A 9-year-old boy presented to the emergency department with a facial eruption that emerged following a weekend camping trip. Four days after the trip, the patient developed a progressively worsening rash that initially involved the face characterized by erythema, edema, and pruritus. The patient also developed lesions on the trunk and proximal extremities.

A 52-year-old woman with a history of kidney and pancreas transplantation (17 years prior), end-stage renal disease on dialysis, type 1 diabetes mellitus, hypertension, and class 2 pulmonary hypertension presented to the emergency department (ED) for abdominal distention and pain following surgical repair of a right tibial fracture one week ago.

Mastocytosis is a rare heterogenous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organs, mostly skin and bone marrow and, less frequently, gastrointestinal tract, liver, spleen, and lymph nodes

This case involves an 83-year-old woman with a past medical history of hypertension, colonic polyps, diverticulosis, osteopenia, hypothyroidism, and Stage IIIC1 Grade 3 endometrioid endometrial carcinoma diagnosed 13 months before presentation. The patient presented to the hospital with poor oral intake, failure to thrive, hypotension, and delirium.