Ajanta Pharma (India)

Background: Hypertension, affecting 31% of the Indian population, is a major risk factor for cardiovascular diseases. Cilnidipine is used in its management, alone or in combination with ARB. The objective of the current KAP survey was to assess the knowledge of healthcare professionals (HCPs) regarding hypertension management, their attitudes toward its treatment, and the application of this knowledge in clinical practice. Method: A pan-India cross-sectional KAP survey was conducted from April 2022 to March 2023. The survey utilized a specially designed questionnaire focusing on various aspects of using cilnidipine and its combination with Telmisartan in hypertension management. A total of 1,254 HCPs with recognized qualifications participated. Descriptive statistics were employed for data analysis. Results: Around 56% of HCPs initiated monotherapy of an antihypertensive drug at an SBP level of 140 mmHg, while 57% initiated combination therapy at an SBP>160 mmHg. Nearly 43% reported initiating combination therapy in 20-30% of patients as initial treatment. Cilnidipine was preferred over amlodipine mainly due to decreased pedal edema. Cilnidipine monotherapy benefits young hypertensive patients (46%) and those with chronic kidney disease (CKD, 44%). Cilnidipine and telmisartan combination benefits patients with uncontrolled hypertension (46%), diabetes (43%), and CKD (41%). Advantages of this combination include less fluid retention, better compliance and tolerability, and less pedal edema. Conclusion: This KAP survey highlights current practices in hypertension management, emphasizing the use of cilnidipine and its combination, attributed to their favorable tolerability and suitability for diverse patient profiles.

We describe an unusual clinical presentation of autoimmune Bartter syndrome in a patient with primary hypothyroidism. A 65-year-old female patient was admitted with neuromuscular weakness associated with hypokalemia and metabolic alkalosis. She had a suboptimal response to potassium supplementation and potassium-sparing diuretic resulting in re-hospitalization with the same symptoms. A detailed serum and urinary biochemistry analysis in the absence of other causes of potassium wasting helped diagnose Bartter syndrome, a rare entity in adults. An autoimmune profile showed anti-Scl-70 antibody to be positive, although she did not develop other systemic features of the disease. Our patient responded to a steroid-based regimen potassium supplement, Indomethacin, and aldosterone antagonist with remarkable resolution of symptoms and correction of electrolyte derangement. We reviewed the literature to search for similar cases and included twenty-seven full-length publications on acquired and autoimmune causes of Bartter syndrome. Our case highlights the fact that hypokalemia with metabolic alkalosis in an adult patient should prompt clinicians to evaluate for common and uncommon conditions. While assessing for abnormal conditions, acquired Bartter syndrome should be considered if a patient has an underlying autoimmune, endocrine, or connective tissue disease.

BJOG: An International Journal of Obstetrics & GynaecologyVolume 124, Issue 12 p. 1908-1909 BJOG Exchange Re: Quality of life among women in Bangladesh following ileal conduit urinary diversion operations for irreparable vesicovaginal fistula and bladder exstrophy; observational study Saumya Pandey, Saumya Pandey Department of Obstetrics-Gynecology, Ajanta Hospital and IVF Centre, Lucknow, UP, India Department of Biochemistry & Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX, USASearch for more papers by this author Saumya Pandey, Saumya Pandey Department of Obstetrics-Gynecology, Ajanta Hospital and IVF Centre, Lucknow, UP, India Department of Biochemistry & Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX, USASearch for more papers by this author First published: 09 August 2017 https://doi.org/10.1111/1471-0528.14775Citations: 4Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume124, Issue12November 2017Pages 1908-1909 RelatedInformation

From the Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH. Address correspondence and reprint requests to William Abdu, MD, MS, Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756; E-mail: [email protected] Acknowledgment date: April 10, 2015. Acceptance date: April 13, 2015. The manuscript submitted does not contain information about medical device(s)/drug(s). No funds were received in support of this work. No relevant financial activities outside the submitted work.

Anjos has such peculiar characteristics that impart him an isolated position in theBrazilianliterarytradition.Theaimofthisdissertationistoinvestigatethe particularities of his work to make it possible to apprehend its main concepts andmeanings.

more evidence of the origin of the Freinet method in Las Hurdes