Multi-Class Breast Cancer Classification using Deep Learning Convolutional Neural Network

Thousands of women worldwide are diagnosed with breast cancer yearly, which may be fatal if not treated. The diagnosis of the condition may take years, by which time the patient has little choice except to have the affected breast removed. Early diagnosis and treatments are the best ways to stop this disease's spread. In this study, the authors presented a Computer Aided Diagnosis (CAD) system to assist in breast cancer diagnosis. The study uses the Wisconsin breast cancer dataset to classify benign and malignant data. For the classification, three pre-trained Deep learning algorithms: Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), Multilayer Perceptron (MLP), were used. A novel CNN model that exceeds the performance efficiency of three pre-trained models and requires minimal compilation time is proposed. A number of evaluation matrices are used to analyze the models' classification abilities. Upon closer inspection, it has been established that the proposed CNN model outperforms CNN, LSTM, and MLP models with validation accuracy of 97.85%. CNN and LSTM performed with accuracies of 94.12% with the Adagrad optimizer and 93.5% with the Adam optimizer, respectively. Furthermore, MLP performance with 92.44% accuracy using the Adam optimizer. The proposed CNN model achieves the lowest Loss value and compilation time. In addition, the models' recall value, precision, and f1-score are computed to pick out the most effective model for diagnosing breast cancer on numeric data.

In this study, a multiscale framework combining the Lifting Wavelet Transform (LWT) and multi-path Convolutional Neural Network (CNN) is proposed to enhance the analysis of histopathological breast cancer images. LWT is employed due to its capability to obtain multi-resolution features that effectively retain key textural details. In particular, a multi-path CNN facilitates the concurrent processing of features at multiple levels of wavelet decompositions, thereby preserving diagnostic information that sole-path CNN models may lose. The approach was evaluated on the BreakHis dataset, which contains 7,638 rated images at varying magnifications, achieving 99.34% test accuracy by combining magnification levels using a Haar wavelet filter. Results obtained from comparative analyses against general CNN models confirm that the new strategy performs better, thereby validating the efficacy of integrating wavelet-based textural extraction and state-of-the-art CNN models for early-stage breast cancer diagnosis.

Breast cancer is the most common cancer worldwide with high death rate especially for women, early diagnosis can increase the survival opportunity with correct treatment in the hospital. The Computer-Assisted Diagnosis (CAD) system is of vital significant for improving the diagnostic accuracy as the diagnosis process is tedious and the result may be different between pathologists. In this paper, we proceed research on breast cancer histopathological images classification based on deep Convolutional Neural Network (CNN). The approach proposed in this work utilize CNN to extract features of histopathological images and classify the images into begin tumors and malignant tumors by softmax function. Eliminate overfitting phenomenon by data augmentation and fine tune technology while improving the performance of networks by cross validation training strategy. The experiments in this paper were conducted on BreaKHis database [4] available to scientific study from 2014 and the results proved the algorithm's advantage on accuracy.

Simple SummaryBreast cancer is one of the leading causes of cancer death among women. Developing machine learning-based diagnosis models receives great attention from researchers and scientists using histopathology images. Deep learning (DL) algorithms automatically extract features from raw data through convolutional operations. The generalization of the DL models’ results relies on large datasets, although they eliminate the expert knowledge in the feature extraction stage. This work aimed to compare the performance of the features extracted via deep learning and a knowledge-based approach in breast cancer detection from histopathology images.Cancer develops when a single or a group of cells grows and spreads uncontrollably. Histopathology images are used in cancer diagnosis since they show tissue and cell structures under a microscope. Knowledge-based and deep learning-based computer-aided detection is an ongoing research field in cancer diagnosis using histopathology images. Feature extraction is vital in both approaches since the feature set is fed to a classifier and determines the performance. This paper evaluates three feature extraction methods and their performance in breast cancer diagnosis. Features are extracted by (1) a Convolutional Neural Network, (2) a transfer learning architecture VGG16, and (3) a knowledge-based system. The feature sets are tested by seven classifiers, including Neural Network (64 units), Random Forest, Multilayer Perceptron, Decision Tree, Support Vector Machines, K-Nearest Neighbors, and Narrow Neural Network (10 units) on the BreakHis 400× image dataset. The CNN achieved up to 85% for the Neural Network and Random Forest, the VGG16 method achieved up to 86% for the Neural Network, and the knowledge-based features achieved up to 98% for Neural Network, Random Forest, Multilayer Perceptron classifiers.

The growing development of IoT (Internet of Things) devices creates a large attack surface for cybercriminals to conduct potentially more destructive cyberattacks; as a result, the security industry has seen an exponential increase in cyber-attacks. Many of these attacks have effectively accomplished their malicious goals because intruders conduct cyber-attacks using novel and innovative techniques. An anomaly-based IDS (Intrusion Detection System) uses machine learning techniques to detect and classify attacks in IoT networks. In the presence of unpredictable network technologies and various intrusion methods, traditional machine learning techniques appear inefficient. In many research areas, deep learning methods have shown their ability to identify anomalies accurately. Convolutional neural networks are an excellent alternative for anomaly detection and classification due to their ability to automatically categorize main characteristics in input data and their effectiveness in performing faster computations. In this paper, we design and develop a novel anomaly-based intrusion detection model for IoT networks. First, a convolutional neural network model is used to create a multiclass classification model. The proposed model is then implemented using convolutional neural networks in 1D, 2D, and 3D. The proposed convolutional neural network model is validated using the BoT-IoT, IoT Network Intrusion, MQTT-IoT-IDS2020, and IoT-23 intrusion detection datasets. Transfer learning is used to implement binary and multiclass classification using a convolutional neural network multiclass pre-trained model. Our proposed binary and multiclass classification models have achieved high accuracy, precision, recall, and F1 score compared to existing deep learning implementations.

Breast cancer is considered the second most common reason for death among women. The gold standard for detecting breast cancer is the visual interpretation of histopathological images, but it is a complicated process that takes years of experience and a lot of skills of the pathologists. Sometimes, the limitations of the visual interpretation and the lack of experience result in the failure of diagnosing breast cancer. So, the computer-aided diagnosis (CAD) system can be taken into consideration as a helping tool to reduce the error of diagnosis of breast cancer. In this paper, a novel approach based on convolutional neural networks is introduced to classify breast cancer from the histopathological images of the breast tissues. In the clinical process of breast cancer diagnosis, pathologists examine the histopathological images of the breast tissue at different magnification levels. In this research, a single convolutional neural networks model is used to take the input of the same image with four different magnification levels parallelly. Our proposed approach outperformed existing state-of-the-art approaches by a substantial margin.

Breast cancer (BC) is one of the diseases that women suffer most, especially in the world. Routine breast checks are vital for both early diagnosis and early treatment of the person concerned. Computer aided diagnosis systems have also come a long way in being a helpful tool for pathologists during diagnosis. In this work, a novel convolutional neural network (CNN) is proposed for the effective diagnosis of BC from histopathological images. Since classical CNNs have only one input, the network is to use only the raw images from the dataset in the training process. This limits the network from using an extra feature as an input. However, the proposed model has two inputs, unlike classical CNN structures. One input of the network uses histopathological raw images and the other input uses deep features of related images. All of the experimental studies were performed on the widely used BreaKHis dataset. For the test of performance, the accuracy criterion was preferred and the 5-fold cross-validation technique was taken into account. Accuracy scores of 99.94%, 98.94%, 99.05%, and 97.30% were obtained in 40×, 100×, 200× and 400× sub-datasets, respectively. While the results obtained were highly effective values for the diagnosis of BC, they were also far superior to other results reported in the literature.

Oral squamous cell carcinoma (OSCC) is a malignancy that destroys the ability of the tissues surrounding the mouth to develop layers and membranes. Automated early diagnosis of oral histopathological images has allowed for the successful diagnosis of oral cancer, thanks to recent advancements in Deep Learning (DL) for biomedical image classification. By using a convolutional neural network (CNN) model based on deep learning for the initial analysis of oral squamous cell carcinoma (OSCC), this work aims to automate the classification of benign and malignant oral biopsy histopathological images. For this study, the CNN model Inception-Resnet-V2 is selected using the transfer learning approach. To enhance OSCC detection, additional layers are incorporated into this pretrained model. By mining a repository of oral cancer histopathology images, we can gauge how well these tweaked models perform. We examine the modified structure of the pre-trained Inception-Resnet-V2 model and suggest a DL-CNN model that uses it. With an accuracy of 91.78%, it has outperformed in terms of performance metrics.

Excessive withdrawal of groundwater for agricultural irrigation can cause seawater intrusion into coastal aquifers. Such a case will in turn results in deterioration of irrigation water quality. Determination of irrigation water quality with traditional methods is a time-consuming and costly process. However, machine learning algorithms can be useful tools for modeling and estimating groundwater quality used for irrigation water purposes. In this study, TDS, PS, SAR, and Cl parameters of groundwater were estimated with models based on EC and pH variables. For this purpose, prediction performances of two different deep learning methods (convolutional neural network (CNN) and deep neural network (DNN)) and two different classical machine learning (Random Forest (RF) and extreme gradient boosting (XGBoost)) methods were compared. In addition, predictive uncertainty of the models was determined by quantile regression (QR) analysis. Performance criteria and results of uncertainty analysis revealed that CNN (in testing phase, NSE = 0.95 for TDS, NSE = 0.96 for PS, NSE = 0.67 for SAR and NSE = 0.93 for CI) and DNN (in testing phase, NSE = 0.91 for TDS, NSE = 0.91 for PS, NSE = 0.57 for SAR and NSE = 0.94 for Cl) models had quite a close performance in estimation of TDS, PS, SAR, and Cl parameters and higher than the other two classical machine learning methods. As a result, the CNN model can be considered the best performing model in estimating all quality parameters due to the highest NSE and lowest RMSE values. In addition, the Taylor diagram showed that the values estimated using the CNN model had the highest correlation with the measured data. It was determined that the model with the lowest uncertainty based on the PICP statistics was DNN, followed by the CNN model. However, the CNN model has predicted outliers more accurately. Present findings proved that deep learning models could offer efficient tools for predicting irrigation water quality parameters.

Breast cancer is one of the most common causes of death in women in the modern world. Cancerous tissue detection in histopathological images relies on complex features related to tissue structure and staining properties. Convolutional neural network (CNN) models like ResNet50, Inception‐V1, and VGG‐16, while useful in many applications, cannot capture the patterns of cell layers and staining properties. Most previous approaches, such as stain normalization and instance‐based vision transformers, either miss important features or do not process the whole image effectively. Therefore, a deep fusion‐based vision Transformer model (DFViT) that combines CNNs and transformers for better feature extraction is proposed. DFViT captures local and global patterns more effectively by fusing RGB and stain‐normalized images. Trained and tested on several datasets, such as BreakHis, breast cancer histology (BACH), and UCSC cancer genomics (UC), the results demonstrate outstanding accuracy, F1 score, precision, and recall, setting a new milestone in histopathological image analysis for diagnosing breast cancer.

Every year, millions of women across the globe are diagnosed with breast cancer (BC), an illness that is both common and potentially fatal. To provide effective therapy and enhance patient outcomes, it is essential to make an accurate diagnosis as soon as possible. In recent years, deep-learning (DL) approaches have shown great effectiveness in a variety of medical imaging applications, including the processing of histopathological images. Using DL techniques, the objective of this study is to recover the detection of BC by merging qualitative and quantitative data. Using deep mutual learning (DML), the emphasis of this research was on BC. In addition, a wide variety of breast cancer imaging modalities were investigated to assess the distinction between aggressive and benign BC. Based on this, deep convolutional neural networks (DCNNs) have been established to assess histopathological images of BC. In terms of the Break His-200×, BACH, and PUIH datasets, the results of the trials indicate that the level of accuracy achieved by the DML model is 98.97%, 96.78, and 96.34, respectively. This indicates that the DML model outperforms and has the greatest value among the other methodologies. To be more specific, it improves the results of localization without compromising the performance of the classification, which is an indication of its increased utility. We intend to proceed with the development of the diagnostic model to make it more applicable to clinical settings.

BreastNet: A novel convolutional neural network model through histopathological images for the diagnosis of breast cancer

Breast cancer (BC) remains a leading cause of cancer-related mortality among women globally, with early detection playing a crucial role in improving patient outcomes. While deep learning models—particularly Convolutional Neural Networks (CNNs)—have demonstrated exceptional performance in breast cancer detection, their high computational demands limit deployment in low-resource environments such as mobile devices and rural clinics. To bridge this gap, we propose a lightweight CNN model for breast cancer detection using Knowledge Distillation (KD), a technique that transfers knowledge from a complex, high-capacity "teacher" model to a compact and efficient "student" model. In this study, we develop and evaluate both teacher and student models using the Wisconsin Diagnostic Breast Cancer (WDBC), Breast Cancer Diagnosis (BCD), and Primary Breast Cancer vs Normal Breast Tissue (PBCT) datasets. The student model is designed to operate with only 0.06% of the parameters used by the teacher model, significantly reducing memory and computational overhead. Despite its lightweight architecture, the student model achieves up to 100% classification accuracy and demonstrates robust generalization across multiple datasets. Our approach enables high-accuracy breast cancer detection while ensuring fast inference and low resource consumption, making it well-suited for deployment in real-world, resource-constrained environments such as mobile health platforms and embedded medical devices. The findings highlight the transformative potential of knowledge distillation in democratizing access to advanced AI-driven diagnostics.

BACKGROUND AND AIM: Outdoor ultrafine particles (UFP; 100 nm) and black carbon (BC) vary greatly within cities and may have adverse impacts on human health such as cardiovascular mortality and brain tumour incidence. Traditional regression methods for estimating spatial distributions of ambient air pollution depend on extensive, curated geospatial information system databases. This has resulted in a disparity wherein little is known about local air pollution in the data-sparse settings of low- and middle- income countries. We used a hybrid approach to develop new models to estimate within-city spatial variations in outdoor UFP and BC concentrations across Bucaramanga, Colombia. METHODS: We conducted a large-scale mobile monitoring campaign over twenty days in 2019. Land use regression (LUR) models were developed using land use parameters from curated and open-source databases. Convolutional Neural Network (CNN) models were developed using Google Maps satellite view and street view images. Combined models were developed by combining predictions from the LUR and CNN models. After training in the training and validation sets, predictions were generated in the test set and compared to measured values. RESULTS:The combined UFP model (R2=0.54) outperformed the CNN (R2=0.47) and land use regression (LUR) models (R2=0.47) on their own. Similarly, the combined BC model also outperformed the CNN and LUR BC models (R2 = 0.51 vs 0.43 and 0.45 respectively). Spatial variations in model performance were more stable for the CNN and combined models compared to the LUR models suggesting that the combined approach may be less likely to contribute to differential exposure measurement error in epidemiological studies. CONCLUSIONS:Estimates from these models can then be applied to population-based cohorts in order to evaluate population health risks. Additionally, our findings demonstrated that satellite and street-level images can be combined with a traditional LUR modelling approach to improve predictions of within-city spatial variations in outdoor UFP and BC concentrations. KEYWORDS: Ultrafine particles, Black Carbon, Deep learning, Images, Land use regression

Prediction of the stage of cancer plays an important role in planning the course of treatment and has been largely reliant on imaging tools which do not capture molecular events that cause cancer progression. Gene-expression data-based analyses are able to identify these events, allowing RNA-sequence and microarray cancer data to be used for cancer analyses. Breast cancer is the most common cancer worldwide, and is classified into four stages - stages 1, 2, 3, and 4 [2]. While machine learning models have previously been explored to perform stage classification with limited success, multi-class stage classification has not had significant progress. There is a need for improved multi-class classification models, such as by investigating deep learning models. Gene-expression-based cancer data is characterised by the small size of available datasets, class imbalance, and high dimensionality. Class balancing methods must be applied to the dataset. Since all the genes are not necessary for stage prediction, retaining only the necessary genes can improve classification accuracy. The breast cancer samples are to be classified into 4 classes of stages 1 to 4. Invasive ductal carcinoma breast cancer samples are obtained from The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) datasets and combined. Two class balancing techniques are explored, synthetic minority oversampling technique (SMOTE) and SMOTE followed by random undersampling. A hybrid feature selection pipeline is proposed, with three pipelines explored involving combinations of filter and embedded feature selection methods: Pipeline 1 - minimum-redundancy maximum-relevancy (mRMR) and correlation feature selection (CFS), Pipeline 2 - mRMR, mutual information (MI) and CFS, and Pipeline 3 - mRMR and support vector machine-recursive feature elimination (SVM-RFE). The classification is done using deep learning models, namely deep neural network, convolutional neural network, recurrent neural network, a modified deep neural network, and an AutoKeras generated model. Classification performance post class-balancing and various feature selection techniques show marked improvement over classification prior to feature selection. The best multiclass classification was found to be by a deep neural network post SMOTE and random undersampling, and feature selection using mRMR and recursive feature elimination, with a Cohen-Kappa score of 0.303 and a classification accuracy of 53.1%. For binary classification into early and late-stage cancer, the best performance is obtained by a modified deep neural network (DNN) post SMOTE and random undersampling, and feature selection using mRMR and recursive feature elimination, with an accuracy of 81.0% and a Cohen-Kappa score (CKS) of 0.280. This pipeline also showed improved multiclass classification performance on neuroblastoma cancer data, with a best area under the receiver operating characteristic (auROC) curve score of 0.872, as compared to 0.71 obtained in previous work, an improvement of 22.81%. The results and analysis reveal that feature selection techniques play a vital role in gene-expression data-based classification, and the proposed hybrid feature selection pipeline improves classification performance. Multi-class classification is possible using deep learning models, though further improvement particularly in late-stage classification is necessary and should be explored further.