Centro Laser

Patient: Female, 43-year-oldFinal Diagnosis: Hypertrophic and retracting scar on the left upper lipSymptoms: Restriction in upper lip mobility • slight difficulty with oral competence • considerable emotional, social and aesthetic discomfortClinical Procedure: —Specialty: Dermatology • SurgeryObjective: Congenital defects/diseasesBackgroundScars, particularly those that are hypertrophic and retracting, are a major difficulty in dermatological and plastic surgery. Laser therapy offers a versatile approach to managing hypertrophic lip scars, addressing aspects of scar tissue, such as vascularity and collagen.Case ReportThis case report describes a 43-year-old woman treated for a hypertrophic, retracting lip scar using fractional CO2 laser (10 W, 1500 μs dwell time, D-pulse, 500 μm spacing, stack 1, double pass). Two sessions, 56 days apart, led to marked aesthetic and psychosocial improvement without complications. Post-treatment care included 7 days of antibiotic ointment, followed by sun protection and nightly silicone gel. Images were captured before and after the second treatment. During the procedure, the patient reported a perceived pain level of 3 on a scale of 1 to 5, indicating a moderate and tolerable level of discomfort. The Modified Vancouver Scar Scale (mVSS) chart indicated an overall improvement in scar characteristics, especially in pliability, vascularity, and pigmentation, with minimal changes in height; pain and pruritus levels remained unchanged from before the therapy. After treatments, the patient expressed extreme satisfaction with the results achieved. She reported being “extremely content and satisfied” with the improvement in her scar after laser treatment. No significant adverse effects were observed. The estimated reduced daily activity time was approximately 1 week after each session, with normal activities resumed shortly thereafter.ConclusionsThis case highlights the potential of CO2 laser treatment in managing a complex hypertrophic and retracting scar, leading to notable esthetic improvement and a positive impact on the patient’s emotional well-being.

Despite the widespread use of laser heat treatment, a fundamental understanding of austenite formation kinetics at high heating rates remains a challenge. This gap is addressed by developing a novel model that uniquely accounts for the initial pearlite colony size and interlamellar spacing as critical input parameters. The model's predictions are validated against experimental observations, where the spatial variation of hardness reveals a distinct two‐zone microstructure: a fully austenitized region and a partially transformed intercritical layer. The results show that the relative size of these zones is directly controlled by the initial microstructure. This research provides a crucial insight that austenite formation under rapid heating conditions occurs with negligible superheating, which is essential for optimizing laser processing parameters to achieve a desired microstructure.

Quasi-bound states in the continuum in dielectric metasurfacessupport sharp Fano resonances that emerge from the interference betweenbrightand dark modes. We exploit this modal interplay to demonstrate tunablethird-harmonic emission, controlled through the driving pulse’swavelength and intensity. Our experiments show imbalances in third-harmonicdiffraction patterns and non-Gaussian third-harmonic spectral featuresthat exhibit strong variations near the Fano resonance. We explainthe observations via a coupled-oscillator model that captures theinterplay between the driving field and the nonlinear response ofthe modes, explaining our observations and providing a predictiveframework for optimizing the third-harmonic diffraction efficiency.These results establish pulse-engineered metasurfaces as a powerfulplatform for nonlinear wavefront shaping and frequency conversionapplications while simultaneously serving as a warning that pulseproperties play a vital role in metasurface function design.

Betatron x rays generated from laser-wakefield accelerators are a promising source for imaging dynamic processes in materials. Here, we present proof-of-concept imaging of microstructural evolution in a hypermonotectic <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"> <a:mi>Al</a:mi> </a:math> - <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"> <c:mi>Bi</c:mi> </c:math> alloy, which consists of liquid <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" display="inline"> <e:mi>Bi</e:mi> </e:math> particles in a solid <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" display="inline"> <g:mi>Al</g:mi> </g:math> matrix. The images capture the elongation and fragmentation of <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" display="inline"> <i:mi>Bi</i:mi> </i:math> particles upon isothermal annealing. Because of the femtosecond time scale of the betatron source, the images are not subject to motion blur, whereas the accessibility of the source allows for studies of long-term processes such as annealing. The high-resolution data reveal that the evolution of <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" display="inline"> <k:mi>Bi</k:mi> </k:math> particles is mediated by an interplay of grain-boundary wetting and morphological instability, in stark contrast to an earlier proposal for (inverse) coarsening.

This work presents a method for synthesis of ternary defined architecture material based on nickel cobalt double layered hydroxide (NiCoLDH), reduced graphene oxide (RGO) and graphitic carbon nitride (g-CN). Each individual component and ternary material was characterized using SEM, FTIR, Raman and XRD spectroscopy. The CV and GCD measurements were performed in 1M KOH aqueous solution demonstrating this material has a promising potential as cathode active material for aqueous supercapacitors.

Proton transfer is a fundamental process underlying chemical and biological phenomena, and its dynamics are significantly influenced by the surrounding environment. This paper studies the excited state intramolecular proton transfer (ESIPT) process, which is crucial to the photostability of hydroxyanthraquinone-based pigments through efficient energy dissipation, by investigating how crystalline packing influences photoinduced proton transfer dynamics in single crystals of dihydroxyanthraquinone (DHAQ) constitutional isomers. Comparing the proton transfer dynamics in crystalline and solution phases, we show substantial differences due to the crystalline environment, particularly in the 1,4- and 1,5-DHAQ isomers. These isomers show intermolecular hydrogen bonding within the crystal lattice, resulting in larger excitonic couplings, which significantly alters their reaction pathways compared to their behavior in solution. We show that 1,8-DHAQ, which does not form intermolecular hydrogen bonds in the crystal, shows minimal changes in dynamics between the phases. In contrast, in the case of 1,4-DHAQ, intermolecular interactions within the molecular crystal phase open up an ESIPT relaxation channel, which is not observed in the solution phase. These findings highlight the critical role of crystal packing in modulating proton transfer dynamics and offer insights into how molecular packing can be strategically manipulated to control and optimize reaction pathways in solid-state environments.

ABSTRACTBackgroundConventional photodynamic treatment (cPDT) of thin basal cell carcinomas (BCCs) has uncomfortably high rates of incomplete clearance. Incomplete clearance/recurrence rates for superficial BCCs are as high as 40% and even higher for tumours treated on the head and neck. Our experience has been that flushing is more pronounced on the head and neck during cPDT photoactivation. We postulated that haemoglobin, although delivering oxygen, may be acting as a competing chromophore.ObjectivesTo determine whether a 2‐phased photoactivation protocol, in which blood is removed before the second phase intense pulsed light (IPL) activation, improves clearance rates.MethodsRetrospective observational study of 206 treatment‐naïve BCCs ≤ 1 mm thickness treated over a 7‐year period with a 2‐phased photoactivation protocol (‘biphasic PDT’). The first phase consists of conventional red‐light activation (20−37 Jcm−2). Second phase photoactivation uses IPL (30−45 Jcm−2) delivered with sufficient mechanical pressure in the handpiece to blanch the skin.Optical coherence tomography (OCT) has been used to aid in lesion diagnosis, to establish suitability of tumour for treatment and to improve verification of treatment outcomes.ResultsIn the final group of 175 tumours, of which most were located on the head and neck and over 40% were nodular, there were only four incomplete treatments over a 2‐year median follow‐up period (up to 7 years). The few incomplete clearances were easily managed.ConclusionsOne or two biphasic photodynamic treatments are highly effective (98% clearance) in thin, treatment‐naïve BCCs (≤ 1 mm in thickness) selected on clinical and OCT assessment.

Energy-based devices (EBDs) and injectable hyaluronic acid gels, such as VYC-12L, are each effective treatment modalities for improving skin quality. To assess the rationale and potential benefits of adding VYC-12L to EBD treatments, and consider how they can be practically integrated into a single treatment plan. Eight clinicians with various specialties and extensive experience of these modalities completed a written questionnaire and were individually interviewed. Their collective clinical expertise and experience form the basis of this guidance. Using both VYC-12L and EBDs within a single treatment plan offers many potential benefits for improving skin quality-based on mechanistic synergies and complementary abilities to address different attributes and multiple anatomical layers. Careful consideration should be given to appropriate sequencing. VYC-12L and non-ablative EBDs can be used on the same day, but treatment fields must be appropriately managed and aseptic technique rigorously upheld. When administering VYC-12L, maintaining the correct injection depth is essential to positive outcomes. Practitioners should undertake appropriate training and select the injection tools that optimize control. Multimodal treatment using VYC-12L and EBDs together can provide a more comprehensive, tailored approach to skin-quality improvement, delivering high levels of patient satisfaction.

A estética é um fator muito importante em vários âmbitos da sociedade, e a busca pela aparência perfeita e pelo padrão de beleza tem aumentado nos últimos tempos. A reabilitação estética de dentes anteriores é procurada por indivíduos, independente do gênero e da idade. O objetivo deste estudo foi realizar uma revisão de literatura, analisando as evidências científicas disponíveis, sobre a utilização da resina composta na reabilitação estética dos dentes anteriores. A coleta de dados ocorreu entre março de 2022 e julho de 2022 , nas bases de dados Scielo (Brasil Scientific Electronic Library Online) e Lilacs (Scientific and Technical Information on Health in Latin America and the Caribbean) utilizando como descritores: “Reabilitação bucal” (Mouth Rehabilitation); “Materiais Dentários” (Dental Materials); ‘‘Resina Composta (Resina Composta) e “Estética Dental’’ (Esthetics, Dental) Foram incluídos artigos que delimitaram os objetivos do referido tema. A presente revisão mostrou, de acordo com as evidências utilizadas, diversas maneiras de utilização da resina composta na reabilitação estética em dentes anteriores. Assim pode-se concluir que a resina composta mostra-se como material de alta qualidade, a depender do caso, longa duração e alternativa favorável na preservação do elemento dental.

Background: Acne is a pathology of the pilosebaceous unit. It is characterized by a highly complex etiopathology which includes inflammation, hyperkeratinization, increased sebum production, colonization of Cutibacterium acne, hyperandrogenemia, and hyperinsulinemia. This condition, together with hirsutism, androgenic alopecia, and acanthosis nigricans, are highly prevalent cutaneous manifestations of the polycystic ovary syndrome (PCOS). While conventional therapies represent effective treatment options, they are not free from side effects which may reduce compliance. In this context, considerable attention has been directed toward nutraceutical supplements, which include different molecules with great potential to reduce inflammation, hyperkeratinization, hyperseborrhea, and hyperinsulinemia. Myo-inositol has been shown to be effective in improving some of the signs and symptoms of patients with microcystic ovaries: reducing body mass index (BMI), testosterone free levels, dehydroepiandrosterone sulfate (DHEAS) levels, and improving ovarian function and insulin sensitivity. Methods: The authors conducted a retrospective study that included 200 patients suffering from PCOS. Over 6 months, they analyzed the effects of the supplementation of LEVIGON™ (Sanitpharma; Milan, Italy)-a specific nutraceutical formulation containing myo-inositol, microlipodispersed magnesium, and folic acid-on the clinical picture of acne and hirsutism. Results: The supplementation of LEVIGON™ showed a significant reduction of BMI, testosterone, testosterone free, and DHEAS levels, thus improving the clinical picture of acne and hirsutism. Moreover, the impact of acne on the quality of life, assessed using the Cardiff Acne Disability Index (CADI) and Dermatology Life Quality Index (DLQI) scale, improved significantly after 3 and 6 months. Women with hirsutism benefited also from a significant improvement of the Ferriman-Gallwey score after both 3 and 6 months (p < 0.0001; p < 0.0001 respectively compared to the baseline). Conclusions: Myo-inositol supplementation, associated with microlipodispersed magnesium in a bioaccessible form, proved to be extremely useful in reducing acne and hirsutism in patients suffering from microcystic ovaries. In addition, there were no side effects, thus confirming excellent compliance. Further long-term randomized clinical trials are needed to confirm this preliminary evidence.