National Forensic Institute

Latent fingerprint research requires reproducible test materials that realistically mimic natural prints for the evaluation of development techniques. This study presents a novel artificial latent fingerprint solution that incorporates lipid components derived from the human body, simulating the composition of natural sweat and sebum, and combines them with traditional amino acid-based solutions. To improve solubility of non-polar lipid molecules, a 1:1 (v/v) mixture of n-hexane and isopropyl alcohol was used as the solvent, and the solution was loaded into printer cartridges to deposit standardized fingerprint-sized images on A4 paper, OHP film, and thermal paper. Development was carried out using established reagents, including ninhydrin, 1,2-indandione (1,2-IND), oil red O (ORO), and nile red (NR) for porous substrates; cyanoacrylate (CA) fuming with basic yellow 40 (BY 40), black, and fluorescent powders for nonporous substrates; and ThermaNin®, 1,2-IND + polyvinylpyrrolidone (1,2-IND + PVP), ORO, and NR for thermal paper. The artificial prints showed broad compatibility across porous, nonporous, and thermal surfaces. Clear ridge detail and identifiable minutiae were consistently observed with most reagents, although NR exhibited limited fluorescence. All developed prints were identical, ensuring reproducibility for controlled testing. These findings demonstrate that the proposed solution provides a realistic and standardized tool for forensic validation of fingerprint development methods, including challenging substrates such as thermal paper.

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Violence toward healthcare professionals represents a critical challenge to clinical safety and the therapeutic alliance. 1lthough most individuals with schizophrenia are not violent, a small subgroup may commit severe acts when untreated psychosis and treatment non-adherence converge. 2We report five forensic cases involving male patients with schizophrenia who perpetrated homicide (n=2) or attempted homicide (n=3) against their treating physicians.These cases were reviewed as part of routinely collected clinical and legal records within the National Forensic Hospital; the Institutional Review Board approved this analysis and waived the requirement for written consent due to the retrospective design and the use of anonymized information (Approval No. 1-219577-AB-N-01-202503-BR-002-01).Across all cases, several shared clinical patterns were observed.The patients were single, unemployed, and had experienced long illness durations with repeated relapses.The most striking commonality was the presence of active persecutory delusions explicitly directed toward the physician or the treatment process.These delusions produced a total rupture of trust, transforming the physician-typically the core therapeutic figure-into a perceived persecutor.A second shared pattern was severe treatment non-adherence.Four of the five patients had discontinued medication or were receiving irregular treatment immediately before the offense.Despite the psychotic motivation, all cases showed elements of planning: acquiring a knife or blunt object in advance, choosing the timing of the attack, or waiting for a mo-

BackgroundHuman papillomavirus (HPV) independent cervical malignancies (HPV-IDCMs) have recently been classified by the World Health Organization (WHO) 5th edition. These malignancies have historically received limited attention due to their rarity and the potential for evasion of HPV-based screening.MethodsWe retrospectively reviewed 5,854 biopsy-confirmed cervical malignancies from 22 institutions over 3 years (July 2020–June 2023). Histologic classification followed the WHO guidelines. HPV independence was confirmed by dual negativity for p16 and HPV; discordant cases (p16-positive/HPV-negative) underwent additional HPV testing using paraffin-embedded tissue. Cytological results were matched sequentially to histological confirmation.ResultsThe prevalence of HPV-IDCM was 4.4% (257/5,854) overall and was 3.6% (208/5,805 cases) among primary cervical malignancy. Patient age of HPV-IDCM was 29 to 89 years (median, 57.79). Its histologic subtypes included primary adenocarcinoma (n = 116), endometrial adenocarcinoma (n = 35), squamous cell carcinoma (n = 72), metastatic carcinoma (n = 14), carcinoma, not otherwise specified (n = 10), neuroendocrine carcinoma (n = 3), and others (n = 7). Among 155 cytology-histological matched cases, the overall and primary Pap test detection rates were 85.2% (132/155) and 83.2% (104/125), respectively. The interval between cytology and histologic confirmation extended up to 38 months.ConclusionsHPV-IDCMs comprised 3.6% of primary cervical malignancies with a high detection rate via cytology (83.2%). These findings affirm the value of cytological screening, particularly in patients with limited screening history or at risk for HPV-independent lesions, and may guide future screening protocols.