Leeds College of Building

<bold>Background:</bold> The treatment landscape of SSc-ILD has changed over the past decades. <bold>Objective:</bold> Evaluate current treatment regimens and identify factors associated with these strategies. <bold>Methods:</bold> SSc-ILD patients from the EUSTAR database starting immunesuppresive and/or anti-fibrotic therapies ≥2017 were included. Treatment regimens, including mono and combination therapies, switch and discontinuation and factors associated with treatment decisions, were analyzed using multivariable logistic regression. <bold>Results:</bold> Among 277 patients, 159 (57.4%) were started on treatment: 377 regimens with mycophenolate mofetil, 186 with methotrexate, 257 with rituximab and 122 with tocilizumab were identified, Figure 1 summarized combinations. 14% of regimens were switched and 24% were discontinued. Factors associated with combination therapies included younger age (OR 0.97, p<0.001), lower %pDLCO (OR 0.98, p=0.008), and diffuse SSc (OR 1.77, p=0.009). Switching therapies was associated with diffuse SSc (OR 1.90, p=0.038) and arthritis (OR 2.97, p=0.012); no factors were identified for discontinuation. <bold>Conclusion:</bold> Currently, the majority of SSc-ILD patients are treated with an immunosuppressive agent, often in combination regimes. Multiorgan manifestation significantly impact treatment choices. Figure 1. Treatment regimens in SSc-ILD: A mycophenolate mofetil-; B methotrexate-; C rituximab-,D tocilizumab -based regimens. <fig><object-id>erj;66/suppl_69/PA4060/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Most alumni donation studies rely on retrospective analysis and generic donor profiles. This research adopts a novel approach by identifying critical touchpoints in the undergraduate student journey to predict future alumni donors. The results uncover new factors that significantly contribute towards enhancing the quality of higher education. This broader perspective of the critical factors impacting higher education quality has major implications for the management and allocation of scarce university resources. The study confirms that student centred pedagogy significantly influences future donation intentions. Additionally, the results reveal that learning transferable skills, confidence in achieving career aspirations, confidence in meeting income expectations and having valued social experiences significantly impact a student's intention to donate. These findings have major practical and strategic implications for university executives and alumni departments seeking to generate policies that enhance quality in higher education through investments that result in a positive and holistic learning experience, ultimately leading to an increased likelihood of future donations from current students. This research offers university leadership a lifeline to address the current financial crisis that higher education institutions (HEIs) find themselves in due to capped tuition fees, high inflation, increased salary and tax obligations and falling numbers of international students.

JPB is an employee of Gilead Sciences, Inc. SLR and KLD are employees of Pfizer. JB is an employee of EMD Serono. JPB, SLR, KLD, and JB holds stock in their respective companies. DJP is an employee of Lhasa Limited, a nonprofit organization. RT is an employee of the University of Washington and declares no conflict of interest. Table S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Abstract The impact of the external environment on strategy is a long debate in the “traditional” strategic management theory. In contrast, future studies have a clearer view, having established that the environment is perceived and has a direct impact on how the future is anticipated. The same field has grown significantly, in the last two decades, with regard to how companies should foresight the future, looking into their external environment. However, we observe that there is a lack of retrospective research on how companies have embraced extreme environmental events, surprises, and wildcards which led to crisis with regard to their perception of the external environment and the strategies developed for the future. This study fills this gap with a multimethodological approach, combining survey and archival data, to examine the relationship between the perceived environmental turbulence and corporate strategy in some of the largest UK‐listed companies. We use the recession of the UK economy in 2008 as the key phenomenon to compare the relationship between perceptions of the environment and corporate strategy before the economic recession (2007) and after (2009). With our analysis, we provide evidence of how the environment influences corporate strategy and we show how a wildcard, like the recession, changed the perception of environmental turbulence, which resulted in greater adoption of the risk averse, retrenchment strategies.

The aim was to assess study factors that impact the association of cognitive disorders in people with periodontal disease (PD). Medline, EMBASE and Cochrane databases were searched until February 2022 using keywords and MeSH: (periodon* OR tooth loss OR missing teeth) AND (dementia OR Alzheimer's Disease OR cognitive*). Observational studies reporting prevalence or risk of cognitive decline, dementia or Alzheimer's disease (AD) in people with PD compared with healthy controls were included. Meta-analysis quantified the prevalence and risk (relative risk[RR]) of cognitive decline, dementia/AD, respectively. Meta-regression/subgroup analysis explored the impact of study factors including PD severity and classification type, and gender. Overall, 39 studies were eligible for meta-analysis: 13 cross-sectional and 26 longitudinal studies. PD demonstrated increased risks of cognitive disorders (cognitive decline-RR = 1.33, 95% CI = 1.13-1.55; dementia/AD-RR = 1.22, 95% CI = 1.14-1.31). Risk of cognitive decline increased with PD severity (moderate-[RR] = 1.14, 95% confidence interval [CI] = 1.07-1.22; severe-RR = 1.25, 95% CI = 1.18-1.32). For every 10% population increase in females, the risk of cognitive decline increased by 34% (RR = 1.34, 95% CI = 1.16-1.55). Self-reported PD showed a lower risk of cognitive disorders compared with clinical classification (cognitive decline-RR = 0.77, 95% CI = 0.65-0.91; dementia/AD-RR = 0.86, 95% CI = 0.77-0.96). The prevalence and risk estimates of cognitive disorders in association with PD can be influenced by gender, the disease classification of PD and its severity. Further homologous evidence taking these study factors into consideration is needed to form robust conclusions.

This chapter argues for leaderless organizations, but more than preaching for their desirability, it outlines their practicability. To do so, a key argument is that different forms of learning and development are required within leaderless organizations, and we present two specific coaching practices. The first is a learning informed coaching, with a focus on coachees and their learning styles, to enable learning about operating in a network where values of cooperation, trust and collaboration become important. The second approach is community of discoveries where the coach facilitates learning through diversity. It supports the exploration of multiple worldviews, social positions and ways of knowing within a community to understand how we think differently. Both are eco-friendly practices that are community-centric to sustain collective leadership, standing in sharp contrast with dominant coaching practices principally concerned with “massaging egos” through the reproduction of established positions with an exaggerated preoccupation of selves.

PurposeThis paper aims to develop and test a conceptual model of supplier selection decisions in the public sector. The study seeks to determine the relative importance of a broad range of non-economic variables in explaining supplier selection decisions during strategic organizational purchases.Design/methodology/approachData were collected from a national sample of 341 senior staff and top management team (TMT) members in 40 public sector organizations in Nigeria by using structured questionnaires.FindingsResults of structural equation modeling (SEM) analysis shows that government policy requirements, social ties of organizational actors, party politics, decision-makers’ experience and the perception of instrumental ethical work climates are the most important determinants of strategic supplier selection decisions, followed in a descending order of importance by the perception of rules ethical work climates, self-enhancement personal values, CEOs’ structural position, self-transcendent personal values and the perception of time pressure. Findings also indicate that the choice of a supplier per se is not an important determinant of organizational performance.Originality/valueNo prior study has brought together, in a single model, the broad range of variables employed in this study with a view to exploring their relative importance in explaining public sector supplier selection decisions in a non-western country context. The findings of this study have implications for Marketing Managers looking to do business with public sector firms in emerging markets.