Brockenhurst College

As 2023, dawns we are faced with a very different world than at the start of 2022, COVID-19 is in the rear-view mirror, but we now face the war in Ukraine, energy prices and inflation. Perhaps this is a glimpse of the ‘new world’ where we will be continually challenged by crisis whether it be conflict, infectious disease or the impacts of global warming. On a more positive note it has been another busy and productive year for Veterinary Evidence as we strive to continually improve the journal whether you are a reader, author or reviewer. In April we said ‘goodbye’ to Daniel Edwards who had covered Bridget Sheppard’s maternity leave as Managing Editor. I would like to take the opportunity to thank Dan for all his hard work for Veterinary Evidence initiating a number of projects that have come to fruition through the year and to welcome Bridget back. As Veterinary Evidence has grown, we have been fortunate to be able to expand our staff to meet the need and ensure efficient turnaround of submissions so another welcome, William Smith has joined the team and is now a permanent full time Editorial Assistant. It is not just staff changes that happened in 2022, we have also improved the governance of Veterinary Evidence with the appointment of new board members and creation of a Deputy Editor-in-Chief position ably filled by Louise Buckley. We also submitted a successful application to COPE (The Committee on Publication Ethics) further strengthening the journal’s oversight and reputation. We have had a major website redesign, now live, which has greatly improved the look, feel, and functionality of Veterinary Evidence for all users. Readers can find relevant papers quickly and efficiently. Our student awards continue to be a success and I would like to thank the whole team of staff and reviewers for turning round these submissions so quickly. I had the pleasure of talking to the prize-winning authors and it was great to hear their enthusiasm but also how much they have valued the help and support from the journal. We have also been developing our processes for reviewing papers to make sure that papers are ready to go out for review. We are working on ways to make sure that, for papers requiring revision, authors respond to each of the comments made by reviewers, and reviewers can quickly see that there has been an author response to their comments and suggestions. A new submission system, Editorial Manager, has been implemented that should make life easier for everyone as well as provide accessible data on papers as they go through the system so we can see what we do well and where we can do better. None of this would be possible without the input from our reviewers and I would like to take this opportunity to say a huge thank you to all our reviewers and everyone who has served on the Editorial Board this year for their tireless efforts on behalf of Veterinary Evidence – without your support the journal could not exist. This year the Board has again had three online meetings, which have been essential in helping develop the strategy for Veterinary Evidence such as how we ensure our Knowledge Summaries remain current, what literature should be included in Knowledge Summaries and how we improve the reviewer and author experience. Once again, a massive thank you to everyone who works for and supports Veterinary Evidence, wishing you all a safe and productive 2023. Kit Sturgess Editor-in-Chief

Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased protein expression. While reducing CaMK1D expression has a potentially beneficial effect on glucose processing in human hepatocytes, there are no known selective inhibitors of CaMK1 kinases that can be used to validate or translate these findings. Here we describe the development of a series of potent, selective, and drug-like CaMK1 inhibitors that are able to provide significant free target cover in mouse models and are therefore useful as in vivo tool compounds. Our results show that a lead compound from this series improves insulin sensitivity and glucose control in the diet-induced obesity mouse model after both acute and chronic administration, providing the first in vivo validation of CaMK1D as a target for diabetes therapeutics.

The current study reports on a cross-cultural validation of the recently developed Resiliency Scale for Young Adults (RSYA) with two samples consisting of 617 Canadian university students and 651 Chinese university students. Confirmatory factor analysis, tests of cultural invariance, and correlations with relevant individual difference variables were conducted as tests of validity. In the Chinese sample, confirmatory factor analysis supported the factor structure of the RSYA and internal consistency reliabilities for the three factors and 10 facets were good-to-excellent. Cultural and gender invariance were supported. Correlations with depression, anxiety, stress, flourishing, and life satisfaction were also in the expected direction in the Chinese sample. These findings provide additional support for the RSYA as a reliable and valid measure of personal resiliency for Chinese young adults. Findings support the three-factor model of personal resiliency in both Canadian and Chinese young adults, as well as cultural and gender invariance. The robustness of this model has implications for assessing and developing resiliency cross-culturally.

Today, we can create beautiful deep-sky images without capturing a single photon of our own. Some professional observatories put their data online and allow people to access it for free. So all we need to do in order to create our own professional-quality deep-sky images is download this freely available data and then process it for ourselves. However, this puts us in a very difficult position. Why should we spend our hard-earned money and put in hundreds of hours of blood, sweat and tears to get our own imaging system together, if we can produce the pretty pictures without collecting the photons ourselves? After reading this chapter, a few people who had initially thought about building their own imaging system, will be able to bypass this step and simply use freely-available professional data. They would be showing a great deal more common sense than I have.

Preview this chapter: Lack of an association between blood genotype and haemoplasma infection in UK cats, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/10.22233/9781910443446/9781910443446.63.2-1.gif

The aims of this study were to conduct the proof of concept study and to develop and evaluate an educational intervention that promotes the evidence-based supply of non-prescription medicines (NPMs). An educational intervention was delivered to pharmacy assistants and pharmacists in three pharmacies in England. The intervention included the provision of summaries of evidence for the treatment of four minor ailments and resulted in the preparation of evidence-based portfolios for the treatment of the following ailments: athlete's foot, cough, nasal congestion and period pain. The effect of the intervention was evaluated using a combination of direct overt observation, vignettes, self-reported behaviour and interviews. Evaluation data were collected from the three pharmacies. Data were derived from 3 pharmacists and 13 assistants, of whom 10 (3 pharmacists; 7 assistants) attended the training event. Comparing pre- and post-intervention practice, 8/11 (pre-) versus 5/6 (post-) observed, 46/80 versus 62/80 vignette and 25/30 versus 39/40 self-reported recommendations were evidence based. Prior to the intervention, 3/16 participants understood the role of evidence regarding the supply of NPMs compared with 16/16 post-intervention. Participants reported relying upon experiential knowledge to inform their decision making prior to the educational intervention. Thereafter, the participants reported using evidence to a greater extent. Barriers and facilitators for evidence-based practice were also identified. A one-off educational intervention increased participants' self-reported awareness and potential application of evidence to inform their supply of NPMs. Further research is needed to assess the effectiveness, long-term impact, generalisability and cost-effectiveness of this intervention for a wider range of common conditions.

This paper sets out to consider the requirement that social work students studying for the Degree in Social Work should be prepared for and assessed as ready and fit to practice before undertaking their first practice learning opportunity. The purpose of the study is to examine the essential elements of good preparation and to evaluate how well the teaching and assessment has prepared students in the South Yorkshire and North East Midland partnership from the perspective of their practice assessors.This qualitative study involved two key stages. Firstly, a focus group eliciting views from practice assessors on what the purpose and content of preparation for practice should be. Secondly, semi-structured interviews with practice assessors considering how well prepared for practice the first group of Social Work Degree students had been. Interviews were transcribed and data analysed using a ‘framework’ approach. Three major themes emerged, the communication of information on the preparation between student and practice assessor, the ability of students to relate their previous learning to practice and the understanding students demonstrated of the social work task and role.All practice assessors were positive about the benefits that preparation at the universities could have for practice but the majority of students did not share information on their preparation with their practice assessor. From this project it has been possible to make recommendations concerning the content of preparation but most importantly the importance of requiring that information on the content and learning in preparation should be shared by students with their practice assessor as the starting point for making direct links into their first practice learning opportunity.

The area occupied by the former J.A. Symes match factory, Highbridge Road, Barking, was once home to a large steam- and water-powered flourmill. The mill was originally driven by the tidal flow of the River Roding, prior to its expansion and gradual conversion to steam. A residential redevelopment, undertaken in spring 2006, provided an opportunity to conduct a developer-funded archaeological investigation, carried out by Pre-Construct Archaeology Ltd. The excavation exposed the partial, multi-phase remains of the mill's below-ground foundations, in particular the evidence for successive power systems. These remains were interpreted with the help of documentary research, demonstrating the complementary nature of these two forms of evidence on an urban industrial site.