Aiming at construction of First-class curriculum, the courses "Microcomputer Principle and Interface Technology" and "Single-chip Microcomputer" are combined into one course according to there are similar instruction architecture. Two main section include into this combined course, microcomputer principle and interface technology. In the part of microcomputer principle focuses on the intel 80X86 processor architecture and instruction set. In the part of interface technology focuses on intel 8051 interface circuit and C language programming. The related experimental topics are also increased to provide more practical opportunities for students. The start time of this combined course is moved up to spring semester in second year. With these reforms above made this course to provide beneficial support for innovative practice of students. After more than three years of practice, the ability for students to use microcomputers and practical innovation have been greatly improved, which is reflected in the fact that students have achieved very good results in various innovation competitions.