Deep convolutional neural network for mammographic density segmentation

Breast density is one of the most significant factors that is associated with cancer risk. In this study, our purpose was to develop a supervised deep learning approach for automated estimation of percentage density (PD) on digital mammograms (DMs). The input ‘for processing’ DMs was first log-transformed, enhanced by a multi-resolution preprocessing scheme, and subsampled to a pixel size of 800 µm × 800 µm from 100 µm × 100 µm. A deep convolutional neural network (DCNN) was trained to estimate a probability map of breast density (PMD) by using a domain adaptation resampling method. The PD was estimated as the ratio of the dense area to the breast area based on the PMD. The DCNN approach was compared to a feature-based statistical learning approach. Gray level, texture and morphological features were extracted and a least absolute shrinkage and selection operator was used to combine the features into a feature-based PMD. With approval of the Institutional Review Board, we retrospectively collected a training set of 478 DMs and an independent test set of 183 DMs from patient files in our institution. Two experienced mammography quality standards act radiologists interactively segmented PD as the reference standard. Ten-fold cross-validation was used for model selection and evaluation with the training set. With cross-validation, DCNN obtained a Dice’s coefficient (DC) of 0.79 ± 0.13 and Pearson’s correlation (r) of 0.97, whereas feature-based learning obtained DC = 0.72 ± 0.18 and r = 0.85. For the independent test set, DCNN achieved DC = 0.76 ± 0.09 and r = 0.94, while feature-based learning achieved DC = 0.62 ± 0.21 and r = 0.75. Our DCNN approach was significantly better and more robust than the feature-based learning approach for automated PD estimation on DMs, demonstrating its potential use for automated density reporting as well as for model-based risk prediction.

Recommending music based on a user’s music preference is a way to improve user listening experience. Finding the correlation between the user data (e.g., location, time of the day, music listening history, emotion, etc.) and the music is a challenging task. In this paper, we propose an emotion-aware personalized music recommendation system (EPMRS) to extract the correlation between the user data and the music. To achieve this correlation, we combine the outputs of two approaches: the deep convolutional neural networks (DCNN) approach and the weighted feature extraction (WFE) approach. The DCNN approach is used to extract the latent features from music data (e.g., audio signals and corresponding metadata) for classification. In the WFE approach, we generate the implicit user rating for music to extract the correlation between the user data and the music data. In the WFE approach, we use the term-frequency and inverse document frequency (TF-IDF) approach to generate the implicit user ratings for the music. Later, the EPMRS recommends songs to the user based on calculated implicit user rating for the music. We use the million songs dataset (MSD) to train the EPMRS. For performance comparison, we take the content similarity music recommendation system (CSMRS) as well as the personalized music recommendation system based on electroencephalography feedback (PMRSE) as the baseline systems. Experimental results show that the EPMRS produces better accuracy of music recommendations than the CSMRS and the PMRSE. Moreover, we build the Android and iOS APPs to get realistic data of user experience on the EPMRS. The collected feedback from anonymous users also show that the EPMRS sufficiently reflect their preference on music.

The deep convolutional neural network has been extensively applied for clinical computer-aided diagnosis. In this study, we combine deep learning feature extraction and eXtreme gradient boosting (XGBoost) classifier for predicting the risk of esophageal varices (EV). First, the quantitative deep learning features and radiomics features of the regions of interest which includes spleen, liver and esophageal are extracted and concatenated. Then, XGBoost and the Least Absolute Shrinkage and Selection Operator (LASSO) are applied for the optimal predictive features selection and prediction of EV risk. XGBoost is used to assess the significance of the extracted features and LASSO is used to select the distinctive features. Finally, random forest, XGBoost and support vector machine classification methods are applied for predicting the low-risk and high-risk of esophageal varices. We collected computed tomography images of cirrhotic patients in two hospitals as the independent training and validation sets. Experimental results show that the features of esophageal are more distinctive than that of other organs. Moreover, the combination of deep learning and radiomics features based on XGBoost algorithm has outperforming classification performance in predicting the severity of EV disease compared to existing approaches.KeywordsEsophageal varicesDeep learningRadiomicsXGBoost

e18052 {\rtf1\ansi\ansicpg936\cocoartf1347\cocoasubrtf570 {\fonttbl\f0\froman\fcharset0 Times-Roman;\f1\fnil\fcharset0 Calibri;\f2\fswiss\fcharset0 Helvetica; \f3\fnil\fcharset134 STHeitiSC-Light;\f4\froman\fcharset0 TimesNewRomanPSMT;} {\colortbl;\red255\green255\blue255;\red0\green0\blue0;} \paperw11900\paperh16840\margl1440\margr1440\vieww25400\viewh13600\viewkind0 \deftab720 \pard\pardeftab720 \f0\fs24 \cf2 \expnd0\expndtw0\kerning0 \outl0\strokewidth0 \strokec2 AI platform in mammagraphy to screening breast cancer: a sole center experence. \f1\fs21 \cf0 \kerning1\expnd0\expndtw0 \outl0\strokewidth0 \ \pard\pardeftab720\ri714\qj \cf0 Background: The aim of this study was to use deep convolutional neural network (DCNN) to relieve radiologists ' burden and to minimize misses and interpretation errors of suspicious lesions at digital mammography. Methods: We developed and trained the DCNN model on the training set, then validated it in an internal validation set. The labeled data were used for training the DCNN model, and the mass detection, calcification detection and benign and malignant diagnosis were interpreted respectively. After verifying the feasibility of the DCNN model in the diagnosis of breast cancer, we gradually increased the number of cases in the training set and established the verification set to test the training results. The latest training sets include 21100 atlas of our hospital between April 2010 and October 2017, among which the malignant case atlas is 1774. Each atlas contains 2 ipsilateral mammography images. The verification set includes 1307 atlas, among which the malignant case atlas is 248. Results: The DCNN model achieved high performance in identifying breast cancer patients in the validation sets tested, with sensitivity of 98.02%, specificity of 91.86% \f3 \'a3\'ac \f2 and area under the curve values of 0.9813. As for mass detection, we reached a recall rate of 89.6% on the premise of lowing the false positive to 0.168%. For the latest clinical data between October 2018 and November 2018 including 1043 atlas from 576 patients, the sensitivity was 78.6% (95%CI 62.8-89.1) versus 90.5% (95%CI 76.5 \f4 - \f2 96.9; p=0.021) and specificity was 93.4% (95%CI 91.6 \f4 - \f2 94.8) versus 82.7% (95%CI 80.2 \f4 - \f2 85 \f4 . \f2 0; p<0.0001). Conclusions: The DCNN model showed improved specificity in diagnosis breast cancer compared with a group of skilled radiologists. As the number of cases in the training set increases, the capacity of DCNN model will be further improved.

This paper presents a model of Deep Convolutional Neural Networks (CNN) based on transfer learning for image recognition. This means to use a Deep CNN system pretrained on the large ImageNet dataset of 14 million images and 1000 classes in order to learn feature selection. The results of the pretraining phase are transferred to the problem of classification for the images belonging to the UC Merced Land Use dataset with 21 classes. As benchmark, we have considered a Deep CNN trained with a fraction of the same UC Merced Land Use dataset containing the test images for classification. The experimental results have pointed out the obvious advantage of the Deep CNN with transfer learning (accuracy of 0.87 using pretraining over 0.46 for fully training on the same dataset).

Self-mixing interferometry (SMI) is superior to other laser interferometry methods due to its simplicity and compactness. However, SMI signals are often complex and difficult to process due to interference in the form of variations in the effective reflectivity of the target, noisy signals, complex signal shapes, and other dependencies. Deep neural networks have been a very popular area of research in computer artificial intelligence in recent years, allowing more implicit features to be uncovered than traditional shallow machine learning. It has been shown that convolutional and back-propagation neural networks can be used for SMI signal processing. There are also studies that have used machine learning genetic algorithms for absolute distance measurement. Based on the above, this study used convolutional neural networks to form a deep neural network for absolute distance measurement based on SMI technology. We first trained the deep convolutional neural network at different feedback strengths. The results of the Convolutional Neural Network (CNN) model showed a coefficient of determination of 0.9987. which is consistent with the required model. The trained network was then used to estimate absolute distances with and without the addition of noise. The comparison proves that the proposed method is noise-proof and has high adaptability for measurements under different conditions.

Optimized ensemble learning with multi-feature fusion for enhanced anti-inflammatory peptide prediction.

Identification of crops is an important topic in the agricultural domain. Hyperspectral remote sensing data are very useful for crop feature extraction and classification. Remote sensing data is an unstructured data and Convolutional Neural Network (CNN) can work on unstructured data efficiently. This paper presents an evaluation of CNN for crop classification using the Indian Pines standard dataset obtained from the AVIRIS sensor and the study area dataset obtained from the EO-1hyperion sensor. Optimized CNN has been tuned by training the model on different parameters. It has been compared with two classification algorithms: Deep Neural Network (DNN) and Convolutional Autoencoder. According to the test results, the proposed optimized CNN model provided better results as compared to the other two methods. CNN has given 97 ± 0.58% overall accuracy for the Indian Pines standard dataset and 78 ± 2.43% for our study area dataset.

BackgroundSurgical site infection (SSI) is one of the most common types of health care–associated infections. It increases mortality, prolongs hospital length of stay, and raises health care costs. Many institutions developed risk assessment models for SSI to help surgeons preoperatively identify high-risk patients and guide clinical intervention. However, most of these models had low accuracies.ObjectiveWe aimed to provide a solution in the form of an Artificial intelligence–based Multimodal Risk Assessment Model for Surgical site infection (AMRAMS) for inpatients undergoing operations, using routinely collected clinical data. We internally and externally validated the discriminations of the models, which combined various machine learning and natural language processing techniques, and compared them with the National Nosocomial Infections Surveillance (NNIS) risk index.MethodsWe retrieved inpatient records between January 1, 2014, and June 30, 2019, from the electronic medical record (EMR) system of Rui Jin Hospital, Luwan Branch, Shanghai, China. We used data from before July 1, 2018, as the development set for internal validation and the remaining data as the test set for external validation. We included patient demographics, preoperative lab results, and free-text preoperative notes as our features. We used word-embedding techniques to encode text information, and we trained the LASSO (least absolute shrinkage and selection operator) model, random forest model, gradient boosting decision tree (GBDT) model, convolutional neural network (CNN) model, and self-attention network model using the combined data. Surgeons manually scored the NNIS risk index values.ResultsFor internal bootstrapping validation, CNN yielded the highest mean area under the receiver operating characteristic curve (AUROC) of 0.889 (95% CI 0.886-0.892), and the paired-sample t test revealed statistically significant advantages as compared with other models (P<.001). The self-attention network yielded the second-highest mean AUROC of 0.882 (95% CI 0.878-0.886), but the AUROC was only numerically higher than the AUROC of the third-best model, GBDT with text embeddings (mean AUROC 0.881, 95% CI 0.878-0.884, P=.47). The AUROCs of LASSO, random forest, and GBDT models using text embeddings were statistically higher than the AUROCs of models not using text embeddings (P<.001). For external validation, the self-attention network yielded the highest AUROC of 0.879. CNN was the second-best model (AUROC 0.878), and GBDT with text embeddings was the third-best model (AUROC 0.872). The NNIS risk index scored by surgeons had an AUROC of 0.651.ConclusionsOur AMRAMS based on EMR data and deep learning methods—CNN and self-attention network—had significant advantages in terms of accuracy compared with other conventional machine learning methods and the NNIS risk index. Moreover, the semantic embeddings of preoperative notes improved the model performance further. Our models could replace the NNIS risk index to provide personalized guidance for the preoperative intervention of SSIs. Through this case, we offered an easy-to-implement solution for building multimodal RAMs for other similar scenarios.

The feasibility of localizing, segmenting, and classifying individual cells in multi-channel confocal microscopy images is highly dependent on image quality. In certain applications, with good image quality, the segmentation can be trivial and accomplished via thresholding, watershed, or a collection of other well-established and studied heuristics; however, at the limit of poor image quality and complex image features, these techniques fail. It is at this limit that deep convolutional neural network (DCNN) approaches excel. Our research studies the interaction of individual immune cells and their shape changes relative to inflammatory immune reactions1 using multi-channel immunofluorescence imaging of renal biopsies from patients with inflammatory kidney disease. We present here a deep learning methodology for application to nuclear and cell membrane immunofluorescent stains to automatically segment and classify multiple T-cell and dendritic cell types. With both T-cells and dendritic cells segmented, we are able to study how T-cells with different surface antigens change shape with proximity to dendritic cells. Shape changes are seen when T-cells move close to dendritic cells and interact. We use a sliding window, max-filtering DCNN to segment and classify 3 cell types from 6 image stains channels within a single DCNN. This DCNN maintains images at original resolution throughout the network using dilated convolutions and max-filtering in place of max pooling layers. In addition, we use 3D convolution kernels with two spatial dimensions and one channel dimension. This allows us to output a multi-class binary classification based on multichannel data at the original image resolution. We trained and validated the network across 24 patients with 8,572 segmented cells. Our results demonstrate a mean Dice-Sorensen score of 0.78 +/- 0.18, a mean classification sensitivity of 0.76, and a mean classification specificity of 0.75 across all 3 segmented cell types.

Deep learning has emerged as a state-of-the-art learning technique across a wide range of applications, including image recognition, object detection and localisation, natural language processing, prediction and forecasting systems. With significant applicability, deep learning could be used in new and broader areas of applications, including remanufacturing. Remanufacturing is a process of taking used products through disassembly, inspection, cleaning, reconditioning, reassembly and testing to ascertain that their condition meets new products conditions with warranty. This process is complex and requires a good understanding of the respective stages for proper analysis. Inspection is a critical process in remanufacturing, which guarantees the quality of the remanufactured products. It is currently an expensive manual operation in the remanufacturing process that depends on operator expertise, in most cases. This research investigates the application of deep learning algorithms to inspection in remanufacturing, towards automating the inspection process. This paper presents a novel vision-based inspection system based on deep convolution neural network (DCNN) for eight types of defects, namely pitting, rust, cracks and other combination faults. The materials used for this feasibility study were 100 cm × 150 cm mild steel plate material, purchased locally, and captured using a USB webcam of 0.3 megapixels. The performance of this preliminary study indicates that the DCNN can classify with up to 100% accuracy on validation data and above 96% accuracy on a live video feed, by using 80% of the sample dataset for training and the remaining 20% for testing. Therefore, in the remanufacturing parts inspection, the DCNN approach has high potential as a method that could surpass the current technologies used in the design of inspection systems. This research is the first to apply deep learning techniques in remanufacturing inspection. The proposed method offers the potential to eliminate expert judgement in inspection, save cost, increase throughput and improve precision. This preliminary study demonstrates that deep learning techniques have the potential to revolutionise inspection in remanufacturing. This research offers valuable insight into these opportunities, serving as a starting point for future applications of deep learning algorithms to remanufacturing.

paper, we focus on exploring the relationship between weave patterns and their mechanical properties in woven fiber composites through Machine Learning. Specifically, we explore the interactions between woven architectures and in-plane stiffness properties through Deep Convolutional Neural Network (DCNN) and Generative Adversarial Network (GAN). Our research is important for exploring how woven composite’s pattern is related to its mechanical properties and accelerating woven composite design as well as optimization. We focus on two tasks: (1) Stiffness prediction: Predicting in-plane stiffness properties for given weave patterns. Our DCNN extracts high-level features through several convolutional and fully connected layers to determine the final predictions. (2) Weave pattern prediction: Predicting weave patterns for target stiffness properties, which can be treated as the reverse task of the first one. Due to many-to-one mapping between weave patterns and the composite properties, we utilize a Decoder Neural Network as our baseline model and compare its performance with GAN and Genetic Algorithm. We represent the weave patterns as 2D checkerboard models and use finite element analysis (FEA) to determine in-plane stiffness properties, which serve as input data for our ML framework. We show that: (1) for stiffness prediction, DCNN can predict stiffness values for a given weave pattern with relatively high accuracy (above 93%); (2) for weave pattern prediction, the GAN model gives the best prediction accuracy (above 92%) while Decoder Neural Network has the best time efficiency. HAOTIAN FENG

Evaluation of the benchmark datasets for testing the efficacy of deep convolutional neural networks

PurposeThis study aims to investigate values of intra- and peri-tumoral regions in the mammography and magnetic resonance imaging (MRI) image for prediction of sentinel lymph node metastasis (SLNM) in invasive breast cancer (BC).MethodsThis study included 208 patients with invasive BC between Spe. 2017 and Apr. 2021. All patients underwent preoperative digital mammography (DM), digital breast tomosynthesis (DBT), dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) scans. Radiomics features were extracted from manually outlined intratumoral regions, and automatically dilated peritumoral tumor regions in each modality. The least absolute shrinkage and selection operator (LASSO) regression was used to select key features from each region to develop radiomics signatures (RSs). Area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity and negative predictive value (NPV) were calculated to evaluate performance of the RSs.ResultsIntra- and peri-tumoral regions of BC can provide complementary information on the SLN status. In each modality, the Com-RSs derived from combined intra- and peri-tumoral regions always yielded higher AUCs than the Intra-RSs or Peri-RSs. A total of 10 and 11 features were identified as the most important predictors from mammography (DM plus DBT) and MRI (DCE-MRI plus DWI), respectively. The DCE-MRI plus DWI generated higher AUCs compared with DM plus DBT in the training (AUCs, DCE-MRI plus DWI vs. DM plus DBT, 0.897 vs. 0.846) and validation (AUCs, DCE-MRI plus DWI vs. DM plus DBT, 0.826 vs. 0.786) cohort.ConclusionsRadiomics features from intra- and peri-tumoral regions can provide complementary information to identify the SLNM in both mammography and MRI. The DCE-MRI plus DWI generated lower specificity, but higher AUC, accuracy, sensitivity and negative predictive value compared with DM plus DBT.

Text recognition in natural scene images is a challenging problem in computer vision. Different than the optical character recognition (OCR), text recognition in natural scene images is more complex due to variations in text size, colors, fonts, orientations, complex backgrounds, occlusion, illuminations and uneven lighting conditions. In this paper, we propose a segmentation-free method based on a deep convolutional recurrent neural network to solve the problem of cursive text recognition, particularly focusing on Urdu text in natural scenes. Compared to the non-cursive scripts, Urdu text recognition is more complex due to variations in the writing styles, several shapes of the same character, connected text, ligature overlapping, stretched, diagonal and condensed text. The proposed model gets a whole word image as an input without pre-segmenting into individual characters, and then transforms into the sequence of the relevant features. Our model is based on three components: a deep convolutional neural network (CNN) with shortcut connections to extract and encode the features, a recurrent neural network (RNN) to decode the convolutional features, and a connectionist temporal classification (CTC) to map the predicted sequences into the target labels. To increase the text recognition accuracy further, we explore deeper CNN architectures like VGG-16, VGG-19, ResNet-18 and ResNet-34 to extract more appropriate Urdu text features, and compare the recognition results. To conduct the experiments, a new large-scale benchmark dataset of cropped Urdu word images in natural scenes is developed. The experimental results show that the proposed deep CRNN network with shortcut connections outperform than other network architectures. The dataset is publicly available and can be downloaded from <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://data.mendeley.com/datasets/k5fz57zd9z/1</uri> .