of their kernel function to the one which corresponds to the particle with the best value of the classification accuracy. The offered PSO algorithm allows reducing the time expenditures for the developed SVM classifiers, which is very important for Big Data classification problem. In most cases such SVM classifier provides the high quality of data classification. In exceptional cases the SVM ensembles based on the decorrelation maximization algorithm for the different strategies of the decision-making on the data classification and the majority vote rule can be used. Also, the two-level SVM classifier has been offered. This classifier works as the group of the SVM classifiers at the first level and as the SVM classifier on the base of the modified PSO algorithm at the second level. The results of experimental studies confirm the efficiency of the offered approaches for Big Data classification.