Prediction of Coronary Heart Disease using Supervised Machine Learning Algorithms

An Innovative Machine Learning-Based Algorithm for Diagnosing Pediatric Ovarian Torsion.

An intrusion detection system (IDS) is an important protection instrument for detecting complex network attacks. Various machine learning (ML) or deep learning (DL) algorithms have been proposed for implementing anomaly-based IDS (AIDS). Our review of the AIDS literature identifies some issues in related work, including the randomness of the selected algorithms, parameters, and testing criteria, the application of old datasets, or shallow analyses and validation of the results. This paper comprehensively reviews previous studies on AIDS by using a set of criteria with different datasets and types of attacks to set benchmarking outcomes that can reveal the suitable AIDS algorithms, parameters, and testing criteria. Specifically, this paper applies 10 popular supervised and unsupervised ML algorithms for identifying effective and efficient ML-AIDS of networks and computers. These supervised ML algorithms include the artificial neural network (ANN), decision tree (DT), k-nearest neighbor (k-NN), naive Bayes (NB), random forest (RF), support vector machine (SVM), and convolutional neural network (CNN) algorithms, whereas the unsupervised ML algorithms include the expectation-maximization (EM), k-means, and self-organizing maps (SOM) algorithms. Several models of these algorithms are introduced, and the turning and training parameters of each algorithm are examined to achieve an optimal classifier evaluation. Unlike previous studies, this study evaluates the performance of AIDS by measuring the true positive and negative rates, accuracy, precision, recall, and F-Score of 31 ML-AIDS models. The training and testing time for ML-AIDS models are also considered in measuring their performance efficiency given that time complexity is an important factor in AIDSs. The ML-AIDS models are tested by using a recent and highly unbalanced multiclass CICIDS2017 dataset that involves real-world network attacks. In general, the k-NN-AIDS, DT-AIDS, and NB-AIDS models obtain the best results and show a greater capability in detecting web attacks compared with other models that demonstrate irregular and inferior results.

Heart disease is among the conditions that people suffer from most frequently. Millions of people worldwide pass away each year as a result of it, making it one of the main causes of mortality. Heart disease can be characterised by issues with the heart valves, heart failure, arrhythmias, and coronary artery disease. Heart disease comes in more than 30 distinct forms. By allowing for prompt intervention and the right kind of care, early and precise cardiac disease prediction can greatly improve patient outcomes. In this model, we investigate the application of machine learning techniques for anticipating cardiac disease. We investigate a large dataset made up of patient details, such as demographics, medical histories, and clinical measures. It is absolutely mind-blowing to think that machine learning algorithms could one day properly forecast when cardiac disease will start and how to diagnose it. Machine learning techniques including logistic regression, decision trees, XGBoost, gradient boosting, random forests, support vector machines (SVMs), and artificial neural networks (ANNs) are utilised to construct predictive models. A hybrid model including ANN, gradient boost, Decision Tree, SVM, random forests, & Logistic Regression makes up the forecasting model. To increase the model's accuracy. To manage missing values, normalise features and solve class imbalance. The dataset has been pre-processed. The best accurate heart disease predictions are found using feature selection approaches. Area under the receiver's operating characteristic curve, recall, accuracy, and precision are some of the performance measures used for training and evaluating the models. The major goal of this model is to put out a novel strategy for creating a model that successfully solves practical issues

Software Bug Prediction (SBP) is an important issue in software development and maintenance processes, which concerns with the overall of software successes. This is because predicting the software faults in earlier phase improves the software quality, reliability, efficiency and reduces the software cost. However, developing robust bug prediction model is a challenging task and many techniques have been proposed in the literature. This paper presents a software bug prediction model based on machine learning (ML) algorithms. Three supervised ML algorithms have been used to predict future software faults based on historical data. These classifiers are Naïve Bayes (NB), Decision Tree (DT) and Artificial Neural Networks (ANNs). The evaluation process showed that ML algorithms can be used effectively with high accuracy rate. Furthermore, a comparison measure is applied to compare the proposed prediction model with other approaches. The collected results showed that the ML approach has a better performance.

Despite careful patient selection, induction chemotherapy for acute myeloid leukemia (AML) is associated with a considerable risk for treatment-related mortality (5%-20%). We evaluated machine learning (ML) algorithms trained using factors available at the time of admission for AML therapy to predict death during the hospitalization. We included AML discharges with age > 17 years who received inpatient chemotherapy from State Inpatient Database from Arizona, Florida, New York, Maryland, Washington, and New Jersey for years 2008-2014. The primary objective was to predict inpatient mortality in patients undergoing chemotherapy using covariates present before initiation of chemotherapy. ML algorithms logistic regression (LR), decision tree, and random forest were compared. 29,613 hospitalizations for patients with AML were included in the analysis each with 4,177 features. The median age was 58.9 (18-101) years, 13,689 (53.7%) were male, and 20,203 (69%) were White. The mean time from admission to chemotherapy was 3 days (95% CI, 2.9 to 3.1), and 2,682 (9.1%) died during the hospitalization. Both LR and random forest models achieved an area under the curve (AUC) score of 0.78, whereas decision tree achieved an AUC of 0.70. The baseline LR model with age yielded an AUC of 0.62. To clinically balance and minimize false positives, we selected a decision threshold of 0.7 and at this threshold, 51 of our test set of 5,923 could have potentially averted treatment-related mortality. Using readily accessible variables, inpatient mortality of patients on track for chemotherapy to treat AML can be predicted through ML algorithms. The model also predicted inpatient mortality when tested on different data representations and paves the way for future research.

Slope stability prediction using integrated metaheuristic and machine learning approaches: A comparative study

Diabetes is a long-term health condition that impacts millions of people worldwide, and correct and timely diagnosis is required to manage it effectively. In the present research study, we propose an improved model of diabetes prediction based on the usage of Big Data Analytics (BDA) and Machine Learning (ML) algorithms for enhancing the predictability of diabetes. Our research is based on the ideas developed in the reference paper, where the application of BDA in enabling healthcare decisionmaking was proposed. With the inclusion of the usage of advanced ML algorithms like Decision Trees, Random Forest, Logistic Regression, Naive Bayes, and Artificial Neural Networks (ANN), we enhance predictability for the diagnosis of diabetes. We employed a comprehensive healthcare dataset with various health metrics, including blood pressure, cholesterol, BMI, smoking, and physical activity. The data was heavily preprocessed, ranging from feature engineering to normalization, to get better model performance. All the models were trained and tested on accuracy, precision, recall, and ROC-AUC. Among the models, Random Forest and ANN were better with higher accuracy, detecting diabetic patients at risk effectively. Our model not only increases prediction accuracy but also facilitates scalability with Big Data technology and practices. The ANN model, in particular, proved effective in finding complex patterns within the data, yielding a reliable solution towards real-time diabetes prediction. This effort illustrates the potential of integrating BDA and ML in healthcare for data-driven decision-making and supporting early diagnosis and management of diabetes. The model is deployed as an interactive user-friendly web application using Streamlet, where users can input health indicators and receive predictions from different models. Through its interactive interface, it facilitates healthcare professionals and patients by offering themreal-time information, thereby ultimately improving diabetes management and patient care.

In Mild Cognitive Impairment (MCI), identifying a high risk of conversion to Alzheimer’s Disease Dementia (AD) is a primary goal for patient management. Machine Learning (ML) algorithms are widely employed to pursue data-driven diagnostic and prognostic goals. An agreement on the stability of these algorithms –when applied to different biomarkers and other conditions– is far from being reached. In this study, we compared the different prognostic performances of three supervised ML algorithms fed with multimodal biomarkers of MCI subjects obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Random Forest, Gradient Boosting, and eXtreme Gradient Boosting algorithms predict MCI conversion to AD. They can also be simultaneously employed –with the voting procedure– to improve predictivity. AD prediction accuracy is influenced by the nature of the data (i.e., neuropsychological test scores, cerebrospinal fluid AD-related proteins and APOE ε4, cerebral structural MRI (sMRI) data). In our study, independent of the applied ML algorithms, sMRI data showed the lowest accuracy (0.79) compared to other classes. Multimodal data were helpful in the algorithms’ performances by combining clinical and biological measures. Accordingly, using the three ML algorithms, the highest accuracy (0.90) was reached by employing neuropsychological and AD-related biomarkers. Finally, the feature selection procedure indicated that the most critical variables in the respective classes were the ADAS-Cog-13 scale, the medial temporal lobe and hippocampus atrophy, and the ratio between phosphorylated Tau and Aβ42 proteins. In conclusion, our data support the notion that using multiple ML algorithms and multimodal biomarkers helps make more accurate and solid predictions.

Background To assess the feasibility of a machine learning (ML) approach using radiomics features of perfusion defects on rest myocardial perfusion imaging (MPI) to detect the presence of hibernating myocardium. Methodology Data of patients who underwent 99mTc-sestamibi MPI and 18F-FDG PET/CT for myocardial viability assessment were retrieved. Rest MPI data were processed on ECToolbox, and polar maps were saved using theNFile PMap tool. The reference standard for defining hibernating myocardium was the presence of mismatched perfusion-metabolism defect with impaired myocardial contractility at rest. Perfusion defects on the polar maps were delineated with regions of interest (ROIs) after spatial resampling and intensity discretization. Replicable random sampling allocated 80% (257) of the perfusion defects of the patients from January 2017 to September 2022 to the training set and the remaining 20% (64) to the validation set. An independent dataset of perfusion defects from 29 consecutive patients from October 2022 to January 2023 was used as the testing set for model evaluation. One hundred ten first and second-order texture features were extracted for each ROI. After feature normalization and imputation, 14 best-ranked features were selected using a multistep feature selection process including the Logistic Regression and Fast Correlation-Based Filter. Thirteen supervised ML algorithms were trained with stratified five-fold cross-validation on the training set and validated on the validation set. The ML algorithms with a Log Loss of <0.688 and <0.672 in the cross-validation and validation steps were evaluated on the testing set. Performance matrices of the algorithms assessed included area under the curve (AUC), classification accuracy (CA), F1 score, precision, recall, and specificity. To provide transparency and interpretability, SHapley Additive exPlanations (SHAP) values were assessed and depicted as beeswarm plots. Results Two hundred thirty-nine patients (214 males; mean age 56 ± 11 years) were enrolled in the study. There were 371 perfusion defects (321 in the training and validation sets; 50 in the testing set). Based on the reference standard, 168 perfusion defects had hibernating myocardium (139 in the training and validation sets; 29 in the testing set). On cross-validation, six ML algorithms with Log Loss <0.688 had AUC >0.800. On validation, 10 ML algorithms had a Log Loss value <0.672, among which six had AUC >0.800. On model evaluation of the selected models on the unseen testing set, nine ML models had AUC >0.800 with Gradient Boosting Random Forest (xgboost) [GB RF (xgboost)] achieving the highest AUC of 0.860 and could detect the presence of hibernating myocardium in 21/29 (72.4%) perfusion defects with a precision of 87.5% (21/24), specificity 85.7% (18/21), CA 78.0% (39/50) and F1 Score 0.792. Four models depicted a clear pattern of model interpretability based on the beeswarm SHAP plots. These were GB RF (xgboost), GB (scikit-learn), GB (xgboost), and Random Forest. Conclusion Our study demonstrates the potential of ML in detecting hibernating myocardium using radiomics features extracted from perfusion defects on rest MPI images. This proof-of-concept underscores the notion that radiomics features capture nuanced information beyond what is perceptible to the human eye, offering promising avenues for improved myocardial viability assessment.

In recent years, the microbiome has been recognized as an important factor associated with cardiovascular disease (CVD), which is the leading cause of human mortality worldwide. Disparities in gut microbial compositions between individuals with and without CVD were reported, whereby, we hypothesized that utilizing such microbiome-based data for training with supervised machine learning (ML) models could be exploited as a new strategy for evaluation of cardiovascular health. To test our hypothesis, we analyzed the metagenomics data extracted from the American Gut Project. Specifically, 16S rRNA reads from stool samples of 478 CVD and 473 non-CVD control samples were analyzed using five supervised ML algorithms: random forest (RF), support vector machine with radial kernel (svmRadial), decision tree (DT), elastic net (ENet) and neural networks (NN). Thirty-nine differential bacterial taxa (LEfSe: LDA &gt; 2) were identified between CVD and non-CVD groups. ML classifications, using these taxonomic features, achieved an AUC (area under the receiver operating characteristic curve) of ~0.58 (RF). However, by choosing the top 500 high-variance features of operational taxonomic units (OTUs) for training ML models, an improved AUC of ~0.65 (RF) was achieved. Further, by limiting the selection to only the top 25 highly contributing OTU features to reduce the dimensionality of feature space, the AUC was further significantly enhanced to ~0.70 (RF). In summary, this study is the first to demonstrate the successful development of a ML model using microbiome-based datasets for a systematic diagnostic screening of CVD.

BackgroundNearly 20% of pregnancies in patients with Systemic lupus erythematosus (SLE) result in an adverse pregnancy outcome (APO); early identification of women with SLE who are at high risk of...

Detecting the presence of a disease requires laboratory tests, testing kits, and devices; however, these were not always available on hand. This study proposes a new approach in disease detection using machine learning algorithms by analyzing symptoms experienced by a person without requiring laboratory tests. Six supervised machine learning algorithms such as J48 decision tree, random forest, support vector machine, k-nearest neighbors, naïve Bayes algorithms, and artificial neural networks were applied in the “COVID-19 Symptoms and Presence Dataset” from Kaggle. Through hyperparameter optimization and 10-fold cross validation, we attained the highest possible performance of each algorithm. A comparative analysis was performed according to accuracy, sensitivity, specificity, and area under the ROC curve. Results show that random forest, support vector machine, k-nearest neighbors, and artificial neural networks outweighed other algorithms by attaining 98.84% accuracy, 100% sensitivity, 98.79% specificity, and 98.84% area under the ROC curve. Finally, we developed a web application that will allow users to select symptoms currently being experienced, and use it to predict the presence of COVID-19 through the developed prediction model. Based on this mechanism, the proposed method can effectively predict the presence or absence of COVID-19 in a person immediately without using laboratory tests, kits, and devices in a real-time manner.

The problem persists despite the heavy consequences of jail and the death penalty imposed on those found guilty of selling drugs. This situation creates an alarm among academics and managers who work in practice. Hotbeds for drug dealers are on the rise, and their financial impact on the global economy is moving forward. Drug peddlers distract society by warping peace, justice, and order and threaten the Sustainable Development Goals (SDGs). This study evaluated secondary data containing qualities and suspect drug groups to determine whether machine learning techniques could predict the suspect drug group. We developed a prediction model using nine machine learning algorithms: AdaBoost (AB), naïve Bayes (NB), logistic regression (LR), K nearest neighbour (KNN), random forest (RF), decision tree (DT), neural network (NN), CN2 and support vector machine (SVM). The study utilized Orange data mining software to obtain a more accurate perspective on the data. Predictive accuracy was determined using 5-fold stratified cross-validation. Friedman’s test was conducted, and the results showed that the performance of each algorithm was significantly different. Also, the study compared the models and compiled the results. The results reveal that the random forest has the highest accuracy compared to the others. This prediction model implies that high accuracy can help the government make informed decisions by accurately identifying and classifying suspected individuals and offenders. This prediction will help the government refer suspected individuals and offenders who meet the qualifications for specific drug law sections, like prosecution or rehabilitation, to those sections with a faster and more accurate rate. The outcome of this study should be helpful to law enforcement agents, analysts, and other drug practitioners who may find machine learning tools dependable to detect and classify drug offenders.KeywordsDrug groupClassificationMachine learningOffendersDrug peddling

Characteristics of the mandible structures have been relevant in anthropological and forensic studies for sex prediction. This study aims to evaluate the coronoid process, condyle, and sigmoid notch patterns in sex prediction through supervised machine learning algorithms. Cephalometric radiographs from 410 dental records of patients were screened to investigate the morphology of the coronoid process, condyle, and sigmoid notch and the Co-Gn distance. The following machine learning algorithms were used to build the predictive models: Decision Tree, Gradient Boosting Classifier, K-Nearest Neighbors (KNN), Logistic Regression, Multilayer Perceptron Classifier, Random Forest Classifier, and Support Vector Machine (SVM). A 5-fold cross-validation approach was adopted to validate each model. Metrics such as area under the curve (AUC), accuracy, recall, precision, and F1 Score were calculated for each model, and ROC curves were constructed. All tested variables demonstrated statistical significance (p < 0.10) and were included in the construction of the predictive model. The Co-Gn variable stood out as the most important among the evaluated independent variables, showing greater relevance in three of the four algorithms used in assessing feature importance. In the analysis of the models’ performance, the AUC ranged from 0.82 [95% CI = 0.72–0.93] to 0.66 [95% CI = 0.53–0.76] for the test data, and from 0.83 [95% CI = 0.80–0.87] to 0.71 [95% CI = 0.61–0.75] for cross-validation. The precision of the models ranged from 0.83 [95% CI = 0.75–0.91] to 0.68 [95% CI = 0.58–0.78] in the test phase, and from 0.78 [95% CI = 0.74–0.82] to 0.69 [95% CI = 0.65–0.75] in cross-validation. The SVM, KNN, and Gradient Boosting Classifier algorithms stood out with the highest AUC and precision values in both cross-validation and testing. The use of condyle, coronoid process, and sigmoid notch characteristics, in combination with supervised machine learning predictive models, shows potential for contributing to sex prediction based on morphometric bone characteristics, particularly regarding the distance between the condyle and gnathion. However, given the study’s limitations, these findings should be interpreted with caution.

Hypertension is the one of the leading causes of cardiovascular morbidity and mortality. Early detection of individuals at elevated risk is critical, yet conventional prediction models fail to capture nonlinear and high-dimensional interactions among epidemiological and behavioral determinants. Machine learning (ML) offers new opportunities for accurate, population-level risk stratification. We conducted a secondary analysis of the Tamil Nadu STEPS survey 2020, applying supervised ML algorithms—including boosting, k-nearest neighbours, decision tree, random forest, and support vector machine—to predict hypertension risk. Predictors included demographic, anthropometric, lifestyle, and behavioral variables. Models were implemented in JASP, and their performance was evaluated using accuracy, area under the receiver operating characteristic curve (AUC), precision, recall, and F1 score. Among the algorithms tested, the random forest classifier demonstrated the most balanced performance (accuracy 65.5%, AUC 0.708, precision 64.2%, recall 65.5%, F1 score 64.7%). Feature importance analysis identified age as the strongest predictor, followed by waist circumference, while diet and physical activity contributed minimally. The confusion matrix confirmed the model’s balanced sensitivity and specificity, reducing both false negatives and false positives. This study highlights the potential of machine learning, particularly random forest models, for hypertension risk prediction in Indian populations. By leveraging routinely collected survey data, ML can enable scalable, non-invasive screening and inform targeted public health interventions. Integration of richer clinical and genetic features and ensemble methods may further improve predictive accuracy.