Predicting Heart Disease Using Machine Learning: Analysis and New Insights.

Machine learning (ML) algorithms are increasingly used to predict outcomes in orthopaedic surgery, but their utility in hip arthroscopy remains unclear. This study aimed to (1) evaluate ML models for predicting outcomes, complications, and resource use following hip arthroscopy, (2) compare ML performance to traditional statistical methods, and (3) critically appraise the quality of existing literature. A systematic search of PUBMED, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials was conducted on 4 April 2023. Included studies used ML models for clinical prediction in hip arthroscopy. Data on study design, outcomes, model development, validation and adherence to TRIPOD guidelines were extracted. Seventeen studies involving 37,549 patients (52.8% female; mean age 34.4 ± 6.1 years) were included. ML was used to predict clinical outcomes (47.1%), adverse events (47.1%) and resource utilisation (5.9%). The median area under the curve was 0.66 (range 0.5-0.94) for clinical outcomes and 0.7 (range 0.6-0.9) for adverse events. Resource utilisation was reported with a root-mean-square error of $3800, a logarithmic error of 0.2, and R² of 0.8. Only four studies compared ML to traditional regression; two found no difference, while two favoured ML. On average, studies met 12.3 of the 22 TRIPOD criteria, with only 29.4% meeting more than two-thirds. ML models in hip arthroscopy show variable performance in predicting outcomes and complications. Furthermore, most studies comparing ML models to traditional regression did not report any significant difference. Lastly, variability in adherence to TRIPOD guidelines highlights the need for future studies to improve transparency and reporting in the development of ML algorithms for hip arthroscopy. Given the potential of ML models in enhancing clinical decision-making for hip arthroscopy, along with the findings of the current study, their application should be used with caution. Level IV, systematic review of level II-IV studies.

Background: Cardiovascular diseases belong to the top three leading causes of mortality in the Philippines with 17.8 % of the total deaths. Lifestyle-related habits such as alcohol consumption, smoking, poor diet and nutrition, high sedentary behavior, overweight, and obesity have been increasingly implicated in the high rates of heart disease among Filipinos leading to a significant burden to the country's healthcare system. The objective of this study was to predict the presence of heart disease using various machine learning algorithms (support vector machine, naïve Bayes, random forest, logistic regression, decision tree, and adaptive boosting) evaluated on an anonymized publicly available cardiovascular disease dataset. Methodology: Various machine learning algorithms were applied on an anonymized publicly available cardiovascular dataset from a machine learning data repository (IEEE Dataport). A web-based application system named Heart Alert was developed based on the best machine learning model that would predict the risk of developing heart disease. An assessment of the effects of different optimization techniques as to the imputation methods (mean, median, mode, and multiple imputation by chained equations) and as to the feature selection method (recursive feature elimination) on the classification performance of the machine learning algorithms was made. All simulation experiments were implemented via Python 3.8 and its machine learning libraries (Scikit-learn, Keras, Tensorflow, Pandas, Matplotlib, Seaborn, NumPy). Results: The support vector machine without imputation and feature selection obtained the highest performance metrics (90.2% accuracy, 87.7% sensitivity, 93.6% specificity, 94.9% precision, 91.2% F1-score and an area under the receiver operating characteristic curve of 0.902) and was used to implement the heart disease prediction system (Heart Alert). Following very closely were random forest with mean or median imputation and logistic regression with mode imputation, all having no feature selection which also performed well. Conclusion: The performance of the best four machine learning models suggests that for this dataset, imputation technique for missing values may or may not be done. Likewise, recursive feature elimination for feature selection may not apply as all variables seem to be important in heart disease prediction. An early accurate diagnosis leading to prompt intervention efforts is very crucial as it improves the patient's quality of life and diminishes the risk of developing cardiac events.

Health care Management System (HMS) is a key to successful management of any health care industry. Health care management systems have so many research dimensions such as identifying disease and diagnostic, drug discovery manufacturing, Bioinformatics’ problem, personalized treatments, Patient image analysis and so on. Heart Disease Prediction (HDP) is a process of identifying heart disease in advance and recognizes patient health condition by applying techniques on patient heart related symptoms. Now a day’s the problem of identifying heart diseases is solved by machine learning techniques. In this paper we construct a heart disease prediction method using combined feature selection and classification machine learning techniques. According to the existing study the one of the main difficult in heart disease prediction system is that the available data in open sources are not properly recorded the necessary characteristics and there is some lagging in finding the useful features from the available features. The process of removing inappropriate features from an available feature set while preserving sufficient classification accuracy is known as feature selection. A methodology is proposed in this paper that consists of two phases: Phase one employs two broad categories of feature selection techniques to identify the efficient feature sets and it is given to the input of our second phase such as classification. In this work we will concentrate on filter-based method for feature selection such as Chi-square, Fast Correlation Based Filter (FCBF), Gini Index (GI), RelifeF, and wrapper-based method for feature selection such as Backward Feature Elimination (BFE), Exhaustive Feature Selection (EFS), Forward Feature Selection (FFS), and Recursive Feature Elimination (RFE). The UCI heart disease data set is used to evaluate the output in this study. Finally, the proposed system's performance is validated by various experiments setups.

Breath analysis is a non-invasive diagnostic method that offers insights into both physiological and pathological conditions. Exhaled breath contains volatile organic compounds, which act as biomarkers for disease detection, allowing for the monitoring of treatments and the tailoring of medicine to individuals. Recent advancements in chemical sensing, mass spectrometry, and spectroscopy have improved the ability to identify these biomarkers; however, traditional statistical approaches often struggle to handle the complexities of breath data. Artificial intelligence (AI) and machine learning (ML) have revolutionized breath analysis by uncovering intricate patterns among volatile breath markers, enhancing diagnostic precision, and facilitating real-time disease identification. Despite significant progress, challenges remain, including issues with data standardization, model interpretability, and the necessity for extensive and varied datasets. This study reviews the applications of ML in analyzing breath volatile organic compounds, highlighting methodological shortcomings and obstacles to clinical validation. A thorough literature review was performed using the PubMed and Scopus databases, which included studies that focused specifically on the role of machine learning in disease diagnosis and incidence prediction via breath analysis. Among the 524 articles reviewed, 97 satisfied the specified inclusion criteria. The selected studies applied ML techniques, fell within the scope of this review, and emphasize the potential of ML models for non-invasive diagnostics. The findings indicate that traditional ML methods dominate, while ensemble methods are on the rise, and deep learning (DL) techniques (especially CNNs and LSTMs) are increasingly used for classifying respiratory diseases. Techniques for feature selection (such as PCA and ML-based methods) were frequently implemented, though challenges related to explainability and data standardization persist. Future studies should focus on enhancing model transparency and developing methods to further integrate AI into the clinical setting to facilitate early disease detection and advance precision medicine.

Heart disease is the major global cause of death in the modern era. Heart illness might be difficult to diagnose. It requires a number of expensive diagnostic tests to be found. The scientific community is undergoing a transformation thanks to machine learning (ML), a subset of artificial intelligence. In this paper, exploratory data analysis (EDA) utilizing multivariate analysis is utilized to find correlations and outliers in the data. The study's dataset consists of 270 records with 14 variables, including age, chest pain type, blood pressure, blood glucose level, resting ECG, heart rate, and chest pain. Logistic Regression algorithm is employed on the dataset to predict heart disease on the basis of chosen risk factors that are obtained using recursive feature elimination incorporating random forest classifier method. The paper entails pre-processing methods, proposed algorithms, evaluation metrics and an accurate prediction based on the methodology.

Forecasting interest rates is a fundamental task in financial planning, investment strategies, and policy-making. Traditional statistical models, while widely used, often fail to adequately capture complex non-linear relationships and temporal dependencies inherent in financial data. This study addresses these limitations by exploring the potential of machine learning models to improve the accuracy and reliability of interest rate forecasts. The primary objective of this research is to evaluate and compare the performance of multiple machine learning models, including linear regression, support vector machines, and deep learning techniques, in predicting interest rate trends. Historical data spanning two decades was collected and preprocessed, ensuring data quality and consistency. The models were trained and tested on this dataset using well-defined evaluation metrics such as mean absolute error and root mean squared error to ensure robust performance assessments. The results revealed that machine learning approaches, particularly deep learning models, outperformed traditional methods in capturing complex patterns and delivering more accurate forecasts. The findings further discuss the practical implications of implementing machine learning techniques in real-world financial contexts, highlighting both opportunities and challenges. In conclusion, this study provides actionable insights and a robust framework for integrating machine learning into interest rate forecasting, contributing to the advancement of predictive modeling in finance.

Accurate precipitation forecasting is a vital task for many domains, such as agriculture, water management, flood prevention, and crop yield estimation. The use of machine learning (ML) approaches has improved precipitation forecasting accuracy, exhibiting promising results in capturing the intricate connections between various meteorological variables and precipitation patterns. However, given the vast array of available ML models, a comparative analysis is imperative for identifying the most effective models for precipitation prediction. This study aims to examine the capacities of ML algorithms to forecast precipitation based on weather data for the city of Casablanca, Morocco, which faces challenges in water management and climate change adaptation. Eight different ML models’ performances are compared: linear regression, polynomial regression, K-nearest neighbors (KNN), support vector machine (SVM), decision tree (DT), random forest (RF), XGBoost, and an ensemble learning model. These models are evaluated based on their mean absolute error (MAE), mean squared error (MSE), and R-squared (R2 ) value to determine their effectiveness. The study showcases the potential of ML models in predicting precipitation by utilizing meteorological parameters such as temperature, humidity, wind speed, and pressure.

Background: Heart diseases continue to be among the primary causes of morbidity and mortality worldwide, highlighting the need for novel diagnostic methods to accurately, early, and economically predict and diagnose heart diseases. Current physical explores upon expert knowledge, possibly missing intricate and non-linear associations between heart disease risk factors. This is where machine learning (ML)methods emerge as promising alternatives for prediction and diagnosis of heart diseases by emphasizing data availability. Methods: This paper attempts to find out how six popular machine learning algorithms namely, Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF), Gradient Boosting (GB), K-Nearest Neighbors (KNN), and eXtreme Gradient Boosting (XGB) perform on a publicly available heart disease dataset collected from Kaggle. For better performance and to make them comparable to each other, basic preprocessing techniques have also been implemented. The performance of all these algorithms will be measured by their respective definitions of accuracy, precision, recall, and F1 score. Result: With an F1-score of 98.52%, Random Forest and XGBoost surpassed other models, yielding a superior accuracy in predictions, measuring 98.53%. The models recorded a perfect level of precision, 100%, coupled with high values of recall, exceeding 97%. Gradient Boosting recorded impressive results, receiving an accuracy score of 93.17%. Conclusion: The research findings revealed that the Random Forest and XGBoost models are very effective in the prediction and diagnosis of heart disease. These two models have the capacity to support a clinical decision. Novelty: That is to say, the novelty of this research is that it evaluates multiple machine learning models with comparison to each other. The role of machine learning in enhancing cardiovascular disease diagnosis as well as decision support systems in healthcare and educating and aware the people about heart care and health.

This project focuses on predicting heart, lung, and brain diseases using advanced machine learning (ML) and deep learning (DL) techniques. The system analyzes complex patterns from diverse datasets, including patient demographics, clinical information, and diagnostic imaging. By employing algorithms such as Random Forest, Support Vector Machines (SVM), and Convolutional Neural Networks (CNNs), it effectively identifies disease-specific indicators. Recent research demonstrates AI's remarkable accuracy-over 95 % in heart disease prediction, 96.57 % in lung disease detection (including pneumonia and COVID-19), and promising results in early dementia prediction through eye scans. The proposed framework aims to support healthcare professionals by providing data-driven, early diagnostic insights, thereby enhancing decision-making, enabling timely interventions, and improving overall patient care and outcomes.

To construct vocal recognition classification models using 6 machine learning algorithms and vocal emotional characteristics of individuals with subthreshold depression to facilitate early identification of subthreshold depression. We collected voice data from both normal individuals and participants with subthreshold depression by asking them to read specifically chosen words and texts. From each voice sample, 384-dimensional vocal emotional feature variables were extracted, including energy feature, Meir frequency cepstrum coefficient, zero cross rate feature, sound probability feature, fundamental frequency feature, difference feature. The Recursive Feature Elimination (RFE) method was employed to select voice feature variables. Classification models were then built using the machine learning algorithms Adaptive Boosting (AdaBoost), Random Forest (RF), Linear Discriminant Analysis (LDA), Logistic Regression (LR), Lasso Regression (LRLasso), and Support Vector Machine (SVM), and the performance of these models was evaluated. To assess generalization capability of the models, we used real-world speech data to evaluate the best speech recognition classification model. The AdaBoost, RF, and LDA models achieved high prediction accuracies of 100%, 100%, and 93.3% on word-reading speech test set, respectively. In the text-reading speech test set, the accuracies of the AdaBoost, RF, and LDA models were 90%, 80%, and 90%, respectively, while the accuracies of the other 3 models were all below 80%. On real-world word-reading and text-reading speech data, the classification models using AdaBoost and Random Forest still achieved high predictive accuracies (91.7% and 80.6% for AdaBoost and 86.1% and 77.8% for Random, respectively). Analyzing vocal emotional characteristics allows effective identification of individuals with subthreshold depression. The AdaBoost and RF models show excellent performance for classifying subthreshold depression individuals, and may thus potentially offer valuable assistance in the clinical and research settings.

ObjectiveTo develop and validate machine learning (ML)-based models to predict lymph node metastasis (LNM) in patients with gastric cancer (GC).DesignRetrospective cohort study.SettingSecond Affiliated Hospital of Soochow University.ParticipantsA total of 500...

One of the critical issues in medical data analysis is accurately predicting a patient’s risk of heart disease, which is vital for early intervention and reducing mortality rates. Early detection allows for timely treatment and continuous monitoring by healthcare providers, which is essential but often limited by the inability of medical professionals to provide constant patient supervision. Early detection of cardiac problems and continuous patient monitoring by physicians can help reduce death rates. Doctors cannot constantly have contact with patients, and heart disease detection is not always accurate. By offering a more solid foundation for prediction and decision-making based on data provided by healthcare sectors worldwide, machine learning (ML) could help physicians with the prediction and detection of HD. This study aims to use different feature selection strategies to produce an accurate ML algorithm for early heart disease prediction. We have chosen features using chi-square, ANOVA, and mutual information methods. The three feature groups chosen were SF-1, SF-2, and SF-3. The study employed ten machine learning algorithms to determine the most accurate technique and feature subset fit. The classification algorithms used include support vector machines (SVM), XGBoost, bagging, decision trees (DT), and random forests (RF). We evaluated the proposed heart disease prediction technique using a private dataset, a public dataset, and different cross-validation methods. We used the Synthetic Minority Oversampling Technique (SMOTE) to eliminate inconsistent data and discover the machine learning algorithm that achieves the most accurate heart disease predictions. Healthcare providers might identify early-stage heart disease quickly and cheaply with the proposed method. We have used the most effective ML algorithm to create a mobile app that instantly predicts heart disease based on the input symptoms. The experimental results demonstrated that the XGBoost algorithm performed optimally when applied to the combined datasets and the SF-2 feature subset. It had 97.57% accuracy, 96.61% sensitivity, 90.48% specificity, 95.00% precision, a 92.68% F1 score, and a 98% AUC. We have developed an explainable AI method based on SHAP approaches to understand how the system makes its final predictions.

---------------------------------------------------------------------***--------------------------------------------------------------------- Abstract– Cardiovascular diseases remain one of the leading causes of mortality worldwide, making early and reliable risk prediction a critical requirement in modern healthcare systems. Traditional diagnostic approaches often rely on either clinical parameters or medical imaging in isolation, which may limit the predictiveness of the disease. This project aims to build a multimodal heart disease prediction framework that integrates clinical tabular data and echocardiography-based image information to estimate the probability of heart disease in a robust way. The tabular dataset includes demographics and clinical risk factors such as age, sex, chest pain type, blood pressure, cholesterol, electrocardiographic findings, and exercise-related parameters. Multiple classical machine learning models were trained and evaluated, including Logistic Regression, Support Vector Machine, Random Forest, Decision Tree, and XGBoost. Among all these, XGBoost achieved the best performance, with a test accuracy of 89.13% and an F1-score of 0.9029, demonstrating strong predictive capability. For the imaging modality, an echocardiography video-based model was trained using the EchoNet Dynamic dataset, where cardiac abnormality was determined based on an ejection fraction threshold of 50%. The image model achieved a ROC-AUC of 0.915, indicating excellent discriminative performance. Threshold optimization was performed to improve clinical sensitivity, increasing recall from 66.77% to 72.70% and reducing false negative cases. A late fusion approach using weighted averaging of predicted probabilities was adopted to combine both modalities, leveraging their complementary strengths. The system outputs a probabilistic risk score rather than a definitive diagnosis, making it suitable as a clinical decision support tool. Future enhancements include the integration of a RAG-based assistant for user guidance and the adoption of explainable AI techniques to improve transparency and interpretability. Key Words: Heart Disease Prediction, Multimodal Learning, Echocardiography, Machine Learning, Deep Learning, Late Fusion, Clinical Decision Support, Prediction Threshold

Introduction Heart disease is emerging as the single most critical cause of death worldwide and is one of the costliest chronic conditions. Purpose Stimulated by the increasing heart disease mortality rate incidents, an effective, low-cost, and reliable heart disease risk evaluation model is developed using significant non-invasive risk attributes. The significant non-invasive risk attributes like (age, systolic BP, diastolic BP, BMI, hereditary factor, smoking, alcohol, and physical inactivity) are identified by the help of medical domain experts, and their reliability in heart disease prediction is investigated through different feature selection techniques. Methodology. The enhancements of applying specific investigated techniques like random forest, Naïve Bayes, decision tree, support vector machine, and K nearest neighbor to the risk factors are tested. The heart disease risk assessment model is developed using the Jupyter Notebook web application, and its performance is tested not only through medical domain measures but also through the model performance measures. Findings. To evaluate heart disease risk evaluation model, we calculated measures of discrimination like error rate, AUROC, sensitivity, specificity, accuracy, precision, and so on. Experimental results show that the random forest heart disease risk evaluation model outperforms other existing risk models with admirable predictive accuracy and minimum misclassification rate. Originality. The heart disease risk evaluation model is developed based on novel non-invasive heart disease dataset, which consists of 5776 records. This dataset is collected from different heterogeneous data sources of Kashmir (India) through quantitative data collection methods. Research Implications. The risk model is applicable where people lack the facilities of integrated primary medical care technologies for untimely heart disease risk prediction. Future Work. To investigate deep learning and study the significance of other controlled attributes on different age and sex groups in the risk estimation of heart disease.

Cardiovascular diseases remain one of the leading causes of mortality worldwide, particularly in low- and middle-income countries. Early and accurate prediction of heart disease is essential for timely intervention and improved patient outcomes. Machine learning techniques offer promising solutions; however, challenges such as class imbalance, lack of interpretability, and limited real-world validation persist. In this study, a machine learning–based heart disease prediction framework was developed using a real-world clinical dataset comprising 5000 patient records collected from healthcare facilities in Bangladesh. Data preprocessing included cleaning, feature encoding, train–test splitting, and class imbalance handling using the Synthetic Minority Oversampling Technique (SMOTE). Multiple machine learning models—Logistic Regression, Decision Tree, Support Vector Machine, and Random Forest—were evaluated using 10-fold stratified cross-validation. Model performance was assessed using accuracy, precision, recall, and F1-score. SHAP (SHapley Additive exPlanations) was employed to enhance model interpretability. The best-performing model was deployed as a web-based decision support system. Among the evaluated models, the Random Forest classifier achieved the best performance, with an accuracy of 98%, recall of 96%, and F1-score of 96%. Ablation studies demonstrated the effectiveness of SMOTE, feature integration, and ensemble modeling. SHAP analysis identified clinically relevant features contributing to heart disease prediction, enhancing transparency and trust in model decisions. The proposed framework provides an accurate, interpretable, and practical solution for heart disease prediction using real-world clinical data. The integration of explainable machine learning and web-based deployment highlights its potential for clinical decision support. Future work will focus on multi-center prospective validation and adaptive model updating to further improve generalizability and real-world applicability. • A large real-world clinical dataset of 5000 patients was used for robust heart disease prediction. • A Random Forest model with SMOTE achieved high performance (98% accuracy, 96% recall). • Comprehensive ablation and model comparison analyses validate methodological robustness. • SHAP-based explainability provides transparent and clinically interpretable predictions. • The proposed system is deployed as a web-based clinical decision support tool.