<strong class="journal-contentHeaderColor">Abstract.</strong> The reduction of fine particles (PM<sub>2.5</sub>) and reactive N (N<sub>r</sub>) and S (S<sub>r</sub>) species is a key objective for air pollution control policies because of their major adverse effects on human health, ecosystem diversity, and climate. The sensitivity of global and regional N<sub>r</sub>, S<sub>r</sub>, and PM<sub>2.5</sub> to 20 % and 40 % individual and collective reductions in anthropogenic emissions of NH<sub>3</sub>, NO<sub>x</sub>, and SO<sub>x</sub> (with respect to a 2015 baseline) is investigated using the EMEP MSC-W atmospheric chemistry transport model with WRF meteorology. Regional comparisons reveal that the individual emissions reduction has multiple co-benefits and small disbenefits on different species, and those effects are highly geographically variable. Reductions in NH<sub>3</sub> emissions are effective at decreasing NH<sub>3</sub> concentrations and deposition but much less so for NH<sub>4</sub><sup>+</sup>. A 40 % NH<sub>3</sub> emissions reduction decreases regional average NH<sub>3</sub> concentrations by 47–49 %, while sensitivities of NH<sub>4</sub><sup>+</sup> concentrations decrease in the order Euro_Medi (Europe and Mediterranean, 18 %), East Asia (15 %), North America (12 %), and South Asia (4 %), reflecting the increasing regional ammonia-richness. A disbenefit is the increased SO<sub>2</sub> concentrations in these regions (10–16 % for 40 % NH<sub>3</sub> emissions reductions) because reduced NH<sub>3</sub> levels decrease SO<sub>2</sub> deposition by altering atmospheric acidity. The 40 % NO<sub>x</sub> emissions reductions decrease NO<sub>x</sub> concentrations in East Asia by 45 %, Euro_Medi and North America by ~38 %, and South Asia by 22 %, whilst decreases in fine NO<sub>3</sub><sup>-</sup> are regionally reversed, which is related to enhanced O<sub>3</sub> levels in East Asia (and also, but by less, in Euro_Medi), and decreased O<sub>3</sub> levels in South Asia (and also, but by less, in North America). Consequently, the oxidation of NO<sub>x</sub> to NO<sub>3</sub><sup>-</sup> and of SO<sub>2</sub> to SO<sub>4</sub><sup>2-</sup> is enhanced in East Asia but decreased in South Asia, which in East Asia causes a more effective decrease in NO<sub>x</sub> and SO<sub>2</sub> but a less effective decrease in NO<sub>3</sub><sup>-</sup> and even an increase in SO<sub>4</sub><sup>2-</sup>; in South Asia it causes a less effective decrease in NO<sub>x</sub> and an increase in SO<sub>2</sub> but a more effective decrease in NO<sub>3</sub><sup>-</sup> and SO<sub>4</sub><sup>2-</sup>. For regional policy making, it is thus important to reduce NH<sub>3</sub>, NO<sub>x</sub> and SO<sub>x</sub> emissions together and/or go for stronger reductions to minimise such adverse effects in East Asia and Euro_Medi. Reductions in SO<sub>x</sub> emissions are slightly more effective for SO<sub>2</sub> than SO<sub>4</sub><sup>2-</sup>. A disbenefit is that SO<sub>x</sub> emissions reductions increase NH<sub>3</sub> total deposition and ecosystem eutrophication (~12 % increase for 40 % emissions reduction). PM<sub>2.5</sub> mitigation in South Asia is most sensitive to 40 % SO<sub>x</sub> reduction (3.10 μg m<sup>-3</sup>, 10 %) and least sensitive to NH<sub>3</sub> reduction (0.29 μg m<sup>-3</sup>, 1 %), which is because South Asia is so ammonia-rich that reducing NH<sub>3</sub> has little impact. The most effective measure for North America is reducing NO<sub>x</sub> emissions with an 8 % (0.63 μg m<sup>-3</sup>) decrease in PM<sub>2.5</sub> in response to a 40 % reduction. In Euro_Medi, the sensitivities of PM<sub>2.5</sub> to 40 % individual emissions reductions range 5–8 % (0.55–0.82 μg m<sup>-3</sup>). In the UK and Scandinavia PM<sub>2.5</sub> is more sensitive to NH<sub>3</sub>, in central Europe it is more sensitive to NO<sub>x</sub>, while in the Mediterranean it is more sensitive to SO<sub>x</sub>. In East Asia, reductions in SO<sub>x</sub>, NO<sub>x</sub> and NH<sub>3</sub> emissions are almost equally effective with PM<sub>2.5</sub> sensitivities to 40 % reductions of 7–8 % (1.89–2.33 μg m<sup>-3</sup>). Due to the varying contributions of SIA, PM<sub>2.5</sub> sensitivities to 40 % collective reductions in all 3 precursors decrease in the order East Asia (20 %), Euro_Medi and North America (17 %), South Asia (13 %). The geographically-varying non-linear chemical responses of N<sub>r</sub>, S<sub>r</sub>, and PM<sub>2.5</sub> to emissions reductions revealed by this work show the importance of both prioritising emissions strategies in different regions and combining several precursor reductions together to maximise the policy effectiveness.
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