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Interactive Knowledge Discovery for Temporal Lobe Epilepsy

  • Nov 1, 2008
  • Mostafa Ghannad-Rezaie +1 more
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Abstract

Medical data mining and knowledge discovery can benefit from the experience and knowledge of clinicians, however, the implementation of this data mining system is challenging. Unlike traditional data mining methods, in this class of applications we process data with some posterior knowledge and the target function is more complex and even may include the opinion of user. Despite the success of the classical reasoning algorithms in many common data mining applications, they failed to address medical record processing where we need to extract information from incomplete, small samples along with an external rulebase to generate ‘meaningful’ interpretation of biological phenomenon. Swarm intelligence is an alternative class of flexible approaches that is promising in data mining. With full control over the rule extraction target function, particle swarm optimization (PSO) is a suitable approach for data mining subject to a rulebase which defines the quality of rules and constancy with previous observations. In this chapter we describe a complex clinical problem that has been addressed using PSO data mining. A large group of temporal lobe epilepsy patients are studied to find the best surgery candidates. Since there are many parameters involved in the decision process, the problem is not tractable from traditional data mining point of view, while the new approach that uses the field knowledge could extract valuable information. The proposed method allows expert to interaction with data mining process by offering manual manipulation of generated rules. The algorithm adjusts the rule set with regard to manipulations. Each rule has a reasoning which is based on the provided rulebase and similar observed cases. Support vector machine (SVM) classifier and swarm data miner are integrated to handle joint processing of raw data and rules. This approach is used to establish the limits of observations and build decision boundaries based on these critical observations.

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