Peralta Community College District

ABSTRACT After rebounding from near extirpation during the organochlorine era, breeding Peregrine Falcons ( Falco peregrinus ) in California are again facing adversity, this time consistent with an outbreak of a highly pathogenic avian influenza. Following the first detection of the H5N1 variant clade 2.3.4.4b virus in California wild birds in July 2022, we assembled data from long-term monitoring (2000–2025) of peregrine breeding territory occupancy in the broad vicinity of San Francisco Bay to examine possible impacts on falcon populations. Prior to the outbreak, 47 focal breeding territories had shown nearly complete occupancy by pairs (98.5% of 390 site-years), with very few vacancies, single birds in attendance, or subadult pair members. Within 8 mo of the outbreak, occupancy had dropped to 65.1%, and 2 yrs later (2025), only 36.2% of sites remained occupied. An uptick in site-occupancy by single birds also occurred after the outbreak, but it is unclear whether these were survivors or floaters attempting to fill vacant territories where both pair members had perished. The high vacancy rates signaled an impact upon floaters (nonbreeding adults) that normally buffer breeding site-occupancy in healthy peregrine populations. From October 2022 through November 2025, 17 peregrine fatalities were diagnosed with H5N1 within the counties comprising our study area. Evidence that H5N1 caused these territory vacancies includes, (1) the striking temporal coincidence of occupancy loss with the outbreak, and (2) the lethality of the virus to peregrines and its confirmed presence in peregrine prey in our study area. Our study reaffirms the value of long-term territory occupancy monitoring in this sentinel species.

Data visualization has become an increasingly important means of effective data communication and has played a vital role in broadcasting the progression of COVID-19. Accessible data representations, however, have lagged behind, leaving areas of information out of reach for many blind and visually impaired (BVI) users. In this work, we sought to understand (1) the accessibility of current implementations of visualizations on the web; (2) BVI users’ preferences and current experiences when accessing data-driven media; (3) how accessible data representations on the web address these users’ access needs and help them navigate, interpret, and gain insights from the data; and (4) the practical challenges that limit BVI users’ access and use of data representations. To answer these questions, we conducted a mixed-methods study consisting of an accessibility audit of 87 data visualizations on the web to identify accessibility issues, an online survey of 127 screen reader users to understand lived experiences and preferences, and a remote contextual inquiry with 12 of the survey respondents to observe how they navigate, interpret, and gain insights from accessible data representations. Our observations during this critical period of time provide an understanding of the widespread accessibility issues encountered across online data visualizations, the impact that data accessibility inequities have on the BVI community, the ways screen reader users sought access to data-driven information and made use of online visualizations to form insights, and the pressing need to make larger strides towards improving data literacy, building confidence, and enriching methods of access. Based on our findings, we provide recommendations for researchers and practitioners to broaden data accessibility on the web.

Abstract Conserving wide-ranging animals requires knowledge about their year-round movements and resource use. Golden Eagles (Aquila chrysaetos) exhibit a wide range of movement patterns across North America. We combined tracking data from 571 Golden Eagles from multiple independent satellite-telemetry projects from North America to provide a comprehensive look at the magnitude and extent of these movements on a continental scale. We compared patterns of use relative to four alternative administrative and ecological mapping systems, namely Bird Conservation Regions (BCRs), U.S. administrative migratory bird flyways, Migratory Bird Joint Ventures, and Landscape Conservation Cooperatives. Our analyses suggested that eagles initially captured in eastern North America used space differently than those captured in western North America. Other groups of eagles that exhibited distinct patterns in space use included long-distance migrants from northern latitudes, and southwestern and Californian desert residents....

The pitfalls of using key words to support students when problem solving, and an alternative way (quantitative analysis) to support students' sense-making. Research from this article will show teachers how to use quantitative analysis to help guide problem solving in the classroom.

Journal Article BOOK REVIEWS Get access Breast Cancer: Cellular and Molecular Biology. Marc E. Lippman, Robert B. Dickson, eds. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1988, 397 pp. $117.50. HELAN S. SMITH HELAN S. SMITH Peralta Cancer Research Institute3023 Summit St. Oakland, CA 94609 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 7, 5 April 1989, Page 540, https://doi.org/10.1093/jnci/81.7.540 Published: 05 April 1989

By using a unique short-term culture system capable of growing both normal and malignant breast epithelial tissue, human recombinant tumor necrosis factor (TNF) showed preferential cytotoxicity to malignant cells as compared to the corresponding nonmalignant cells. Most of the malignant specimens were sensitive to TNF with 13 of 18 specimens showing 90% inhibition of clonal growth (ID90) by less than 500 units of TNF per ml of culture fluid. In contrast, all 13 nonmalignant specimens tested clustered at the resistant end of the TNF response spectrum, with ID90 values being greater than 5000 units of TNF per ml of culture fluid. This differential sensitivity to TNF was seen in three cases in which malignant and nonmalignant breast epithelial tissues from the same patient were studied. To investigate the mechanism of resistance to TNF by normal cells, the presence of receptors for TNF was determined. Five of six cultures showed specific binding of 125I-labeled TNF and there was no relationship between the degree of resistance and the degree of specific binding. Simultaneous comparison of tumor responsiveness to doxorubicin and TNF revealed a positive correlation in ID90 values; these results may have important implications for the clinical use of TNF in cancer patients heavily pretreated with doxorubicin.