ABSTRACTObjectives:to develop a framework of core competencies for occupational health nurses based on their professional experience.Methods:an exploratory qualitative study, carried out with occupational health nurses linked to Brazilian and multinational companies, with data collection from January to May 2021, through an electronic form (sociodemographic data), followed by a semi-structured interview. Inductive thematic data analysis was carried out. The study was approved by the Research Ethics Committee.Results:eight core professional competencies for occupational health nurses were identified: legal; effective communication; staff and service management; relational; improvement of work processes; continuing education; health and safety; and research. Their knowledge and skills were synthesized in a competency framework.Final Considerations:the construction of a framework for occupational health nurses should guide managers and training centers in improving these professionals’ knowledge and skills within organizations and academia, aiming at changing their profile and professional recognition.