Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets

CancerVolume 15, Issue 5 p. 1009-1018 ArticleFree Access Comparative data on cancer in aging twins Lissy F. Jarvik M.D., PH.D., Lissy F. Jarvik M.D., PH.D. Department of Medical Genetics, New York State Psychiatric Institute, 722 W. 168th St., New York 32, N.YSearch for more papers by this authorArthur Falek PH.D., Arthur Falek PH.D. Department of Medical Genetics, New York State Psychiatric Institute, 722 W. 168th St., New York 32, N.YSearch for more papers by this author Lissy F. Jarvik M.D., PH.D., Lissy F. Jarvik M.D., PH.D. Department of Medical Genetics, New York State Psychiatric Institute, 722 W. 168th St., New York 32, N.YSearch for more papers by this authorArthur Falek PH.D., Arthur Falek PH.D. Department of Medical Genetics, New York State Psychiatric Institute, 722 W. 168th St., New York 32, N.YSearch for more papers by this author First published: September/October 1962 https://doi.org/10.1002/1097-0142(196209/10)15:5<1009::AID-CNCR2820150518>3.0.CO;2-9Citations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume15, Issue5September/October 1962Pages 1009-1018 ReferencesRelatedInformation

Despite a marked increase in treatment for bipolar disorder among youths, little is known about their pattern of service use. This article describes mental health service use in the year before and after a new clinical diagnosis of bipolar disorder. Claims were reviewed between April 1, 2004, and March 31, 2005, for 1,274,726 privately insured youths (17 years and younger) who were eligible for services at least one year before and after a service claim; 2,907 youths had new diagnosis of bipolar disorder during this period. Diagnoses of other mental disorders and prescriptions filled for psychotropic drugs were assessed in the year before and after the initial diagnosis of bipolar disorder. The one-year rate of a new diagnosis of bipolar disorder was .23%. During the year before the new diagnosis of bipolar disorder, youths were commonly diagnosed as having depressive disorder (46.5%) or disruptive behavior disorder (36.7%) and had often filled a prescription for an antidepressant (48.5%), stimulant (33.0%), mood stabilizer (31.8%), or antipsychotic (29.1%). Most youths with a new diagnosis of bipolar disorder had only one (28.8%) or two to four (28.7%) insurance claims for bipolar disorder in the year starting with the index diagnosis. The proportion starting mood stabilizers after the index diagnosis was highest for youths with five or more insurance claims for bipolar disorder (42.1%), intermediate for those with two to four claims (24.2%), and lowest for those with one claim (13.8%). Most youths with a new diagnosis of bipolar disorder had recently received treatment for depressive or disruptive behavior disorders, and many had no claims listing a diagnosis of bipolar disorder after the initial diagnosis. The service pattern suggests that a diagnosis of bipolar disorder is often given tentatively to youths treated for mental disorders with overlapping symptom profiles and is subsequently reconsidered.

Epidemiologic surveys have mapped the terrain of psychiatric disorders.Personality disorders have bedeviled the clinician's practice.Rarely have these two been rearranged in a meaningful clinical dialogue.Using the largest psychiatric epidemiologic survey ever, the National Epidemiologic Survey on Alcoholism and Related Conditions, and among the few to venture into axis II disorders, Skodol et al. (1), in this issue of the Journal, give a community-based national view of a common clinical question: What is the effect of specific personality disorder comorbidity on the course of major depression?The original sample included over 40,000 adults, and 2,422 met criteria for DSM-IV current major depressive disorder.Three years later, 1,996 of the original currently depressed subjects were available for reinterviewing, which makes both a respectable sample size and response rate for generalizability.However, some caution is needed, since the sample was over-represented with Caucasian, college-educated, and married respondents.Fifteen percent of participants had persistent major depressive disorder, and 7.3% of those who remitted had a recurrence over the follow-up period.These figures are within the range of longitudinal studies of patients with major depressive disorder (2).While the presence of any personality disorder elevated the risk for persistence of major depressive disorder, when all axis I and II disorders, age of onset of major depressive disorder, number of previous episodes, family history, treatment, and duration of illness were controlled, borderline personality disorder remained the most robust predictor of major depressive disorder persistence.Neither personality disorders nor other clinical variables predicted recurrence of major depressive disorder.Thus, an epidemiologic survey yielded a practical jewel.The finding, undoubtedly, does not surprise the clinician but is now confirmed nationally.As the authors conclude, borderline personality disorder should be assessed in all depressed patients and considered in prognosis and addressed in treatment.One can raise a number of methodologic issues about this study, including the use of lay interviewers or the instrument for assessing axis II disorders.The diagnostic interview, the Alcohol Use Disorder and Associated Disabilities Interview Schedule, DSM-IV version (3), was developed for this survey.The personality disorders included were adapted from items in the Structured Clinical Interview for DSM-IV Personality Disorders.The test-retest and internal consistency results reported for all personality disorders are fair to good, not great.However, the agreement with clinician interviews for borderline personality disorder (kappa=0.71) is about as good as it gets (4).The only other national survey to venture into assessing all axis II disorders was the National Comorbidity Survey Replication (5), which used the International Personality Disorder Examination.The investigators carried out a clinical reappraisal in a sample of 214 subjects using clinically trained interviewers to follow up screened, positive subjects and reported excellent predictions of classification.They also noted that the International Personality Disorder Examination is commonly regarded as

Public's View of Mental Health Services for the Elderly: Responses to Dear Abby

Corrigendum to “fMRI response to negative words and SSRI treatment outcome in major depressive disorder: A preliminary study” [Psychiatry Res.: Neuroimaging 214 (3) (2013) 296–305

Depression and AnxietyVolume 33, Issue 5 p. 357-358 Commentary PSYCHOLOGIES OF SMALL DIFFERENCES John C. Markowitz M.D., Corresponding Author John C. Markowitz M.D. Professor of Clinical Psychiatry, Columbia University, Research Psychiatrist, New York State Psychiatric Institute, New YorkCorrespondence to: John C. Markowitz, M.D., New York State Psychiatric Institute, 1051 Riverside Drive, Unit #129, New York, NY 10032. E-mail: jcm42@cumc.columbia.eduSearch for more papers by this author John C. Markowitz M.D., Corresponding Author John C. Markowitz M.D. Professor of Clinical Psychiatry, Columbia University, Research Psychiatrist, New York State Psychiatric Institute, New YorkCorrespondence to: John C. Markowitz, M.D., New York State Psychiatric Institute, 1051 Riverside Drive, Unit #129, New York, NY 10032. E-mail: jcm42@cumc.columbia.eduSearch for more papers by this author First published: 26 April 2016 https://doi.org/10.1002/da.22488Citations: 2 The author has no formal conflicts of interest in writing this commentary—but, as he suggests in this commentary, we all have intellectual conflicts of interest. He aspires to evenhandedness. The author thanks Barbara Milrod, M.D. for her comments on an earlier draft of this commentary. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume33, Issue5FOCUS ON TREATMENTMay 2016Pages 357-358 RelatedInformation

Back to table of contents Previous article Next article ColumnFull AccessDatapoints: HIV Infection Linked to Substance Use Among Hospitalized Patients With Severe Mental IllnessKaren McKinnon, M.A., and Francine Cournos, M.D.Karen McKinnonSearch for more papers by this author, M.A., and Francine CournosSearch for more papers by this author, M.D.Published Online:1 Oct 1998https://doi.org/10.1176/ps.49.10.1269AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail Last June the National Institute of Mental Health adopted new priorities to address the AIDS epidemic among people with severe mental illness. Besides prevention and treatment, the priorities emphasize the need for a fuller understanding of the extent and social organization of sexual and drug use behavior, the nationwide prevalence of HIV, and the nature of causality between mental illness and HIV infection (1). Eleven studies of 2,873 predominantly hospital-based psychiatric patients in New York City, Baltimore, and Columbia, South Carolina, indicate the average HIV infection rate among adults with severe mental illness is 7.8 percent (2), nearly 20 times the rate of .4 percent estimated for the general population (3). Across studies, psychiatric patients with identified comorbid alcohol or other drug use disorders have a significantly higher rate of infection than those without (χ2 =47.56, df=9, p<.001) (see Figure 1). Among patients treated on dual diagnosis units, HIV seroprevalence is significantly related to type of substance used (χ2 =8.82, df=2, p<.03) (see Figure 2). Drug injection confers the highest risk, but even use of noninjected drugs or alcohol alone resulted in rates of infection substantially higher than the average rate. Patients with alcohol or other drug use disorders may be members of social networks where sex and drugs combine to create vulnerability to sexually transmitted HIV infection.Mental health care providers are often in the best position to assess patients' sexual and drug use behaviors. Only by asking can providers learn their patients' HIV-related risks and service needs and appropriately address them to reduce the human and economic costs of the AIDS epidemic.AcknowledgmentsThis work was supported by the New York State Office of Mental Health and the Center for Mental Health Services. The authors are affiliated with the department of psychiatry at Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute. Send correspondence to Ms. McKinnon at 722 West 168 Street, Unit 112, New York, New York 10032 (e-mail [email protected]). Harold Alan Pincus, M.D., and Terri L. Tanielian, M.A., are coeditors of this column. Figure 1. HIV infection rate (in percentages) among 2,873 psychiatric patients, by treatment settingFigure 2. HIV infection rate (in percentages) among 174 patients on dual diagnosis units, by type of drug used

Anorexia Nervosa

Departments of Psychiatry and Behavioral Sciences and Pediatrics, and Division of Medical Genetics, University of Washington Medical School and Children's Orthopedic Hospital and Medical Center, Seattle, Washington; Department of Psychiatry, College of Physicians and Surgeons, Columbia University; and New York State Psychiatric Institute, New York, New York Clin. Genet. 29: 284, 1986

Independent foundations' primary focus is grant making.In general, their assets come from the gift of an individual or family.Community foundations' assets usually come from many donors rather than a single source, and grant making is limited to a particular region.Community foundations are usually classified as private charities under the tax law and are subject to different rules and regulations than are other private foundations. Access To CareAccording to 1988 Census Bureau estimates, over thirty-one million Americans are without health insurance.The demographics of these people are diverse, and their ranks continue to grow as the service industry burgeons and as competition in health care increases.Regional disparities in access also exist.Foundation funding in this area ranges from economic analyses of the problem to direct provision of care.

Seminars in DialysisVolume 27, Issue 6 p. 542-544 The Use and Interpretation of Diagnostic Tests in Dialysis Patients Measurement and Interpretation of Serum Sodium in End-Stage Kidney Disease Patients Cecile Courivaud, Cecile Courivaud Department of Nephrology, Dialysis and Renal Transplantation Besançon University Hospital, Besancon, FranceSearch for more papers by this authorAndrew Davenport, Corresponding Author Andrew Davenport Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, United Kingdom Address correspondence to: Andrew Davenport, Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, United Kingdom, Tel.: +44-4726-457, Fax: +44-2073178591, or e-mail: [email protected].Search for more papers by this author Cecile Courivaud, Cecile Courivaud Department of Nephrology, Dialysis and Renal Transplantation Besançon University Hospital, Besancon, FranceSearch for more papers by this authorAndrew Davenport, Corresponding Author Andrew Davenport Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, United Kingdom Address correspondence to: Andrew Davenport, Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, United Kingdom, Tel.: +44-4726-457, Fax: +44-2073178591, or e-mail: [email protected].Search for more papers by this author First published: 27 June 2014 https://doi.org/10.1111/sdi.12265Citations: 7Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume27, Issue6Special Issue: The Use and Interpretation of Diagnostic Tests in Dialysis PatientsNovember–December 2014Pages 542-544 RelatedInformation

Kaposi’s Sarcoma: The Scarlet Letter of AIDS: The Psychological Effects of a Skin Disease

Mental disorders are among the most prevalent, chronic, and disabling health conditions; they touch the lives of all Americans in some way.1 Although these disorders clearly have biological correlates, they are also substantially influenced by modifiable social, economic, and environmental conditions that affect not only individuals, but whole communities, neighborhoods, and populations. Historically, many theories have been postulated to help explain the origins of disease. During the 19th century, miasma theory attributed the causes of disease epidemics to “bad air” and led to a focus on public health interventions to improve living conditions of populations as a means of effectively limiting the incidence and prevalence of disease.2 This theory, although later supplanted by the germ theory of disease, was one of the earliest conceptualizations supporting the role of social factors in causing and sustaining illnesses. Furthermore, miasma theory led to important public health interventions, such as urban sanitation Ruth Shim, MD, MPH, is Associate Professor, Department of Psychiatry and Behavioral Sciences; Associate Director, National Center for Primary Care, Morehouse School of Medicine. Carol Koplan, MD, is Adjunct Assistant Professor, Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University. Frederick J.P. Langheim, MD, PhD, is Joint Director, Consultation and Liaison Psychiatry, St. Mary’s Hospital; Staff Psychiatrist, Dean Health System; Clinical Adjunct Assistant Professor, University of Wisconsin, Madison. Marc W. Manseau, MD, MPH, is Public Psychiatry Fellow, Department of Psychiatry, Columbia University Medical Center, New York State Psychiatric Institute. Rebecca A. Powers, MD, MPH, is Adjunct Clinical Associate Professor of Psychiatry, Stanford University School of Medicine. Michael T. Compton, MD, MPH, is Chairman, Department of Psychiatry, Lenox Hill Hospital; Professor, Department of Psychiatry, Hofstra North Shore – LIJ School of Medicine at Hofstra University. Address correspondence to: Ruth Shim, MD, MPH, National Center for Primary Care, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310; email: rshim@msm. edu. Disclosure: The authors have no relevant financial relationships to disclose. doi: 10.3928/00485713-20140108-04 The Social Determinants of Mental Health: An Overview and Call to Action

Acta Psychiatrica ScandinavicaVolume 121, Issue 2 p. 157-157 Reply M. Weiser, M. Weiser Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorN. Werbeloff, N. Werbeloff Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorD. Dalperin, D. Dalperin Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorE. Kravitz, E. Kravitz Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorR. Yoffe, R. Yoffe Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorM. Davidson, M. Davidson Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this author M. Weiser, M. Weiser Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorN. Werbeloff, N. Werbeloff Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorD. Dalperin, D. Dalperin Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorE. Kravitz, E. Kravitz Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorR. Yoffe, R. Yoffe Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this authorM. Davidson, M. Davidson Department Of Psychiatry, Sheba Medical Center, and Department of Psychiatry, Sackler School of Medicine, Tel Aviv University, Israel E-mail: mweiser@netvision.net.ilSearch for more papers by this author First published: 04 January 2010 https://doi.org/10.1111/j.1600-0447.2009.01499.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume121, Issue2February 2010Pages 157-157 RelatedInformation

Hookah use among college students: Prevalence, mental health and drug use