Sunovion (United Kingdom)

Artificial intelligence (AI) has disrupted human resource management (HRM) and, in particular, performance management systems (PMSs). Using AI for PMS can allow data analytics, machine learning, and automation to create objective, transparent, and efficient means of performance evaluation. As is well known, the IT industry shows a faster pace of adopting new technologies, quickly investing in the automation of performance management tools to optimize workforce productivity while simplifying appraisal tools. On the other hand, acceptance and effectiveness of these AI systems significantly depend on the perception of employees on the same. This research intends to comprehend the perception of IT professionals of Chennai towards AIenabled performance management systems, in terms of trust, satisfaction, and concerns on these aspects. The research issues considered are the effect of AI-based PMS on employee retention; perceived accuracy and fairness of evaluations conducted by the AI system; and problems faced by the employees in adjusting to AI evaluations. Comprehensive insights will lead to an understanding of factors that influence employee acceptance of AI-powered PMS, such as algorithmic biases, concerns about data security, automated decisionmaking without some form of human empathy, and transparency in decision-making. The study results will go ahead in adding practical value to the IT organization whose objective is to install AI-driven PMS in their systems for employee fear curtailment when the implementation of AI technologies is undertaken in their HR activities. As emphasized in the research title, AI should be giving support to, not essentially replacing, human judgments in performance evaluations. Transparency, fairness, and ethics in AI will install trust in employees and will contribute to the more effectual and inclusive AI-based performance management system. Here lays yet another ingredient for building the arguments of AI into HRM with empirical evidence in the field of employee perceptions saluting the fine-tuning of AI strategies of organizations in becoming more involved in making a pronounced direction for a much more human-focused AI use in performance evaluation in the IT arena.

Abstract Counterfeiting has emerged as an increasingly severe global concern, posing significant threats to the security of individuals and society. In this study, a series of multilayered information‐encrypted composite materials is developed by embedding a chiral nematic cellulose nanocrystal ( cn ‐CNC) film inside a shape‐memory polymer (SMP) matrix to produce pressure‐responsive photonic crystals. The design also incorporates a cellulose acetate film, as a thermoset information carrier, and graphene oxide (GO), as a secrecy filter. In its initial state, the composite shows no information, while a pattern becomes visible to reveal the information upon hot‐pressing, due to the region‐dependent differences in its photonic responsiveness caused by the rigid pattern. A discernible mark remains even after recovery, serving as tangible evidence of the decrypted information. Moreover, the high color fidelity of these materials is confirmed using reflectance spectroscopy and color analysis over multiple cycles, demonstrating their potential in cyclic information encryption. By harnessing thermal and mechanical stimuli for anti‐counterfeiting purposes, these composites diversify the strategies available for information encryption.

chamado ao para transformar culturalmente os espaos de cuidado pr-natal, promovendo um ambiente mais respeitoso e equitativo para todas as pessoas gestantes.

automedicao e seus riscos associados.A abordagem no contexto assistencialista do Sistema nico de Sade tambm se faz necessria para abordar os riscos e consequncias da automedicao, considerando que tal prtica pode ter implicaes graves, at mesmo resultando em bitos devido a reaes adversas (RAM).

Estima-se que cerca de 9,2% da população brasileira possua a Diabetes Mellitus tipo 2, uma doença crônica que tem início insidioso e geralmente assintomático, figurando entre as principais doenças responsáveis por uma queda significativa na qualidade de vida na população, sendo muitas vezes correlacionada com o envelhecimento populacional e maus hábitos de vida e alimentares. Um bom controle farmacológico dos níveis glicêmicos faz-se fundamental, principalmente em relação aos desfechos micro e macrovasculares, desse modo, põe-se em revisão o custo-benefício dos tratamentos utilizados nessa doença. OBJETIVOS: Analisar, baseado na literatura disponível, o custo-benefício entre os tratamentos medicamentosos para Diabetes Mellitus tipo 2. METODOLOGIA: Buscou-se artigos completos em inglês do tipo ensaio clínico controlado, publicados na MEDLINE no período entre 2022 e 2023, com a utilização dos descritores "Medicamento", "Diabetes Mellitus Tipo 2" e "Análise Custo-Benefício" unidos pelo operador booleano "AND", com assunto principal sendo Diabetes Mellitus Tipo 2. RESULTADOS: Embora alguns medicamentos possuíssem custo primário mais elevado, os benefícios para saúde evitavam custos secundários por complicações ou efeitos indiretos da medicação. Um dos estudos analisados demonstrou que o uso de 1 mg de semaglutida uma vez por semana, embora com custo mais elevado, é mais vantajoso que 300 mg ao dia de canagliflozina, uma vez que reduz o valor previsto com insulina, além de favorecer maior perda de peso e despesas com problemas cardíacos como infarto, insuficiência cardíaca congestiva e retinopatia. Outro estudo avaliando o medicamento dapagliflozina, evidenciou que em uma perspectiva de 30 anos, o fármaco preveniria 17 eventos macrovasculares (495 X 512) em uma coorte de 1.000 pacientes, comparando-se com o placebo; 17 internações por insuficiência cardíaca (123 X 140) e 7 eventos microvasculares (124 X 131), com um custo total de € 56.984 com dapagliflozina e € 59.905 com placebo, economizando € 2.921, por paciente. CONCLUSÃO: É patente o risco de vida que as complicações que a Diabetes Mellitus 2 predispõe ao paciente. Conclui-se que custos adicionais de aquisição de algumas medicações, sobretudo as mencionadas, são compensados por benefícios para a saúde do paciente, pois reduzem despesas com eventos micro e macrovasculares.

Describe the use of maintenance oral carbidopa/levodopa (CD/LD), adjunctive treatment (“ON-extenders”), and “on-demand” treatment in patients with Parkinson’s disease (PD) that reside in long-term care (LTC) facilities.

<p><strong>Постановка проблеми.</strong> Міжнародні відносини у сфері вирішення екологічних проблем, і зокрема проблеми зміни клімату, характеризуються використанням різноманітних інструментів, які охоплюють як традиційні джерела міжнародного права (так зване hard law), так і ті, які не мають юридично зобов’язальної сили (soft law). Складність управління змінами клімату, його фрагментарність та децентралізованість, зумовлюють необхідність пошуку гнучких засобів та методів його здійснення. Тому визначення особливостей правової природи та ролі "політичних домовленостей" як елементів екологічній дипломатії має як теоретичне, так і практичне значення. <strong>Метою</strong> статті є визначення впливу неформальних угод та інших джерел м’якого права на регулювання відносин у сфері охорони навколишнього середовища, зокрема їх роль у кліматичній дипломатії. <strong>Методи. </strong>Для досягнення мети дослідження було використано комплекс загальнонаукових і спеціальних методів дослідження. Формально-юридичний метод використовувався для здійснення аналізу змісту міжнародних актів з охорони клімату, що використовуються у дипломатичній практиці; порівняльно-правовий метод – для з’ясування особливостей використання актів м’якого права та традиційних міжнародних договорів для регулювання співробітництва держав у сфері зміни клімату; метод системного аналізу – для виявлення внутрішніх зв’язків між нормами неформальних угод та формальними джерелами міжнародного права у сфері охорони клімату. <strong>Результати.</strong> Встановлено,<strong> </strong>що хоча формальні правила є важливими характеристиками сучасного глобального управління, у деяких ситуаціях неформальні практики можуть скасовувати, замінювати чи доповнювати формальні положення. Особливо яскраво це проявляється у співпраці держав у сфері охорони навколишнього середовища. <strong>Висновки. </strong>Показано, що взаємодія держав поза межами традиційних міжнародних організацій за допомогою неформальних угод та інших політичних інструментів створює основу для гнучкого реагування на нові виклики розвитку та дозволяє знаходити рішення проблем, які охоплюють багато різних сфер.</p>\n\n<p><strong>Problem statement</strong>. International relations in the field of solving environmental problems, and in particular the problem of climate change, are characterized by the use of a variety of instruments, and tools, covering both traditional sources of international law (the so-called hard law) and non-legally binding force (soft law). The complexity of climate change management, its fragmentation and decentralization necessitate the search for flexible means and methods for its implementation. Therefore, the definition of the features of the legal nature and the role of political agreements as elements of environmental diplomacy is of both theoretical and practical importance. The article<strong> purpose</strong> to determine the impact of informal agreements and other sources of soft law on the regulation of relations in the field of environmental protection, in particular their role in climate diplomacy. <strong>Methods.</strong> To achieve the goal of the study, a set of general scientific and special research methods was used. The formal-legal method was used to analyze the content of international acts on climate protection used in diplomatic practice; the comparative law method – was to clarify the peculiarities of the use of soft law and traditional international treaties to regulate cooperation between states in the field of climate change; method of system analysis – to identify internal links between the rules of informal agreements and formal sources of international law in the field of climate protection. <strong>Results.</strong> It has been found that while formal rules are important features of modern global governance, in some situations informal practices may repeal, replace or supplement formal provisions. This is especially evident in the cooperation of states in the field of environmental protection. <strong>Conclusions.</strong> The interaction of states outside traditional international organizations through informal agreements and other policy instruments provides a basis for a flexible response to new development challenges and allows solutions to problems that cover many different areas.</p>

To compare motor improvement after apomorphine sublingual film (APL) versus levodopa administration in patients with Parkinson’s disease (PD) and “OFF” episodes.